Remission & chronicity

Spontaneous remission

Disease course unchanged in ~85% of patients at 10 years on standard care; ~23% (CD) and ~12% (UC) relapse within 12 months of thiopurine withdrawal in sustained remission

Best-intervention remission

Anti-IL-23 biologics (mirikizumab, risankizumab) maintain steroid-free remission in >60% at 2 years — but on the drug, not drug-free

Gap size

Large -- but between 'no remission' and 'on-drug remission'; drug-free remission remains rare

Primary barrier

biological

Biologic revolution has raised on-drug remission without meaningfully improving drug-free remission rates; true disease modification (cure-like durability off treatment) remains elusive

Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.

ATG16L1 1 FOXP3 2 IL10 20 IL12B 14 IL23A 8 IL23R 178 ITGA4 9 JAK1 30 JAK2 256 MADCAM1 2 NOD2 202 S1PR1 211 TNF 91 TYK2 216

ATG16L1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
ADALIMUMAB	? unclear	Mechanistic		DGIdb

FOXP3

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
EPIRUBICIN	? unclear	Mechanistic		DGIdb
METHOTREXATE	? unclear	Mechanistic		DGIdb

IL10

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
EFAVIRENZ	? unclear	Mechanistic	DGIdb
ANESTHETIC AGENT	? unclear	Mechanistic	DGIdb
ACYCLOVIR	? unclear	Mechanistic	DGIdb
MACROLIDE ANTIBIOTIC	? unclear	Mechanistic	DGIdb
LISOFYLLINE	? unclear	Mechanistic	DGIdb
PROTON PUMP INHIBITOR	? unclear	Mechanistic	DGIdb
SCH-708980	↓ inhibits	Mechanistic	DGIdb
SIROLIMUS	? unclear	Mechanistic	DGIdb
SHO-SAIKO-TO	? unclear	Mechanistic	DGIdb
RABEPRAZOLE	? unclear	Mechanistic	DGIdb
AMOXICILLIN ANHYDROUS	? unclear	Mechanistic	DGIdb
CLARITHROMYCIN	? unclear	Mechanistic	DGIdb
ILODECAKIN	? unclear	Mechanistic	DGIdb
FLUTICASONE	? unclear	Mechanistic	DGIdb
TRETINOIN	? unclear	Mechanistic	DGIdb
MESALAMINE	? unclear	Mechanistic	DGIdb
ROFECOXIB	? unclear	Mechanistic	DGIdb
ETANERCEPT	? unclear	Mechanistic	DGIdb
PEGILODECAKIN	? unclear	Mechanistic	DGIdb
ZIDOVUDINE	? unclear	Mechanistic	DGIdb

IL12B

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
TILDRAKIZUMAB	↓ inhibits	Mechanistic	DGIdb
EGEN-001	? unclear	Mechanistic	DGIdb
USTEKINUMAB	↓ inhibits	Mechanistic	DGIdb
BRAZIKUMAB	↓ inhibits	Mechanistic	DGIdb
GUSELKUMAB	↓ inhibits	Mechanistic	DGIdb
BRIAKINUMAB	↓ inhibits	Mechanistic	DGIdb
ISOPROTERENOL	? unclear	Mechanistic	DGIdb
EBDAROKIMAB	↓ inhibits	Mechanistic	DGIdb
HUMANIZED SMART ANTI-IL-12 ANTIBODY	? unclear	Mechanistic	DGIdb
ADENOVIRAL TRANSDUCED HIL-12-EXPRESSING AUTOLOGOUS DENDRITIC CELLS INXN-3001 PLUS ACTIVATOR LIGAND INXN-1001	? unclear	Mechanistic	DGIdb
VIRULIZIN	? unclear	Mechanistic	DGIdb
RISANKIZUMAB	↓ inhibits	Mechanistic	DGIdb
MIRIKIZUMAB	↓ inhibits	Mechanistic	DGIdb
INFLIXIMAB	? unclear	Mechanistic	DGIdb

