Disease Overview
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: Clinical > Mechanistic > Correlative.
GRIN1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| COMPOUND 53 [PMID: 33038794] | ↑ activates | Mechanistic | DGIdb | |
| PAREGORIC | ? unclear | Mechanistic | DGIdb | |
| STING AGONIST 2 | ↑ activates | Mechanistic | DGIdb | |
| LATREPIRDINE | ? unclear | Mechanistic | DGIdb | |
| CNS-5161 | ↓ inhibits | Mechanistic | DGIdb | |
| MEMANTINE HYDROCHLORIDE | ~ modulates | Mechanistic | DGIdb | |
| LANICEMINE | ↓ inhibits | Mechanistic | DGIdb | |
| ULEVOSTINAG | ↑ activates | Mechanistic | DGIdb | |
| ELIPRODIL | ? unclear | Mechanistic | DGIdb | |
| NBQX | ? unclear | Mechanistic | DGIdb | |
| RAPASTINEL | ? unclear | Mechanistic | DGIdb | |
| DEXANABINOL | ? unclear | Mechanistic | DGIdb | |
| NEBOGLAMINE | ~ modulates | Mechanistic | DGIdb | |
| HALOPERIDOL DECANOATE | ? unclear | Mechanistic | DGIdb | |
| ORPHENADRINE | ? unclear | Mechanistic | DGIdb | |
| GW468816 | ↓ inhibits | Mechanistic | DGIdb | |
| ACAMPROSATE CALCIUM | ↓ inhibits | Mechanistic | DGIdb | |
| AMANTADINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| H-151 | ↓ inhibits | Mechanistic | DGIdb | |
| D-SERINE | ? unclear | Mechanistic | DGIdb | |
| AZD8108 | ↓ inhibits | Mechanistic | DGIdb | |
| KETAMINE HYDROCHLORIDE | ~ modulates | Mechanistic | DGIdb | |
| DELUCEMINE | ↓ inhibits | Mechanistic | DGIdb | |
| EVT-101 | ↓ inhibits | Mechanistic | DGIdb | |
| MSA-2 | ↑ activates | Mechanistic | DGIdb | |
| ESKETAMINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| 2'3'-CGAMP | ↑ activates | Mechanistic | DGIdb | |
| COMPOUND 40 [PMID: 33470814] | ↑ activates | Mechanistic | DGIdb | |
| PHILANTHOTOXIN 343 | ? unclear | Mechanistic | DGIdb | |
| FELBAMATE | ↓ inhibits | Mechanistic | DGIdb | |
| INDANTADOL | ↓ inhibits | Mechanistic | DGIdb | |
| STING AGONIST 3 | ↑ activates | Mechanistic | DGIdb | |
| ORPHENADRINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CYCLOSERINE | ? unclear | Mechanistic | DGIdb | |
| RADIPRODIL | ↓ inhibits | Mechanistic | DGIdb | |
| PERZINFOTEL | ↓ inhibits | Mechanistic | DGIdb | |
| ESKETAMINE | ~ modulates | Mechanistic | DGIdb | |
| ADU-S100 | ↑ activates | Mechanistic | DGIdb | |
| RALFINAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| SNX281 | ↑ activates | Mechanistic | DGIdb |
Showing top 40 of 183 agents ranked by evidence tier.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CISPLATIN | ? unclear | Mechanistic | DGIdb | |
| ZILTIVEKIMAB | ~ modulates | Mechanistic | DGIdb | |
| CHINESE HERBS | ? unclear | Mechanistic | DGIdb | |
| PF-04236921 | ↓ inhibits | Mechanistic | DGIdb | |
| MRA 003 US | ↓ inhibits | Mechanistic | DGIdb | |
| SIGNAL TRANSDUCTION INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| BINETRAKIN | ? unclear | Mechanistic | DGIdb | |
| IBUDILAST | ? unclear | Mechanistic | DGIdb | |
| INSULIN, REGULAR, HUMAN | ? unclear | Mechanistic | DGIdb | |
| SILTUXIMAB | ↓ inhibits | Mechanistic | DGIdb | |
| METRONIDAZOLE | ? unclear | Mechanistic | DGIdb | |
| CLAZAKIZUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| GALLIUM NITRATE | ? unclear | Mechanistic | DGIdb | |
| INTERFERON ALFA-2B | ? unclear | Mechanistic | DGIdb | |
| DULOXETINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| MEDI-5117 | ↓ inhibits | Mechanistic | DGIdb | |
| GEMFIBROZIL | ? unclear | Mechanistic | DGIdb | |
| BIAFINE CREAM | ? unclear | Mechanistic | DGIdb | |
| ETANERCEPT | ? unclear | Mechanistic | DGIdb | |
| ELSILIMOMAB | ↓ inhibits | Mechanistic | DGIdb | |
| SAQUINAVIR | ? unclear | Mechanistic | DGIdb | |
| INFLIXIMAB | ? unclear | Mechanistic | DGIdb | |
| LINEZOLID | ? unclear | Mechanistic | DGIdb | |
| IFOSFAMIDE | ? unclear | Mechanistic | DGIdb | |
| OLOKIZUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| HMG-COA REDUCTASE INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| MIDOSTAURIN | ? unclear | Mechanistic | DGIdb | |
