Disease Overview
Spontaneous remission
Not established
Best-intervention remission
—
Gap size
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Primary barrier
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Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: Clinical > Mechanistic > Correlative.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| SALVIANOLIC ACID B | ? unclear | Mechanistic | DGIdb | |
| CANDOXATRIL | ? unclear | Mechanistic | DGIdb | |
| CILAZAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| TP0556351 | ↓ inhibits | Mechanistic | DGIdb | |
| PRAVASTATIN SODIUM | ? unclear | Mechanistic | DGIdb | |
| SILDENAFIL | ? unclear | Mechanistic | DGIdb | |
| GEMFIBROZIL | ? unclear | Mechanistic | DGIdb | |
| RESCINNAMINE | ? unclear | Mechanistic | DGIdb | |
| SPIRAPRIL | ? unclear | Mechanistic | DGIdb | |
| INDOMETHACIN | ? unclear | Mechanistic | DGIdb | |
| HYDROCHLOROTHIAZIDE | ? unclear | Mechanistic | DGIdb | |
| ARGIPRESSIN | ? unclear | Mechanistic | DGIdb | |
| METOPROLOL | ? unclear | Mechanistic | DGIdb | |
| DELAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| ACETYLCHOLINE | ? unclear | Mechanistic | DGIdb | |
| THERAPEUTIC GLUCOCORTICOID | ? unclear | Mechanistic | DGIdb | |
| IMIDAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| MALATHION | ↓ inhibits | Mechanistic | DGIdb | |
| MOEXIPRIL | ? unclear | Mechanistic | 56.0 nM (IC50) | DGIdb |
| VORINOSTAT | ? unclear | Mechanistic | DGIdb | |
| ILEPATRIL | ↓ inhibits | Mechanistic | DGIdb | |
| RXP470.1 | ↓ inhibits | Mechanistic | DGIdb | |
| CGS-27023A | ? unclear | Mechanistic | DGIdb | |
| NITROPRUSSIDE | ? unclear | Mechanistic | DGIdb | |
| ENALAPRILAT ANHYDROUS | ↓ inhibits | Mechanistic | 1.2 nM (IC50) | DGIdb |
| TORSEMIDE | ? unclear | Mechanistic | DGIdb | |
| ATORVASTATIN CALCIUM TRIHYDRATE | ? unclear | Mechanistic | DGIdb | |
| FOSINOPRIL | ? unclear | Mechanistic | DGIdb | |
| FUROSEMIDE | ? unclear | Mechanistic | DGIdb | |
| TEMOCAPRIL HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| BENAZEPRIL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CARBARIL | ↓ inhibits | Mechanistic | DGIdb | |
| BUPROPION HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| QUINAPRIL | ? unclear | Mechanistic | 8.3 nM (IC50) | DGIdb |
| COMPOUND 1 [PMID: 24900526] | ↓ inhibits | Mechanistic | DGIdb | |
| COMPOUND 20 [PMID: 22153340] | ↓ inhibits | Mechanistic | DGIdb | |
| BUMETANIDE | ? unclear | Mechanistic | DGIdb | |
| GALLOPAMIL | ? unclear | Mechanistic | DGIdb | |
| FLUOXETINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| AZD6605 | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 229 agents ranked by evidence tier.