IL23A

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
USTEKINUMAB	↓ inhibits	Mechanistic	DGIdb
RISANKIZUMAB	↓ inhibits	Mechanistic	DGIdb
MIRIKIZUMAB	↓ inhibits	Mechanistic	DGIdb
BRAZIKUMAB	↓ inhibits	Mechanistic	DGIdb
TILDRAKIZUMAB	↓ inhibits	Mechanistic	DGIdb
GUSELKUMAB	↓ inhibits	Mechanistic	DGIdb
EBDAROKIMAB	↓ inhibits	Mechanistic	DGIdb
BRIAKINUMAB	↓ inhibits	Mechanistic	DGIdb

IL23R

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
INFLIXIMAB	? unclear	Mechanistic		DGIdb
AZATHIOPRINE	? unclear	Mechanistic		DGIdb
CELECOXIB	? unclear	Mechanistic		DGIdb
CHEMBL4206167	↓ inhibits	Mechanistic	1.81 nM (Kd)	ChEMBL
CHEMBL4567228	↓ inhibits	Mechanistic	113.0 nM (IC50)	ChEMBL
CHEMBL4555885	↓ inhibits	Mechanistic	32.0 nM (IC50)	ChEMBL
CHEMBL4529484	↓ inhibits	Mechanistic	25.0 nM (IC50)	ChEMBL
CHEMBL4577218	↓ inhibits	Mechanistic	39.0 nM (IC50)	ChEMBL
CHEMBL4442232	↓ inhibits	Mechanistic	892.0 nM (IC50)	ChEMBL
CHEMBL4565015	↓ inhibits	Mechanistic	37.0 nM (IC50)	ChEMBL
CHEMBL4515769	↓ inhibits	Mechanistic	199.0 nM (IC50)	ChEMBL
CHEMBL4451305	↓ inhibits	Mechanistic	79.0 nM (IC50)	ChEMBL
CHEMBL4441983	↓ inhibits	Mechanistic	220.0 nM (IC50)	ChEMBL
CHEMBL4537768	↓ inhibits	Mechanistic	102.0 nM (IC50)	ChEMBL
CHEMBL4458363	↓ inhibits	Mechanistic	78.0 nM (IC50)	ChEMBL
CHEMBL4454287	↓ inhibits	Mechanistic	183.0 nM (IC50)	ChEMBL
CHEMBL4452903	↓ inhibits	Mechanistic	57.0 nM (IC50)	ChEMBL
CHEMBL4457621	↓ inhibits	Mechanistic	52.0 nM (IC50)	ChEMBL
CHEMBL4543753	↓ inhibits	Mechanistic	518.0 nM (IC50)	ChEMBL
CHEMBL4527549	↓ inhibits	Mechanistic	153.0 nM (IC50)	ChEMBL
CHEMBL4540496	↓ inhibits	Mechanistic	223.0 nM (IC50)	ChEMBL
CHEMBL4524632	↓ inhibits	Mechanistic	79.0 nM (IC50)	ChEMBL
CHEMBL4459265	↓ inhibits	Mechanistic	124.0 nM (IC50)	ChEMBL
CHEMBL4550853	↓ inhibits	Mechanistic	2584.0 nM (IC50)	ChEMBL
CHEMBL4435141	↓ inhibits	Mechanistic	30000.0 nM (IC50)	ChEMBL
CHEMBL4446365	↓ inhibits	Mechanistic	100.0 nM (IC50)	ChEMBL
CHEMBL4462185	↓ inhibits	Mechanistic	96.0 nM (IC50)	ChEMBL
CHEMBL4454702	↓ inhibits	Mechanistic	99.0 nM (IC50)	ChEMBL
CHEMBL4576008	↓ inhibits	Mechanistic	95.0 nM (IC50)	ChEMBL
CHEMBL4589681	↓ inhibits	Mechanistic	107.0 nM (IC50)	ChEMBL
CHEMBL4583420	↓ inhibits	Mechanistic	101.0 nM (IC50)	ChEMBL
CHEMBL4440544	↓ inhibits	Mechanistic	107.0 nM (IC50)	ChEMBL
CHEMBL4564118	↓ inhibits	Mechanistic	47.0 nM (IC50)	ChEMBL
CHEMBL4537038	↓ inhibits	Mechanistic	59.0 nM (IC50)	ChEMBL
CHEMBL4547985	↓ inhibits	Mechanistic	206.0 nM (IC50)	ChEMBL
CHEMBL4558328	↓ inhibits	Mechanistic	40.0 nM (IC50)	ChEMBL
CHEMBL4567670	↓ inhibits	Mechanistic	139.0 nM (IC50)	ChEMBL
CHEMBL4582731	↓ inhibits	Mechanistic	1885.0 nM (IC50)	ChEMBL
CHEMBL4435308	↓ inhibits	Mechanistic	134.0 nM (IC50)	ChEMBL
CHEMBL4564607	↓ inhibits	Mechanistic	48.0 nM (IC50)	ChEMBL