| SELENIUM | ? unclear | Mechanistic | DGIdb | |
| SIRUKUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| PEGINTERFERON ALFA-2B | ? unclear | Mechanistic | DGIdb | |
| ECHINACEA PREPARATION | ? unclear | Mechanistic | DGIdb | |
| ENZYME INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| FENOFIBRATE MICRONIZED | ? unclear | Mechanistic | DGIdb | |
| VITAMIN K | ? unclear | Mechanistic | DGIdb | |
| PEGINTERFERON ALFA-2A | ? unclear | Mechanistic | DGIdb | |
| RIBAVIRIN | ? unclear | Mechanistic | DGIdb | |
| VITAMIN A PALMITATE | ? unclear | Mechanistic | DGIdb | |
| ARSENIC TRIOXIDE | ? unclear | Mechanistic | DGIdb | |
| DIHYDROSPHINGOSINE | ? unclear | Mechanistic | DGIdb | |
| LEVOFLOXACIN ANHYDROUS | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 173 agents ranked by evidence tier.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| MEDI-578 | ↓ inhibits | Mechanistic | DGIdb | |
| CERE-110 | ? unclear | Mechanistic | DGIdb | |
| FASINUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| TANEZUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| FRUNEVETMAB | ~ modulates | Mechanistic | DGIdb | |
| FULRANUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| BEDINVETMAB | ~ modulates | Mechanistic | DGIdb | |
| PG-110 | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL1397270 | ↓ inhibits | Mechanistic | 1000.0 nM (IC50) | ChEMBL |
PTGS2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CARPROFEN | ↓ inhibits | Mechanistic | 102.0 nM (IC50) | DGIdb |
| INDOMETHACIN SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| DARBUFELONE | ? unclear | Mechanistic | DGIdb | |
| MEFENAMIC ACID | ↓ inhibits | Mechanistic | DGIdb | |
| MECLOFENAMATE SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| DICLOFENAC SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| CAPECITABINE | ? unclear | Mechanistic | DGIdb | |
| PIRPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| ESFLURBIPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| SULFASALAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| BROMFENAC | ? unclear | Mechanistic | DGIdb | |
| IBUPROFEN, SODIUM SALT | ↓ inhibits | Mechanistic | DGIdb | |
| ALOXIPRIN | ↓ inhibits | Mechanistic | DGIdb | |
| TENOXICAM | ? unclear | Mechanistic | DGIdb | |
| FLURBIPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| SALICYLIC ACID | ? unclear | Mechanistic | DGIdb | |
| ATENOLOL | ? unclear | Mechanistic | DGIdb | |
| DEXKETOPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| ETORICOXIB | ↓ inhibits | Mechanistic | DGIdb | |
| LUMIRACOXIB | ↓ inhibits | Mechanistic | DGIdb | |
| SUPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| NS-398 | ? unclear | Mechanistic | DGIdb | |
| NABUMETONE | ↓ inhibits | Mechanistic | DGIdb | |
| URSOLIC ACID | ? unclear | Mechanistic | DGIdb | |
| IBUPROFEN LYSINE | ↓ inhibits | Mechanistic | DGIdb | |
| ACECLOFENAC | ↓ inhibits | Mechanistic | DGIdb | |
| IBUFENAC | ↓ inhibits | Mechanistic | DGIdb | |
| BALSALAZIDE | ? unclear | Mechanistic | DGIdb | |
| DIFLUNISAL | ↓ inhibits | Mechanistic | DGIdb | |
| BALSALAZIDE DISODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| VACCINE | ? unclear | Mechanistic | DGIdb | |
| KETOROLAC TROMETHAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| BENZYDAMINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| TIAPROFENIC ACID | ? unclear | Mechanistic | DGIdb | |
| RALOXIFENE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| NAPROXCINOD | ↓ inhibits | Mechanistic | DGIdb | |
| IGURATIMOD | ↓ inhibits | Mechanistic | DGIdb | |
| ETODOLAC | ↓ inhibits | Mechanistic | DGIdb | |
| DICLOFENAC ETALHYALURONATE SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| ROFECOXIB | ↓ inhibits | Mechanistic | 530.0 nM (IC50) | DGIdb |
Showing top 40 of 299 agents ranked by evidence tier.
