Remission & chronicity

Spontaneous remission

Relapse in 19-45% within 1 year of antidepressant discontinuation after remission; relapse risk ratio (off-medication vs on) falls from 3.69x at 2 months to 1.34x at 5 years

Best-intervention remission

55-80% remain relapse-free at 1 year after well-managed discontinuation; psychotherapy (CBT) achieves comparable remission with better durability; psilocybin-assisted therapy showing 29-71% response at 3 months in treatment-resistant cases

Gap size

Moderate; narrows substantially over time for maintenance medication question

Primary barrier

practice

Guidelines push long maintenance durations partly because short-term relapse risk is high, but long-term maintenance evidence is weaker than commonly assumed; psychotherapy significantly underutilized relative to medication

Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.

BDNF 123 CRH 9 DRD2 427 FKBP5 194 GRIN2B 238 HTR1A 82 HTR2A 122 IL6 173 MAOA 39 MAOB 218 NTRK2 206 SLC6A2 269 SLC6A3 176 SLC6A4 104

BDNF

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
TRAMADOL	? unclear	Mechanistic	DGIdb
FLUTICASONE	↑ activates	Mechanistic	DGIdb
IONOMYCIN	? unclear	Mechanistic	DGIdb
MONOAMINE OXIDASE INHIBITOR	? unclear	Mechanistic	DGIdb
FREUND'S ADJUVANT	? unclear	Mechanistic	DGIdb
LITHIUM	? unclear	Mechanistic	DGIdb
ZINC SULFATE ANHYDROUS	? unclear	Mechanistic	DGIdb
CAPSAICIN	? unclear	Mechanistic	DGIdb
PROPRANOLOL HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
MARIJUANA	? unclear	Mechanistic	DGIdb
NORTRIPTYLINE	? unclear	Mechanistic	DGIdb
BORTEZOMIB	? unclear	Mechanistic	DGIdb
GLUCAGON (RDNA)	? unclear	Mechanistic	DGIdb
COLCHICINE	? unclear	Mechanistic	DGIdb
DOXEPIN HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
DRONABINOL	? unclear	Mechanistic	DGIdb
TANAPROGET	↑ activates	Mechanistic	DGIdb
CYCLOOXYGENASE INHIBITOR	? unclear	Mechanistic	DGIdb
VERTEPORFIN	? unclear	Mechanistic	DGIdb
ANTIOXIDANT	? unclear	Mechanistic	DGIdb
DITIOCARB	? unclear	Mechanistic	DGIdb
APR19	↓ inhibits	Mechanistic	DGIdb
DOXORUBICIN HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
OPIATE	? unclear	Mechanistic	DGIdb
OXIDOPAMINE	? unclear	Mechanistic	DGIdb
TETRADECANOYLPHORBOL ACETATE	? unclear	Mechanistic	DGIdb
INSULIN, REGULAR, HUMAN	? unclear	Mechanistic	DGIdb
PROPYLTHIOURACIL	? unclear	Mechanistic	DGIdb
TROGLITAZONE	? unclear	Mechanistic	DGIdb
TYROSINE HYDROXYLASE INHIBITOR	? unclear	Mechanistic	DGIdb
ALTEPLASE	? unclear	Mechanistic	DGIdb
MEDICATION	? unclear	Mechanistic	DGIdb
HALOPERIDOL DECANOATE	? unclear	Mechanistic	DGIdb
ASOPRISNIL	↓ inhibits	Mechanistic	DGIdb
ANALGESIC AGENT	? unclear	Mechanistic	DGIdb
TCDD	? unclear	Mechanistic	DGIdb
THERAPEUTIC GONADOTROPIN	? unclear	Mechanistic	DGIdb
METHADONE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
RECOMBINANT TRANSFORMING GROWTH FACTOR	? unclear	Mechanistic	DGIdb
ONAPRISTONE	↓ inhibits	Mechanistic	DGIdb

Showing top 40 of 123 agents ranked by evidence tier.

CRH

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
ROSIGLITAZONE	? unclear	Mechanistic		DGIdb
ACIVICIN	↓ inhibits	Mechanistic		DGIdb
MEDICATION	? unclear	Mechanistic		DGIdb
GGSTOP	↓ inhibits	Mechanistic		DGIdb
ANTIDEPRESSANT AGENT	? unclear	Mechanistic		DGIdb
IRX-2	? unclear	Mechanistic		DGIdb
ANTISERUM	? unclear	Mechanistic		DGIdb
NALOXONE HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
CHEMBL5286255	↓ inhibits	Mechanistic	0.7 nM (Ki)	ChEMBL

