Biomarker & Intervention Discovery
Overactive Bladder (OAB)
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
Spontaneous remissionSpontaneous fluctuation common; resolution in ~25% at 1 year; bladder training alone achieves 50-80% improvement in…
Best-intervention remissionBladder training + pelvic floor exercises: 60-80% improvement (first-line guideline recommendation)…
Gap sizeLarge — most patients receive pharmacotherapy as first-line without adequate behavioural therapy trial…
Primary barrierframing/practice
Full remission profile →
Remission & chronicity
Spontaneous remission
Spontaneous fluctuation common; resolution in ~25% at 1 year; bladder training alone achieves 50-80% improvement in urgency frequency; OAB worsens with age without intervention
Best-intervention remission
Bladder training + pelvic floor exercises: 60-80% improvement (first-line guideline recommendation); anticholinergics/beta-3 agonist (mirabegron): 30-60% significant improvement; botulinum toxin A (OnabotulinumtoxinA, Botox): 30-50% complete continence at 12 weeks; sacral neuromodulation (InterStim): 72% success at 5 years
Gap size
Large — most patients receive pharmacotherapy as first-line without adequate behavioural therapy trial; anticholinergics overused in elderly
Primary barrier
framing/practice
Behavioural interventions (pelvic floor training, bladder diary, timed voiding) are first-line by all guidelines but most patients receive anticholinergics immediately; anticholinergic cognitive burden in elderly patients is significant (dementia risk association with chronic use — JAMA Intern Med 2019); mirabegron has better cognitive safety profile but is underused relative to older anticholinergics
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Overactive Bladder (OAB)” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."