Remission & chronicity

Spontaneous remission

Not well-characterized as population baseline; routinely framed as irreversible in clinical culture despite contrary trial evidence

Best-intervention remission

Up to 93% had medications discontinued or reduced with intensive residential lifestyle intervention; DASH + weight loss reduced guideline-based medication indication from 51% to 18%; Lancet eClinicalMedicine 2024 meta-analysis confirms lifestyle superiority in motivated patients

Gap size

Large — primarily a framing and practice gap

Primary barrier

framing/practice

The 'requires lifelong medication' framing is contradicted by multiple trials when intensive lifestyle intervention is actually delivered; the gap is delivery infrastructure, not biology

Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.

ACE 63 ADRB1 101 ADRB2 335 AGT 22 AGTR1 64 AGTR2 202 CACNA1C 216 EDN1 18 NOS3 0 NPR1 104 NR3C2 213 REN 10 SLC12A3 18

ACE

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
SALVIANOLIC ACID B	? unclear	Mechanistic	DGIdb
CANDOXATRIL	? unclear	Mechanistic	DGIdb
CILAZAPRIL	↓ inhibits	Mechanistic	DGIdb
TP0556351	↓ inhibits	Mechanistic	DGIdb
PRAVASTATIN SODIUM	? unclear	Mechanistic	DGIdb
SILDENAFIL	? unclear	Mechanistic	DGIdb
GEMFIBROZIL	? unclear	Mechanistic	DGIdb
RESCINNAMINE	? unclear	Mechanistic	DGIdb
SPIRAPRIL	? unclear	Mechanistic	DGIdb
INDOMETHACIN	? unclear	Mechanistic	DGIdb
HYDROCHLOROTHIAZIDE	? unclear	Mechanistic	DGIdb
ARGIPRESSIN	? unclear	Mechanistic	DGIdb
METOPROLOL	? unclear	Mechanistic	DGIdb
DELAPRIL	↓ inhibits	Mechanistic	DGIdb
ACETYLCHOLINE	? unclear	Mechanistic	DGIdb
THERAPEUTIC GLUCOCORTICOID	? unclear	Mechanistic	DGIdb
IMIDAPRIL	↓ inhibits	Mechanistic	DGIdb
MALATHION	↓ inhibits	Mechanistic	DGIdb
MOEXIPRIL	? unclear	Mechanistic	DGIdb
VORINOSTAT	? unclear	Mechanistic	DGIdb
ILEPATRIL	↓ inhibits	Mechanistic	DGIdb
RXP470.1	↓ inhibits	Mechanistic	DGIdb
CGS-27023A	? unclear	Mechanistic	DGIdb
NITROPRUSSIDE	? unclear	Mechanistic	DGIdb
ENALAPRILAT ANHYDROUS	↓ inhibits	Mechanistic	DGIdb
TORSEMIDE	? unclear	Mechanistic	DGIdb
ATORVASTATIN CALCIUM TRIHYDRATE	? unclear	Mechanistic	DGIdb
FOSINOPRIL	? unclear	Mechanistic	DGIdb
FUROSEMIDE	? unclear	Mechanistic	DGIdb
TEMOCAPRIL HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
BENAZEPRIL HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
CARBARIL	↓ inhibits	Mechanistic	DGIdb
BUPROPION HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
QUINAPRIL	? unclear	Mechanistic	DGIdb
COMPOUND 1 [PMID: 24900526]	↓ inhibits	Mechanistic	DGIdb
COMPOUND 20 [PMID: 22153340]	↓ inhibits	Mechanistic	DGIdb
BUMETANIDE	? unclear	Mechanistic	DGIdb
GALLOPAMIL	? unclear	Mechanistic	DGIdb
FLUOXETINE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
AZD6605	↓ inhibits	Mechanistic	DGIdb

Showing top 40 of 63 agents ranked by evidence tier.