Showing top 40 of 178 agents ranked by evidence tier.

ITGA4

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
SENKTIDE	? unclear	Mechanistic	DGIdb
VEDOLIZUMAB	↓ inhibits	Mechanistic	DGIdb
R1295	? unclear	Mechanistic	DGIdb
ABRILUMAB	↓ inhibits	Mechanistic	DGIdb
UCB-1184197	↓ inhibits	Mechanistic	DGIdb
ATL1102	? unclear	Mechanistic	DGIdb
NATALIZUMAB	↓ inhibits	Mechanistic	DGIdb
FIRATEGRAST	↓ inhibits	Mechanistic	DGIdb
BIO1211	? unclear	Mechanistic	DGIdb

JAK1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
RUXOLITINIB	↓ inhibits	Mechanistic	DGIdb
IZENCITINIB	↓ inhibits	Mechanistic	DGIdb
PEMBROLIZUMAB	? unclear	Mechanistic	DGIdb
RUXOLITINIB PHOSPHATE	↓ inhibits	Mechanistic	DGIdb
GOLIDOCITINIB	↓ inhibits	Mechanistic	DGIdb
FILGOTINIB MALEATE	↓ inhibits	Mechanistic	DGIdb
MOMELOTINIB	↓ inhibits	Mechanistic	DGIdb
AZD1480	↓ inhibits	Mechanistic	DGIdb
DELGOCITINIB	↓ inhibits	Mechanistic	DGIdb
TRICETAMIDE	↓ inhibits	Mechanistic	DGIdb
TOFACITINIB	↓ inhibits	Mechanistic	DGIdb
PEFICITINIB	↓ inhibits	Mechanistic	DGIdb
BREPOCITINIB	↓ inhibits	Mechanistic	DGIdb
UPADACITINIB HEMIHYDRATE	↓ inhibits	Mechanistic	DGIdb
CYCLOSPORINE	? unclear	Mechanistic	DGIdb
INCB-047986	↓ inhibits	Mechanistic	DGIdb
ABROCITINIB	↓ inhibits	Mechanistic	DGIdb
ENZASTAURIN	? unclear	Mechanistic	DGIdb
CERDULATINIB	↓ inhibits	Mechanistic	DGIdb
NEZULCITINIB	↓ inhibits	Mechanistic	DGIdb
FILGOTINIB	↓ inhibits	Mechanistic	DGIdb
GLPG-0555	↓ inhibits	Mechanistic	DGIdb
SOLCITINIB	↓ inhibits	Mechanistic	DGIdb
GUSACITINIB	↓ inhibits	Mechanistic	DGIdb
ITACITINIB	↓ inhibits	Mechanistic	DGIdb
BARICITINIB	↓ inhibits	Mechanistic	DGIdb
MOMELOTINIB DIHYDROCHLORIDE MONOHYDRATE	? unclear	Mechanistic	Open Targets
DEURUXOLITINIB PHOSPHATE	? unclear	Mechanistic	Open Targets
TOFACITINIB CITRATE	? unclear	Mechanistic	Open Targets
UPADACITINIB	? unclear	Mechanistic	Open Targets