SCN9A
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| MERETHOXYLLINE PROCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| ETIDOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| FOSPHENYTOIN | ↓ inhibits | Mechanistic | DGIdb | |
| VERATRIDINE | ↑ activates | Mechanistic | DGIdb | |
| ORPHENADRINE CITRATE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENACEMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LACOSAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| VIXOTRIGINE | ↓ inhibits | Mechanistic | DGIdb | |
| DSP-2230 | ↓ inhibits | Mechanistic | DGIdb | |
| SAXITOXIN | ↓ inhibits | Mechanistic | DGIdb | |
| ESLICARBAZEPINE ACETATE | ↓ inhibits | Mechanistic | DGIdb | |
| SAFINAMIDE | ? unclear | Mechanistic | DGIdb | |
| LIDOCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| RILUZOLE | ↓ inhibits | Mechanistic | DGIdb | |
| ROPIVACAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| FUNAPIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DYCLONINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| EVENAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROPOFOL | ? unclear | Mechanistic | DGIdb | |
| AM-6120 | ↓ inhibits | Mechanistic | DGIdb | |
| RG7893 | ↓ inhibits | Mechanistic | DGIdb | |
| RG6029 | ↓ inhibits | Mechanistic | DGIdb | |
| QUINIDINE SULFATE | ↓ inhibits | Mechanistic | DGIdb | |
| ZONISAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| NERISPIRDINE | ↓ inhibits | Mechanistic | DGIdb | |
| RALFINAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DS-1971A | ↓ inhibits | Mechanistic | DGIdb | |
| HEXYLCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| MEPIVACAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROCAINAMIDE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROPAFENONE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LIDOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| QUINIDINE GLUCONATE | ↓ inhibits | Mechanistic | DGIdb | |
| PRILOCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| ETHOTOIN | ↓ inhibits | Mechanistic | DGIdb | |
| PF-05089771 | ↓ inhibits | Mechanistic | DGIdb | |
| DICHLOROBENZYL ALCOHOL | ↓ inhibits | Mechanistic | DGIdb | |
| RANOLAZINE | ? unclear | Mechanistic | DGIdb | |
| PRILOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ORPHENADRINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 271 agents ranked by evidence tier.
TRPV1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| STREPTOZOCIN | ? unclear | Mechanistic | DGIdb | |
| BENZYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| ACETAMINOPHEN | ↑ activates | Mechanistic | DGIdb | |
| POLYGODIAL | ? unclear | Mechanistic | DGIdb | |
| PROPOFOL | ? unclear | Mechanistic | DGIdb | |
| SAF312 | ↓ inhibits | Mechanistic | DGIdb | |
| GRC-15300 | ? unclear | Mechanistic | DGIdb | |
| AZD1386 | ↓ inhibits | Mechanistic | DGIdb | |
| TIVANISIRAN | ↓ inhibits | Mechanistic | DGIdb | |
| MAVATREP | ↓ inhibits | Mechanistic | DGIdb | |
| MR-1817 | ↓ inhibits | Mechanistic | DGIdb | |
| FERRUGINENE B | ? unclear | Mechanistic | DGIdb | |
| CAPSAICIN | ↑ activates | Mechanistic | 19.95 nM (EC50) | DGIdb |
| RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN | ? unclear | Mechanistic | DGIdb | |
| PHENETHYLISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| VOACANGINE | ? unclear | Mechanistic | DGIdb | |
| RESINIFERATOXIN | ↑ activates | Mechanistic | 23.1 nM (Ki) | DGIdb |
| DWP05195 | ↓ inhibits | Mechanistic | DGIdb | |
| XEN-D0501 | ↓ inhibits | Mechanistic | DGIdb | |
| PAC-14028 | ↓ inhibits | Mechanistic | DGIdb | |
| SB-705498 | ↓ inhibits | Mechanistic | DGIdb | |
| MASOPROCOL | ? unclear | Mechanistic | DGIdb | |
| ALLYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| NGD-8243 | ↓ inhibits | Mechanistic | DGIdb | |
| GRC-6211 | ↓ inhibits | Mechanistic | DGIdb | |
| RESERPINE | ? unclear | Mechanistic | DGIdb | |
| NABIXIMOLS | ? unclear | Mechanistic | DGIdb | |
