Biomarker & Intervention Discovery
Tinnitus
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
US DALYs176.4KWHO GHE 2021 · all ages
Global DALYs3.71MWHO GHE 2021 · worldwide
US mortality120 deaths/yrWHO GHE 2021
Global mortality760 deaths/yrWHO GHE 2021 · worldwide
Spontaneous remissionSpontaneous resolution in 50-60% of acute tinnitus (<3 months) without treatment; chronic tinnitus (>3 months): only…
Best-intervention remissionCognitive behavioural therapy (CBT): 50-60% reduction in tinnitus-related distress (not sound elimination); tinnitus…
Gap sizeVery large — no pharmacological treatment exists; CBT and TRT are evidence-based but massively under-accessed
Primary barrierbiological + access
Full remission profile →
Remission & chronicity
Spontaneous remission
Spontaneous resolution in 50-60% of acute tinnitus (<3 months) without treatment; chronic tinnitus (>3 months): only 10-15% spontaneous resolution; habituated tinnitus (not distressing) in 75% at 5 years but sound remains in most
Best-intervention remission
Cognitive behavioural therapy (CBT): 50-60% reduction in tinnitus-related distress (not sound elimination); tinnitus retraining therapy (TRT): 80% improvement in distress over 18 months; hearing aids for comorbid hearing loss: modest tinnitus reduction; sound therapy (masking): symptom relief without cure
Gap size
Very large — no pharmacological treatment exists; CBT and TRT are evidence-based but massively under-accessed
Primary barrier
biological + access
No effective pharmacotherapy exists (multiple drug classes tried and failed); sound therapy and CBT are the only evidence-based interventions but trained tinnitus therapists are scarce; most patients are told to 'live with it'; digital CBT for tinnitus (iCBT) emerging as scalable solution
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Tinnitus” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."