Disease Overview
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.
GRIN1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| COMPOUND 53 [PMID: 33038794] | ↑ activates | Mechanistic | DGIdb | |
| PAREGORIC | ? unclear | Mechanistic | DGIdb | |
| STING AGONIST 2 | ↑ activates | Mechanistic | DGIdb | |
| LATREPIRDINE | ? unclear | Mechanistic | DGIdb | |
| CNS-5161 | ↓ inhibits | Mechanistic | DGIdb | |
| MEMANTINE HYDROCHLORIDE | ~ modulates | Mechanistic | DGIdb | |
| LANICEMINE | ↓ inhibits | Mechanistic | DGIdb | |
| ULEVOSTINAG | ↑ activates | Mechanistic | DGIdb | |
| ELIPRODIL | ? unclear | Mechanistic | DGIdb | |
| NBQX | ? unclear | Mechanistic | DGIdb | |
| RAPASTINEL | ? unclear | Mechanistic | DGIdb | |
| DEXANABINOL | ? unclear | Mechanistic | DGIdb | |
| NEBOGLAMINE | ~ modulates | Mechanistic | DGIdb | |
| HALOPERIDOL DECANOATE | ? unclear | Mechanistic | DGIdb | |
| ORPHENADRINE | ? unclear | Mechanistic | DGIdb | |
| GW468816 | ↓ inhibits | Mechanistic | DGIdb | |
| ACAMPROSATE CALCIUM | ↓ inhibits | Mechanistic | DGIdb | |
| AMANTADINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| H-151 | ↓ inhibits | Mechanistic | DGIdb | |
| D-SERINE | ? unclear | Mechanistic | DGIdb | |
| AZD8108 | ↓ inhibits | Mechanistic | DGIdb | |
| KETAMINE HYDROCHLORIDE | ~ modulates | Mechanistic | DGIdb | |
| DELUCEMINE | ↓ inhibits | Mechanistic | DGIdb | |
| EVT-101 | ↓ inhibits | Mechanistic | DGIdb | |
| MSA-2 | ↑ activates | Mechanistic | DGIdb | |
| ESKETAMINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| 2'3'-CGAMP | ↑ activates | Mechanistic | DGIdb | |
| COMPOUND 40 [PMID: 33470814] | ↑ activates | Mechanistic | DGIdb | |
| PHILANTHOTOXIN 343 | ? unclear | Mechanistic | DGIdb | |
| FELBAMATE | ↓ inhibits | Mechanistic | DGIdb | |
| INDANTADOL | ↓ inhibits | Mechanistic | DGIdb | |
| STING AGONIST 3 | ↑ activates | Mechanistic | DGIdb | |
| ORPHENADRINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CYCLOSERINE | ? unclear | Mechanistic | DGIdb | |
| RADIPRODIL | ↓ inhibits | Mechanistic | DGIdb | |
| PERZINFOTEL | ↓ inhibits | Mechanistic | DGIdb | |
| ESKETAMINE | ~ modulates | Mechanistic | DGIdb | |
| ADU-S100 | ↑ activates | Mechanistic | DGIdb | |
| RALFINAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| SNX281 | ↑ activates | Mechanistic | DGIdb |
Showing top 40 of 183 agents ranked by evidence tier.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CISPLATIN | ? unclear | Mechanistic | DGIdb | |
| ZILTIVEKIMAB | ~ modulates | Mechanistic | DGIdb | |
| CHINESE HERBS | ? unclear | Mechanistic | DGIdb | |
| PF-04236921 | ↓ inhibits | Mechanistic | DGIdb | |
| MRA 003 US | ↓ inhibits | Mechanistic | DGIdb | |
| SIGNAL TRANSDUCTION INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| BINETRAKIN | ? unclear | Mechanistic | DGIdb | |
| IBUDILAST | ? unclear | Mechanistic | DGIdb | |
| INSULIN, REGULAR, HUMAN | ? unclear | Mechanistic | DGIdb | |
| SILTUXIMAB | ↓ inhibits | Mechanistic | DGIdb | |
| METRONIDAZOLE | ? unclear | Mechanistic | DGIdb | |
| CLAZAKIZUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| GALLIUM NITRATE | ? unclear | Mechanistic | DGIdb | |
| INTERFERON ALFA-2B | ? unclear | Mechanistic | DGIdb | |
| DULOXETINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| MEDI-5117 | ↓ inhibits | Mechanistic | DGIdb | |
| GEMFIBROZIL | ? unclear | Mechanistic | DGIdb | |
| BIAFINE CREAM | ? unclear | Mechanistic | DGIdb | |
| ETANERCEPT | ? unclear | Mechanistic | DGIdb | |
| ELSILIMOMAB | ↓ inhibits | Mechanistic | DGIdb | |
| SAQUINAVIR | ? unclear | Mechanistic | DGIdb | |
| INFLIXIMAB | ? unclear | Mechanistic | DGIdb | |
| LINEZOLID | ? unclear | Mechanistic | DGIdb | |
| IFOSFAMIDE | ? unclear | Mechanistic | DGIdb | |
| OLOKIZUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| HMG-COA REDUCTASE INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| MIDOSTAURIN | ? unclear | Mechanistic | DGIdb | |
