Biomarker & Intervention Discovery

Low Back Pain

Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.

US DALYs5.98MWHO GHE 2021 · all ages
Global DALYs90.46MWHO GHE 2021 · worldwide
US mortality1,573 deaths/yrWHO GHE 2021
Global mortality6,796 deaths/yrWHO GHE 2021 · worldwide
NIH funding$80MFY2025 · RCDC estimate
Funding levelSeverely Underfunded
Spontaneous remission~90% of acute LBP episodes resolve within 6 weeks regardless of treatment; chronic LBP (>3 months) shows only 30-40%…
Best-intervention remissionCognitive behavioral therapy (CBT) + graded exercise: 50-70% sustained improvement at 1 year in chronic LBP; Pain…
Gap sizeLarge for psychologically-informed approaches vs current opioid/surgical dominant model
Primary barrierpractice
Full remission profile →
Research Tracker / Chronic Disease Interventions / Low Back Pain / Biomarker Atlas →

Remission & chronicity

Spontaneous remission
~90% of acute LBP episodes resolve within 6 weeks regardless of treatment; chronic LBP (>3 months) shows only 30-40% recovery at 1 year and high recurrence; opioid prescribing correlates inversely with recovery
Best-intervention remission
Cognitive behavioral therapy (CBT) + graded exercise: 50-70% sustained improvement at 1 year in chronic LBP; Pain Reprocessing Therapy (PRT) — 66% pain-free or nearly pain-free at 1 year (JAMA Psychiatry 2021, vs 20% placebo); early active rehabilitation (vs bed rest) dramatically reduces chronification
Gap size
Large for psychologically-informed approaches vs current opioid/surgical dominant model
Primary barrier
practice
Opioid prescribing for chronic LBP is associated with worse long-term outcomes yet remains extremely common; spinal fusion surgery rates 40x higher in US than UK despite no superiority over conservative care in most indications; active rehabilitation demonstrably superior to passive treatment but requires patient effort and provider time
Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.

COMP 2GRIN1 183IL6 173NGF 9OPRM1 316PTGS2 299SCN9A 271TNF 277TRPV1 160

COMP

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
BC11-38 ↓ inhibits Mechanistic DGIdb
TADALAFIL ↓ inhibits Mechanistic DGIdb

GRIN1

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
COMPOUND 53 [PMID: 33038794] ↑ activates Mechanistic DGIdb
PAREGORIC ? unclear Mechanistic DGIdb
STING AGONIST 2 ↑ activates Mechanistic DGIdb
LATREPIRDINE ? unclear Mechanistic DGIdb
CNS-5161 ↓ inhibits Mechanistic DGIdb
MEMANTINE HYDROCHLORIDE ~ modulates Mechanistic DGIdb
LANICEMINE ↓ inhibits Mechanistic DGIdb
ULEVOSTINAG ↑ activates Mechanistic DGIdb
ELIPRODIL ? unclear Mechanistic DGIdb
NBQX ? unclear Mechanistic DGIdb
RAPASTINEL ? unclear Mechanistic DGIdb
DEXANABINOL ? unclear Mechanistic DGIdb
NEBOGLAMINE ~ modulates Mechanistic DGIdb
HALOPERIDOL DECANOATE ? unclear Mechanistic DGIdb
ORPHENADRINE ? unclear Mechanistic DGIdb
GW468816 ↓ inhibits Mechanistic DGIdb
ACAMPROSATE CALCIUM ↓ inhibits Mechanistic DGIdb
AMANTADINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
H-151 ↓ inhibits Mechanistic DGIdb
D-SERINE ? unclear Mechanistic DGIdb
AZD8108 ↓ inhibits Mechanistic DGIdb
KETAMINE HYDROCHLORIDE ~ modulates Mechanistic DGIdb
DELUCEMINE ↓ inhibits Mechanistic DGIdb
EVT-101 ↓ inhibits Mechanistic DGIdb
MSA-2 ↑ activates Mechanistic DGIdb
ESKETAMINE HYDROCHLORIDE ? unclear Mechanistic DGIdb
2'3'-CGAMP ↑ activates Mechanistic DGIdb
COMPOUND 40 [PMID: 33470814] ↑ activates Mechanistic DGIdb
PHILANTHOTOXIN 343 ? unclear Mechanistic DGIdb
FELBAMATE ↓ inhibits Mechanistic DGIdb
INDANTADOL ↓ inhibits Mechanistic DGIdb
STING AGONIST 3 ↑ activates Mechanistic DGIdb
ORPHENADRINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
CYCLOSERINE ? unclear Mechanistic DGIdb
RADIPRODIL ↓ inhibits Mechanistic DGIdb
PERZINFOTEL ↓ inhibits Mechanistic DGIdb
ESKETAMINE ~ modulates Mechanistic DGIdb
ADU-S100 ↑ activates Mechanistic DGIdb
RALFINAMIDE ↓ inhibits Mechanistic DGIdb
SNX281 ↑ activates Mechanistic DGIdb