DRD2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
ASENAPINE	? unclear	Mechanistic		DGIdb
MEPHENTERMINE	? unclear	Mechanistic		DGIdb
HALOPERIDOL LACTATE	↓ inhibits	Mechanistic		DGIdb
BREXPIPRAZOLE	↑ activates	Mechanistic		DGIdb
ANALGESIC AGENT	? unclear	Mechanistic		DGIdb
AXITINIB	↓ inhibits	Mechanistic		DGIdb
RG-1530	↓ inhibits	Mechanistic		DGIdb
LOXAPINE SUCCINATE	↓ inhibits	Mechanistic		DGIdb
QUETIAPINE FUMARATE	↓ inhibits	Mechanistic		DGIdb
PROCHLORPERAZINE	↓ inhibits	Mechanistic		DGIdb
APOMORPHINE	↑ activates	Mechanistic		DGIdb
PRAMIPEXOLE	? unclear	Mechanistic		DGIdb
THIETHYLPERAZINE MALEATE	↓ inhibits	Mechanistic		DGIdb
IBCASERTIB	↓ inhibits	Mechanistic		DGIdb
FAMITINIB	↓ inhibits	Mechanistic		DGIdb
SOXATALTINIB	↓ inhibits	Mechanistic		DGIdb
SUMANIROLE	↑ activates	Mechanistic	9.0 nM (Ki)	DGIdb
DOCARPAMINE	? unclear	Mechanistic		DGIdb
PALIPERIDONE	↓ inhibits	Mechanistic		DGIdb
PRIDOPIDINE	~ modulates	Mechanistic		DGIdb
OLANZAPINE	↓ inhibits	Mechanistic	20.0 nM (Ki)	DGIdb
PEGDINETANIB	↓ inhibits	Mechanistic		DGIdb
RISPERIDONE	↓ inhibits	Mechanistic		DGIdb
PERGOLIDE MESYLATE	↑ activates	Mechanistic		DGIdb
LISURIDE	? unclear	Mechanistic	0.5 nM (Ki)	DGIdb
ZICRONAPINE	? unclear	Mechanistic		DGIdb
CLEBOPRIDE	↓ inhibits	Mechanistic		DGIdb
LAZERTINIB	↓ inhibits	Mechanistic		DGIdb
REMOXIPRIDE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
CABERGOLINE	↑ activates	Mechanistic		DGIdb
JNJ-37822681	↓ inhibits	Mechanistic		DGIdb
ERGOT ALKALOIDS	? unclear	Mechanistic		DGIdb
(-)-STEPHOLIDINE	? unclear	Mechanistic		DGIdb
SARIZOTAN HYDROCHLORIDE	↑ activates	Mechanistic		DGIdb
5-OH-DPAT	? unclear	Mechanistic		DGIdb
LITHIUM	? unclear	Mechanistic		DGIdb
DIHYDROERGOTOXINE	? unclear	Mechanistic		DGIdb
REMOXIPRIDE	↓ inhibits	Mechanistic		DGIdb
BROMPERIDOL	↓ inhibits	Mechanistic		DGIdb
PHENTOLAMINE	? unclear	Mechanistic		DGIdb

Showing top 40 of 427 agents ranked by evidence tier.

FKBP5

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
CITALOPRAM	? unclear	Mechanistic		DGIdb
CLOMIPRAMINE	? unclear	Mechanistic		DGIdb
ZAK INHIBITOR 6P	↓ inhibits	Mechanistic		DGIdb
GEMCITABINE	? unclear	Mechanistic		DGIdb
KC-130	↓ inhibits	Mechanistic		DGIdb
THERAPEUTIC CORTICOSTEROID	? unclear	Mechanistic		DGIdb
NEFAZODONE	? unclear	Mechanistic		DGIdb
COMPOUND 15B [PMID: 16539403]	↓ inhibits	Mechanistic		DGIdb
LIOTHYRONINE	? unclear	Mechanistic		DGIdb
LITHIUM	? unclear	Mechanistic		DGIdb
BUPROPION HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
CLOZAPINE	? unclear	Mechanistic		DGIdb
CHEMBL321022	↓ inhibits	Mechanistic	6300.0 nM (IC50)	ChEMBL
CHEMBL2058222	↓ inhibits	Mechanistic	62800.0 nM (IC50)	ChEMBL
CHEMBL2058223	↓ inhibits	Mechanistic	30700.0 nM (IC50)	ChEMBL
CHEMBL2058224	↓ inhibits	Mechanistic	11600.0 nM (IC50)	ChEMBL
CHEMBL2058226	↓ inhibits	Mechanistic	67100.0 nM (IC50)	ChEMBL
CHEMBL2058227	↓ inhibits	Mechanistic	28500.0 nM (IC50)	ChEMBL
CHEMBL2058228	↓ inhibits	Mechanistic	47200.0 nM (IC50)	ChEMBL
CHEMBL2058229	↓ inhibits	Mechanistic	45400.0 nM (IC50)	ChEMBL
CHEMBL2058232	↓ inhibits	Mechanistic	54050.0 nM (IC50)	ChEMBL
CHEMBL2058233	↓ inhibits	Mechanistic	15780.0 nM (IC50)	ChEMBL
CHEMBL2058234	↓ inhibits	Mechanistic	22600.0 nM (IC50)	ChEMBL
CHEMBL2058237	↓ inhibits	Mechanistic	29600.0 nM (IC50)	ChEMBL
CHEMBL2058238	↓ inhibits	Mechanistic	88200.0 nM (IC50)	ChEMBL
CHEMBL2058494	↓ inhibits	Mechanistic	6200.0 nM (IC50)	ChEMBL
CHEMBL2058495	↓ inhibits	Mechanistic	16400.0 nM (IC50)	ChEMBL
CHEMBL2058496	↓ inhibits	Mechanistic	16100.0 nM (IC50)	ChEMBL
CHEMBL2058498	↓ inhibits	Mechanistic	27200.0 nM (IC50)	ChEMBL
CHEMBL2058500	↓ inhibits	Mechanistic	18400.0 nM (IC50)	ChEMBL
CHEMBL2058787	↓ inhibits	Mechanistic	14700.0 nM (IC50)	ChEMBL
CHEMBL2058791	↓ inhibits	Mechanistic	66270.0 nM (IC50)	ChEMBL
CHEMBL2058794	↓ inhibits	Mechanistic	456.0 nM (IC50)	ChEMBL
CHEMBL2058796	↓ inhibits	Mechanistic	2030.0 nM (IC50)	ChEMBL
CHEMBL2058797	↓ inhibits	Mechanistic	12300.0 nM (IC50)	ChEMBL
CHEMBL2058800	↓ inhibits	Mechanistic	9690.0 nM (IC50)	ChEMBL
CHEMBL2058801	↓ inhibits	Mechanistic	51500.0 nM (IC50)	ChEMBL
CHEMBL2058802	↓ inhibits	Mechanistic	32730.0 nM (IC50)	ChEMBL
CHEMBL2059024	↓ inhibits	Mechanistic	4150.0 nM (IC50)	ChEMBL
CHEMBL2059025	↓ inhibits	Mechanistic	15340.0 nM (IC50)	ChEMBL

Showing top 40 of 194 agents ranked by evidence tier.

