Biomarker & Intervention Discovery

Other Musculoskeletal Disorders

This page lists 5 druggable gene targets for Other Musculoskeletal Disorders, with each agent ranked by the strength of its evidence (clinical, mechanistic or correlative). Sources are linked so you can check every claim.

Research Tracker Chronic Disease Interventions Other Musculoskeletal Disorders

Disease Overview

Spontaneous remission
Not established
Best-intervention remission
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Gap size
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Primary barrier
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Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: Clinical > Mechanistic > Correlative.

IL6 173PTGS2 299SCN9A 271TNF 277TRPV1 160

IL6

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
CISPLATIN ? unclear Mechanistic DGIdb
ZILTIVEKIMAB ~ modulates Mechanistic DGIdb
CHINESE HERBS ? unclear Mechanistic DGIdb
PF-04236921 ↓ inhibits Mechanistic DGIdb
MRA 003 US ↓ inhibits Mechanistic DGIdb
SIGNAL TRANSDUCTION INHIBITOR ? unclear Mechanistic DGIdb
BINETRAKIN ? unclear Mechanistic DGIdb
IBUDILAST ? unclear Mechanistic DGIdb
INSULIN, REGULAR, HUMAN ? unclear Mechanistic DGIdb
SILTUXIMAB ↓ inhibits Mechanistic DGIdb
METRONIDAZOLE ? unclear Mechanistic DGIdb
CLAZAKIZUMAB ↓ inhibits Mechanistic DGIdb
GALLIUM NITRATE ? unclear Mechanistic DGIdb
INTERFERON ALFA-2B ? unclear Mechanistic DGIdb
DULOXETINE HYDROCHLORIDE ? unclear Mechanistic DGIdb
MEDI-5117 ↓ inhibits Mechanistic DGIdb
GEMFIBROZIL ? unclear Mechanistic DGIdb
BIAFINE CREAM ? unclear Mechanistic DGIdb
ETANERCEPT ? unclear Mechanistic DGIdb
ELSILIMOMAB ↓ inhibits Mechanistic DGIdb
SAQUINAVIR ? unclear Mechanistic DGIdb
INFLIXIMAB ? unclear Mechanistic DGIdb
LINEZOLID ? unclear Mechanistic DGIdb
IFOSFAMIDE ? unclear Mechanistic DGIdb
OLOKIZUMAB ↓ inhibits Mechanistic DGIdb
HMG-COA REDUCTASE INHIBITOR ? unclear Mechanistic DGIdb
MIDOSTAURIN ? unclear Mechanistic DGIdb
SELENIUM ? unclear Mechanistic DGIdb
SIRUKUMAB ↓ inhibits Mechanistic DGIdb
PEGINTERFERON ALFA-2B ? unclear Mechanistic DGIdb
ECHINACEA PREPARATION ? unclear Mechanistic DGIdb
ENZYME INHIBITOR ? unclear Mechanistic DGIdb
FENOFIBRATE MICRONIZED ? unclear Mechanistic DGIdb
VITAMIN K ? unclear Mechanistic DGIdb
PEGINTERFERON ALFA-2A ? unclear Mechanistic DGIdb
RIBAVIRIN ? unclear Mechanistic DGIdb
VITAMIN A PALMITATE ? unclear Mechanistic DGIdb
ARSENIC TRIOXIDE ? unclear Mechanistic DGIdb
DIHYDROSPHINGOSINE ? unclear Mechanistic DGIdb
LEVOFLOXACIN ANHYDROUS ? unclear Mechanistic DGIdb

Showing top 40 of 173 agents ranked by evidence tier.

PTGS2

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
CARPROFEN ↓ inhibits Mechanistic 102.0 nM (IC50) DGIdb
INDOMETHACIN SODIUM ↓ inhibits Mechanistic DGIdb
DARBUFELONE ? unclear Mechanistic DGIdb
MEFENAMIC ACID ↓ inhibits Mechanistic DGIdb
MECLOFENAMATE SODIUM ↓ inhibits Mechanistic DGIdb
DICLOFENAC SODIUM ↓ inhibits Mechanistic DGIdb
CAPECITABINE ? unclear Mechanistic DGIdb
PIRPROFEN ↓ inhibits Mechanistic DGIdb
ESFLURBIPROFEN ↓ inhibits Mechanistic DGIdb
SULFASALAZINE ↓ inhibits Mechanistic DGIdb
BROMFENAC ? unclear Mechanistic DGIdb
IBUPROFEN, SODIUM SALT ↓ inhibits Mechanistic DGIdb
ALOXIPRIN ↓ inhibits Mechanistic DGIdb
TENOXICAM ? unclear Mechanistic DGIdb
FLURBIPROFEN ↓ inhibits Mechanistic DGIdb
SALICYLIC ACID ? unclear Mechanistic DGIdb
ATENOLOL ? unclear Mechanistic DGIdb
DEXKETOPROFEN ↓ inhibits Mechanistic DGIdb
ETORICOXIB ↓ inhibits Mechanistic DGIdb
LUMIRACOXIB ↓ inhibits Mechanistic DGIdb
SUPROFEN ↓ inhibits Mechanistic DGIdb
NS-398 ? unclear Mechanistic DGIdb
NABUMETONE ↓ inhibits Mechanistic DGIdb
URSOLIC ACID ? unclear Mechanistic DGIdb
IBUPROFEN LYSINE ↓ inhibits Mechanistic DGIdb
ACECLOFENAC ↓ inhibits Mechanistic DGIdb
IBUFENAC ↓ inhibits Mechanistic DGIdb
BALSALAZIDE ? unclear Mechanistic DGIdb
DIFLUNISAL ↓ inhibits Mechanistic DGIdb
BALSALAZIDE DISODIUM ↓ inhibits Mechanistic DGIdb
VACCINE ? unclear Mechanistic DGIdb
KETOROLAC TROMETHAMINE ↓ inhibits Mechanistic DGIdb
BENZYDAMINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
TIAPROFENIC ACID ? unclear Mechanistic DGIdb
RALOXIFENE HYDROCHLORIDE ? unclear Mechanistic DGIdb
NAPROXCINOD ↓ inhibits Mechanistic DGIdb
IGURATIMOD ↓ inhibits Mechanistic DGIdb
ETODOLAC ↓ inhibits Mechanistic DGIdb
DICLOFENAC ETALHYALURONATE SODIUM ↓ inhibits Mechanistic DGIdb
ROFECOXIB ↓ inhibits Mechanistic 530.0 nM (IC50) DGIdb