Showing top 40 of 183 agents ranked by evidence tier.

IL6

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
CISPLATIN ? unclear Mechanistic DGIdb
ZILTIVEKIMAB ~ modulates Mechanistic DGIdb
CHINESE HERBS ? unclear Mechanistic DGIdb
PF-04236921 ↓ inhibits Mechanistic DGIdb
MRA 003 US ↓ inhibits Mechanistic DGIdb
SIGNAL TRANSDUCTION INHIBITOR ? unclear Mechanistic DGIdb
BINETRAKIN ? unclear Mechanistic DGIdb
IBUDILAST ? unclear Mechanistic DGIdb
INSULIN, REGULAR, HUMAN ? unclear Mechanistic DGIdb
SILTUXIMAB ↓ inhibits Mechanistic DGIdb
METRONIDAZOLE ? unclear Mechanistic DGIdb
CLAZAKIZUMAB ↓ inhibits Mechanistic DGIdb
GALLIUM NITRATE ? unclear Mechanistic DGIdb
INTERFERON ALFA-2B ? unclear Mechanistic DGIdb
DULOXETINE HYDROCHLORIDE ? unclear Mechanistic DGIdb
MEDI-5117 ↓ inhibits Mechanistic DGIdb
GEMFIBROZIL ? unclear Mechanistic DGIdb
BIAFINE CREAM ? unclear Mechanistic DGIdb
ETANERCEPT ? unclear Mechanistic DGIdb
ELSILIMOMAB ↓ inhibits Mechanistic DGIdb
SAQUINAVIR ? unclear Mechanistic DGIdb
INFLIXIMAB ? unclear Mechanistic DGIdb
LINEZOLID ? unclear Mechanistic DGIdb
IFOSFAMIDE ? unclear Mechanistic DGIdb
OLOKIZUMAB ↓ inhibits Mechanistic DGIdb
HMG-COA REDUCTASE INHIBITOR ? unclear Mechanistic DGIdb
MIDOSTAURIN ? unclear Mechanistic DGIdb
SELENIUM ? unclear Mechanistic DGIdb
SIRUKUMAB ↓ inhibits Mechanistic DGIdb
PEGINTERFERON ALFA-2B ? unclear Mechanistic DGIdb
ECHINACEA PREPARATION ? unclear Mechanistic DGIdb
ENZYME INHIBITOR ? unclear Mechanistic DGIdb
FENOFIBRATE MICRONIZED ? unclear Mechanistic DGIdb
VITAMIN K ? unclear Mechanistic DGIdb
PEGINTERFERON ALFA-2A ? unclear Mechanistic DGIdb
RIBAVIRIN ? unclear Mechanistic DGIdb
VITAMIN A PALMITATE ? unclear Mechanistic DGIdb
ARSENIC TRIOXIDE ? unclear Mechanistic DGIdb
DIHYDROSPHINGOSINE ? unclear Mechanistic DGIdb
LEVOFLOXACIN ANHYDROUS ? unclear Mechanistic DGIdb

Showing top 40 of 173 agents ranked by evidence tier.