| A425619 | ? unclear | Mechanistic | DGIdb | |
| PHE377 | ↓ inhibits | Mechanistic | DGIdb | |
| ANTISENSE OLIGONUCLEOTIDES | ? unclear | Mechanistic | DGIdb | |
| WORTMANNIN | ? unclear | Mechanistic | DGIdb | |
| JTS-653 | ↓ inhibits | Mechanistic | DGIdb | |
| LEVODOPA | ? unclear | Mechanistic | DGIdb | |
| AMG517 | ↓ inhibits | Mechanistic | DGIdb | |
| CAPSAZEPINE | ? unclear | Mechanistic | 120.0 nM (Ki) | DGIdb |
| ZUCAPSAICIN | ↑ activates | Mechanistic | DGIdb | |
| INDOMETHACIN | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL191534 | ? unclear | Mechanistic | DGIdb | |
| ABT-102 | ↓ inhibits | Mechanistic | DGIdb | |
| ISOPROPYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 160 agents ranked by evidence tier.
Clinical Trials
Drug, biologic and supplement trials (treatment or prevention) from ClinicalTrials.gov whose main condition is Neck Pain (Chronic): recruiting, active or completed, most recently updated first. Data retrieved 2026-10-28.
Neck pain is a common health problem in the general population. Approximately 71% of adults experience neck pain at some point in their lives, and its annual prevalence ranges between 30-50% in both the general and working populations. Although neck pain often resolves spontaneously within a few day...
Neck pain frequently present comorbidities in peridiaphragmatic organs. The innervation of these organs include the phrenic nerve. It is known that peridiaphragmatic organs trigger referred pain in the neck area. As well, previous studies have shown that visceral disorders increase sensitization in ...
A multi-center randomized controlled trial assessing the comparative effectiveness and cost-effectiveness of Chuna manual therapy for chronic neck pain
Study Title: Evaluation of the Effectiveness of Adding Greater Occipital Nerve Block to Trigger Point Injection in Patients with Neck Pain Due to Upper Trapezius Trigger Points: A Single-Blind Randomized Controlled Trial Purpose of the Study: This study aims to evaluate whether adding a Greater Occi...
The purpose of this study is to objectively assess lymphatic function before, during, and immediately after Neuroglide treatment in lower trunk and leg lymphatic vessels, torso, axillary regions, inguinal regions, upper extremities, and cervical/neck and to determine any VAS (Visual Analog Scale, a ...
In this randomized, double-blind, placebo-controlled crossover study, up to 84 patients with non-radicular neck pain will be allocated in a 1:1 ratio to receive up to 3 topical lidocaine or placebo patches, to be applied 12 hours per day. At the end of 4 weeks, patients will return for patients' pos...
The purpose of this study was to assess the effect of cyclobenzaprine hydrochloride (HCl) extended release (CER) 15 mg capsule once daily in participants with muscle spasms associated with acute painful musculoskeletal conditions.
The objective of this prospective randomized and controlled study is to evaluate the efficacy and safety of low dose of amitriptyline (5 mg) in the management of chronic neck pain.
The purpose of this study is to evaluate the efficacy and safety of east-west collaborative treatment using bee venom acupuncture and NSAIDs on pain intensity, functional status and quality of life of patients with chronic cervicalgia
The purpose of this study is to determine whether chiropractic manipulation or medical therapy is effective in the treatment of chronic neck pain.
Purpose: The purpose of this study is to demonstrate the potential efficacy of venlafaxine administration in reducing acute and chronic musculoskeletal pain in individuals presenting to the ED for evaluation after motor vehicle collision. Participants: Participants will consist of 60 patients betwee...
Agents Found By Disease-Level Search
Searched directly from “Neck Pain (Chronic)” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 6-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."