GRIN2B

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
DIMIRACETAM	? unclear	Mechanistic		DGIdb
KETAMINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
PERZINFOTEL	↓ inhibits	Mechanistic		DGIdb
[3H]CGP39653	↓ inhibits	Mechanistic		DGIdb
PHENCYCLIDINE	↓ inhibits	Mechanistic		DGIdb
DEXANABINOL	? unclear	Mechanistic		DGIdb
RAPASTINEL	↑ activates	Mechanistic		DGIdb
DELUCEMINE	↓ inhibits	Mechanistic		DGIdb
AMANTADINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
RISLENEMDAZ	↓ inhibits	Mechanistic		DGIdb
ORPHENADRINE CITRATE	↓ inhibits	Mechanistic		DGIdb
ELIPRODIL	? unclear	Mechanistic	13.0 nM (Ki)	DGIdb
INDANTADOL	? unclear	Mechanistic		DGIdb
SEVOFLURANE	? unclear	Mechanistic		DGIdb
SAGE-718	~ modulates	Mechanistic		DGIdb
L689560	↓ inhibits	Mechanistic		DGIdb
ONFASPRODIL	~ modulates	Mechanistic		DGIdb
HOMOQUINOLINIC ACID	↑ activates	Mechanistic		DGIdb
NEBOGLAMINE	~ modulates	Mechanistic		DGIdb
DIZOCILPINE	↓ inhibits	Mechanistic		DGIdb
LY233053	↓ inhibits	Mechanistic		DGIdb
GLYCINE	↑ activates	Mechanistic		DGIdb
ESKETAMINE	~ modulates	Mechanistic		DGIdb
[3H]CGP61594	↓ inhibits	Mechanistic		DGIdb
ORPHENADRINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
[3H]MDL105519	↓ inhibits	Mechanistic		DGIdb
RADIPRODIL	? unclear	Mechanistic		DGIdb
NBQX	? unclear	Mechanistic		DGIdb
SEMAPIMOD	↓ inhibits	Mechanistic		DGIdb
SELFOTEL	↓ inhibits	Mechanistic		DGIdb
SERINE, D-	↑ activates	Mechanistic		DGIdb
COMPOUND 18C [PMID: 25901531]	↓ inhibits	Mechanistic		DGIdb
AZD8108	↓ inhibits	Mechanistic		DGIdb
[3H]L689560	↓ inhibits	Mechanistic		DGIdb
TRAXOPRODIL	↓ inhibits	Mechanistic	74.0 nM (IC50)	DGIdb
HALOPERIDOL DECANOATE	? unclear	Mechanistic		DGIdb
N1-DANSYL-SPERMINE	↓ inhibits	Mechanistic		DGIdb
[3H]D-ASPARTIC ACID	↑ activates	Mechanistic		DGIdb
NERAMEXANE	? unclear	Mechanistic		DGIdb
NVP-AAM077	↓ inhibits	Mechanistic		DGIdb

Showing top 40 of 238 agents ranked by evidence tier.

HTR1A

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
SERTRALINE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
QUETIAPINE FUMARATE	? unclear	Mechanistic	DGIdb
FLIBANSERIN	? unclear	Mechanistic	DGIdb
SARIZOTAN HYDROCHLORIDE	↑ activates	Mechanistic	DGIdb
LISURIDE	? unclear	Mechanistic	DGIdb
CLOZAPINE	? unclear	Mechanistic	DGIdb
BIFEPRUNOX	↑ activates	Mechanistic	DGIdb
DU 125530	↓ inhibits	Mechanistic	DGIdb
ILOPERIDONE	? unclear	Mechanistic	DGIdb
XALIPRODEN	↑ activates	Mechanistic	DGIdb
BUSPIRONE HYDROCHLORIDE	↑ activates	Mechanistic	DGIdb
ENSACULIN HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
VORTIOXETINE HYDROBROMIDE	↑ activates	Mechanistic	DGIdb
NORTRIPTYLINE	? unclear	Mechanistic	DGIdb
ELTOPRAZINE	? unclear	Mechanistic	DGIdb
ARIPIPRAZOLE LAUROXIL	↑ activates	Mechanistic	DGIdb
METHYSERGIDE	? unclear	Mechanistic	DGIdb
TRAZODONE	? unclear	Mechanistic	DGIdb
PIROMELATINE	? unclear	Mechanistic	DGIdb
ULOTARONT	↑ activates	Mechanistic	DGIdb
MN-305	? unclear	Mechanistic	DGIdb
CLOMIPRAMINE	? unclear	Mechanistic	DGIdb
OXYMETAZOLINE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
BUSPIRONE	? unclear	Mechanistic	DGIdb
MILNACIPRAN	? unclear	Mechanistic	DGIdb
MONOAMINE OXIDASE INHIBITOR	? unclear	Mechanistic	DGIdb
TRIMIPRAMINE	? unclear	Mechanistic	DGIdb
MIRTAZAPINE	? unclear	Mechanistic	DGIdb
GEPIRONE	↑ activates	Mechanistic	DGIdb
OPC-14523	? unclear	Mechanistic	DGIdb
BREXPIPRAZOLE	↑ activates	Mechanistic	DGIdb
ALVERINE	↓ inhibits	Mechanistic	DGIdb
NALUZOTAN	↑ activates	Mechanistic	DGIdb
PARDOPRUNOX	↑ activates	Mechanistic	DGIdb
MAZAPERTINE SUCCINATE	? unclear	Mechanistic	DGIdb
METHAMPHETAMINE	? unclear	Mechanistic	DGIdb
DOXEPIN HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
AMISULPRIDE	↓ inhibits	Mechanistic	DGIdb
DEXFENFLURAMINE HYDROCHLORIDE	↑ activates	Mechanistic	DGIdb
NARATRIPTAN	? unclear	Mechanistic	DGIdb

Showing top 40 of 82 agents ranked by evidence tier.