ADRB1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| BRETYLIUM | ? unclear | Mechanistic | DGIdb | |
| PINDOLOL | ↑ activates | Mechanistic | DGIdb | |
| BISOPROLOL | ? unclear | Mechanistic | DGIdb | |
| FLECAINIDE ACETATE | ? unclear | Mechanistic | DGIdb | |
| METIPRANOLOL | ? unclear | Mechanistic | DGIdb | |
| METOPROLOL | ? unclear | Mechanistic | DGIdb | |
| ATENOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| BUCINDOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| METIPRANOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ALPRENOLOL | ? unclear | Mechanistic | 4.88 nM (IC50) | DGIdb |
| PRACTOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| XAMOTEROL | ↑ activates | Mechanistic | DGIdb | |
| PENBUTOLOL | ? unclear | Mechanistic | DGIdb | |
| DOBUTAMINE | ? unclear | Mechanistic | DGIdb | |
| BETHANIDINE | ? unclear | Mechanistic | DGIdb | |
| BETAXOLOL | ? unclear | Mechanistic | 37.1 nM (IC50) | DGIdb |
| MURAGLITAZAR | ? unclear | Mechanistic | DGIdb | |
| ACEBUTOLOL | ? unclear | Mechanistic | DGIdb | |
| LABETALOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ACEBUTOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| NOREPINEPHRINE | ? unclear | Mechanistic | DGIdb | |
| OT-730 | ? unclear | Mechanistic | DGIdb | |
| CARVEDILOL | ↓ inhibits | Mechanistic | DGIdb | |
| NADOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| LEVOBUNOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| LABETALOL | ? unclear | Mechanistic | DGIdb | |
| TERTATOLOL | ? unclear | Mechanistic | DGIdb | |
| ARBUTAMINE | ? unclear | Mechanistic | DGIdb | |
| PROPRANOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ZIPRASIDONE | ? unclear | Mechanistic | DGIdb | |
| BUPRANOLOL | ? unclear | Mechanistic | DGIdb | |
| LANDIOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| OXPRENOLOL | ? unclear | Mechanistic | DGIdb | |
| MEPINDOLOL | ? unclear | Mechanistic | DGIdb | |
| CELIPROLOL | ↓ inhibits | Mechanistic | DGIdb | |
| BISOPROLOL FUMARATE | ↓ inhibits | Mechanistic | DGIdb | |
| DESIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| DOPAMINE | ↑ activates | Mechanistic | DGIdb | |
| ISOPROTERENOL | ↑ activates | Mechanistic | DGIdb | |
| DOBUTAMINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb |
Showing top 40 of 288 agents ranked by evidence tier.
AGTR1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CANDESARTAN CILEXETIL | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL586135 | ? unclear | Mechanistic | DGIdb | |
| VALSARTAN | ↓ inhibits | Mechanistic | 4700.0 nM (Ki) | DGIdb |
| EPROSARTAN MESYLATE | ↓ inhibits | Mechanistic | DGIdb | |
| FIMASARTAN | ↓ inhibits | Mechanistic | DGIdb | |
| ASCORBIC ACID | ? unclear | Mechanistic | DGIdb | |
| OLMESARTAN MEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| AZILSARTAN MEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| THERAPEUTIC ANDROSTANOLONE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL347610 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL421088 | ? unclear | Mechanistic | DGIdb | |
| LOSARTAN POTASSIUM | ↓ inhibits | Mechanistic | 5.5 nM (IC50) | DGIdb |
| CHEMBL:CHEMBL1492017 | ? unclear | Mechanistic | DGIdb | |
| SPARSENTAN | ↓ inhibits | Mechanistic | DGIdb | |
| SODIUM CHLORIDE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL261693 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1972216 | ? unclear | Mechanistic | DGIdb | |
| EPROSARTAN | ? unclear | Mechanistic | 7.3 nM (IC50) | DGIdb |
| C-FOS ANTISENSE | ? unclear | Mechanistic | DGIdb | |
| SARALASIN ACETATE | ↓ inhibits | Mechanistic | DGIdb | |
| IRBESARTAN | ↓ inhibits | Mechanistic | 1.1 nM (Ki) | DGIdb |
| DISULFIRAM | ? unclear | Mechanistic | DGIdb | |
| SAPRISARTAN | ? unclear | Mechanistic | DGIdb | |
| H2O2 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL591834 | ? unclear | Mechanistic | DGIdb | |
| CAPTOPRIL | ? unclear | Mechanistic | DGIdb | |
| ANGIOTENSIN II | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL400912 | ? unclear | Mechanistic | DGIdb | |
| ATORVASTATIN CALCIUM TRIHYDRATE | ? unclear | Mechanistic | DGIdb | |
| IDOXIFENE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL528694 | ? unclear | Mechanistic | DGIdb | |
| IL-6 | ? unclear | Mechanistic | DGIdb | |
| ANGIOTENSIN II ACETATE | ↑ activates | Mechanistic | DGIdb | |
| LEVODOPA | ? unclear | Mechanistic | DGIdb | |
| GAMMA-INTERFERON | ? unclear | Mechanistic | DGIdb | |
| AZILSARTAN KAMEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| HYDROCHLOROTHIAZIDE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1445650 | ? unclear | Mechanistic | DGIdb | |
| MUSCLE RELAXANT | ? unclear | Mechanistic | DGIdb | |
| CL-329167 | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 249 agents ranked by evidence tier.