JAK2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
TYRPHOSTIN 23	? unclear	Mechanistic		DGIdb
AZD1480	↓ inhibits	Mechanistic		DGIdb
PF-562271	? unclear	Mechanistic		DGIdb
JAK2V617F INHIBITOR INCB160058	? unclear	Mechanistic		DGIdb
PEMBROLIZUMAB	? unclear	Mechanistic		DGIdb
TOFACITINIB	↓ inhibits	Mechanistic	11.0 nM (IC50)	DGIdb
RUXOLITINIB	↓ inhibits	Mechanistic		DGIdb
FEDRATINIB	↓ inhibits	Mechanistic		DGIdb
TENALISIB	? unclear	Mechanistic		DGIdb
FILGOTINIB	↓ inhibits	Mechanistic		DGIdb
PACRITINIB	↓ inhibits	Mechanistic		DGIdb
BARICITINIB	↓ inhibits	Mechanistic		DGIdb
NS-018	↓ inhibits	Mechanistic		DGIdb
TANESPIMYCIN	? unclear	Mechanistic		DGIdb
AZD1208	? unclear	Mechanistic		DGIdb
PICTILISIB	? unclear	Mechanistic		DGIdb
DOVITINIB	? unclear	Mechanistic	7000.0 nM (Kd)	DGIdb
AZ960	? unclear	Mechanistic		DGIdb
GANDOTINIB	↓ inhibits	Mechanistic		DGIdb
PEGINTERFERON ALFA-2B	? unclear	Mechanistic		DGIdb
LUMINESPIB	? unclear	Mechanistic		DGIdb
ROPEGINTERFERON ALFA-2B	? unclear	Mechanistic		DGIdb
MOMELOTINIB	↓ inhibits	Mechanistic		DGIdb
AZD-1480	↓ inhibits	Mechanistic		DGIdb
NEZULCITINIB	↓ inhibits	Mechanistic		DGIdb
TYRPHOSTIN AG 555	? unclear	Mechanistic		DGIdb
GELDANAMYCIN	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL546797	? unclear	Mechanistic		DGIdb
ERLOTINIB	? unclear	Mechanistic	4000.0 nM (IC50)	DGIdb
BINIMETINIB	? unclear	Mechanistic		DGIdb
PD-0166285	? unclear	Mechanistic		DGIdb
SGI-1776	? unclear	Mechanistic		DGIdb
XL-019	↓ inhibits	Mechanistic		DGIdb
THIRAM	? unclear	Mechanistic		DGIdb
RIBOCICLIB	? unclear	Mechanistic		DGIdb
ALFENTANIL HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL29197	? unclear	Mechanistic		DGIdb
CEP-11981	? unclear	Mechanistic		DGIdb
DACTOLISIB	? unclear	Mechanistic		DGIdb
AT-9283	↓ inhibits	Mechanistic	1.2 nM (IC50)	DGIdb

Showing top 40 of 256 agents ranked by evidence tier.

MADCAM1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
ONTAMALIMAB	↓ inhibits	Mechanistic		DGIdb
NAVARIXIN	? unclear	Mechanistic		DGIdb