| SELENIUM | ? unclear | Mechanistic | DGIdb | |
| SIRUKUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| PEGINTERFERON ALFA-2B | ? unclear | Mechanistic | DGIdb | |
| ECHINACEA PREPARATION | ? unclear | Mechanistic | DGIdb | |
| ENZYME INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| FENOFIBRATE MICRONIZED | ? unclear | Mechanistic | DGIdb | |
| VITAMIN K | ? unclear | Mechanistic | DGIdb | |
| PEGINTERFERON ALFA-2A | ? unclear | Mechanistic | DGIdb | |
| RIBAVIRIN | ? unclear | Mechanistic | DGIdb | |
| VITAMIN A PALMITATE | ? unclear | Mechanistic | DGIdb | |
| ARSENIC TRIOXIDE | ? unclear | Mechanistic | DGIdb | |
| DIHYDROSPHINGOSINE | ? unclear | Mechanistic | DGIdb | |
| LEVOFLOXACIN ANHYDROUS | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 173 agents ranked by evidence tier.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| MEDI-578 | ↓ inhibits | Mechanistic | DGIdb | |
| CERE-110 | ? unclear | Mechanistic | DGIdb | |
| FASINUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| TANEZUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| FRUNEVETMAB | ~ modulates | Mechanistic | DGIdb | |
| FULRANUMAB | ↓ inhibits | Mechanistic | DGIdb | |
| BEDINVETMAB | ~ modulates | Mechanistic | DGIdb | |
| PG-110 | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL1397270 | ↓ inhibits | Mechanistic | 1000.0 nM (IC50) | ChEMBL |
PTGS2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CARPROFEN | ↓ inhibits | Mechanistic | 102.0 nM (IC50) | DGIdb |
| INDOMETHACIN SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| DARBUFELONE | ? unclear | Mechanistic | DGIdb | |
| MEFENAMIC ACID | ↓ inhibits | Mechanistic | DGIdb | |
| MECLOFENAMATE SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| DICLOFENAC SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| CAPECITABINE | ? unclear | Mechanistic | DGIdb | |
| PIRPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| ESFLURBIPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| SULFASALAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| BROMFENAC | ? unclear | Mechanistic | DGIdb | |
| IBUPROFEN, SODIUM SALT | ↓ inhibits | Mechanistic | DGIdb | |
| ALOXIPRIN | ↓ inhibits | Mechanistic | DGIdb | |
| TENOXICAM | ? unclear | Mechanistic | DGIdb | |
| FLURBIPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| SALICYLIC ACID | ? unclear | Mechanistic | DGIdb | |
| ATENOLOL | ? unclear | Mechanistic | DGIdb | |
| DEXKETOPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| ETORICOXIB | ↓ inhibits | Mechanistic | DGIdb | |
| LUMIRACOXIB | ↓ inhibits | Mechanistic | DGIdb | |
| SUPROFEN | ↓ inhibits | Mechanistic | DGIdb | |
| NS-398 | ? unclear | Mechanistic | DGIdb | |
| NABUMETONE | ↓ inhibits | Mechanistic | DGIdb | |
| URSOLIC ACID | ? unclear | Mechanistic | DGIdb | |
| IBUPROFEN LYSINE | ↓ inhibits | Mechanistic | DGIdb | |
| ACECLOFENAC | ↓ inhibits | Mechanistic | DGIdb | |
| IBUFENAC | ↓ inhibits | Mechanistic | DGIdb | |
| BALSALAZIDE | ? unclear | Mechanistic | DGIdb | |
| DIFLUNISAL | ↓ inhibits | Mechanistic | DGIdb | |
| BALSALAZIDE DISODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| VACCINE | ? unclear | Mechanistic | DGIdb | |
| KETOROLAC TROMETHAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| BENZYDAMINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| TIAPROFENIC ACID | ? unclear | Mechanistic | DGIdb | |
| RALOXIFENE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| NAPROXCINOD | ↓ inhibits | Mechanistic | DGIdb | |
| IGURATIMOD | ↓ inhibits | Mechanistic | DGIdb | |
| ETODOLAC | ↓ inhibits | Mechanistic | DGIdb | |
| DICLOFENAC ETALHYALURONATE SODIUM | ↓ inhibits | Mechanistic | DGIdb | |
| ROFECOXIB | ↓ inhibits | Mechanistic | 530.0 nM (IC50) | DGIdb |
Showing top 40 of 299 agents ranked by evidence tier.
