Disease Overview
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| SALVIANOLIC ACID B | ? unclear | Mechanistic | DGIdb | |
| CANDOXATRIL | ? unclear | Mechanistic | DGIdb | |
| CILAZAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| TP0556351 | ↓ inhibits | Mechanistic | DGIdb | |
| PRAVASTATIN SODIUM | ? unclear | Mechanistic | DGIdb | |
| SILDENAFIL | ? unclear | Mechanistic | DGIdb | |
| GEMFIBROZIL | ? unclear | Mechanistic | DGIdb | |
| RESCINNAMINE | ? unclear | Mechanistic | DGIdb | |
| SPIRAPRIL | ? unclear | Mechanistic | DGIdb | |
| INDOMETHACIN | ? unclear | Mechanistic | DGIdb | |
| HYDROCHLOROTHIAZIDE | ? unclear | Mechanistic | DGIdb | |
| ARGIPRESSIN | ? unclear | Mechanistic | DGIdb | |
| METOPROLOL | ? unclear | Mechanistic | DGIdb | |
| DELAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| ACETYLCHOLINE | ? unclear | Mechanistic | DGIdb | |
| THERAPEUTIC GLUCOCORTICOID | ? unclear | Mechanistic | DGIdb | |
| IMIDAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| MALATHION | ↓ inhibits | Mechanistic | DGIdb | |
| MOEXIPRIL | ? unclear | Mechanistic | 56.0 nM (IC50) | DGIdb |
| VORINOSTAT | ? unclear | Mechanistic | DGIdb | |
| ILEPATRIL | ↓ inhibits | Mechanistic | DGIdb | |
| RXP470.1 | ↓ inhibits | Mechanistic | DGIdb | |
| CGS-27023A | ? unclear | Mechanistic | DGIdb | |
| NITROPRUSSIDE | ? unclear | Mechanistic | DGIdb | |
| ENALAPRILAT ANHYDROUS | ↓ inhibits | Mechanistic | 1.2 nM (IC50) | DGIdb |
| TORSEMIDE | ? unclear | Mechanistic | DGIdb | |
| ATORVASTATIN CALCIUM TRIHYDRATE | ? unclear | Mechanistic | DGIdb | |
| FOSINOPRIL | ? unclear | Mechanistic | DGIdb | |
| FUROSEMIDE | ? unclear | Mechanistic | DGIdb | |
| TEMOCAPRIL HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| BENAZEPRIL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CARBARIL | ↓ inhibits | Mechanistic | DGIdb | |
| BUPROPION HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| QUINAPRIL | ? unclear | Mechanistic | 8.3 nM (IC50) | DGIdb |
| COMPOUND 1 [PMID: 24900526] | ↓ inhibits | Mechanistic | DGIdb | |
| COMPOUND 20 [PMID: 22153340] | ↓ inhibits | Mechanistic | DGIdb | |
| BUMETANIDE | ? unclear | Mechanistic | DGIdb | |
| GALLOPAMIL | ? unclear | Mechanistic | DGIdb | |
| FLUOXETINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| AZD6605 | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 229 agents ranked by evidence tier.
ADRB1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| BRETYLIUM | ? unclear | Mechanistic | DGIdb | |
| PINDOLOL | ↑ activates | Mechanistic | DGIdb | |
| BISOPROLOL | ? unclear | Mechanistic | DGIdb | |
| FLECAINIDE ACETATE | ? unclear | Mechanistic | DGIdb | |
| METIPRANOLOL | ? unclear | Mechanistic | DGIdb | |
| METOPROLOL | ? unclear | Mechanistic | DGIdb | |
| ATENOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| BUCINDOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| METIPRANOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ALPRENOLOL | ? unclear | Mechanistic | 4.88 nM (IC50) | DGIdb |
| PRACTOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| XAMOTEROL | ↑ activates | Mechanistic | DGIdb | |
| PENBUTOLOL | ? unclear | Mechanistic | DGIdb | |
| DOBUTAMINE | ? unclear | Mechanistic | DGIdb | |
| BETHANIDINE | ? unclear | Mechanistic | DGIdb | |
| BETAXOLOL | ? unclear | Mechanistic | 37.1 nM (IC50) | DGIdb |
| MURAGLITAZAR | ? unclear | Mechanistic | DGIdb | |
| ACEBUTOLOL | ? unclear | Mechanistic | DGIdb | |
| LABETALOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ACEBUTOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| NOREPINEPHRINE | ? unclear | Mechanistic | DGIdb | |
| OT-730 | ? unclear | Mechanistic | DGIdb | |
| CARVEDILOL | ↓ inhibits | Mechanistic | DGIdb | |
| NADOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| LEVOBUNOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| LABETALOL | ? unclear | Mechanistic | DGIdb | |
| TERTATOLOL | ? unclear | Mechanistic | DGIdb | |
| ARBUTAMINE | ? unclear | Mechanistic | DGIdb | |
| PROPRANOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ZIPRASIDONE | ? unclear | Mechanistic | DGIdb | |
| BUPRANOLOL | ? unclear | Mechanistic | DGIdb | |
| LANDIOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| OXPRENOLOL | ? unclear | Mechanistic | DGIdb | |
| MEPINDOLOL | ? unclear | Mechanistic | DGIdb | |
| CELIPROLOL | ↓ inhibits | Mechanistic | DGIdb | |
| BISOPROLOL FUMARATE | ↓ inhibits | Mechanistic | DGIdb | |
| DESIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| DOPAMINE | ↑ activates | Mechanistic | DGIdb | |
| ISOPROTERENOL | ↑ activates | Mechanistic | DGIdb | |
| DOBUTAMINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb |
Showing top 40 of 288 agents ranked by evidence tier.