NOD2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
INARIGIVIR SOPROXIL	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL1351908	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL585502	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL577660	? unclear	Mechanistic		DGIdb
MICROPARTICLE MDP/BACTERIAL DNA-CONTAINING MIS416	? unclear	Mechanistic		DGIdb
CYCLOVALONE	? unclear	Mechanistic	9950.0 nM (EC50)	DGIdb
CHEMBL:CHEMBL1456848	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL599890	? unclear	Mechanistic		DGIdb
MIFAMURTIDE	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL578944	? unclear	Mechanistic		DGIdb
MURABUTIDE	? unclear	Mechanistic		DGIdb
ANHYDROUS TACROLIMUS	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL590706	? unclear	Mechanistic		DGIdb
CYCLOSPORINE	? unclear	Mechanistic		DGIdb
CHEMBL1542558	↓ inhibits	Mechanistic	16600.0 nM (IC50)	ChEMBL
CHEMBL1717353	↓ inhibits	Mechanistic	8440.0 nM (IC50)	ChEMBL
CHEMBL1373066	↓ inhibits	Mechanistic	17300.0 nM (IC50)	ChEMBL
CHEMBL1586616	↓ inhibits	Mechanistic	3990.0 nM (IC50)	ChEMBL
CHEMBL1708503	↓ inhibits	Mechanistic	1720.0 nM (IC50)	ChEMBL
CHEMBL1312200	↓ inhibits	Mechanistic	7040.0 nM (IC50)	ChEMBL
CHEMBL599890	↓ inhibits	Mechanistic	19700.0 nM (IC50)	ChEMBL
CHEMBL1561275	↓ inhibits	Mechanistic	5900.0 nM (IC50)	ChEMBL
CHEMBL1405985	↓ inhibits	Mechanistic	2930.0 nM (IC50)	ChEMBL
CHEMBL1543504	↓ inhibits	Mechanistic	5900.0 nM (IC50)	ChEMBL
CHEMBL1710033	↓ inhibits	Mechanistic	1620.0 nM (IC50)	ChEMBL
CHEMBL1729430	↓ inhibits	Mechanistic	7930.0 nM (IC50)	ChEMBL
CHEMBL1519375	↓ inhibits	Mechanistic	16900.0 nM (IC50)	ChEMBL
CHEMBL1388356	↓ inhibits	Mechanistic	17800.0 nM (IC50)	ChEMBL
CHEMBL1700643	↓ inhibits	Mechanistic	15300.0 nM (IC50)	ChEMBL
CHEMBL1719980	↓ inhibits	Mechanistic	19000.0 nM (IC50)	ChEMBL
CHEMBL1314048	↓ inhibits	Mechanistic	11700.0 nM (IC50)	ChEMBL
CHEMBL1508723	↓ inhibits	Mechanistic	6080.0 nM (IC50)	ChEMBL
CHEMBL1542483	↓ inhibits	Mechanistic	9140.0 nM (IC50)	ChEMBL
CHEMBL1599782	↓ inhibits	Mechanistic	12000.0 nM (IC50)	ChEMBL
CHEMBL1491541	↓ inhibits	Mechanistic	11400.0 nM (IC50)	ChEMBL
CHEMBL1712022	↓ inhibits	Mechanistic	18500.0 nM (IC50)	ChEMBL
CHEMBL1529494	↓ inhibits	Mechanistic	8210.0 nM (IC50)	ChEMBL
CHEMBL1299637	↓ inhibits	Mechanistic	2160.0 nM (IC50)	ChEMBL
CHEMBL1426966	↓ inhibits	Mechanistic	6900.0 nM (IC50)	ChEMBL
CHEMBL1731774	↓ inhibits	Mechanistic	1120.0 nM (IC50)	ChEMBL

Showing top 40 of 202 agents ranked by evidence tier.