HTR2A

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
RISPERIDONE	↓ inhibits	Mechanistic	DGIdb
THIORIDAZINE	↓ inhibits	Mechanistic	DGIdb
BREXPIPRAZOLE	↓ inhibits	Mechanistic	DGIdb
CHLORPROMAZINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
PRUVANSERIN	↓ inhibits	Mechanistic	DGIdb
OCAPERIDONE	? unclear	Mechanistic	DGIdb
IFERANSERIN	↓ inhibits	Mechanistic	DGIdb
SARPOGRELATE	↓ inhibits	Mechanistic	DGIdb
KETANSERIN	? unclear	Mechanistic	DGIdb
LOXAPINE	↓ inhibits	Mechanistic	DGIdb
CHLORPROTHIXENE	↓ inhibits	Mechanistic	DGIdb
CHLORPROMAZINE	↓ inhibits	Mechanistic	DGIdb
VABICASERIN HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
ARIPIPRAZOLE LAUROXIL	↓ inhibits	Mechanistic	DGIdb
HALOPERIDOL DECANOATE	↓ inhibits	Mechanistic	DGIdb
METHYSERGIDE	? unclear	Mechanistic	DGIdb
TRELANSERIN	↓ inhibits	Mechanistic	DGIdb
MINAPRINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
ZIPRASIDONE	↓ inhibits	Mechanistic	DGIdb
QUETIAPINE FUMARATE	↓ inhibits	Mechanistic	DGIdb
MIANSERIN	? unclear	Mechanistic	DGIdb
DOXEPIN HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
LOXAPINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
VOLINANSERIN	↓ inhibits	Mechanistic	DGIdb
ANIRACETAM	? unclear	Mechanistic	DGIdb
LUMATEPERONE	↓ inhibits	Mechanistic	DGIdb
TEDATIOXETINE	↓ inhibits	Mechanistic	DGIdb
ONDANSETRON HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
DROPERIDOL	↓ inhibits	Mechanistic	DGIdb
TERGURIDE	? unclear	Mechanistic	DGIdb
PALIPERIDONE	↓ inhibits	Mechanistic	DGIdb
NELOTANSERIN	↓ inhibits	Mechanistic	DGIdb
CLOTHIAPINE	↓ inhibits	Mechanistic	DGIdb
THIOTHIXENE	↓ inhibits	Mechanistic	DGIdb
ZOTEPINE	? unclear	Mechanistic	DGIdb
LOXAPINE SUCCINATE	↓ inhibits	Mechanistic	DGIdb
MINAPRINE	↓ inhibits	Mechanistic	DGIdb
USTEKINUMAB	? unclear	Mechanistic	DGIdb
HALOPERIDOL LACTATE	↓ inhibits	Mechanistic	DGIdb
ERGOT ALKALOIDS	? unclear	Mechanistic	DGIdb

Showing top 40 of 122 agents ranked by evidence tier.

IL6

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
CISPLATIN	? unclear	Mechanistic	DGIdb
ZILTIVEKIMAB	~ modulates	Mechanistic	DGIdb
CHINESE HERBS	? unclear	Mechanistic	DGIdb
PF-04236921	↓ inhibits	Mechanistic	DGIdb
MRA 003 US	↓ inhibits	Mechanistic	DGIdb
SIGNAL TRANSDUCTION INHIBITOR	? unclear	Mechanistic	DGIdb
BINETRAKIN	? unclear	Mechanistic	DGIdb
IBUDILAST	? unclear	Mechanistic	DGIdb
INSULIN, REGULAR, HUMAN	? unclear	Mechanistic	DGIdb
SILTUXIMAB	↓ inhibits	Mechanistic	DGIdb
METRONIDAZOLE	? unclear	Mechanistic	DGIdb
CLAZAKIZUMAB	↓ inhibits	Mechanistic	DGIdb
GALLIUM NITRATE	? unclear	Mechanistic	DGIdb
INTERFERON ALFA-2B	? unclear	Mechanistic	DGIdb
DULOXETINE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
MEDI-5117	↓ inhibits	Mechanistic	DGIdb
GEMFIBROZIL	? unclear	Mechanistic	DGIdb
BIAFINE CREAM	? unclear	Mechanistic	DGIdb
ETANERCEPT	? unclear	Mechanistic	DGIdb
ELSILIMOMAB	↓ inhibits	Mechanistic	DGIdb
SAQUINAVIR	? unclear	Mechanistic	DGIdb
INFLIXIMAB	? unclear	Mechanistic	DGIdb
LINEZOLID	? unclear	Mechanistic	DGIdb
IFOSFAMIDE	? unclear	Mechanistic	DGIdb
OLOKIZUMAB	↓ inhibits	Mechanistic	DGIdb
HMG-COA REDUCTASE INHIBITOR	? unclear	Mechanistic	DGIdb
MIDOSTAURIN	? unclear	Mechanistic	DGIdb
SELENIUM	? unclear	Mechanistic	DGIdb
SIRUKUMAB	↓ inhibits	Mechanistic	DGIdb
PEGINTERFERON ALFA-2B	? unclear	Mechanistic	DGIdb
ECHINACEA PREPARATION	? unclear	Mechanistic	DGIdb
ENZYME INHIBITOR	? unclear	Mechanistic	DGIdb
FENOFIBRATE MICRONIZED	? unclear	Mechanistic	DGIdb
VITAMIN K	? unclear	Mechanistic	DGIdb
PEGINTERFERON ALFA-2A	? unclear	Mechanistic	DGIdb
RIBAVIRIN	? unclear	Mechanistic	DGIdb
VITAMIN A PALMITATE	? unclear	Mechanistic	DGIdb
ARSENIC TRIOXIDE	? unclear	Mechanistic	DGIdb
DIHYDROSPHINGOSINE	? unclear	Mechanistic	DGIdb
LEVOFLOXACIN ANHYDROUS	? unclear	Mechanistic	DGIdb

Showing top 40 of 173 agents ranked by evidence tier.