ADRB1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
BRETYLIUM	? unclear	Mechanistic	DGIdb
PINDOLOL	↑ activates	Mechanistic	DGIdb
BISOPROLOL	? unclear	Mechanistic	DGIdb
FLECAINIDE ACETATE	? unclear	Mechanistic	DGIdb
METIPRANOLOL	? unclear	Mechanistic	DGIdb
METOPROLOL	? unclear	Mechanistic	DGIdb
ATENOLOL	↓ inhibits	Mechanistic	DGIdb
BUCINDOLOL HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
METIPRANOLOL HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
ALPRENOLOL	? unclear	Mechanistic	DGIdb
PRACTOLOL	↓ inhibits	Mechanistic	DGIdb
XAMOTEROL	↑ activates	Mechanistic	DGIdb
PENBUTOLOL	? unclear	Mechanistic	DGIdb
DOBUTAMINE	? unclear	Mechanistic	DGIdb
BETHANIDINE	? unclear	Mechanistic	DGIdb
BETAXOLOL	? unclear	Mechanistic	DGIdb
MURAGLITAZAR	? unclear	Mechanistic	DGIdb
ACEBUTOLOL	? unclear	Mechanistic	DGIdb
LABETALOL HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
ACEBUTOLOL HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
NOREPINEPHRINE	? unclear	Mechanistic	DGIdb
OT-730	? unclear	Mechanistic	DGIdb
CARVEDILOL	↓ inhibits	Mechanistic	DGIdb
NADOLOL	↓ inhibits	Mechanistic	DGIdb
LEVOBUNOLOL	↓ inhibits	Mechanistic	DGIdb
LABETALOL	? unclear	Mechanistic	DGIdb
TERTATOLOL	? unclear	Mechanistic	DGIdb
ARBUTAMINE	? unclear	Mechanistic	DGIdb
PROPRANOLOL HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
ZIPRASIDONE	? unclear	Mechanistic	DGIdb
BUPRANOLOL	? unclear	Mechanistic	DGIdb
LANDIOLOL	↓ inhibits	Mechanistic	DGIdb
OXPRENOLOL	? unclear	Mechanistic	DGIdb
MEPINDOLOL	? unclear	Mechanistic	DGIdb
CELIPROLOL	↓ inhibits	Mechanistic	DGIdb
BISOPROLOL FUMARATE	↓ inhibits	Mechanistic	DGIdb
DESIPRAMINE	? unclear	Mechanistic	DGIdb
DOPAMINE	↑ activates	Mechanistic	DGIdb
ISOPROTERENOL	↑ activates	Mechanistic	DGIdb
DOBUTAMINE HYDROCHLORIDE	↑ activates	Mechanistic	DGIdb

Showing top 40 of 101 agents ranked by evidence tier.

ADRB2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
CARVEDILOL	↓ inhibits	Mechanistic	DGIdb
CHEMBL:CHEMBL1257092	? unclear	Mechanistic	DGIdb
SODIUM CHLORIDE	? unclear	Mechanistic	DGIdb
PENBUTOLOL SULFATE	↓ inhibits	Mechanistic	DGIdb
DESIPRAMINE	? unclear	Mechanistic	DGIdb
METIPRANOLOL	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL531322	? unclear	Mechanistic	DGIdb
NADOLOL	↓ inhibits	Mechanistic	DGIdb
PIRBUTEROL	? unclear	Mechanistic	DGIdb
FENOTEROL	↑ activates	Mechanistic	DGIdb
TIMOLOL	↓ inhibits	Mechanistic	DGIdb
ABEDITEROL	↑ activates	Mechanistic	DGIdb
PINDOLOL	↑ activates	Mechanistic	DGIdb
BRONCHODILATOR	? unclear	Mechanistic	DGIdb
TULOBUTEROL	↑ activates	Mechanistic	DGIdb
PHENYLEPHRINE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
GSK159802	↑ activates	Mechanistic	DGIdb
PRILOCAINE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
CLENBUTEROL	↑ activates	Mechanistic	DGIdb
PROPRANOLOL HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
INDACATEROL MALEATE	↑ activates	Mechanistic	DGIdb
VILANTEROL	? unclear	Mechanistic	DGIdb
TERTATOLOL	? unclear	Mechanistic	DGIdb
ARFORMOTEROL	↑ activates	Mechanistic	DGIdb
INDACATEROL	? unclear	Mechanistic	DGIdb
FORMOTEROL FUMARATE	↑ activates	Mechanistic	DGIdb
CHEMBL:CHEMBL111201	? unclear	Mechanistic	DGIdb
RITODRINE	? unclear	Mechanistic	DGIdb
RISPERIDONE	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL599896	? unclear	Mechanistic	DGIdb
VILANTEROL TRIFENATATE	↑ activates	Mechanistic	DGIdb
RITODRINE HYDROCHLORIDE	↑ activates	Mechanistic	DGIdb
DISULFIRAM	? unclear	Mechanistic	DGIdb
BUCINDOLOL HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
LEVALBUTEROL TARTRATE	↑ activates	Mechanistic	DGIdb
LAS190792	↑ activates	Mechanistic	DGIdb
ALPRENOLOL	? unclear	Mechanistic	DGIdb
CELIPROLOL	↑ activates	Mechanistic	DGIdb
ALBUTEROL SULFATE	↑ activates	Mechanistic	DGIdb
CARTEOLOL	? unclear	Mechanistic	DGIdb

