Biomarker & Intervention Discovery

Psoriatic Arthritis

Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.

US DALYs4.08MWHO GHE 2021 · all ages
Global DALYs45.69MWHO GHE 2021 · worldwide
US mortality12.5K deaths/yrWHO GHE 2021
Global mortality110.0K deaths/yrWHO GHE 2021 · worldwide
NIH funding$334MFY2025 · RCDC estimate
Funding levelUnderfunded
Spontaneous remissionSpontaneous remission uncommon (<5%); progressive joint damage in 40-60% without adequate treatment; enthesitis…
Best-intervention remissionIL-17 inhibitors: ACR50 response 58-62%, MDA (minimal disease activity) in 40-50%; IL-23 inhibitors (guselkumab…
Gap sizeLarge — most patients are undertreated on methotrexate or NSAIDs alone; treat-to-target poorly implemented
Primary barrierpractice/access
Full remission profile →
Research Tracker / Chronic Disease Interventions / Psoriatic Arthritis

Remission & chronicity

Spontaneous remission
Spontaneous remission uncommon (<5%); progressive joint damage in 40-60% without adequate treatment; enthesitis, dactylitis, axial involvement accumulate over time
Best-intervention remission
IL-17 inhibitors: ACR50 response 58-62%, MDA (minimal disease activity) in 40-50%; IL-23 inhibitors (guselkumab, risankizumab): similar efficacy with better skin clearance; JAK inhibitors (upadacitinib): ACR50 71% at 26 weeks; drug-free remission in ~15% in early PsA with T2T
Gap size
Large — most patients are undertreated on methotrexate or NSAIDs alone; treat-to-target poorly implemented
Primary barrier
practice/access
Diagnostic delay (mean 5-7 years from symptom onset to PsA diagnosis); methotrexate has modest efficacy in PsA but is gatekept as mandatory step before biologic access in many health systems; treat-to-target (MDA as goal) poorly implemented; most patients cycle through multiple NSAIDs before biologic access
Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.

CTLA4 32IL17A 72IL23A 8IL23R 178JAK1 189PDE4D 184TNF 277

CTLA4

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
TREMELIMUMAB ↓ inhibits Mechanistic DGIdb
IPILIMUMAB ↓ inhibits Mechanistic DGIdb
CYCLOSPORINE ? unclear Mechanistic DGIdb
ATEZOLIZUMAB ? unclear Mechanistic DGIdb
VISILIZUMAB ? unclear Mechanistic DGIdb
BLEOMYCIN ? unclear Mechanistic DGIdb
ANTIBIOTIC ? unclear Mechanistic DGIdb
METHIMAZOLE ? unclear Mechanistic DGIdb
RETRO-INVERSO PEPTIDE ? unclear Mechanistic DGIdb
MELPHALAN ? unclear Mechanistic DGIdb
RECOMBINANT FAS LIGAND ? unclear Mechanistic DGIdb
ZALIFRELIMAB ↓ inhibits Mechanistic DGIdb
RIBAVIRIN ? unclear Mechanistic DGIdb
ANTI-THYMOCYTE GLOBULIN ? unclear Mechanistic DGIdb
QUAVONLIMAB ↓ inhibits Mechanistic DGIdb
COMPOUND 32 [PMID: 20471253] ↓ inhibits Mechanistic DGIdb
SIROLIMUS ? unclear Mechanistic DGIdb
BISPECIFIC ANTIBODY ? unclear Mechanistic DGIdb
CADONILIMAB ↓ inhibits Mechanistic DGIdb
APLITHIANINE A ↓ inhibits Mechanistic DGIdb
PEGINTERFERON ALFA-2A ? unclear Mechanistic DGIdb
INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE INHIBITOR FF-10501-01 ? unclear Mechanistic DGIdb
ABATACEPT ? unclear Mechanistic DGIdb
WORTMANNIN ? unclear Mechanistic DGIdb
ERFONRILIMAB ↓ inhibits Mechanistic DGIdb
THALIDOMIDE ? unclear Mechanistic DGIdb
FF-10501-01 ? unclear Mechanistic DGIdb
PEGINTERFERON ALFA-2B ? unclear Mechanistic DGIdb
TETRADECANOYLPHORBOL ACETATE ? unclear Mechanistic DGIdb
DEHYDRATED ALCOHOL ? unclear Mechanistic DGIdb
PREDNISONE ? unclear Mechanistic DGIdb
CHEMBL5291170 ↓ inhibits Mechanistic 31000.0 nM (Kd) ChEMBL