SCN9A
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| MERETHOXYLLINE PROCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| ETIDOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| FOSPHENYTOIN | ↓ inhibits | Mechanistic | DGIdb | |
| VERATRIDINE | ↑ activates | Mechanistic | DGIdb | |
| ORPHENADRINE CITRATE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENACEMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LACOSAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| VIXOTRIGINE | ↓ inhibits | Mechanistic | DGIdb | |
| DSP-2230 | ↓ inhibits | Mechanistic | DGIdb | |
| SAXITOXIN | ↓ inhibits | Mechanistic | DGIdb | |
| ESLICARBAZEPINE ACETATE | ↓ inhibits | Mechanistic | DGIdb | |
| SAFINAMIDE | ? unclear | Mechanistic | DGIdb | |
| LIDOCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| RILUZOLE | ↓ inhibits | Mechanistic | DGIdb | |
| ROPIVACAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| FUNAPIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DYCLONINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| EVENAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROPOFOL | ? unclear | Mechanistic | DGIdb | |
| AM-6120 | ↓ inhibits | Mechanistic | DGIdb | |
| RG7893 | ↓ inhibits | Mechanistic | DGIdb | |
| RG6029 | ↓ inhibits | Mechanistic | DGIdb | |
| QUINIDINE SULFATE | ↓ inhibits | Mechanistic | DGIdb | |
| ZONISAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| NERISPIRDINE | ↓ inhibits | Mechanistic | DGIdb | |
| RALFINAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DS-1971A | ↓ inhibits | Mechanistic | DGIdb | |
| HEXYLCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| MEPIVACAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROCAINAMIDE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROPAFENONE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LIDOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| QUINIDINE GLUCONATE | ↓ inhibits | Mechanistic | DGIdb | |
| PRILOCAINE | ↓ inhibits | Mechanistic | DGIdb | |
| ETHOTOIN | ↓ inhibits | Mechanistic | DGIdb | |
| PF-05089771 | ↓ inhibits | Mechanistic | DGIdb | |
| DICHLOROBENZYL ALCOHOL | ↓ inhibits | Mechanistic | DGIdb | |
| RANOLAZINE | ? unclear | Mechanistic | DGIdb | |
| PRILOCAINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ORPHENADRINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 271 agents ranked by evidence tier.
TRPV1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| STREPTOZOCIN | ? unclear | Mechanistic | DGIdb | |
| BENZYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| ACETAMINOPHEN | ↑ activates | Mechanistic | DGIdb | |
| POLYGODIAL | ? unclear | Mechanistic | DGIdb | |
| PROPOFOL | ? unclear | Mechanistic | DGIdb | |
| SAF312 | ↓ inhibits | Mechanistic | DGIdb | |
| GRC-15300 | ? unclear | Mechanistic | DGIdb | |
| AZD1386 | ↓ inhibits | Mechanistic | DGIdb | |
| TIVANISIRAN | ↓ inhibits | Mechanistic | DGIdb | |
| MAVATREP | ↓ inhibits | Mechanistic | DGIdb | |
| MR-1817 | ↓ inhibits | Mechanistic | DGIdb | |
| FERRUGINENE B | ? unclear | Mechanistic | DGIdb | |
| CAPSAICIN | ↑ activates | Mechanistic | 19.95 nM (EC50) | DGIdb |
| RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN | ? unclear | Mechanistic | DGIdb | |
| PHENETHYLISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| VOACANGINE | ? unclear | Mechanistic | DGIdb | |
| RESINIFERATOXIN | ↑ activates | Mechanistic | 23.1 nM (Ki) | DGIdb |
| DWP05195 | ↓ inhibits | Mechanistic | DGIdb | |
| XEN-D0501 | ↓ inhibits | Mechanistic | DGIdb | |
| PAC-14028 | ↓ inhibits | Mechanistic | DGIdb | |
| SB-705498 | ↓ inhibits | Mechanistic | DGIdb | |
| MASOPROCOL | ? unclear | Mechanistic | DGIdb | |
| ALLYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb | |
| NGD-8243 | ↓ inhibits | Mechanistic | DGIdb | |
| GRC-6211 | ↓ inhibits | Mechanistic | DGIdb | |
| RESERPINE | ? unclear | Mechanistic | DGIdb | |
| NABIXIMOLS | ? unclear | Mechanistic | DGIdb | |
| A425619 | ? unclear | Mechanistic | DGIdb | |
| PHE377 | ↓ inhibits | Mechanistic | DGIdb | |
| ANTISENSE OLIGONUCLEOTIDES | ? unclear | Mechanistic | DGIdb | |
| WORTMANNIN | ? unclear | Mechanistic | DGIdb | |
| JTS-653 | ↓ inhibits | Mechanistic | DGIdb | |
| LEVODOPA | ? unclear | Mechanistic | DGIdb | |
| AMG517 | ↓ inhibits | Mechanistic | DGIdb | |
| CAPSAZEPINE | ? unclear | Mechanistic | 120.0 nM (Ki) | DGIdb |
| ZUCAPSAICIN | ↑ activates | Mechanistic | DGIdb | |
| INDOMETHACIN | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL191534 | ? unclear | Mechanistic | DGIdb | |
| ABT-102 | ↓ inhibits | Mechanistic | DGIdb | |
| ISOPROPYL ISOTHIOCYANATE | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 160 agents ranked by evidence tier.
Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-03.
The aim of this study is to compare the effects of single-session motor imagery and motor control exercises on pain, pressure pain threshold, cervical proprioception, and motor imagery in individuals with chronic neck pain.
A randomized controlled trial to evaluate the effectiveness of Sensory Motor Control training combined with Muscle Energy Technique in reducing pain and improving function, cervical range of motion, proprioception, and kinesiophobia in individuals with chronic mechanical neck pain
The goal of this clinical trial is to determine whether acupuncture can improve neck pain and shoulder movement in people with chronic neck pain. Researchers will compare acupuncture with sham acupuncture (a procedure designed to resemble acupuncture without therapeutic effects) to determine whether...
Chronic non-specific neck pain is a common musculoskeletal condition affecting a large proportion of the population worldwide. It is characterized by persistent neck pain lasting more than three months without a specific underlying pathology. Many patients experience ongoing symptoms such as pain, r...
Chronic musculoskeletal pain (CP) is a major public health concern. Psychosocial treatments have been shown to be efficacious when compared to largely inert control conditions, but they are characterized by modest effects on primary outcomes. One strategy to boost efficacy is to increase our underst...
This study will be conducted to investigate the effect of mechanical traction on pain, disability, cervical range of motion, sleep quality and insomnia in patients with chronic neck pain. Forty four female patients with chronic neck pain will participate in this study. The patients will be diagnosed...
This study evaluates whether a single session of percussion therapy can reduce muscle tension and increase blood flow in the transverse cervical artery in individuals with neck pain. The investigators will evaluate muscle stiffness using ultrasound elastography, and assess blood flow in the transver...
This prospective single-center study aims to evaluate the clinical efficacy of fluoroscopy-guided cervical interlaminar epidural steroid injection (CIESI) in patients with unilateral, single-level cervical radiculopathy due to cervical disc herniation. Unlike previous studies that assessed neck and ...
The purpose of the clinical trial is to investigate the effect of the combined Kendall and scapulothoracic exercises program on mechanosensitivity of brachial plexus, cervical range of motion, neck functional ability, and craniovertebral angle in patients with chronic non-specific neck pain. we hav...
Mechanical neck pain (MNP) refers to aches and pains in the cervical spine and around the cervicothoracic junction that do not have a specific anatomical or physical source. Multiple non-invasive physiotherapy methods can be used for treating MNP including bowen therapy and myofascial release therap...
The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the contribution of non-mechanical pathways associated with this type of pain in wo...
This study is a pragmatic randomized controlled study that assessed 250 subjects complaining of chronic bothersome neck pain with mild discomfort in a 1:1 ratio: chuna maintenance therapy group (125 subjects, 1 time/2 weeks, total 20 weeks) and lifestyle management \& self-exercise group (125 subjec...
Non-specific chronic neck pain represents a major global health burden, affecting 30% to 50% of the general population. It is particularly prevalent among office workers, computer users, and women, with a notable rise in young adults aged 20 to 24. While acute episodes of neck pain may initially res...
The research aims to treat chronic non-specific neck pain using virtual reality (VR) technologies with sensory-motor training. Chronic neck pain is widespread and highly prevalent in Egyptian society due to many factors, such as sitting for long periods in front of a computer or smartphone, which le...
The present study aims to evaluate the effects of deep neck stabilizers retraining with pressure biofeedback on cervical range of motion, pain, and temporomandibular dysfunction in patients with chronic neck pain. Participants will receive biofeedback-assisted deep neck flexor retraining in one gro...
Searched directly from “Neck Pain (Chronic)” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 6-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."