Disease Overview
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: Clinical > Mechanistic > Correlative.
GRIN2B
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| DIMIRACETAM | ? unclear | Mechanistic | DGIdb | |
| KETAMINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PERZINFOTEL | ↓ inhibits | Mechanistic | DGIdb | |
| [3H]CGP39653 | ↓ inhibits | Mechanistic | DGIdb | |
| PHENCYCLIDINE | ↓ inhibits | Mechanistic | DGIdb | |
| DEXANABINOL | ? unclear | Mechanistic | DGIdb | |
| RAPASTINEL | ↑ activates | Mechanistic | DGIdb | |
| DELUCEMINE | ↓ inhibits | Mechanistic | DGIdb | |
| AMANTADINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| RISLENEMDAZ | ↓ inhibits | Mechanistic | DGIdb | |
| ORPHENADRINE CITRATE | ↓ inhibits | Mechanistic | DGIdb | |
| ELIPRODIL | ? unclear | Mechanistic | 13.0 nM (Ki) | DGIdb |
| INDANTADOL | ? unclear | Mechanistic | DGIdb | |
| SEVOFLURANE | ? unclear | Mechanistic | DGIdb | |
| SAGE-718 | ~ modulates | Mechanistic | DGIdb | |
| L689560 | ↓ inhibits | Mechanistic | DGIdb | |
| ONFASPRODIL | ~ modulates | Mechanistic | DGIdb | |
| HOMOQUINOLINIC ACID | ↑ activates | Mechanistic | DGIdb | |
| NEBOGLAMINE | ~ modulates | Mechanistic | DGIdb | |
| DIZOCILPINE | ↓ inhibits | Mechanistic | DGIdb | |
| LY233053 | ↓ inhibits | Mechanistic | DGIdb | |
| GLYCINE | ↑ activates | Mechanistic | DGIdb | |
| ESKETAMINE | ~ modulates | Mechanistic | DGIdb | |
| [3H]CGP61594 | ↓ inhibits | Mechanistic | DGIdb | |
| ORPHENADRINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| [3H]MDL105519 | ↓ inhibits | Mechanistic | DGIdb | |
| RADIPRODIL | ? unclear | Mechanistic | DGIdb | |
| NBQX | ? unclear | Mechanistic | DGIdb | |
| SEMAPIMOD | ↓ inhibits | Mechanistic | DGIdb | |
| SELFOTEL | ↓ inhibits | Mechanistic | DGIdb | |
| SERINE, D- | ↑ activates | Mechanistic | DGIdb | |
| COMPOUND 18C [PMID: 25901531] | ↓ inhibits | Mechanistic | DGIdb | |
| AZD8108 | ↓ inhibits | Mechanistic | DGIdb | |
| [3H]L689560 | ↓ inhibits | Mechanistic | DGIdb | |
| TRAXOPRODIL | ↓ inhibits | Mechanistic | 74.0 nM (IC50) | DGIdb |
| HALOPERIDOL DECANOATE | ? unclear | Mechanistic | DGIdb | |
| N1-DANSYL-SPERMINE | ↓ inhibits | Mechanistic | DGIdb | |
| [3H]D-ASPARTIC ACID | ↑ activates | Mechanistic | DGIdb | |
| NERAMEXANE | ? unclear | Mechanistic | DGIdb | |
| NVP-AAM077 | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 238 agents ranked by evidence tier.