NGF

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
MEDI-578 ↓ inhibits Mechanistic DGIdb
CERE-110 ? unclear Mechanistic DGIdb
FASINUMAB ↓ inhibits Mechanistic DGIdb
TANEZUMAB ↓ inhibits Mechanistic DGIdb
FRUNEVETMAB ~ modulates Mechanistic DGIdb
FULRANUMAB ↓ inhibits Mechanistic DGIdb
BEDINVETMAB ~ modulates Mechanistic DGIdb
PG-110 ↓ inhibits Mechanistic DGIdb
CHEMBL1397270 ↓ inhibits Mechanistic 1000.0 nM (IC50) ChEMBL

OPRM1

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
DIFENOXIN HYDROCHLORIDE ↑ activates Mechanistic DGIdb
SUMATRIPTAN ? unclear Mechanistic DGIdb
DIACETYLMORPHINE ↑ activates Mechanistic DGIdb
NALTALIMIDE ↑ activates Mechanistic DGIdb
CLOCINNAMOX ? unclear Mechanistic DGIdb
METHADONE HYDROCHLORIDE ↑ activates Mechanistic DGIdb
NALTREXONE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
CP-866087 ↓ inhibits Mechanistic DGIdb
PENTAZOCINE ? unclear Mechanistic DGIdb
MONOAMINE OXIDASE INHIBITOR ? unclear Mechanistic DGIdb
PAREGORIC ? unclear Mechanistic DGIdb
NALOXONE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
BUPRENORPHINE ↑ activates Mechanistic DGIdb
CEBRANOPADOL ↑ activates Mechanistic DGIdb
OXYCODONE ↑ activates Mechanistic DGIdb
CODEINE PHOSPHATE ↑ activates Mechanistic DGIdb
AXELOPRAN ↓ inhibits Mechanistic DGIdb
SAMIDORPHAN L-MALATE ↓ inhibits Mechanistic DGIdb
ALFENTANIL HYDROCHLORIDE ↑ activates Mechanistic DGIdb
TIANEPTINE ? unclear Mechanistic DGIdb
METENKEFALIN ? unclear Mechanistic DGIdb
SUFENTANIL ? unclear Mechanistic DGIdb
OXYCODONE TEREPHTHALATE ↑ activates Mechanistic DGIdb
LEVALLORPHAN TARTRATE ↓ inhibits Mechanistic DGIdb
CHEMBL:CHEMBL409225 ? unclear Mechanistic DGIdb
BUTORPHANOL ? unclear Mechanistic DGIdb
LOPERAMIDE ↑ activates Mechanistic DGIdb
CODEINE ANHYDROUS ↑ activates Mechanistic DGIdb
ORP-101 ↑ activates Mechanistic DGIdb
ANILERIDINE HYDROCHLORIDE ↑ activates Mechanistic DGIdb
BEVENOPRAN ? unclear Mechanistic DGIdb
IBUPROFEN, SODIUM SALT ? unclear Mechanistic DGIdb
NALMEFENE ? unclear Mechanistic DGIdb
NALOXONE HYDROCHLORIDE DIHYDRATE ↓ inhibits Mechanistic DGIdb
METHYLSAMIDORPHAN ↓ inhibits Mechanistic DGIdb
PHENCYCLIDINE HYDROCHLORIDE ? unclear Mechanistic DGIdb
FENTANYL HYDROCHLORIDE ↑ activates Mechanistic DGIdb
ELUXADOLINE ↑ activates Mechanistic DGIdb
PROPOXYPHENE NAPSYLATE ↑ activates Mechanistic DGIdb
PROPOXYPHENE ? unclear Mechanistic DGIdb

Showing top 40 of 316 agents ranked by evidence tier.