IL17A

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
SIMVASTATIN ? unclear Mechanistic DGIdb
IL-12 ? unclear Mechanistic DGIdb
SECUKINUMAB ↓ inhibits Mechanistic DGIdb
TIBULIZUMAB ↓ inhibits Mechanistic DGIdb
BIMEKIZUMAB ↓ inhibits Mechanistic DGIdb
ANTI-IL17A MONOCLONAL ANTIBODY CJM112 ? unclear Mechanistic DGIdb
VUNAKIZUMAB ↓ inhibits Mechanistic DGIdb
M-1095 ↓ inhibits Mechanistic DGIdb
AFASEVIKUMAB ↓ inhibits Mechanistic DGIdb
PERAKIZUMAB ↓ inhibits Mechanistic DGIdb
SIROLIMUS ? unclear Mechanistic DGIdb
GENTAMICIN ? unclear Mechanistic DGIdb
AZATHIOPRINE ? unclear Mechanistic DGIdb
VIDOFLUDIMUS ? unclear Mechanistic DGIdb
COVA322 ? unclear Mechanistic DGIdb
BRODALUMAB ? unclear Mechanistic DGIdb
IXEKIZUMAB ↓ inhibits Mechanistic DGIdb
IZOKIBEP ↓ inhibits Mechanistic DGIdb
REMTOLUMAB ? unclear Mechanistic DGIdb
TETRACYCLINE ? unclear Mechanistic DGIdb
ERYTHROMYCIN ? unclear Mechanistic DGIdb
MANNITOL ? unclear Mechanistic DGIdb
ABBV-257 ? unclear Mechanistic DGIdb
CJM-112 ~ modulates Mechanistic DGIdb
CHEMBL4872876 ↓ inhibits Mechanistic 110.0 nM (Kd) ChEMBL
CHEMBL4858175 ↓ inhibits Mechanistic 12.3 nM (Kd) ChEMBL
CHEMBL4854787 ↓ inhibits Mechanistic 89.0 nM (Kd) ChEMBL
CHEMBL4878993 ↓ inhibits Mechanistic 12.9 nM (Kd) ChEMBL
CHEMBL4869568 ↓ inhibits Mechanistic 6.2 nM (Kd) ChEMBL
CHEMBL4876088 ↓ inhibits Mechanistic 10.1 nM (IC50) ChEMBL
CHEMBL4860250 ↓ inhibits Mechanistic 14.3 nM (IC50) ChEMBL
CHEMBL4866932 ↓ inhibits Mechanistic 10.1 nM (IC50) ChEMBL
CHEMBL4874078 ↓ inhibits Mechanistic 7.0 nM (IC50) ChEMBL
CHEMBL4845695 ↓ inhibits Mechanistic 2.8 nM (IC50) ChEMBL
CHEMBL4855085 ↓ inhibits Mechanistic 4.6 nM (IC50) ChEMBL
CHEMBL4860574 ↓ inhibits Mechanistic 2.0 nM (IC50) ChEMBL
CHEMBL4865978 ↓ inhibits Mechanistic 2.0 nM (IC50) ChEMBL
CHEMBL4870813 ↓ inhibits Mechanistic 1.0 nM (IC50) ChEMBL
CHEMBL4850368 ↓ inhibits Mechanistic 3.0 nM (IC50) ChEMBL
CHEMBL4851738 ↓ inhibits Mechanistic 3.0 nM (IC50) ChEMBL

Showing top 40 of 72 agents ranked by evidence tier.

IL23A

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
USTEKINUMAB ↓ inhibits Mechanistic DGIdb
RISANKIZUMAB ↓ inhibits Mechanistic DGIdb
MIRIKIZUMAB ↓ inhibits Mechanistic DGIdb
BRAZIKUMAB ↓ inhibits Mechanistic DGIdb
TILDRAKIZUMAB ↓ inhibits Mechanistic DGIdb
GUSELKUMAB ↓ inhibits Mechanistic DGIdb
EBDAROKIMAB ↓ inhibits Mechanistic DGIdb
BRIAKINUMAB ↓ inhibits Mechanistic DGIdb