MYH7
NPPB
Pipeline results not yet available for this target. Run the pipeline to populate.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| MURAGLITAZAR | ? unclear | Mechanistic | DGIdb | |
| HYDROCHLOROTHIAZIDE | ? unclear | Mechanistic | DGIdb | |
| IMARIKIREN HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| 1.ALPHA.-HYDROXYVITAMIN D5 | ? unclear | Mechanistic | DGIdb | |
| ALISKIREN FUMARATE | ↓ inhibits | Mechanistic | DGIdb | |
| TERLAKIREN | ? unclear | Mechanistic | DGIdb | |
| SITOKIREN | ↓ inhibits | Mechanistic | DGIdb | |
| REMIKIREN | ? unclear | Mechanistic | DGIdb | |
| ALISKIREN | ? unclear | Mechanistic | DGIdb | |
| VTP-27999 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL47918 | ↓ inhibits | Mechanistic | 30.0 nM (IC50) | ChEMBL |
| CHEMBL50217 | ↓ inhibits | Mechanistic | 2.2 nM (IC50) | ChEMBL |
| CHEMBL301347 | ↓ inhibits | Mechanistic | 2.5 nM (IC50) | ChEMBL |
| CHEMBL48624 | ↓ inhibits | Mechanistic | 2.4 nM (IC50) | ChEMBL |
| CHEMBL101874 | ↓ inhibits | Mechanistic | 1400.0 nM (IC50) | ChEMBL |
| CHEMBL300504 | ↓ inhibits | Mechanistic | 67.0 nM (IC50) | ChEMBL |
| CHEMBL49225 | ↓ inhibits | Mechanistic | 2.1 nM (IC50) | ChEMBL |
| CHEMBL49218 | ↓ inhibits | Mechanistic | 1.3 nM (IC50) | ChEMBL |
| CHEMBL297129 | ↓ inhibits | Mechanistic | 1.5 nM (IC50) | ChEMBL |
| CHEMBL49286 | ↓ inhibits | Mechanistic | 1.0 nM (IC50) | ChEMBL |
| CHEMBL318242 | ↓ inhibits | Mechanistic | 1200.0 nM (IC50) | ChEMBL |
| CHEMBL297701 | ↓ inhibits | Mechanistic | 2.7 nM (IC50) | ChEMBL |
| CHEMBL49379 | ↓ inhibits | Mechanistic | 1.3 nM (IC50) | ChEMBL |
| CHEMBL295048 | ↓ inhibits | Mechanistic | 2.5 nM (IC50) | ChEMBL |
| CHEMBL46240 | ↓ inhibits | Mechanistic | 110.0 nM (IC50) | ChEMBL |
| CHEMBL301395 | ↓ inhibits | Mechanistic | 1.7 nM (IC50) | ChEMBL |
| CHEMBL295838 | ↓ inhibits | Mechanistic | 1.3 nM (IC50) | ChEMBL |
| CHEMBL300711 | ↓ inhibits | Mechanistic | 1.5 nM (IC50) | ChEMBL |
| CHEMBL301966 | ↓ inhibits | Mechanistic | 2.4 nM (IC50) | ChEMBL |
| CHEMBL48591 | ↓ inhibits | Mechanistic | 1.5 nM (IC50) | ChEMBL |
| CHEMBL97865 | ↓ inhibits | Mechanistic | 69000.0 nM (IC50) | ChEMBL |
| CHEMBL46115 | ↓ inhibits | Mechanistic | 0.9 nM (IC50) | ChEMBL |
| CHEMBL265560 | ↓ inhibits | Mechanistic | 2.7 nM (IC50) | ChEMBL |
| CHEMBL51935 | ↓ inhibits | Mechanistic | 17.0 nM (IC50) | ChEMBL |
| CHEMBL48481 | ↓ inhibits | Mechanistic | 6.0 nM (IC50) | ChEMBL |
| CHEMBL98582 | ↓ inhibits | Mechanistic | 4600.0 nM (IC50) | ChEMBL |
| CHEMBL301146 | ↓ inhibits | Mechanistic | 5.0 nM (IC50) | ChEMBL |
| CHEMBL321937 | ↓ inhibits | Mechanistic | 280.0 nM (IC50) | ChEMBL |
| CHEMBL49172 | ↓ inhibits | Mechanistic | 2.0 nM (IC50) | ChEMBL |
| CHEMBL51401 | ↓ inhibits | Mechanistic | 1.0 nM (IC50) | ChEMBL |
Showing top 40 of 146 agents ranked by evidence tier.