Showing top 40 of 335 agents ranked by evidence tier.

AGT

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
ENALAPRIL MALEATE	? unclear	Mechanistic		DGIdb
ANGIOGENESIS INHIBITOR	? unclear	Mechanistic		DGIdb
IMIDAPRIL	? unclear	Mechanistic		DGIdb
ADENOVIRUS VECTOR	? unclear	Mechanistic		DGIdb
BENAZEPRIL	? unclear	Mechanistic		DGIdb
CHLORTHALIDONE	? unclear	Mechanistic		DGIdb
CYCLOSPORINE	? unclear	Mechanistic		DGIdb
HYDROCORTISONE BUTYRATE	? unclear	Mechanistic		DGIdb
MESTRANOL	? unclear	Mechanistic		DGIdb
CYT006-ANGQB	? unclear	Mechanistic		DGIdb
QUINAPRIL	? unclear	Mechanistic		DGIdb
HYDROCHLOROTHIAZIDE	? unclear	Mechanistic		DGIdb
GSK-2586881	? unclear	Mechanistic		DGIdb
LISINOPRIL ANHYDROUS	? unclear	Mechanistic		DGIdb
ADRIAMYCIN	? unclear	Mechanistic		DGIdb
AMLODIPINE BESYLATE	? unclear	Mechanistic		DGIdb
CILAZAPRIL	? unclear	Mechanistic		DGIdb
ASPIRIN	? unclear	Mechanistic		DGIdb
CHEMBL297425	↓ inhibits	Mechanistic	3.5 nM (IC50)	ChEMBL
CHEMBL295174	↓ inhibits	Mechanistic	27.0 nM (IC50)	ChEMBL
CHEMBL5275762	↓ inhibits	Mechanistic	22.0 nM (IC50)	ChEMBL
CHEMBL5281619	↓ inhibits	Mechanistic	22.0 nM (IC50)	ChEMBL