MAOA

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
CLORGILINE	? unclear	Mechanistic	DGIdb
METHAMPHETAMINE	? unclear	Mechanistic	DGIdb
ISOCARBOXAZID	↓ inhibits	Mechanistic	DGIdb
CHEMBL:CHEMBL1927670	? unclear	Mechanistic	DGIdb
MEBANAZINE	↓ inhibits	Mechanistic	DGIdb
NIALAMIDE	↓ inhibits	Mechanistic	DGIdb
HARMINE	? unclear	Mechanistic	DGIdb
MINAPRINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
NAPHTHOQUINONE	? unclear	Mechanistic	DGIdb
MOCLOBEMIDE	↓ inhibits	Mechanistic	DGIdb
CHEMBL:CHEMBL1927684	? unclear	Mechanistic	DGIdb
NICOTINE POLACRILEX	? unclear	Mechanistic	DGIdb
TRANYLCYPROMINE	↓ inhibits	Mechanistic	DGIdb
INDANTADOL	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL1813518	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL602466	? unclear	Mechanistic	DGIdb
ANTIDEPRESSANT AGENT	? unclear	Mechanistic	DGIdb
PHENELZINE	? unclear	Mechanistic	DGIdb
PIPERINE	? unclear	Mechanistic	DGIdb
PARGYLINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
CX157	? unclear	Mechanistic	DGIdb
IPRONIAZID	↓ inhibits	Mechanistic	DGIdb
PHENOXYPROPAZINE	↓ inhibits	Mechanistic	DGIdb
SELEGILINE	? unclear	Mechanistic	DGIdb
PSORALEN	? unclear	Mechanistic	DGIdb
TRYPTAMINE	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL1642672	? unclear	Mechanistic	DGIdb
PHENELZINE SULFATE	↓ inhibits	Mechanistic	DGIdb
1-PHENETHYLPIPERIDINE	? unclear	Mechanistic	DGIdb
TOLOXATONE	↓ inhibits	Mechanistic	DGIdb
CHEMBL:CHEMBL602260	? unclear	Mechanistic	DGIdb
MINAPRINE	↓ inhibits	Mechanistic	DGIdb
CHEMBL:CHEMBL2088301	? unclear	Mechanistic	DGIdb
PROXIBARBAL	↑ activates	Mechanistic	DGIdb
LADOSTIGIL	? unclear	Mechanistic	DGIdb
VITAMIN K3	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL2088303	? unclear	Mechanistic	DGIdb
PARGYLINE	? unclear	Mechanistic	Open Targets
TRANYLCYPROMINE SULFATE	? unclear	Mechanistic	Open Targets

MAOB

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
SAFINAMIDE	↓ inhibits	Mechanistic	450.0 nM (Ki)	DGIdb
LEVODOPA	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL1927670	? unclear	Mechanistic		DGIdb
MOCLOBEMIDE	↓ inhibits	Mechanistic	100000.0 nM (Ki)	DGIdb
CHEMBL:CHEMBL1927684	? unclear	Mechanistic		DGIdb
SELEGILINE	↓ inhibits	Mechanistic	970.0 nM (Ki)	DGIdb
BIFEMELANE	↓ inhibits	Mechanistic		DGIdb
MEBANAZINE	↓ inhibits	Mechanistic		DGIdb
MELATONIN	? unclear	Mechanistic		DGIdb
PARGYLINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
CHEMBL:CHEMBL602260	? unclear	Mechanistic		DGIdb
ISOCARBOXAZID	↓ inhibits	Mechanistic		DGIdb
SEROTONIN	? unclear	Mechanistic		DGIdb
[18F]FLUORORASAGILINE	? unclear	Mechanistic		DGIdb
RASAGILINE	↓ inhibits	Mechanistic	700.0 nM (Ki)	DGIdb
CHEMBL:CHEMBL1642672	? unclear	Mechanistic		DGIdb
PHENOXYPROPAZINE	↓ inhibits	Mechanistic		DGIdb
LAZABEMIDE	↓ inhibits	Mechanistic	84.0 nM (Ki)	DGIdb
NIALAMIDE	↓ inhibits	Mechanistic		DGIdb
CHEMBL:CHEMBL1813518	? unclear	Mechanistic		DGIdb
SAFINAMIDE MESYLATE	↓ inhibits	Mechanistic		DGIdb
COBALAMIN	? unclear	Mechanistic		DGIdb
PHENELZINE	↓ inhibits	Mechanistic		DGIdb
RASAGILINE TARTRATE	↓ inhibits	Mechanistic		DGIdb
RALFINAMIDE	↓ inhibits	Mechanistic		DGIdb
SELEGILINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
VITAMIN K3	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL2088303	? unclear	Mechanistic		DGIdb
TRANYLCYPROMINE	↓ inhibits	Mechanistic		DGIdb
PARGYLINE	? unclear	Mechanistic	1800.0 nM (Ki)	DGIdb
ANTIDEPRESSANT AGENT	? unclear	Mechanistic		DGIdb
MOFEGILINE	? unclear	Mechanistic		DGIdb
INDANTADOL	? unclear	Mechanistic		DGIdb
NAPHTHOQUINONE	? unclear	Mechanistic		DGIdb
METHAMPHETAMINE	? unclear	Mechanistic		DGIdb
HALOPERIDOL DECANOATE	? unclear	Mechanistic		DGIdb
PHENELZINE SULFATE	↓ inhibits	Mechanistic		DGIdb
IPRONIAZID	↓ inhibits	Mechanistic	7540.0 nM (IC50)	DGIdb
LINEZOLID	↓ inhibits	Mechanistic		DGIdb
CHEMBL:CHEMBL602466	? unclear	Mechanistic		DGIdb

Showing top 40 of 218 agents ranked by evidence tier.

