Biomarker & Intervention Discovery
HIV/AIDS
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
NIH funding$3.29BFY2025 · RCDC estimate
Funding levelWell-Funded
Spontaneous remissionSpontaneous elite control (natural viremic suppression without ART) in <1% of people living with HIV; untreated…
Best-intervention remissionModern ART (integrase inhibitor-based): viral suppression to undetectable in >95% within 6 months, maintained…
Gap sizeVery large (sterilising cure); near-zero biological gap for quality-of-life control on ART; large access gap globally
Primary barrierbiological (sterilising cure) + access (ART, particularly in LMIC)
Full remission profile →
Remission & chronicity
Spontaneous remission
Spontaneous elite control (natural viremic suppression without ART) in <1% of people living with HIV; untreated, median time to AIDS ~10 years; viral rebound within weeks of ART interruption in 99%+ of patients
Best-intervention remission
Modern ART (integrase inhibitor-based): viral suppression to undetectable in >95% within 6 months, maintained indefinitely on treatment; life expectancy near-normalised with early treatment; 7 documented sterilising cures worldwide (all via CCR5-Δ32 stem cell transplantation); post-treatment controllers (VISCONTI cohort): ~5-15% of early-treated individuals achieve durable ART-free viremic suppression
Gap size
Very large (sterilising cure); near-zero biological gap for quality-of-life control on ART; large access gap globally
Primary barrier
biological (sterilising cure) + access (ART, particularly in LMIC)
ART is the most successful chronic disease management story in medicine but is definitionally not a cure; 39 million people living with HIV globally, only 77% on ART, only 72% virally suppressed (2023 UNAIDS); broadly neutralising antibodies (bNAbs) showing promising functional remission signals (ACTG A5386, 2025)
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “HIV/AIDS” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."