PTGS2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CARPROFEN | ↓ inhibits | Mechanistic | 102.0 nM (IC50) | DGIdb |
| INDOMETHACIN SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| DARBUFELONE | ? unclear | Mechanistic | DGIdb | |
| MEFENAMIC ACID | ↓ inhibits | Mechanistic | DGIdb | |
| MECLOFENAMATE SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| DICLOFENAC SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| CAPECITABINE | ? unclear | Mechanistic | DGIdb | |
| PIRPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| ESFLURBIPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| SULFASALAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| BROMFENAC | ? unclear | Mechanistic | DGIdb | |
| IBUPROFEN, SODIUM SALT | ↓ inhibits | Mechanistic | DGIdb | |
| ALOXIPRIN | ↓ inhibits | Mechanistic | DGIdb | |
| TENOXICAM | ? unclear | Mechanistic | DGIdb | |
| FLURBIPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| SALICYLIC ACID | ? unclear | Mechanistic | DGIdb | |
| ATENOLOL | ? unclear | Mechanistic | DGIdb | |
| DEXKETOPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| ETORICOXIB | ↓ inhibits | Mechanistic | DGIdb | |
| LUMIRACOXIB | ↓ inhibits | Mechanistic | DGIdb | |
| SUPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| NS-398 | ? unclear | Mechanistic | DGIdb | |
| NABUMETONE | ↓ inhibits | Mechanistic | DGIdb | |
| URSOLIC ACID | ? unclear | Mechanistic | DGIdb | |
| IBUPROFEN LYSINE | ↓ inhibits | Mechanistic | DGIdb | |
| ACECLOFENAC | ↓ inhibits | Mechanistic | DGIdb | |
| IBUFENAC | ↓ inhibits | Mechanistic | DGIdb | |
| BALSALAZIDE | ? unclear | Mechanistic | DGIdb | |
| DIFLUNISAL | ↓ inhibits | Mechanistic | DGIdb | |
| BALSALAZIDE DISODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| VACCINE | ? unclear | Mechanistic | DGIdb | |
| KETOROLAC TROMETHAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| BENZYDAMINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| TIAPROFENIC ACID | ? unclear | Mechanistic | DGIdb | |
| RALOXIFENE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| NAPROXCINOD | ↓ inhibits | Mechanistic | DGIdb | |
| IGURATIMOD | ↓ inhibits | Mechanistic | DGIdb | |
| ETODOLAC | ↓ inhibits | Mechanistic | DGIdb | |
| DICLOFENAC ETALHYALURONATE SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| ROFECOXIB | ↓ inhibits | Mechanistic | 530.0 nM (IC50) | DGIdb |
Showing top 40 of 299 agents ranked by evidence tier.
SCN9A
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| MERETHOXYLLINE PROCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| ETIDOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| FOSPHENYTOIN | ↓ inhibits | Mechanistic | DGIdb | |
| VERATRIDINE | ↑ activates | Mechanistic | DGIdb | |
| ORPHENADRINE CITRATE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENACEMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LACOSAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| VIXOTRIGINE | ↓ inhibits | Mechanistic | DGIdb | |
| DSP-2230 | ↓ inhibits | Mechanistic | DGIdb | |
| SAXITOXIN | ↓ inhibits | Mechanistic | DGIdb | |
| ESLICARBAZEPINE ACETATE | ↓ inhibits | Mechanistic | DGIdb | |
| SAFINAMIDE | ? unclear | Mechanistic | DGIdb | |
| LIDOCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| RILUZOLE | ↓ inhibits | Mechanistic | DGIdb | |
| ROPIVACAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| FUNAPIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DYCLONINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| EVENAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROPOFOL | ? unclear | Mechanistic | DGIdb | |
| AM-6120 | ↓ inhibits | Mechanistic | DGIdb | |
| RG7893 | ↓ inhibits | Mechanistic | DGIdb | |
| RG6029 | ↓ inhibits | Mechanistic | DGIdb | |
| QUINIDINE SULFATE | ↓ inhibits | Mechanistic | DGIdb | |
| ZONISAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| NERISPIRDINE | ↓ inhibits | Mechanistic | DGIdb | |
| RALFINAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DS-1971A | ↓ inhibits | Mechanistic | DGIdb | |
| HEXYLCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| MEPIVACAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROCAINAMIDE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROPAFENONE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LIDOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| QUINIDINE GLUCONATE | ↓ inhibits | Mechanistic | DGIdb | |
| PRILOCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| ETHOTOIN | ↓ inhibits | Mechanistic | DGIdb | |
| PF-05089771 | ↓ inhibits | Mechanistic | DGIdb | |
| DICHLOROBENZYL ALCOHOL | ↓ inhibits | Mechanistic | DGIdb | |
| RANOLAZINE | ? unclear | Mechanistic | DGIdb | |
| PRILOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ORPHENADRINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 271 agents ranked by evidence tier.