NTRK2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
CYCLOSPORINE	? unclear	Mechanistic		DGIdb
CLOZAPINE	? unclear	Mechanistic		DGIdb
DIETHYLDITHIOCARBAMATE	? unclear	Mechanistic		DGIdb
CENEGERMIN	↑ activates	Mechanistic		DGIdb
LINIFANIB	? unclear	Mechanistic	1100.0 nM (Kd)	DGIdb
DORAMAPIMOD	? unclear	Mechanistic	570.0 nM (Kd)	DGIdb
AZD-6918	↓ inhibits	Mechanistic		DGIdb
ENTRECTINIB	↓ inhibits	Mechanistic	2.512 nM (Ki)	DGIdb
TAMATINIB	? unclear	Mechanistic		DGIdb
PD-0166285	? unclear	Mechanistic	1584.89 nM (Ki)	DGIdb
SORAFENIB	? unclear	Mechanistic	2100.0 nM (Kd)	DGIdb
LITHIUM	? unclear	Mechanistic		DGIdb
REPOTRECTINIB	↓ inhibits	Mechanistic		DGIdb
CRIZOTINIB	? unclear	Mechanistic	399.0 nM (IC50)	DGIdb
DOXORUBICIN HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
UTATRECTINIB	↓ inhibits	Mechanistic		DGIdb
GW-2580	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL546797	? unclear	Mechanistic		DGIdb
CORTICOTROPIN	? unclear	Mechanistic		DGIdb
CISPLATIN	? unclear	Mechanistic		DGIdb
ZM447439	? unclear	Mechanistic		DGIdb
PLX-7486	↓ inhibits	Mechanistic		DGIdb
METHADONE HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
AST-487	? unclear	Mechanistic	190.0 nM (Kd)	DGIdb
SB202190	? unclear	Mechanistic		DGIdb
BMS-754807	? unclear	Mechanistic		DGIdb
PILOCARPINE HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
HESPERADIN	↓ inhibits	Mechanistic		DGIdb
LESTAURTINIB	↓ inhibits	Mechanistic	14.0 nM (Kd)	DGIdb
TALETRECTINIB	↓ inhibits	Mechanistic		DGIdb
CEP-2563 DIHYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
GAMBOGIC AMIDE	? unclear	Mechanistic		DGIdb
LAUROGUADINE	? unclear	Mechanistic		DGIdb
PF-562271	? unclear	Mechanistic		DGIdb
CENISERTIB	? unclear	Mechanistic		DGIdb
JNJ-7706621	? unclear	Mechanistic		DGIdb
ALTIRATINIB	↓ inhibits	Mechanistic		DGIdb
ALISERTIB	? unclear	Mechanistic		DGIdb
TOZASERTIB	? unclear	Mechanistic	240.0 nM (Kd)	DGIdb
DOVITINIB	? unclear	Mechanistic	720.0 nM (Kd)	DGIdb

Showing top 40 of 206 agents ranked by evidence tier.

SLC6A2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
TESOFENSINE	↓ inhibits	Mechanistic		DGIdb
PHENMETRAZINE	? unclear	Mechanistic		DGIdb
VENLAFAXINE	? unclear	Mechanistic	1060.0 nM (Kd)	DGIdb
SIBUTRAMINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
DEXMETHYLPHENIDATE	↓ inhibits	Mechanistic		DGIdb
TRIMIPRAMINE	? unclear	Mechanistic		DGIdb
CLOMIPRAMINE	? unclear	Mechanistic		DGIdb
GUANADREL SULFATE	? unclear	Mechanistic		DGIdb
TAPENTADOL HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
LISDEXAMFETAMINE DIMESYLATE	? unclear	Mechanistic		DGIdb
PROTRIPTYLINE	? unclear	Mechanistic		DGIdb
DESVENLAFAXINE SUCCINATE	↓ inhibits	Mechanistic		DGIdb
ATOMOXETINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
IOBENGUANE I-123	? unclear	Mechanistic		DGIdb
SURONACRINE MALEATE	? unclear	Mechanistic		DGIdb
REBOXETINE	↓ inhibits	Mechanistic	1.1 nM (Ki)	DGIdb
BICIFADINE	↓ inhibits	Mechanistic		DGIdb
DOXEPIN HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
LIAFENSINE	↓ inhibits	Mechanistic		DGIdb
ORPHENADRINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
DULOXETINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
DASOTRALINE	↓ inhibits	Mechanistic		DGIdb
DESIPRAMINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
METHYLPHENIDATE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
AMITIFADINE	↓ inhibits	Mechanistic		DGIdb
NEFAZODONE	? unclear	Mechanistic	360.0 nM (Kd)	DGIdb
AMITIFADINE HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
DEXTROAMPHETAMINE SULFATE	? unclear	Mechanistic		DGIdb
TYROSINE HYDROXYLASE INHIBITOR	? unclear	Mechanistic		DGIdb
NORTRIPTYLINE	? unclear	Mechanistic	6.3 nM (Ki)	DGIdb
MAPROTILINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
ST. JOHN'S WORT	? unclear	Mechanistic		DGIdb
DEXTROAMPHETAMINE SACCHARATE	? unclear	Mechanistic		DGIdb
AMOXAPINE	↓ inhibits	Mechanistic		DGIdb
PHENDIMETRAZINE	↓ inhibits	Mechanistic		DGIdb
PHENYLPROPANOLAMINE HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
BUPROPION HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
BETHANIDINE	? unclear	Mechanistic		DGIdb
TRAMADOL	? unclear	Mechanistic		DGIdb
MILNACIPRAN	? unclear	Mechanistic		DGIdb

Showing top 40 of 269 agents ranked by evidence tier.