Showing top 40 of 299 agents ranked by evidence tier.

SCN9A

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
MERETHOXYLLINE PROCAINE ↓ inhibits Mechanistic DGIdb
ETIDOCAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
FOSPHENYTOIN ↓ inhibits Mechanistic DGIdb
VERATRIDINE ↑ activates Mechanistic DGIdb
ORPHENADRINE CITRATE ↓ inhibits Mechanistic DGIdb
PHENACEMIDE ↓ inhibits Mechanistic DGIdb
LACOSAMIDE ↓ inhibits Mechanistic DGIdb
VIXOTRIGINE ↓ inhibits Mechanistic DGIdb
DSP-2230 ↓ inhibits Mechanistic DGIdb
SAXITOXIN ↓ inhibits Mechanistic DGIdb
ESLICARBAZEPINE ACETATE ↓ inhibits Mechanistic DGIdb
SAFINAMIDE ? unclear Mechanistic DGIdb
LIDOCAINE ↓ inhibits Mechanistic DGIdb
RILUZOLE ↓ inhibits Mechanistic DGIdb
ROPIVACAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
FUNAPIDE ↓ inhibits Mechanistic DGIdb
DYCLONINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
EVENAMIDE ↓ inhibits Mechanistic DGIdb
PROPOFOL ? unclear Mechanistic DGIdb
AM-6120 ↓ inhibits Mechanistic DGIdb
RG7893 ↓ inhibits Mechanistic DGIdb
RG6029 ↓ inhibits Mechanistic DGIdb
QUINIDINE SULFATE ↓ inhibits Mechanistic DGIdb
ZONISAMIDE ↓ inhibits Mechanistic DGIdb
NERISPIRDINE ↓ inhibits Mechanistic DGIdb
RALFINAMIDE ↓ inhibits Mechanistic DGIdb
DS-1971A ↓ inhibits Mechanistic DGIdb
HEXYLCAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
MEPIVACAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
PROCAINAMIDE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
PROPAFENONE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
LIDOCAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
QUINIDINE GLUCONATE ↓ inhibits Mechanistic DGIdb
PRILOCAINE ↓ inhibits Mechanistic DGIdb
ETHOTOIN ↓ inhibits Mechanistic DGIdb
PF-05089771 ↓ inhibits Mechanistic DGIdb
DICHLOROBENZYL ALCOHOL ↓ inhibits Mechanistic DGIdb
RANOLAZINE ? unclear Mechanistic DGIdb
PRILOCAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
ORPHENADRINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb

Showing top 40 of 271 agents ranked by evidence tier.