IL23R

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
INFLIXIMAB ? unclear Mechanistic DGIdb
AZATHIOPRINE ? unclear Mechanistic DGIdb
CELECOXIB ? unclear Mechanistic DGIdb
CHEMBL4206167 ↓ inhibits Mechanistic 1.81 nM (Kd) ChEMBL
CHEMBL4567228 ↓ inhibits Mechanistic 113.0 nM (IC50) ChEMBL
CHEMBL4555885 ↓ inhibits Mechanistic 32.0 nM (IC50) ChEMBL
CHEMBL4529484 ↓ inhibits Mechanistic 25.0 nM (IC50) ChEMBL
CHEMBL4577218 ↓ inhibits Mechanistic 39.0 nM (IC50) ChEMBL
CHEMBL4442232 ↓ inhibits Mechanistic 892.0 nM (IC50) ChEMBL
CHEMBL4565015 ↓ inhibits Mechanistic 37.0 nM (IC50) ChEMBL
CHEMBL4515769 ↓ inhibits Mechanistic 199.0 nM (IC50) ChEMBL
CHEMBL4451305 ↓ inhibits Mechanistic 79.0 nM (IC50) ChEMBL
CHEMBL4441983 ↓ inhibits Mechanistic 220.0 nM (IC50) ChEMBL
CHEMBL4537768 ↓ inhibits Mechanistic 102.0 nM (IC50) ChEMBL
CHEMBL4458363 ↓ inhibits Mechanistic 78.0 nM (IC50) ChEMBL
CHEMBL4454287 ↓ inhibits Mechanistic 183.0 nM (IC50) ChEMBL
CHEMBL4452903 ↓ inhibits Mechanistic 57.0 nM (IC50) ChEMBL
CHEMBL4457621 ↓ inhibits Mechanistic 52.0 nM (IC50) ChEMBL
CHEMBL4543753 ↓ inhibits Mechanistic 518.0 nM (IC50) ChEMBL
CHEMBL4527549 ↓ inhibits Mechanistic 153.0 nM (IC50) ChEMBL
CHEMBL4540496 ↓ inhibits Mechanistic 223.0 nM (IC50) ChEMBL
CHEMBL4524632 ↓ inhibits Mechanistic 79.0 nM (IC50) ChEMBL
CHEMBL4459265 ↓ inhibits Mechanistic 124.0 nM (IC50) ChEMBL
CHEMBL4550853 ↓ inhibits Mechanistic 2584.0 nM (IC50) ChEMBL
CHEMBL4435141 ↓ inhibits Mechanistic 30000.0 nM (IC50) ChEMBL
CHEMBL4446365 ↓ inhibits Mechanistic 100.0 nM (IC50) ChEMBL
CHEMBL4462185 ↓ inhibits Mechanistic 96.0 nM (IC50) ChEMBL
CHEMBL4454702 ↓ inhibits Mechanistic 99.0 nM (IC50) ChEMBL
CHEMBL4576008 ↓ inhibits Mechanistic 95.0 nM (IC50) ChEMBL
CHEMBL4589681 ↓ inhibits Mechanistic 107.0 nM (IC50) ChEMBL
CHEMBL4583420 ↓ inhibits Mechanistic 101.0 nM (IC50) ChEMBL
CHEMBL4440544 ↓ inhibits Mechanistic 107.0 nM (IC50) ChEMBL
CHEMBL4564118 ↓ inhibits Mechanistic 47.0 nM (IC50) ChEMBL
CHEMBL4537038 ↓ inhibits Mechanistic 59.0 nM (IC50) ChEMBL
CHEMBL4547985 ↓ inhibits Mechanistic 206.0 nM (IC50) ChEMBL
CHEMBL4558328 ↓ inhibits Mechanistic 40.0 nM (IC50) ChEMBL
CHEMBL4567670 ↓ inhibits Mechanistic 139.0 nM (IC50) ChEMBL
CHEMBL4582731 ↓ inhibits Mechanistic 1885.0 nM (IC50) ChEMBL
CHEMBL4435308 ↓ inhibits Mechanistic 134.0 nM (IC50) ChEMBL
CHEMBL4564607 ↓ inhibits Mechanistic 48.0 nM (IC50) ChEMBL

Showing top 40 of 178 agents ranked by evidence tier.

