Biomarker & Intervention Discovery
Stroke (Ischaemic / Cerebrovascular Disease)
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
NIH funding$422MFY2025 · RCDC estimate
Funding levelUnderfunded
Spontaneous remissionSpontaneous early neurological improvement in 10-20% within 24 hours of ischaemic stroke without intervention…
Best-intervention remissionIV thrombolysis (tPA/tenecteplase) within 4.5 hours: increases odds of favourable outcome by 30%; thrombectomy for…
Gap sizeVery large — enormous treatment gap; only 2-15% of eligible patients receive thrombolysis; <5% receive thrombectomy…
Primary barrieraccess/practice
Full remission profile →
Remission & chronicity
Spontaneous remission
Spontaneous early neurological improvement in 10-20% within 24 hours of ischaemic stroke without intervention; functional independence at 3 months in only 40-50% without revascularisation; 15% 30-day mortality untreated
Best-intervention remission
IV thrombolysis (tPA/tenecteplase) within 4.5 hours: increases odds of favourable outcome by 30%; thrombectomy for large vessel occlusion within 24 hours: 46% functional independence vs 27% control (DAWN/DEFUSE); combined thrombolysis + thrombectomy: best outcomes in eligible patients
Gap size
Very large — enormous treatment gap; only 2-15% of eligible patients receive thrombolysis; <5% receive thrombectomy worldwide
Primary barrier
access/practice
The 4.5-hour and 24-hour time windows are frequently missed due to delayed recognition, delayed presentation, or lack of stroke centre access; in-hospital treatment delays add further losses; secondary prevention (antihypertensives, statins, anticoagulation for AF) chronically underprescribed post-stroke
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Stroke (Ischaemic / Cerebrovascular Disease)” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."