PTGS2

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
CARPROFEN ↓ inhibits Mechanistic 102.0 nM (IC50) DGIdb
INDOMETHACIN SODIUM ↓ inhibits Mechanistic DGIdb
DARBUFELONE ? unclear Mechanistic DGIdb
MEFENAMIC ACID ↓ inhibits Mechanistic DGIdb
MECLOFENAMATE SODIUM ↓ inhibits Mechanistic DGIdb
DICLOFENAC SODIUM ↓ inhibits Mechanistic DGIdb
CAPECITABINE ? unclear Mechanistic DGIdb
PIRPROFEN ↓ inhibits Mechanistic DGIdb
ESFLURBIPROFEN ↓ inhibits Mechanistic DGIdb
SULFASALAZINE ↓ inhibits Mechanistic DGIdb
BROMFENAC ? unclear Mechanistic DGIdb
IBUPROFEN, SODIUM SALT ↓ inhibits Mechanistic DGIdb
ALOXIPRIN ↓ inhibits Mechanistic DGIdb
TENOXICAM ? unclear Mechanistic DGIdb
FLURBIPROFEN ↓ inhibits Mechanistic DGIdb
SALICYLIC ACID ? unclear Mechanistic DGIdb
ATENOLOL ? unclear Mechanistic DGIdb
DEXKETOPROFEN ↓ inhibits Mechanistic DGIdb
ETORICOXIB ↓ inhibits Mechanistic DGIdb
LUMIRACOXIB ↓ inhibits Mechanistic DGIdb
SUPROFEN ↓ inhibits Mechanistic DGIdb
NS-398 ? unclear Mechanistic DGIdb
NABUMETONE ↓ inhibits Mechanistic DGIdb
URSOLIC ACID ? unclear Mechanistic DGIdb
IBUPROFEN LYSINE ↓ inhibits Mechanistic DGIdb
ACECLOFENAC ↓ inhibits Mechanistic DGIdb
IBUFENAC ↓ inhibits Mechanistic DGIdb
BALSALAZIDE ? unclear Mechanistic DGIdb
DIFLUNISAL ↓ inhibits Mechanistic DGIdb
BALSALAZIDE DISODIUM ↓ inhibits Mechanistic DGIdb
VACCINE ? unclear Mechanistic DGIdb
KETOROLAC TROMETHAMINE ↓ inhibits Mechanistic DGIdb
BENZYDAMINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
TIAPROFENIC ACID ? unclear Mechanistic DGIdb
RALOXIFENE HYDROCHLORIDE ? unclear Mechanistic DGIdb
NAPROXCINOD ↓ inhibits Mechanistic DGIdb
IGURATIMOD ↓ inhibits Mechanistic DGIdb
ETODOLAC ↓ inhibits Mechanistic DGIdb
DICLOFENAC ETALHYALURONATE SODIUM ↓ inhibits Mechanistic DGIdb
ROFECOXIB ↓ inhibits Mechanistic 530.0 nM (IC50) DGIdb

Showing top 40 of 299 agents ranked by evidence tier.

SCN9A

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
MERETHOXYLLINE PROCAINE ↓ inhibits Mechanistic DGIdb
ETIDOCAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
FOSPHENYTOIN ↓ inhibits Mechanistic DGIdb
VERATRIDINE ↑ activates Mechanistic DGIdb
ORPHENADRINE CITRATE ↓ inhibits Mechanistic DGIdb
PHENACEMIDE ↓ inhibits Mechanistic DGIdb
LACOSAMIDE ↓ inhibits Mechanistic DGIdb
VIXOTRIGINE ↓ inhibits Mechanistic DGIdb
DSP-2230 ↓ inhibits Mechanistic DGIdb
SAXITOXIN ↓ inhibits Mechanistic DGIdb
ESLICARBAZEPINE ACETATE ↓ inhibits Mechanistic DGIdb
SAFINAMIDE ? unclear Mechanistic DGIdb
LIDOCAINE ↓ inhibits Mechanistic DGIdb
RILUZOLE ↓ inhibits Mechanistic DGIdb
ROPIVACAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
FUNAPIDE ↓ inhibits Mechanistic DGIdb
DYCLONINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
EVENAMIDE ↓ inhibits Mechanistic DGIdb
PROPOFOL ? unclear Mechanistic DGIdb
AM-6120 ↓ inhibits Mechanistic DGIdb
RG7893 ↓ inhibits Mechanistic DGIdb
RG6029 ↓ inhibits Mechanistic DGIdb
QUINIDINE SULFATE ↓ inhibits Mechanistic DGIdb
ZONISAMIDE ↓ inhibits Mechanistic DGIdb
NERISPIRDINE ↓ inhibits Mechanistic DGIdb
RALFINAMIDE ↓ inhibits Mechanistic DGIdb
DS-1971A ↓ inhibits Mechanistic DGIdb
HEXYLCAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
MEPIVACAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
PROCAINAMIDE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
PROPAFENONE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
LIDOCAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
QUINIDINE GLUCONATE ↓ inhibits Mechanistic DGIdb
PRILOCAINE ↓ inhibits Mechanistic DGIdb
ETHOTOIN ↓ inhibits Mechanistic DGIdb
PF-05089771 ↓ inhibits Mechanistic DGIdb
DICHLOROBENZYL ALCOHOL ↓ inhibits Mechanistic DGIdb
RANOLAZINE ? unclear Mechanistic DGIdb
PRILOCAINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
ORPHENADRINE HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb

Showing top 40 of 271 agents ranked by evidence tier.