S1PR1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
CHEMBL:CHEMBL171699	? unclear	Mechanistic		DGIdb
(S)-FTY720P	? unclear	Mechanistic		DGIdb
CHEMBL:CHEMBL1362503	? unclear	Mechanistic		DGIdb
SAR247799	? unclear	Mechanistic		DGIdb
ASP-4058	? unclear	Mechanistic		DGIdb
MOCRAVIMOD HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
BMS-986104	? unclear	Mechanistic		DGIdb
PONESIMOD	↑ activates	Mechanistic		DGIdb
ISOVELLERAL	? unclear	Mechanistic		DGIdb
SIPONIMOD	↑ activates	Mechanistic		DGIdb
AMISELIMOD HYDROCHLORIDE	~ modulates	Mechanistic		DGIdb
GSK-2018682	? unclear	Mechanistic		DGIdb
FINGOLIMOD LAURYL SULFATE	~ modulates	Mechanistic		DGIdb
FINGOLIMOD HYDROCHLORIDE	↑ activates	Mechanistic		DGIdb
CHEMBL:CHEMBL586135	? unclear	Mechanistic		DGIdb
OZANIMOD HYDROCHLORIDE	~ modulates	Mechanistic		DGIdb
CHEMBL:CHEMBL579318	? unclear	Mechanistic		DGIdb
KRP203	↑ activates	Mechanistic		DGIdb
AMISELIMOD	? unclear	Mechanistic		DGIdb
CENERIMOD	~ modulates	Mechanistic		DGIdb
9,10-PHENANTHRENEQUINONE	? unclear	Mechanistic		DGIdb
ETRASIMOD ARGININE	~ modulates	Mechanistic		DGIdb
ETRASIMOD	↑ activates	Mechanistic		DGIdb
SIPONIMOD FUMARIC ACID	↑ activates	Mechanistic		DGIdb
OZANIMOD	? unclear	Mechanistic		DGIdb
FINGOLIMOD	? unclear	Mechanistic		DGIdb
SONEPCIZUMAB	? unclear	Mechanistic		DGIdb
PINAFIDE	? unclear	Mechanistic		DGIdb
CHEMBL117910	↓ inhibits	Mechanistic	1.4 nM (IC50)	ChEMBL
CHEMBL332050	↑ activates	Mechanistic	82.0 nM (EC50)	ChEMBL
CHEMBL115505	↑ activates	Mechanistic	322.1 nM (EC50)	ChEMBL
CHEMBL115344	↑ activates	Mechanistic	260.0 nM (EC50)	ChEMBL
CHEMBL324358	↑ activates	Mechanistic	598.4 nM (EC50)	ChEMBL
CHEMBL332472	↑ activates	Mechanistic	12.7 nM (EC50)	ChEMBL
CHEMBL422074	↑ activates	Mechanistic	58.0 nM (EC50)	ChEMBL
CHEMBL225155	↑ activates	Mechanistic	0.9 nM (EC50)	ChEMBL
CHEMBL116953	↑ activates	Mechanistic	130.0 nM (EC50)	ChEMBL
CHEMBL334038	↑ activates	Mechanistic	8.6 nM (EC50)	ChEMBL
CHEMBL325408	↑ activates	Mechanistic	1805.0 nM (EC50)	ChEMBL
CHEMBL114031	↑ activates	Mechanistic	550.0 nM (EC50)	ChEMBL

Showing top 40 of 211 agents ranked by evidence tier.

TNF

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
NERELIMOMAB	↓ inhibits	Mechanistic	DGIdb
CROMOLYN SODIUM	? unclear	Mechanistic	DGIdb
PLACULUMAB	↓ inhibits	Mechanistic	DGIdb
METHYLENE BLUE	? unclear	Mechanistic	DGIdb
ALTEPLASE	? unclear	Mechanistic	DGIdb
CARBOPLATIN	? unclear	Mechanistic	DGIdb
GENTAMICIN	? unclear	Mechanistic	DGIdb
GOLIMUMAB	↓ inhibits	Mechanistic	DGIdb
BUPIVACAINE	? unclear	Mechanistic	DGIdb
PENTOXIFYLLINE	? unclear	Mechanistic	DGIdb
BENZO[E]PYRENE	? unclear	Mechanistic	DGIdb
THALIDOMIDE	? unclear	Mechanistic	DGIdb
PYRAZINAMIDE	? unclear	Mechanistic	DGIdb
GLIMEPIRIDE	? unclear	Mechanistic	DGIdb
OMEPRAZOLE	? unclear	Mechanistic	DGIdb
LENERCEPT	↓ inhibits	Mechanistic	DGIdb
ADALIMUMAB	↓ inhibits	Mechanistic	DGIdb
PRAZOSIN HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
REMTOLUMAB	? unclear	Mechanistic	DGIdb
MIDOSTAURIN	? unclear	Mechanistic	DGIdb
LENABASUM	? unclear	Mechanistic	DGIdb
MAGNESIUM SULFATE ANHYDROUS	? unclear	Mechanistic	DGIdb
PICIBANIL	? unclear	Mechanistic	DGIdb
FLUOCINOLONE ACETONIDE	? unclear	Mechanistic	DGIdb
MILTEFOSINE	? unclear	Mechanistic	DGIdb
HOMIDIUM BROMIDE	? unclear	Mechanistic	DGIdb
OZORALIZUMAB	↓ inhibits	Mechanistic	DGIdb
PEGSUNERCEPT	↓ inhibits	Mechanistic	DGIdb
CERTOLIZUMAB PEGOL	↓ inhibits	Mechanistic	DGIdb
THERAPEUTIC HORMONE	? unclear	Mechanistic	DGIdb
NAFAMOSTAT	? unclear	Mechanistic	DGIdb
FOLIC ACID	? unclear	Mechanistic	DGIdb
ABBV-257	? unclear	Mechanistic	DGIdb
RISPERIDONE	? unclear	Mechanistic	DGIdb
COVA322	? unclear	Mechanistic	DGIdb
HYDROXYCHLOROQUINE	? unclear	Mechanistic	DGIdb
CERTOLIZUMAB	? unclear	Mechanistic	DGIdb
AN0128	? unclear	Mechanistic	DGIdb
5,7-DIHYDROXY-4-METHYLCOUMARIN	? unclear	Mechanistic	DGIdb
SORAFENIB	? unclear	Mechanistic	DGIdb