AGTR1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CANDESARTAN CILEXETIL | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL586135 | ? unclear | Mechanistic | DGIdb | |
| VALSARTAN | ↓ inhibits | Mechanistic | 4700.0 nM (Ki) | DGIdb |
| EPROSARTAN MESYLATE | ↓ inhibits | Mechanistic | DGIdb | |
| FIMASARTAN | ↓ inhibits | Mechanistic | DGIdb | |
| ASCORBIC ACID | ? unclear | Mechanistic | DGIdb | |
| OLMESARTAN MEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| AZILSARTAN MEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| THERAPEUTIC ANDROSTANOLONE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL347610 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL421088 | ? unclear | Mechanistic | DGIdb | |
| LOSARTAN POTASSIUM | ↓ inhibits | Mechanistic | 5.5 nM (IC50) | DGIdb |
| CHEMBL:CHEMBL1492017 | ? unclear | Mechanistic | DGIdb | |
| SPARSENTAN | ↓ inhibits | Mechanistic | DGIdb | |
| SODIUM CHLORIDE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL261693 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1972216 | ? unclear | Mechanistic | DGIdb | |
| EPROSARTAN | ? unclear | Mechanistic | 7.3 nM (IC50) | DGIdb |
| C-FOS ANTISENSE | ? unclear | Mechanistic | DGIdb | |
| SARALASIN ACETATE | ↓ inhibits | Mechanistic | DGIdb | |
| IRBESARTAN | ↓ inhibits | Mechanistic | 1.1 nM (Ki) | DGIdb |
| DISULFIRAM | ? unclear | Mechanistic | DGIdb | |
| SAPRISARTAN | ? unclear | Mechanistic | DGIdb | |
| H2O2 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL591834 | ? unclear | Mechanistic | DGIdb | |
| CAPTOPRIL | ? unclear | Mechanistic | DGIdb | |
| ANGIOTENSIN II | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL400912 | ? unclear | Mechanistic | DGIdb | |
| ATORVASTATIN CALCIUM TRIHYDRATE | ? unclear | Mechanistic | DGIdb | |
| IDOXIFENE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL528694 | ? unclear | Mechanistic | DGIdb | |
| IL-6 | ? unclear | Mechanistic | DGIdb | |
| ANGIOTENSIN II ACETATE | ↑ activates | Mechanistic | DGIdb | |
| LEVODOPA | ? unclear | Mechanistic | DGIdb | |
| GAMMA-INTERFERON | ? unclear | Mechanistic | DGIdb | |
| AZILSARTAN KAMEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| HYDROCHLOROTHIAZIDE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1445650 | ? unclear | Mechanistic | DGIdb | |
| MUSCLE RELAXANT | ? unclear | Mechanistic | DGIdb | |
| CL-329167 | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 249 agents ranked by evidence tier.