JAK1

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
RUXOLITINIB ↓ inhibits Mechanistic 3.0 nM (IC50) DGIdb
IZENCITINIB ↓ inhibits Mechanistic DGIdb
PEMBROLIZUMAB ? unclear Mechanistic DGIdb
RUXOLITINIB PHOSPHATE ↓ inhibits Mechanistic DGIdb
GOLIDOCITINIB ↓ inhibits Mechanistic DGIdb
FILGOTINIB MALEATE ↓ inhibits Mechanistic DGIdb
MOMELOTINIB ↓ inhibits Mechanistic 11.0 nM (IC50) DGIdb
AZD1480 ↓ inhibits Mechanistic DGIdb
DELGOCITINIB ↓ inhibits Mechanistic DGIdb
TRICETAMIDE ↓ inhibits Mechanistic DGIdb
TOFACITINIB ↓ inhibits Mechanistic 112.0 nM (IC50) DGIdb
PEFICITINIB ↓ inhibits Mechanistic DGIdb
BREPOCITINIB ↓ inhibits Mechanistic DGIdb
UPADACITINIB HEMIHYDRATE ↓ inhibits Mechanistic DGIdb
CYCLOSPORINE ? unclear Mechanistic DGIdb
INCB-047986 ↓ inhibits Mechanistic DGIdb
ABROCITINIB ↓ inhibits Mechanistic DGIdb
ENZASTAURIN ? unclear Mechanistic DGIdb
CERDULATINIB ↓ inhibits Mechanistic DGIdb
NEZULCITINIB ↓ inhibits Mechanistic DGIdb
FILGOTINIB ↓ inhibits Mechanistic DGIdb
GLPG-0555 ↓ inhibits Mechanistic DGIdb
SOLCITINIB ↓ inhibits Mechanistic DGIdb
GUSACITINIB ↓ inhibits Mechanistic DGIdb
ITACITINIB ↓ inhibits Mechanistic DGIdb
BARICITINIB ↓ inhibits Mechanistic DGIdb
MOMELOTINIB DIHYDROCHLORIDE MONOHYDRATE ? unclear Mechanistic Open Targets
DEURUXOLITINIB PHOSPHATE ? unclear Mechanistic Open Targets
TOFACITINIB CITRATE ? unclear Mechanistic Open Targets
UPADACITINIB ? unclear Mechanistic Open Targets
CHEMBL538798 ↓ inhibits Mechanistic 39810.72 nM (IC50) ChEMBL
CHEMBL154580 ↓ inhibits Mechanistic 19952.62 nM (IC50) ChEMBL
SUNITINIB ↓ inhibits Mechanistic 9.2 nM (Kd) ChEMBL
CHEMBL386637 ↓ inhibits Mechanistic 1300.0 nM (IC50) ChEMBL
CHEMBL21156 ↓ inhibits Mechanistic 15.0 nM (IC50) ChEMBL
CHEMBL56543 ↓ inhibits Mechanistic 3380.0 nM (IC50) ChEMBL
DOVITINIB ↓ inhibits Mechanistic 380.0 nM (Kd) ChEMBL
JNJ-7706621 ↓ inhibits Mechanistic 21.0 nM (Kd) ChEMBL
SU-014813 ↓ inhibits Mechanistic 97.0 nM (Kd) ChEMBL
SOTRASTAURIN ↓ inhibits Mechanistic 7300.0 nM (IC50) ChEMBL

Showing top 40 of 189 agents ranked by evidence tier.

PDE4D

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
CILOMILAST ↓ inhibits Mechanistic 63.0 nM (IC50) DGIdb
TRANIMILAST ↓ inhibits Mechanistic DGIdb
RESVERATROL ? unclear Mechanistic DGIdb
DIFAMILAST ↓ inhibits Mechanistic DGIdb
MK-0873 ↓ inhibits Mechanistic DGIdb
REVAMILAST ↓ inhibits Mechanistic DGIdb
THEOPHYLLINE ↓ inhibits Mechanistic DGIdb
DYPHYLLINE ↓ inhibits Mechanistic DGIdb
IBUDILAST ↓ inhibits Mechanistic DGIdb
HT-0712 ↓ inhibits Mechanistic DGIdb
ENSIFENTRINE ↓ inhibits Mechanistic DGIdb
LIRIMILAST ? unclear Mechanistic DGIdb
OXTRIPHYLLINE ↓ inhibits Mechanistic DGIdb
DROTAVERIN ↓ inhibits Mechanistic DGIdb
TOFIMILAST ↓ inhibits Mechanistic DGIdb
THEOPHYLLINE SODIUM GLYCINATE ↓ inhibits Mechanistic DGIdb
DIPYRIDAMOLE ↓ inhibits Mechanistic DGIdb
GSK-356278 ? unclear Mechanistic DGIdb
APREMILAST ↓ inhibits Mechanistic DGIdb
ETAZOLATE ? unclear Mechanistic DGIdb
OGLEMILAST ↓ inhibits Mechanistic DGIdb
ZATOLMILAST ↓ inhibits Mechanistic DGIdb
TETOMILAST ↓ inhibits Mechanistic DGIdb
ROLIPRAM ↓ inhibits Mechanistic 390.0 nM (IC50) DGIdb
DENBUFYLLINE ? unclear Mechanistic DGIdb
LOTAMILAST ↓ inhibits Mechanistic DGIdb
PENTOXIFYLLINE ↓ inhibits Mechanistic DGIdb
AMLEXANOX ↓ inhibits Mechanistic DGIdb
AMINOPHYLLINE ↓ inhibits Mechanistic DGIdb
CRISABOROLE ↓ inhibits Mechanistic DGIdb
ROFLUMILAST ↓ inhibits Mechanistic DGIdb
PICLAMILAST ? unclear Mechanistic 0.8 nM (IC50) DGIdb
PAPAVERINE ? unclear Mechanistic DGIdb
GSK-256066 ↓ inhibits Mechanistic DGIdb
DIURETIC ? unclear Mechanistic DGIdb
BPN14770 ? unclear Mechanistic DGIdb
FLAVOXATE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
SELECTIVE CYTOKINE INHIBITORY DRUG CC-1088 ? unclear Mechanistic DGIdb
DOVRAMILAST ↓ inhibits Mechanistic DGIdb
QUETIAPINE FUMARATE ? unclear Mechanistic DGIdb