TNF

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
NERELIMOMAB ↓ inhibits Mechanistic DGIdb
CROMOLYN SODIUM ? unclear Mechanistic DGIdb
PLACULUMAB ↓ inhibits Mechanistic DGIdb
METHYLENE BLUE ? unclear Mechanistic DGIdb
ALTEPLASE ? unclear Mechanistic DGIdb
CARBOPLATIN ? unclear Mechanistic DGIdb
GENTAMICIN ? unclear Mechanistic DGIdb
GOLIMUMAB ↓ inhibits Mechanistic DGIdb
BUPIVACAINE ? unclear Mechanistic DGIdb
PENTOXIFYLLINE ? unclear Mechanistic 85000.0 nM (IC50) DGIdb
BENZO[E]PYRENE ? unclear Mechanistic DGIdb
THALIDOMIDE ? unclear Mechanistic DGIdb
PYRAZINAMIDE ? unclear Mechanistic DGIdb
GLIMEPIRIDE ? unclear Mechanistic DGIdb
OMEPRAZOLE ? unclear Mechanistic DGIdb
LENERCEPT ↓ inhibits Mechanistic DGIdb
ADALIMUMAB ↓ inhibits Mechanistic DGIdb
PRAZOSIN HYDROCHLORIDE ? unclear Mechanistic DGIdb
REMTOLUMAB ? unclear Mechanistic DGIdb
MIDOSTAURIN ? unclear Mechanistic DGIdb
LENABASUM ? unclear Mechanistic DGIdb
MAGNESIUM SULFATE ANHYDROUS ? unclear Mechanistic DGIdb
PICIBANIL ? unclear Mechanistic DGIdb
FLUOCINOLONE ACETONIDE ? unclear Mechanistic DGIdb
MILTEFOSINE ? unclear Mechanistic DGIdb
HOMIDIUM BROMIDE ? unclear Mechanistic DGIdb
OZORALIZUMAB ↓ inhibits Mechanistic DGIdb
PEGSUNERCEPT ↓ inhibits Mechanistic DGIdb
CERTOLIZUMAB PEGOL ↓ inhibits Mechanistic DGIdb
THERAPEUTIC HORMONE ? unclear Mechanistic DGIdb
NAFAMOSTAT ? unclear Mechanistic DGIdb
FOLIC ACID ? unclear Mechanistic DGIdb
ABBV-257 ? unclear Mechanistic DGIdb
RISPERIDONE ? unclear Mechanistic DGIdb
COVA322 ? unclear Mechanistic DGIdb
HYDROXYCHLOROQUINE ? unclear Mechanistic DGIdb
CERTOLIZUMAB ? unclear Mechanistic DGIdb
AN0128 ? unclear Mechanistic DGIdb
5,7-DIHYDROXY-4-METHYLCOUMARIN ? unclear Mechanistic DGIdb
SORAFENIB ? unclear Mechanistic DGIdb

Showing top 40 of 277 agents ranked by evidence tier.

TRPV1

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
STREPTOZOCIN ? unclear Mechanistic DGIdb
BENZYL ISOTHIOCYANATE ? unclear Mechanistic DGIdb
ACETAMINOPHEN ↑ activates Mechanistic DGIdb
POLYGODIAL ? unclear Mechanistic DGIdb
PROPOFOL ? unclear Mechanistic DGIdb
SAF312 ↓ inhibits Mechanistic DGIdb
GRC-15300 ? unclear Mechanistic DGIdb
AZD1386 ↓ inhibits Mechanistic DGIdb
TIVANISIRAN ↓ inhibits Mechanistic DGIdb
MAVATREP ↓ inhibits Mechanistic DGIdb
MR-1817 ↓ inhibits Mechanistic DGIdb
FERRUGINENE B ? unclear Mechanistic DGIdb
CAPSAICIN ↑ activates Mechanistic 19.95 nM (EC50) DGIdb
RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN ? unclear Mechanistic DGIdb
PHENETHYLISOTHIOCYANATE ? unclear Mechanistic DGIdb
VOACANGINE ? unclear Mechanistic DGIdb
RESINIFERATOXIN ↑ activates Mechanistic 23.1 nM (Ki) DGIdb
DWP05195 ↓ inhibits Mechanistic DGIdb
XEN-D0501 ↓ inhibits Mechanistic DGIdb
PAC-14028 ↓ inhibits Mechanistic DGIdb
SB-705498 ↓ inhibits Mechanistic DGIdb
MASOPROCOL ? unclear Mechanistic DGIdb
ALLYL ISOTHIOCYANATE ? unclear Mechanistic DGIdb
NGD-8243 ↓ inhibits Mechanistic DGIdb
GRC-6211 ↓ inhibits Mechanistic DGIdb
RESERPINE ? unclear Mechanistic DGIdb
NABIXIMOLS ? unclear Mechanistic DGIdb
A425619 ? unclear Mechanistic DGIdb
PHE377 ↓ inhibits Mechanistic DGIdb
ANTISENSE OLIGONUCLEOTIDES ? unclear Mechanistic DGIdb
WORTMANNIN ? unclear Mechanistic DGIdb
JTS-653 ↓ inhibits Mechanistic DGIdb
LEVODOPA ? unclear Mechanistic DGIdb
AMG517 ↓ inhibits Mechanistic DGIdb
CAPSAZEPINE ? unclear Mechanistic 120.0 nM (Ki) DGIdb
ZUCAPSAICIN ↑ activates Mechanistic DGIdb
INDOMETHACIN ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL191534 ? unclear Mechanistic DGIdb
ABT-102 ↓ inhibits Mechanistic DGIdb
ISOPROPYL ISOTHIOCYANATE ? unclear Mechanistic DGIdb

Showing top 40 of 160 agents ranked by evidence tier.

Clinical Trials

Drug, biologic and supplement trials (treatment or prevention) from ClinicalTrials.gov whose main condition is Other Musculoskeletal Disorders: recruiting, active or completed, most recently updated first. Data retrieved 2026-10-28.

No recruiting, active or completed drug trials with this main condition were found on ClinicalTrials.gov.

Agents Found By Disease-Level Search

Searched directly from “Other Musculoskeletal Disorders” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 5-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."