TNF

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
NERELIMOMAB ↓ inhibits Mechanistic DGIdb
CROMOLYN SODIUM ? unclear Mechanistic DGIdb
PLACULUMAB ↓ inhibits Mechanistic DGIdb
METHYLENE BLUE ? unclear Mechanistic DGIdb
ALTEPLASE ? unclear Mechanistic DGIdb
CARBOPLATIN ? unclear Mechanistic DGIdb
GENTAMICIN ? unclear Mechanistic DGIdb
GOLIMUMAB ↓ inhibits Mechanistic DGIdb
BUPIVACAINE ? unclear Mechanistic DGIdb
PENTOXIFYLLINE ? unclear Mechanistic 85000.0 nM (IC50) DGIdb
BENZO[E]PYRENE ? unclear Mechanistic DGIdb
THALIDOMIDE ? unclear Mechanistic DGIdb
PYRAZINAMIDE ? unclear Mechanistic DGIdb
GLIMEPIRIDE ? unclear Mechanistic DGIdb
OMEPRAZOLE ? unclear Mechanistic DGIdb
LENERCEPT ↓ inhibits Mechanistic DGIdb
ADALIMUMAB ↓ inhibits Mechanistic DGIdb
PRAZOSIN HYDROCHLORIDE ? unclear Mechanistic DGIdb
REMTOLUMAB ? unclear Mechanistic DGIdb
MIDOSTAURIN ? unclear Mechanistic DGIdb
LENABASUM ? unclear Mechanistic DGIdb
MAGNESIUM SULFATE ANHYDROUS ? unclear Mechanistic DGIdb
PICIBANIL ? unclear Mechanistic DGIdb
FLUOCINOLONE ACETONIDE ? unclear Mechanistic DGIdb
MILTEFOSINE ? unclear Mechanistic DGIdb
HOMIDIUM BROMIDE ? unclear Mechanistic DGIdb
OZORALIZUMAB ↓ inhibits Mechanistic DGIdb
PEGSUNERCEPT ↓ inhibits Mechanistic DGIdb
CERTOLIZUMAB PEGOL ↓ inhibits Mechanistic DGIdb
THERAPEUTIC HORMONE ? unclear Mechanistic DGIdb
NAFAMOSTAT ? unclear Mechanistic DGIdb
FOLIC ACID ? unclear Mechanistic DGIdb
ABBV-257 ? unclear Mechanistic DGIdb
RISPERIDONE ? unclear Mechanistic DGIdb
COVA322 ? unclear Mechanistic DGIdb
HYDROXYCHLOROQUINE ? unclear Mechanistic DGIdb
CERTOLIZUMAB ? unclear Mechanistic DGIdb
AN0128 ? unclear Mechanistic DGIdb
5,7-DIHYDROXY-4-METHYLCOUMARIN ? unclear Mechanistic DGIdb
SORAFENIB ? unclear Mechanistic DGIdb

Showing top 40 of 277 agents ranked by evidence tier.