TGFB1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| INTERFERON ALFA-2B | ? unclear | Mechanistic | DGIdb | |
| PIOGLITAZONE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| SILYMARIN | ? unclear | Mechanistic | DGIdb | |
| RITUXIMAB | ? unclear | Mechanistic | DGIdb | |
| VERAPAMIL | ? unclear | Mechanistic | DGIdb | |
| PROTEASOME INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| FRESOLIMUMAB | ? unclear | Mechanistic | DGIdb | |
| ATENOLOL | ? unclear | Mechanistic | DGIdb | |
| BINTRAFUSP ALFA | ~ modulates | Mechanistic | DGIdb | |
| NISEVOKITUG | ? unclear | Mechanistic | DGIdb | |
| LUSPATERCEPT | ↓ inhibits | Mechanistic | DGIdb | |
| TRETINOIN | ? unclear | Mechanistic | DGIdb | |
| HYDROCORTISONE BUTYRATE | ? unclear | Mechanistic | DGIdb | |
| VITAMIN E | ? unclear | Mechanistic | DGIdb | |
| IRINOTECAN HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| INOSITOL | ? unclear | Mechanistic | DGIdb | |
| NICOTINE POLACRILEX | ? unclear | Mechanistic | DGIdb | |
| FENRETINIDE | ? unclear | Mechanistic | DGIdb | |
| MELATONIN | ? unclear | Mechanistic | DGIdb | |
| ISOTRETINOIN | ? unclear | Mechanistic | DGIdb | |
| VACTOSERTIB | ? unclear | Mechanistic | 12.9 nM (IC50) | DGIdb |
| TRIAMCINOLONE | ? unclear | Mechanistic | DGIdb | |
| TAMOXIFEN | ? unclear | Mechanistic | DGIdb | |
| ADRIAMYCIN | ? unclear | Mechanistic | DGIdb | |
| HEPARAN SULFATE | ? unclear | Mechanistic | DGIdb | |
| GOSSYPOL | ? unclear | Mechanistic | DGIdb | |
| TCDD | ? unclear | Mechanistic | DGIdb | |
| AMIFOSTINE ANHYDROUS | ? unclear | Mechanistic | DGIdb | |
| RAMIPRIL | ? unclear | Mechanistic | DGIdb | |
| ANTIOXIDANT | ? unclear | Mechanistic | DGIdb | |
| SOTATERCEPT | ? unclear | Mechanistic | DGIdb | |
| ASPIRIN | ? unclear | Mechanistic | DGIdb | |
| GALUNISERTIB | ? unclear | Mechanistic | DGIdb | |
| KEYHOLE LIMPET HEMOCYANIN | ? unclear | Mechanistic | DGIdb | |
| PIRFENIDONE | ? unclear | Mechanistic | DGIdb | |
| H2O2 | ? unclear | Mechanistic | DGIdb | |
| THERAPEUTIC ANDROGEN | ? unclear | Mechanistic | DGIdb | |
| SANDOSTATIN | ? unclear | Mechanistic | DGIdb | |
| BROXURIDINE | ? unclear | Mechanistic | DGIdb | |
| DISITERTIDE | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 62 agents ranked by evidence tier.
Clinical Trials
Drug, biologic and supplement trials (treatment or prevention) from ClinicalTrials.gov whose main condition is Hypertensive Heart Disease: recruiting, active or completed, most recently updated first. Data retrieved 2026-10-28.
Objective: to evaluate the effectiveness of using a food product, dry finely dispersed beetroot powder in a dose of 20 g, containing 800 mg of nitrate (NO3-), in relation to the regulation of blood pressure in men with hypertension who reached the target blood pressure level while taking optimal ant...
In Singapore, hypertension is very common in the adult population. Hypertensive heart disease is a leading cause of heart failure and cardiovascular death. Current management relies primarily on achieving blood pressure targets. However, the optimal blood pressure goals are controversial and there a...
72 patients who have been diagnosed with hypertensive bradyarrhythmia were selected and randomly divided into research group and control group. The research group received regular medication against hypertension and the personalized formulas based on syndrome differentiation, meanwhile the control g...
Agents Found By Disease-Level Search
Searched directly from “Hypertensive Heart Disease” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 7-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."