MYH7
NPPB
Pipeline results not yet available for this target. Run the pipeline to populate.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| MURAGLITAZAR | ? unclear | Mechanistic | DGIdb | |
| HYDROCHLOROTHIAZIDE | ? unclear | Mechanistic | DGIdb | |
| IMARIKIREN HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| 1.ALPHA.-HYDROXYVITAMIN D5 | ? unclear | Mechanistic | DGIdb | |
| ALISKIREN FUMARATE | ↓ inhibits | Mechanistic | DGIdb | |
| TERLAKIREN | ? unclear | Mechanistic | DGIdb | |
| SITOKIREN | ↓ inhibits | Mechanistic | DGIdb | |
| REMIKIREN | ? unclear | Mechanistic | DGIdb | |
| ALISKIREN | ? unclear | Mechanistic | DGIdb | |
| VTP-27999 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL47918 | ↓ inhibits | Mechanistic | 30.0 nM (IC50) | ChEMBL |
| CHEMBL50217 | ↓ inhibits | Mechanistic | 2.2 nM (IC50) | ChEMBL |
| CHEMBL301347 | ↓ inhibits | Mechanistic | 2.5 nM (IC50) | ChEMBL |
| CHEMBL48624 | ↓ inhibits | Mechanistic | 2.4 nM (IC50) | ChEMBL |
| CHEMBL101874 | ↓ inhibits | Mechanistic | 1400.0 nM (IC50) | ChEMBL |
| CHEMBL300504 | ↓ inhibits | Mechanistic | 67.0 nM (IC50) | ChEMBL |
| CHEMBL49225 | ↓ inhibits | Mechanistic | 2.1 nM (IC50) | ChEMBL |
| CHEMBL49218 | ↓ inhibits | Mechanistic | 1.3 nM (IC50) | ChEMBL |
| CHEMBL297129 | ↓ inhibits | Mechanistic | 1.5 nM (IC50) | ChEMBL |
| CHEMBL49286 | ↓ inhibits | Mechanistic | 1.0 nM (IC50) | ChEMBL |
| CHEMBL318242 | ↓ inhibits | Mechanistic | 1200.0 nM (IC50) | ChEMBL |
| CHEMBL297701 | ↓ inhibits | Mechanistic | 2.7 nM (IC50) | ChEMBL |
| CHEMBL49379 | ↓ inhibits | Mechanistic | 1.3 nM (IC50) | ChEMBL |
| CHEMBL295048 | ↓ inhibits | Mechanistic | 2.5 nM (IC50) | ChEMBL |
| CHEMBL46240 | ↓ inhibits | Mechanistic | 110.0 nM (IC50) | ChEMBL |
| CHEMBL301395 | ↓ inhibits | Mechanistic | 1.7 nM (IC50) | ChEMBL |
| CHEMBL295838 | ↓ inhibits | Mechanistic | 1.3 nM (IC50) | ChEMBL |
| CHEMBL300711 | ↓ inhibits | Mechanistic | 1.5 nM (IC50) | ChEMBL |
| CHEMBL301966 | ↓ inhibits | Mechanistic | 2.4 nM (IC50) | ChEMBL |
| CHEMBL48591 | ↓ inhibits | Mechanistic | 1.5 nM (IC50) | ChEMBL |
| CHEMBL97865 | ↓ inhibits | Mechanistic | 69000.0 nM (IC50) | ChEMBL |
| CHEMBL46115 | ↓ inhibits | Mechanistic | 0.9 nM (IC50) | ChEMBL |
| CHEMBL265560 | ↓ inhibits | Mechanistic | 2.7 nM (IC50) | ChEMBL |
| CHEMBL51935 | ↓ inhibits | Mechanistic | 17.0 nM (IC50) | ChEMBL |
| CHEMBL48481 | ↓ inhibits | Mechanistic | 6.0 nM (IC50) | ChEMBL |
| CHEMBL98582 | ↓ inhibits | Mechanistic | 4600.0 nM (IC50) | ChEMBL |
| CHEMBL301146 | ↓ inhibits | Mechanistic | 5.0 nM (IC50) | ChEMBL |
| CHEMBL321937 | ↓ inhibits | Mechanistic | 280.0 nM (IC50) | ChEMBL |
| CHEMBL49172 | ↓ inhibits | Mechanistic | 2.0 nM (IC50) | ChEMBL |
| CHEMBL51401 | ↓ inhibits | Mechanistic | 1.0 nM (IC50) | ChEMBL |
Showing top 40 of 146 agents ranked by evidence tier.