AGTR1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
CANDESARTAN CILEXETIL	↓ inhibits	Mechanistic	DGIdb
CHEMBL:CHEMBL586135	? unclear	Mechanistic	DGIdb
VALSARTAN	↓ inhibits	Mechanistic	DGIdb
EPROSARTAN MESYLATE	↓ inhibits	Mechanistic	DGIdb
FIMASARTAN	↓ inhibits	Mechanistic	DGIdb
ASCORBIC ACID	? unclear	Mechanistic	DGIdb
OLMESARTAN MEDOXOMIL	↓ inhibits	Mechanistic	DGIdb
AZILSARTAN MEDOXOMIL	↓ inhibits	Mechanistic	DGIdb
THERAPEUTIC ANDROSTANOLONE	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL347610	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL421088	? unclear	Mechanistic	DGIdb
LOSARTAN POTASSIUM	↓ inhibits	Mechanistic	DGIdb
CHEMBL:CHEMBL1492017	? unclear	Mechanistic	DGIdb
SPARSENTAN	↓ inhibits	Mechanistic	DGIdb
SODIUM CHLORIDE	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL261693	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL1972216	? unclear	Mechanistic	DGIdb
EPROSARTAN	? unclear	Mechanistic	DGIdb
C-FOS ANTISENSE	? unclear	Mechanistic	DGIdb
SARALASIN ACETATE	↓ inhibits	Mechanistic	DGIdb
IRBESARTAN	↓ inhibits	Mechanistic	DGIdb
DISULFIRAM	? unclear	Mechanistic	DGIdb
SAPRISARTAN	? unclear	Mechanistic	DGIdb
H2O2	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL591834	? unclear	Mechanistic	DGIdb
CAPTOPRIL	? unclear	Mechanistic	DGIdb
ANGIOTENSIN II	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL400912	? unclear	Mechanistic	DGIdb
ATORVASTATIN CALCIUM TRIHYDRATE	? unclear	Mechanistic	DGIdb
IDOXIFENE	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL528694	? unclear	Mechanistic	DGIdb
IL-6	? unclear	Mechanistic	DGIdb
ANGIOTENSIN II ACETATE	↑ activates	Mechanistic	DGIdb
LEVODOPA	? unclear	Mechanistic	DGIdb
GAMMA-INTERFERON	? unclear	Mechanistic	DGIdb
AZILSARTAN KAMEDOXOMIL	↓ inhibits	Mechanistic	DGIdb
HYDROCHLOROTHIAZIDE	? unclear	Mechanistic	DGIdb
CHEMBL:CHEMBL1445650	? unclear	Mechanistic	DGIdb
MUSCLE RELAXANT	? unclear	Mechanistic	DGIdb
CL-329167	? unclear	Mechanistic	DGIdb

Showing top 40 of 64 agents ranked by evidence tier.

AGTR2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
RECOMBINANT FIBROBLAST GROWTH FACTOR 2	? unclear	Mechanistic		DGIdb
RECOMBINANT TRANSFORMING GROWTH FACTOR-BETA 1	? unclear	Mechanistic		DGIdb
AZD-4017	? unclear	Mechanistic		DGIdb
ANGIOTENSIN II	? unclear	Mechanistic	2.5 nM (IC50)	DGIdb
OLODANRIGAN	? unclear	Mechanistic	0.58 nM (IC50)	DGIdb
PD123319	? unclear	Mechanistic		DGIdb
ROSIGLITAZONE	? unclear	Mechanistic		DGIdb
SPARSENTAN	? unclear	Mechanistic		DGIdb
PUROMYCIN	? unclear	Mechanistic		DGIdb
SARALASIN	? unclear	Mechanistic	1.32 nM (IC50)	DGIdb
CHEMBL443325	↓ inhibits	Mechanistic	23.0 nM (IC50)	ChEMBL
CHEMBL417584	↓ inhibits	Mechanistic	27.0 nM (IC50)	ChEMBL
CHEMBL414533	↓ inhibits	Mechanistic	0.82 nM (IC50)	ChEMBL
CHEMBL3144487	↓ inhibits	Mechanistic	116.0 nM (IC50)	ChEMBL
ANGIOTENSIN III	↓ inhibits	Mechanistic	1.74 nM (IC50)	ChEMBL
CHEMBL411657	↓ inhibits	Mechanistic	25.0 nM (IC50)	ChEMBL
CHEMBL408885	↓ inhibits	Mechanistic	28.0 nM (IC50)	ChEMBL
CHEMBL385283	↓ inhibits	Mechanistic	0.65 nM (IC50)	ChEMBL
CHEMBL384352	↓ inhibits	Mechanistic	0.47 nM (IC50)	ChEMBL
CHEMBL408773	↓ inhibits	Mechanistic	6.1 nM (IC50)	ChEMBL
CHEMBL413925	↓ inhibits	Mechanistic	12.0 nM (IC50)	ChEMBL
CHEMBL408886	↓ inhibits	Mechanistic	4.8 nM (IC50)	ChEMBL
CHEMBL264450	↓ inhibits	Mechanistic	80.0 nM (IC50)	ChEMBL
CHEMBL384125	↓ inhibits	Mechanistic	7.4 nM (IC50)	ChEMBL
CHEMBL406290	↓ inhibits	Mechanistic	9.1 nM (IC50)	ChEMBL
CHEMBL440063	↓ inhibits	Mechanistic	65.0 nM (IC50)	ChEMBL
CHEMBL413034	↓ inhibits	Mechanistic	86.0 nM (IC50)	ChEMBL
CHEMBL74556	↓ inhibits	Mechanistic	8.0 nM (IC50)	ChEMBL
CHEMBL265790	↓ inhibits	Mechanistic	7.0 nM (IC50)	ChEMBL
CHEMBL311484	↓ inhibits	Mechanistic	65.0 nM (IC50)	ChEMBL
CHEMBL73876	↓ inhibits	Mechanistic	6.2 nM (IC50)	ChEMBL
CHEMBL302102	↓ inhibits	Mechanistic	7.0 nM (IC50)	ChEMBL
CHEMBL305647	↓ inhibits	Mechanistic	4.4 nM (IC50)	ChEMBL
CHEMBL424004	↓ inhibits	Mechanistic	5.1 nM (IC50)	ChEMBL
CHEMBL74442	↓ inhibits	Mechanistic	9.2 nM (IC50)	ChEMBL
CHEMBL17487	↓ inhibits	Mechanistic	65.0 nM (IC50)	ChEMBL
CHEMBL305956	↓ inhibits	Mechanistic	12.0 nM (IC50)	ChEMBL
CHEMBL338514	↓ inhibits	Mechanistic	5870.0 nM (IC50)	ChEMBL
CHEMBL306361	↓ inhibits	Mechanistic	9.8 nM (IC50)	ChEMBL
CHEMBL125542	↓ inhibits	Mechanistic	789.0 nM (IC50)	ChEMBL