Showing top 40 of 184 agents ranked by evidence tier.

TNF

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
NERELIMOMAB ↓ inhibits Mechanistic DGIdb
CROMOLYN SODIUM ? unclear Mechanistic DGIdb
PLACULUMAB ↓ inhibits Mechanistic DGIdb
METHYLENE BLUE ? unclear Mechanistic DGIdb
ALTEPLASE ? unclear Mechanistic DGIdb
CARBOPLATIN ? unclear Mechanistic DGIdb
GENTAMICIN ? unclear Mechanistic DGIdb
GOLIMUMAB ↓ inhibits Mechanistic DGIdb
BUPIVACAINE ? unclear Mechanistic DGIdb
PENTOXIFYLLINE ? unclear Mechanistic 85000.0 nM (IC50) DGIdb
BENZO[E]PYRENE ? unclear Mechanistic DGIdb
THALIDOMIDE ? unclear Mechanistic DGIdb
PYRAZINAMIDE ? unclear Mechanistic DGIdb
GLIMEPIRIDE ? unclear Mechanistic DGIdb
OMEPRAZOLE ? unclear Mechanistic DGIdb
LENERCEPT ↓ inhibits Mechanistic DGIdb
ADALIMUMAB ↓ inhibits Mechanistic DGIdb
PRAZOSIN HYDROCHLORIDE ? unclear Mechanistic DGIdb
REMTOLUMAB ? unclear Mechanistic DGIdb
MIDOSTAURIN ? unclear Mechanistic DGIdb
LENABASUM ? unclear Mechanistic DGIdb
MAGNESIUM SULFATE ANHYDROUS ? unclear Mechanistic DGIdb
PICIBANIL ? unclear Mechanistic DGIdb
FLUOCINOLONE ACETONIDE ? unclear Mechanistic DGIdb
MILTEFOSINE ? unclear Mechanistic DGIdb
HOMIDIUM BROMIDE ? unclear Mechanistic DGIdb
OZORALIZUMAB ↓ inhibits Mechanistic DGIdb
PEGSUNERCEPT ↓ inhibits Mechanistic DGIdb
CERTOLIZUMAB PEGOL ↓ inhibits Mechanistic DGIdb
THERAPEUTIC HORMONE ? unclear Mechanistic DGIdb
NAFAMOSTAT ? unclear Mechanistic DGIdb
FOLIC ACID ? unclear Mechanistic DGIdb
ABBV-257 ? unclear Mechanistic DGIdb
RISPERIDONE ? unclear Mechanistic DGIdb
COVA322 ? unclear Mechanistic DGIdb
HYDROXYCHLOROQUINE ? unclear Mechanistic DGIdb
CERTOLIZUMAB ? unclear Mechanistic DGIdb
AN0128 ? unclear Mechanistic DGIdb
5,7-DIHYDROXY-4-METHYLCOUMARIN ? unclear Mechanistic DGIdb
SORAFENIB ? unclear Mechanistic DGIdb

Showing top 40 of 277 agents ranked by evidence tier.

Clinical Trials

Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-06.

No recent clinical trials found on ClinicalTrials.gov for this condition.

Agents Found By Disease-Level Search

Searched directly from “Psoriatic Arthritis” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 7-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."

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