TGFB1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| INTERFERON ALFA-2B | ? unclear | Mechanistic | DGIdb | |
| PIOGLITAZONE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| SILYMARIN | ? unclear | Mechanistic | DGIdb | |
| RITUXIMAB | ? unclear | Mechanistic | DGIdb | |
| VERAPAMIL | ? unclear | Mechanistic | DGIdb | |
| PROTEASOME INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| FRESOLIMUMAB | ? unclear | Mechanistic | DGIdb | |
| ATENOLOL | ? unclear | Mechanistic | DGIdb | |
| BINTRAFUSP ALFA | ~ modulates | Mechanistic | DGIdb | |
| NISEVOKITUG | ? unclear | Mechanistic | DGIdb | |
| LUSPATERCEPT | ↓ inhibits | Mechanistic | DGIdb | |
| TRETINOIN | ? unclear | Mechanistic | DGIdb | |
| HYDROCORTISONE BUTYRATE | ? unclear | Mechanistic | DGIdb | |
| VITAMIN E | ? unclear | Mechanistic | DGIdb | |
| IRINOTECAN HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| INOSITOL | ? unclear | Mechanistic | DGIdb | |
| NICOTINE POLACRILEX | ? unclear | Mechanistic | DGIdb | |
| FENRETINIDE | ? unclear | Mechanistic | DGIdb | |
| MELATONIN | ? unclear | Mechanistic | DGIdb | |
| ISOTRETINOIN | ? unclear | Mechanistic | DGIdb | |
| VACTOSERTIB | ? unclear | Mechanistic | 12.9 nM (IC50) | DGIdb |
| TRIAMCINOLONE | ? unclear | Mechanistic | DGIdb | |
| TAMOXIFEN | ? unclear | Mechanistic | DGIdb | |
| ADRIAMYCIN | ? unclear | Mechanistic | DGIdb | |
| HEPARAN SULFATE | ? unclear | Mechanistic | DGIdb | |
| GOSSYPOL | ? unclear | Mechanistic | DGIdb | |
| TCDD | ? unclear | Mechanistic | DGIdb | |
| AMIFOSTINE ANHYDROUS | ? unclear | Mechanistic | DGIdb | |
| RAMIPRIL | ? unclear | Mechanistic | DGIdb | |
| ANTIOXIDANT | ? unclear | Mechanistic | DGIdb | |
| SOTATERCEPT | ? unclear | Mechanistic | DGIdb | |
| ASPIRIN | ? unclear | Mechanistic | DGIdb | |
| GALUNISERTIB | ? unclear | Mechanistic | DGIdb | |
| KEYHOLE LIMPET HEMOCYANIN | ? unclear | Mechanistic | DGIdb | |
| PIRFENIDONE | ? unclear | Mechanistic | DGIdb | |
| H2O2 | ? unclear | Mechanistic | DGIdb | |
| THERAPEUTIC ANDROGEN | ? unclear | Mechanistic | DGIdb | |
| SANDOSTATIN | ? unclear | Mechanistic | DGIdb | |
| BROXURIDINE | ? unclear | Mechanistic | DGIdb | |
| DISITERTIDE | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 62 agents ranked by evidence tier.
Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-03.
The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.
aim of this study was to evaluate the relationship between multiple conventional and novel anthropometric measurements and hypertension in patients presenting to the ED with ACS and whether anthropometric indices differ according to admission BP status and evaluated the relationship between regional...
The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.
The aim of this study is to investigate the beneficial impacts of the 6-week standardized CR program applied to hypertensive RA patients whose disease activity is under control with regular pharmacological treatment. Subjects will be randomly assigned to one of two groups: 1.) standard of care (SOC...
This is a single site, single-blinded parallel randomized control trial that investigates a multi-level intervention to improve postpartum blood pressure in women with hypertensive disorder pregnancy. The investigators will recruit women diagnosed with a hypertensive disorder of pregnancy, identifie...
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in Type 2 diabetes mellitus (T2DM) in moderately obese patients. T2DM is ...
The purpose of this research is to study digital health interventions to prevent cardiovascular disease in individuals who have had a hypertensive disorder of pregnancy (HDP).
Hypertension is a major global health problem, affecting about 30% of people and up to two-thirds of those over 60 years. Its prevalence has increased significantly, with over one billion adults affected worldwide and expected to reach 1.56 billion by 2025, especially in developing countries where e...
The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical exercise. The main objective is to analyze cardiovascular responses to ...
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict the likelihood of 30-day readmission throughout a patient's admission. T...
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict patient deterioration throughout a patient's admission. This algorithm w...
The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be delivered in the home with equal quality and safety, reduced cost, and improv...
The study aim is to compare the effects produced by two different exercise training modalities on short-term blood pressure variability and atrial function evaluated by speckle-tracking echocardiography in hypertensive patients with ischemic heart disease. 50 males patients will be randomized to int...
Objective: to evaluate the effectiveness of using a food product, dry finely dispersed beetroot powder in a dose of 20 g, containing 800 mg of nitrate (NO3-), in relation to the regulation of blood pressure in men with hypertension who reached the target blood pressure level while taking optimal ant...
Searched directly from “Hypertensive Heart Disease” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 7-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."