Showing top 40 of 91 agents ranked by evidence tier.

TYK2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
LORPUCITINIB	↓ inhibits	Mechanistic		DGIdb
FILGOTINIB	↓ inhibits	Mechanistic		DGIdb
RG-1530	? unclear	Mechanistic		DGIdb
ZOTIRACICLIB	↓ inhibits	Mechanistic		DGIdb
SAR-20347	↓ inhibits	Mechanistic		DGIdb
DEUCRAVACITINIB	~ modulates	Mechanistic		DGIdb
CERDULATINIB	↓ inhibits	Mechanistic		DGIdb
COMPOUND 6 [PMID: 34333981]	↓ inhibits	Mechanistic		DGIdb
RUXOLITINIB	↓ inhibits	Mechanistic	19.0 nM (IC50)	DGIdb
OCLACITINIB	↓ inhibits	Mechanistic		DGIdb
GDC-0214	↓ inhibits	Mechanistic		DGIdb
JNJ-7706621	? unclear	Mechanistic	32.0 nM (Kd)	DGIdb
BREPOCITINIB	↓ inhibits	Mechanistic		DGIdb
IZENCITINIB	↓ inhibits	Mechanistic		DGIdb
2-TERT-BUTYL-9-FLUORO-1,6-DIHYDROBENZO[H]IMIDAZO[4,5-F]ISOQUINOLIN-7-ONE	↓ inhibits	Mechanistic		DGIdb
PF-562271	? unclear	Mechanistic		DGIdb
UPADACITINIB HEMIHYDRATE	↓ inhibits	Mechanistic		DGIdb
JAK3 INHIBITOR 34	↓ inhibits	Mechanistic		DGIdb
UPADACITINIB	↓ inhibits	Mechanistic		DGIdb
DOVITINIB	? unclear	Mechanistic	150.0 nM (Kd)	DGIdb
ROPSACITINIB	↓ inhibits	Mechanistic		DGIdb
GOLIDOCITINIB	↓ inhibits	Mechanistic		DGIdb
COMPOUND 13AC [PMID: 33256400]	↓ inhibits	Mechanistic		DGIdb
TYK2 INHIBITOR 18 [WO2023227946]	~ modulates	Mechanistic		DGIdb
TAMATINIB	? unclear	Mechanistic		DGIdb
CYC-116	? unclear	Mechanistic	79.43 nM (Ki)	DGIdb
PF-06263276	↓ inhibits	Mechanistic		DGIdb
GO-6976	? unclear	Mechanistic		DGIdb
SJ988497	? unclear	Mechanistic		DGIdb
PEFICITINIB	↓ inhibits	Mechanistic		DGIdb
NVP-TAE684	? unclear	Mechanistic		DGIdb
COMPOUND 25AP [PMID: 37796543]	↓ inhibits	Mechanistic		DGIdb
HESPERADIN	↓ inhibits	Mechanistic	75.0 nM (Kd)	DGIdb
COMPOUND 29 [MOSLIN ET AL., 2017]	↓ inhibits	Mechanistic		DGIdb
ALDESLEUKIN	? unclear	Mechanistic		DGIdb
BMS-986202	↓ inhibits	Mechanistic		DGIdb
SOLCITINIB	↓ inhibits	Mechanistic		DGIdb
MOMELOTINIB	↓ inhibits	Mechanistic		DGIdb
FEDRATINIB	↓ inhibits	Mechanistic	150.0 nM (IC50)	DGIdb
BMS-911543	↓ inhibits	Mechanistic		DGIdb

Showing top 40 of 216 agents ranked by evidence tier.