TRPV1

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
STREPTOZOCIN ? unclear Mechanistic DGIdb
BENZYL ISOTHIOCYANATE ? unclear Mechanistic DGIdb
ACETAMINOPHEN ↑ activates Mechanistic DGIdb
POLYGODIAL ? unclear Mechanistic DGIdb
PROPOFOL ? unclear Mechanistic DGIdb
SAF312 ↓ inhibits Mechanistic DGIdb
GRC-15300 ? unclear Mechanistic DGIdb
AZD1386 ↓ inhibits Mechanistic DGIdb
TIVANISIRAN ↓ inhibits Mechanistic DGIdb
MAVATREP ↓ inhibits Mechanistic DGIdb
MR-1817 ↓ inhibits Mechanistic DGIdb
FERRUGINENE B ? unclear Mechanistic DGIdb
CAPSAICIN ↑ activates Mechanistic 19.95 nM (EC50) DGIdb
RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN ? unclear Mechanistic DGIdb
PHENETHYLISOTHIOCYANATE ? unclear Mechanistic DGIdb
VOACANGINE ? unclear Mechanistic DGIdb
RESINIFERATOXIN ↑ activates Mechanistic 23.1 nM (Ki) DGIdb
DWP05195 ↓ inhibits Mechanistic DGIdb
XEN-D0501 ↓ inhibits Mechanistic DGIdb
PAC-14028 ↓ inhibits Mechanistic DGIdb
SB-705498 ↓ inhibits Mechanistic DGIdb
MASOPROCOL ? unclear Mechanistic DGIdb
ALLYL ISOTHIOCYANATE ? unclear Mechanistic DGIdb
NGD-8243 ↓ inhibits Mechanistic DGIdb
GRC-6211 ↓ inhibits Mechanistic DGIdb
RESERPINE ? unclear Mechanistic DGIdb
NABIXIMOLS ? unclear Mechanistic DGIdb
A425619 ? unclear Mechanistic DGIdb
PHE377 ↓ inhibits Mechanistic DGIdb
ANTISENSE OLIGONUCLEOTIDES ? unclear Mechanistic DGIdb
WORTMANNIN ? unclear Mechanistic DGIdb
JTS-653 ↓ inhibits Mechanistic DGIdb
LEVODOPA ? unclear Mechanistic DGIdb
AMG517 ↓ inhibits Mechanistic DGIdb
CAPSAZEPINE ? unclear Mechanistic 120.0 nM (Ki) DGIdb
ZUCAPSAICIN ↑ activates Mechanistic DGIdb
INDOMETHACIN ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL191534 ? unclear Mechanistic DGIdb
ABT-102 ↓ inhibits Mechanistic DGIdb
ISOPROPYL ISOTHIOCYANATE ? unclear Mechanistic DGIdb

Showing top 40 of 160 agents ranked by evidence tier.

Clinical Trials

Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-06.

No recent clinical trials found on ClinicalTrials.gov for this condition.

Agents Found By Disease-Level Search

Searched directly from “Low Back Pain” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 9-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

44 agents shown (approved or with trial evidence) — 43 not found by the gene-target search above.

Carisoprodol SRNOT in gene-target list

· 2 trials · source: ClinicalTrials.gov
NCT00671502 NCT00671502

Low Intensity Continuous UltrasoundNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04177537

HeatTens (HV-F311-E)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03643731

BM-MSC injectionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06001853

DSMO InjectionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06001853

self-administered acupressureNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05423145

Assessment of postural control, body perception, psychosocial factors and inflammationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06785909

CLEVERNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06506604

UltrasonographyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05206136

LumbaCure®NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06662032

Spinal Cord StimulationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04909593

Anodal tDCS combined with active physiotherapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05757609

Sham anodal tDCS combined with active physiotherapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05757609

x-ray, MRINOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02351206

Lumbar spinal fusionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03673436

ReActiv8NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04803214

Tapentadol (CG5503) Extended Release (ER)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00487435

Telehealth mindfulness-based intervention (MBI)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05698914

Telehealth EducationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05698914

Tapentadol Prolonged ReleaseNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01838616

Oxycodone/Naloxone Prolonged ReleaseNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01838616

SFEX+HNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03031158

SFEXNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03031158

FasciatherapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04812678

PhysiotherapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04812678

DZeroNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07274293

Progressive Exercise PlanNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03502187

NeuromuscularElectricalStimulation(NMES)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03502187

Primary Care Management (PCM)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03502187

Manual therapy and active exercisesNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01496144

Detuned ultrasound and active exercisesNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01496144

Caudal epidural injectionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00370799

Caudal Epidural Injection with generic CelestoneNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00370799

Caudal Epidural Injection with CelestoneNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00370799

Caudal Epidural Injection with DepoMedrolNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00370799

Training and LED groupNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03465228

Training groupNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03465228

Dextrose 15% and lidocaine 1% infiltrationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07296653

Lidocaine 1% infiltrationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07296653

telemedicine digital therapeuticNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05375500

Leg Lateral Reach TestNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06025656

Swiss DolorClast® CLASSIC applicatorNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01835795

Swiss DolorClast® CLASSIC placebo applicatorNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01835795

BUPRENORPHINE

Approved · 0 trials · source: Open Targets

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