SLC6A3

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
ALTROPANE I-123	? unclear	Mechanistic		DGIdb
BUPROPION HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
DEXMETHYLPHENIDATE	↓ inhibits	Mechanistic		DGIdb
AMPHETAMINE ADIPATE	? unclear	Mechanistic		DGIdb
DEXTROAMPHETAMINE SACCHARATE	? unclear	Mechanistic		DGIdb
LIAFENSINE	↓ inhibits	Mechanistic		DGIdb
LISDEXAMFETAMINE DIMESYLATE	? unclear	Mechanistic		DGIdb
METHAMPHETAMINE	↓ inhibits	Mechanistic		DGIdb
SIBUTRAMINE	? unclear	Mechanistic		DGIdb
METHYLPHENIDATE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
3,4-METHYLENEDIOXYMETHAMPHETAMINE	? unclear	Mechanistic		DGIdb
LEVODOPA	? unclear	Mechanistic		DGIdb
DEXTROAMPHETAMINE ADIPATE	? unclear	Mechanistic		DGIdb
METYROSINE	? unclear	Mechanistic		DGIdb
ANESTHETIC AGENT	? unclear	Mechanistic		DGIdb
SERTRALINE HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
BENZTROPINE	? unclear	Mechanistic	312.0 nM (IC50)	DGIdb
BICIFADINE	↓ inhibits	Mechanistic		DGIdb
ALTROPANE	? unclear	Mechanistic		DGIdb
DASOTRALINE	↓ inhibits	Mechanistic		DGIdb
DISULFIRAM	? unclear	Mechanistic		DGIdb
AMITIFADINE HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
AMPHETAMINE ASPARTATE	? unclear	Mechanistic		DGIdb
NICOTINE POLACRILEX	? unclear	Mechanistic		DGIdb
SPIROGLUMIDE	? unclear	Mechanistic		DGIdb
HINOKININ	? unclear	Mechanistic		DGIdb
DIETHYLPROPION HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
SERDEXMETHYLPHENIDATE CHLORIDE	↓ inhibits	Mechanistic		DGIdb
PHENTERMINE RESIN	? unclear	Mechanistic		DGIdb
PSEUDOEPHEDRINE	? unclear	Mechanistic		DGIdb
PHENMETRAZINE	? unclear	Mechanistic		DGIdb
CENTANAFADINE	↓ inhibits	Mechanistic		DGIdb
BUPRENORPHINE	? unclear	Mechanistic		DGIdb
PYROVALERONE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
SERDEXMETHYLPHENIDATE	↓ inhibits	Mechanistic		DGIdb
PHENMETRAZINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
FENCAMFAMIN	? unclear	Mechanistic		DGIdb
IOFLUPANE I-123	? unclear	Mechanistic		DGIdb
PHENDIMETRAZINE	↓ inhibits	Mechanistic		DGIdb
MAZINDOL	↓ inhibits	Mechanistic	42.6 nM (IC50)	DGIdb

Showing top 40 of 176 agents ranked by evidence tier.

SLC6A4

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
CENTANAFADINE	↓ inhibits	Mechanistic	DGIdb
METHAMPHETAMINE	↓ inhibits	Mechanistic	DGIdb
VENLAFAXINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
LUMATEPERONE	↓ inhibits	Mechanistic	DGIdb
TIANEPTINE	? unclear	Mechanistic	DGIdb
IMIPRAMINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
ONDANSETRON HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
PEGINTERFERON ALFA-2B	? unclear	Mechanistic	DGIdb
DEXFENFLURAMINE	? unclear	Mechanistic	DGIdb
BUPROPION HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
CITALOPRAM	↓ inhibits	Mechanistic	DGIdb
TRIMIPRAMINE	? unclear	Mechanistic	DGIdb
VENLAFAXINE	? unclear	Mechanistic	DGIdb
DISULFIRAM	? unclear	Mechanistic	DGIdb
CHLORPHENTERMINE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
PROTRIPTYLINE	? unclear	Mechanistic	DGIdb
MILNACIPRAN HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
CLOMIPRAMINE	? unclear	Mechanistic	DGIdb
NORTRIPTYLINE	? unclear	Mechanistic	DGIdb
DAPOXETINE	↓ inhibits	Mechanistic	DGIdb
AMITRIPTYLINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
TEDATIOXETINE	↓ inhibits	Mechanistic	DGIdb
TRAZODONE	↓ inhibits	Mechanistic	DGIdb
SERTRALINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
EVODIAMINE	? unclear	Mechanistic	DGIdb
PSEUDOEPHEDRINE	? unclear	Mechanistic	DGIdb
FLUOXETINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
SIBUTRAMINE	? unclear	Mechanistic	DGIdb
TRAMADOL	? unclear	Mechanistic	DGIdb
VORTIOXETINE HYDROBROMIDE	↓ inhibits	Mechanistic	DGIdb
BL-1021	? unclear	Mechanistic	DGIdb
DOXEPIN HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
DOTHIEPIN	↓ inhibits	Mechanistic	DGIdb
DEXTROMETHORPHAN POLISTIREX	? unclear	Mechanistic	DGIdb
DESIPRAMINE	? unclear	Mechanistic	DGIdb
PHENTERMINE RESIN	? unclear	Mechanistic	DGIdb
NORTRIPTYLINE HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
MONOAMINE OXIDASE INHIBITOR	? unclear	Mechanistic	DGIdb
MILNACIPRAN	? unclear	Mechanistic	DGIdb
RIBAVIRIN	? unclear	Mechanistic	DGIdb

Showing top 40 of 104 agents ranked by evidence tier.

Clinical Trials

Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-06.

No recent clinical trials found on ClinicalTrials.gov for this condition.