Showing top 40 of 202 agents ranked by evidence tier.

CACNA1C

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
IMAGABALIN	~ modulates	Mechanistic		DGIdb
PHLOROGLUCINOL	↓ inhibits	Mechanistic		DGIdb
AMLODIPINE BESYLATE	↓ inhibits	Mechanistic		DGIdb
LERCANIDIPINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
AMLODIPINE BENZOATE	↓ inhibits	Mechanistic		DGIdb
DEHYDRATED ALCOHOL	? unclear	Mechanistic		DGIdb
AZD1305	↓ inhibits	Mechanistic		DGIdb
RAUWOLFIA SERPENTINA (USP)	? unclear	Mechanistic		DGIdb
PREGABALIN	~ modulates	Mechanistic		DGIdb
CLEVIDIPINE	↓ inhibits	Mechanistic		DGIdb
ELPETRIGINE	↓ inhibits	Mechanistic		DGIdb
TERODILINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
NIMODIPINE	↓ inhibits	Mechanistic	110.0 nM (IC50)	DGIdb
NITRENDIPINE	↓ inhibits	Mechanistic	0.25 nM (Ki)	DGIdb
FELODIPINE	↓ inhibits	Mechanistic		DGIdb
AMLODIPINE MALEATE	↓ inhibits	Mechanistic		DGIdb
IBUTILIDE	? unclear	Mechanistic		DGIdb
ATENOLOL	? unclear	Mechanistic		DGIdb
NICARDIPINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
BENIDIPINE	↓ inhibits	Mechanistic	13800.0 nM (IC50)	DGIdb
ISRADIPINE	↓ inhibits	Mechanistic	2.2 nM (IC50)	DGIdb
ARVERAPAMIL	? unclear	Mechanistic		DGIdb
HALOPERIDOL DECANOATE	? unclear	Mechanistic		DGIdb
DRONEDARONE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
DILTIAZEM HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
CITALOPRAM	? unclear	Mechanistic		DGIdb
CELECOXIB	? unclear	Mechanistic		DGIdb
BEPRIDIL HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
LEVAMLODIPINE MALEATE	↓ inhibits	Mechanistic		DGIdb
CALCIUM CHANNEL BLOCKER	? unclear	Mechanistic		DGIdb
NIFEDIPINE	↓ inhibits	Mechanistic	1.0 nM (Ki)	DGIdb
AZELNIDIPINE	↓ inhibits	Mechanistic		DGIdb
MANIDIPINE	↓ inhibits	Mechanistic		DGIdb
LACIDIPINE	↓ inhibits	Mechanistic		DGIdb
SULOCTIDIL	↓ inhibits	Mechanistic		DGIdb
MEPIRODIPINE	↓ inhibits	Mechanistic		DGIdb
NISOLDIPINE	↓ inhibits	Mechanistic	3.0 nM (IC50)	DGIdb
NICARDIPINE	? unclear	Mechanistic	250.0 nM (IC50)	DGIdb
VERAPAMIL	↓ inhibits	Mechanistic	150.0 nM (IC50)	DGIdb
VALPROIC ACID	? unclear	Mechanistic		DGIdb