TRPV1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| STREPTOZOCIN | ? unclear | Mechanistic | DGIdb | |
| BENZYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| ACETAMINOPHEN | ↑ activates | Mechanistic | DGIdb | |
| POLYGODIAL | ? unclear | Mechanistic | DGIdb | |
| PROPOFOL | ? unclear | Mechanistic | DGIdb | |
| SAF312 | ↓ inhibits | Mechanistic | DGIdb | |
| GRC-15300 | ? unclear | Mechanistic | DGIdb | |
| AZD1386 | ↓ inhibits | Mechanistic | DGIdb | |
| TIVANISIRAN | ↓ inhibits | Mechanistic | DGIdb | |
| MAVATREP | ↓ inhibits | Mechanistic | DGIdb | |
| MR-1817 | ↓ inhibits | Mechanistic | DGIdb | |
| FERRUGINENE B | ? unclear | Mechanistic | DGIdb | |
| CAPSAICIN | ↑ activates | Mechanistic | 19.95 nM (EC50) | DGIdb |
| RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN | ? unclear | Mechanistic | DGIdb | |
| PHENETHYLISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| VOACANGINE | ? unclear | Mechanistic | DGIdb | |
| RESINIFERATOXIN | ↑ activates | Mechanistic | 23.1 nM (Ki) | DGIdb |
| DWP05195 | ↓ inhibits | Mechanistic | DGIdb | |
| XEN-D0501 | ↓ inhibits | Mechanistic | DGIdb | |
| PAC-14028 | ↓ inhibits | Mechanistic | DGIdb | |
| SB-705498 | ↓ inhibits | Mechanistic | DGIdb | |
| MASOPROCOL | ? unclear | Mechanistic | DGIdb | |
| ALLYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| NGD-8243 | ↓ inhibits | Mechanistic | DGIdb | |
| GRC-6211 | ↓ inhibits | Mechanistic | DGIdb | |
| RESERPINE | ? unclear | Mechanistic | DGIdb | |
| NABIXIMOLS | ? unclear | Mechanistic | DGIdb | |
| A425619 | ? unclear | Mechanistic | DGIdb | |
| PHE377 | ↓ inhibits | Mechanistic | DGIdb | |
| ANTISENSE OLIGONUCLEOTIDES | ? unclear | Mechanistic | DGIdb | |
| WORTMANNIN | ? unclear | Mechanistic | DGIdb | |
| JTS-653 | ↓ inhibits | Mechanistic | DGIdb | |
| LEVODOPA | ? unclear | Mechanistic | DGIdb | |
| AMG517 | ↓ inhibits | Mechanistic | DGIdb | |
| CAPSAZEPINE | ? unclear | Mechanistic | 120.0 nM (Ki) | DGIdb |
| ZUCAPSAICIN | ↑ activates | Mechanistic | DGIdb | |
| INDOMETHACIN | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL191534 | ? unclear | Mechanistic | DGIdb | |
| ABT-102 | ↓ inhibits | Mechanistic | DGIdb | |
| ISOPROPYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 160 agents ranked by evidence tier.
Clinical Trials
Drug, biologic and supplement trials (treatment or prevention) from ClinicalTrials.gov whose main condition is Tension Headache / Chronic Daily Headache: recruiting, active or completed, most recently updated first. Data retrieved 2026-10-28.
The goal of this clinical trial is to learn if Zhixuan Analgesic Tablet works to treat frequent episodic tension-type headache in adults aged 18-60 years. It will also learn about the safety of Zhixuan Analgesic Tablet. The main questions it aims to answer are: * Does Zhixuan Analgesic Tablet reduce...
To evaluate whether Desvenlafaxine can reduce the frequency and severity of TTH attacks in patients.
Chronic daily headaches (CDH) poses a significant burden on patients, healthcare systems and the society. Intravenous (IV) ketamine infusion, an intervention that is widely available and scalable, can treat CDH by reversing receptor-mediated sensitization. This study is a multicenter, placebo-contro...
This is a randomized, multicenter, double-blind, placebo-controlled, parallel-group study to evaluate the safety and efficacy of a single dose of TNX-201 (140 mg) for the treatment of a single qualifying Tension-Type-Headache (TTH).
Efficacy and safety of Euminz® (10% ethanolic solution of peppermint oil for topical use) compared to placebo in patients with episodic tension-type headache (ETTH). Prospective, double-blind, placebo-controlled, phase IV clinical trial; Parallel-groups design; Randomisation 1:1; First attack per pa...
The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.
The objective of this prospective, randomized, double-blind, parallel-group, placebo-controlled study is to determine the effectiveness of intranasal oxytocin in subjects suffering from chronic daily headache.
Hypothesis A single subanesthetic dose of propofol will result in improved pain and quality of life for the next 30 days in persons with chronic daily headache (CDH) Specific objectives To measure the effect of a single infusion of propofol at 40 mcg / kg / minute over 60 mins on headache-related qu...
Agents Found By Disease-Level Search
Searched directly from “Tension Headache / Chronic Daily Headache” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 4-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."