Agents Found By Disease-Level Search

Searched directly from “Major Depressive Disorder” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 14-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

60 agents shown (approved or with trial evidence) — 51 not found by the gene-target search above.

escitalopram

Approved · 5 trials · source: ClinicalTrials.gov, Open Targets
NCT01034995 NCT00166114 NCT00464711

BMS-820836NOT in gene-target list

· 4 trials · source: ClinicalTrials.gov
NCT01369095 NCT01369095 NCT01369095

Duloxetine

Approved · 3 trials · source: ClinicalTrials.gov, Open Targets
NCT00331799 NCT01369095 NCT00062673

Placebo + ADTNOT in gene-target list

· 2 trials · source: ClinicalTrials.gov
NCT01360632 NCT01360632

Fluoxetine

Approved · 2 trials · source: ClinicalTrials.gov, Open Targets
NCT00332787 NCT00018057

Cognitive Behavioral TherapyNOT in gene-target list

· 2 trials · source: ClinicalTrials.gov
NCT00018057 NCT02883257

ELE-101NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05434156

ELE-101 PlaceboNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05434156

18FAV45NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01962753

Transcranial Magnetic StimulationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06719427

DT-101NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07610473

Exercise -RunningNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05837351

Desvenlafaxine Succinate Sustained ReleaseNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00952653

MidazolamNOT in gene-target list

Phase 3 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT00952653

SSR125543NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01034995

Re5 Pulsating ElectroMagnetic FieldsNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01353092

Re5 Pulsating ElectroMagnetic Fields (PEMF)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01353092

Collaborative Decision Skills TrainingNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04324944

Leveling UpNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04324944

ZuranoloneNOT in gene-target list

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT05655507

High frequency stimulationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02184221

Low frequency stimulationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02184221

OPC-34712 + ADTNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01360632

Accelerated HF-rTMS (Magstim Rapid 2 stimulator)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02125799

DVS SRNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01371721

Paroxetine

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT00457106

Risperidone

Phase 3 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT00457106

Apo-levocarbNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06626152

Repetitive Transcranial Magnetic StimulationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00104611

Cognitive-Behavioural TherapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05002309

Antidepressant medicationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05002309

Vortioxetine (Lu AA21004)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01323478

Motivational interviewingNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00356304

Treatment as usualNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00356304

Transdiagnostic Internet-delivered REBTNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04179526

Lumateperone

Phase 3 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT06372964

SCH 900636NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00844922

Attention Bias Modification TrainingNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00018057

D-CycloserineNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05591677

Intermittent Theta Burst StimulationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05591677

Desipramine

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT00166114

Expectation confirmationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03780881

Expectation disconfirmationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03780881

Virtual-Reality-based mindfulness interventionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07422519

Esketamine Treatment as Usual (ESK)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07422519

Mindful Self CompassionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06646692

Treatment as Usual (TAU)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06646692

SeltorexantNOT in gene-target list

Phase 3 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT04513912

Matching placebo to SeltorexantNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04513912

Quetiapine XRNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04513912

Matching placebo to Quetiapine XRNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04513912

Ketamine

Phase 3 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT06668571

Normal Saline

· 1 trial · source: ClinicalTrials.gov
NCT06668571

BMS-820836 PlaceboNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01369095

Pregnenolone 500 mgNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03645096

Pregnenolone 800 mgNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03645096

Quetiapine Extended ReleaseNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00723970

Anyu PeiboNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03183505

DVS-233 SRNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00075257

amibegron (SR58611A)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00385307

Major Depressive Disorder

Remission & chronicity

BDNF

CRH

DRD2

FKBP5

GRIN2B

HTR1A

HTR2A

IL6

MAOA

MAOB

NTRK2

SLC6A2

SLC6A3

SLC6A4

escitalopram

BMS-820836NOT in gene-target list

Duloxetine

Placebo + ADTNOT in gene-target list

Fluoxetine

Cognitive Behavioral TherapyNOT in gene-target list

ELE-101NOT in gene-target list

ELE-101 PlaceboNOT in gene-target list

18FAV45NOT in gene-target list

Transcranial Magnetic StimulationNOT in gene-target list

DT-101NOT in gene-target list

Exercise -RunningNOT in gene-target list

Desvenlafaxine Succinate Sustained ReleaseNOT in gene-target list

MidazolamNOT in gene-target list

SSR125543NOT in gene-target list

Re5 Pulsating ElectroMagnetic FieldsNOT in gene-target list

Re5 Pulsating ElectroMagnetic Fields (PEMF)NOT in gene-target list

Collaborative Decision Skills TrainingNOT in gene-target list

Leveling UpNOT in gene-target list

ZuranoloneNOT in gene-target list

High frequency stimulationNOT in gene-target list

Low frequency stimulationNOT in gene-target list

OPC-34712 + ADTNOT in gene-target list

Accelerated HF-rTMS (Magstim Rapid 2 stimulator)NOT in gene-target list

DVS SRNOT in gene-target list

Paroxetine

Risperidone

Apo-levocarbNOT in gene-target list

Repetitive Transcranial Magnetic StimulationNOT in gene-target list

Cognitive-Behavioural TherapyNOT in gene-target list

Antidepressant medicationNOT in gene-target list

Vortioxetine (Lu AA21004)NOT in gene-target list

Motivational interviewingNOT in gene-target list

Treatment as usualNOT in gene-target list

Transdiagnostic Internet-delivered REBTNOT in gene-target list

Lumateperone

SCH 900636NOT in gene-target list

Attention Bias Modification TrainingNOT in gene-target list

D-CycloserineNOT in gene-target list

Intermittent Theta Burst StimulationNOT in gene-target list

Desipramine

Expectation confirmationNOT in gene-target list

Expectation disconfirmationNOT in gene-target list

Virtual-Reality-based mindfulness interventionNOT in gene-target list

Esketamine Treatment as Usual (ESK)NOT in gene-target list

Mindful Self CompassionNOT in gene-target list

Treatment as Usual (TAU)NOT in gene-target list

SeltorexantNOT in gene-target list

Matching placebo to SeltorexantNOT in gene-target list

Quetiapine XRNOT in gene-target list

Matching placebo to Quetiapine XRNOT in gene-target list

Ketamine

Normal Saline

BMS-820836 PlaceboNOT in gene-target list

Pregnenolone 500 mgNOT in gene-target list

Pregnenolone 800 mgNOT in gene-target list

Quetiapine Extended ReleaseNOT in gene-target list

Anyu PeiboNOT in gene-target list

DVS-233 SRNOT in gene-target list

amibegron (SR58611A)NOT in gene-target list

Part of the Open Source Medicine Foundation Network