Clinical Trials

Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-06.

No recent clinical trials found on ClinicalTrials.gov for this condition.

Agents Found By Disease-Level Search

Searched directly from “Inflammatory Bowel Disease (Crohn's / UC)” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 14-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

28 agents shown (approved or with trial evidence) — 22 not found by the gene-target search above.

Vedolizumab

· 4 trials · source: ClinicalTrials.gov
NCT03196427 NCT03138655 NCT07273760

Anti-TNF TherapyNOT in gene-target list

· 2 trials · source: ClinicalTrials.gov
NCT03090139 NCT06896305

Mirikizumab

· 2 trials · source: ClinicalTrials.gov
NCT04844606 NCT04844606

Fecal Microbiota Transplantation (FMT)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02108821

Upadacitinib

· 1 trial · source: ClinicalTrials.gov
NCT06922331

Ustekinumab 90 mg SC q8wNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07303686

Ustekinumab 90 mg SC q12wNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07303686

Risankizumab

· 1 trial · source: ClinicalTrials.gov
NCT04254783

Cytochrome P450 (CYP) SubstratesNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04254783

Vedolizumab IVNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05442567

PF2020-CELL (UC-MSCs) - Allogeneic Human Umbilical Cord Mesenchymal Stem CellsNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05039411

Vitamin D3NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01877577

Multispectral Optoacoustic Tomography (MSOT)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04650867

Ketogenic dietNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07524244

Carnivore (Lion) DietNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07524244

Zasocitinib

· 1 trial · source: ClinicalTrials.gov
NCT06764615

Adalimumab

· 1 trial · source: ClinicalTrials.gov
NCT04089514

Venous blood samples, anal swab samples, vaginal swab samples, high resolution anoscopy (HRA), anal biopsy samplesNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01364896

Dexamethasone (IV)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07385131

InflectraNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03801928

MT-501NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07113522

MT-201NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07113522

CDED (Crohn's Disease Exclusion Diet) in addition to anti-TNF therapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06896305

UTTR1147ANOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02749630

BDHK-2009 TabletsNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07632573

Vedolizumab SCNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06405087

AB (antibiotics)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02033408

CS (corticosteroids) OnlyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02033408

Inflammatory Bowel Disease (Crohn's / UC)

Remission & chronicity

ATG16L1

FOXP3

IL10

IL12B

IL23A

IL23R

ITGA4

JAK1

JAK2

MADCAM1

NOD2

S1PR1

TNF

TYK2

Vedolizumab

Anti-TNF TherapyNOT in gene-target list

Mirikizumab

Fecal Microbiota Transplantation (FMT)NOT in gene-target list

Upadacitinib

Ustekinumab 90 mg SC q8wNOT in gene-target list

Ustekinumab 90 mg SC q12wNOT in gene-target list

Risankizumab

Cytochrome P450 (CYP) SubstratesNOT in gene-target list

Vedolizumab IVNOT in gene-target list

PF2020-CELL (UC-MSCs) - Allogeneic Human Umbilical Cord Mesenchymal Stem CellsNOT in gene-target list

Vitamin D3NOT in gene-target list

Multispectral Optoacoustic Tomography (MSOT)NOT in gene-target list

Ketogenic dietNOT in gene-target list

Carnivore (Lion) DietNOT in gene-target list

Zasocitinib

Adalimumab

Venous blood samples, anal swab samples, vaginal swab samples, high resolution anoscopy (HRA), anal biopsy samplesNOT in gene-target list

Dexamethasone (IV)NOT in gene-target list

InflectraNOT in gene-target list

MT-501NOT in gene-target list

MT-201NOT in gene-target list

CDED (Crohn's Disease Exclusion Diet) in addition to anti-TNF therapyNOT in gene-target list

UTTR1147ANOT in gene-target list

BDHK-2009 TabletsNOT in gene-target list

Vedolizumab SCNOT in gene-target list

AB (antibiotics)NOT in gene-target list

CS (corticosteroids) OnlyNOT in gene-target list

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