Showing top 40 of 216 agents ranked by evidence tier.

EDN1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
OXYGEN THERAPY	? unclear	Mechanistic	DGIdb
CELECOXIB	? unclear	Mechanistic	DGIdb
TAMOXIFEN	? unclear	Mechanistic	DGIdb
DOXORUBICIN HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
THIOURACIL	? unclear	Mechanistic	DGIdb
ALPROSTADIL	? unclear	Mechanistic	DGIdb
ANTIPLATELET AGENT	? unclear	Mechanistic	DGIdb
ANTICONVULSANT AGENT	? unclear	Mechanistic	DGIdb
BUDESONIDE	? unclear	Mechanistic	DGIdb
LANREOTIDE ACETATE	? unclear	Mechanistic	DGIdb
CANDESARTAN CILEXETIL	? unclear	Mechanistic	DGIdb
ANESTHETIC AGENT	? unclear	Mechanistic	DGIdb
BEVACIZUMAB	? unclear	Mechanistic	DGIdb
PROTEIN SYNTHESIS INHIBITOR	? unclear	Mechanistic	DGIdb
DEFEROXAMINE	? unclear	Mechanistic	DGIdb
NORETHINDRONE ACETATE	? unclear	Mechanistic	DGIdb
INSULIN, REGULAR, HUMAN	? unclear	Mechanistic	DGIdb
MURAGLITAZAR	? unclear	Mechanistic	DGIdb

NOS3

UniProt Ensembl DGIdb Open Targets

Pipeline results not yet available for this target. Run the pipeline to populate.

NPR1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
CARPERITIDE	↑ activates	Mechanistic	0.1 nM (EC50)	DGIdb
NITROPRUSSIDE	? unclear	Mechanistic		DGIdb
NESIRITIDE	↑ activates	Mechanistic		DGIdb
ERYTHRITYL TETRANITRATE	? unclear	Mechanistic		DGIdb
ATRIAL NATRIURETIC PEPTIDE	? unclear	Mechanistic		DGIdb
PL-3994	↑ activates	Mechanistic		DGIdb
NITRIC OXIDE	? unclear	Mechanistic		DGIdb
CENDERITIDE	? unclear	Mechanistic		DGIdb
ISOSORBIDE DINITRATE	? unclear	Mechanistic		DGIdb
ATACIGUAT	? unclear	Mechanistic		DGIdb
NITROGLYCERIN	? unclear	Mechanistic		DGIdb
ULARITIDE	? unclear	Mechanistic		DGIdb
ISOSORBIDE MONONITRATE	? unclear	Mechanistic		DGIdb
CHEMBL402664	↑ activates	Mechanistic	215.24 nM (EC50)	ChEMBL
CHEMBL405572	↑ activates	Mechanistic	4.94 nM (EC50)	ChEMBL
MiniANP	↑ activates	Mechanistic	0.68 nM (EC50)	ChEMBL
CHEMBL384862	↑ activates	Mechanistic	8.28 nM (EC50)	ChEMBL
CHEMBL409400	↑ activates	Mechanistic	46.74 nM (EC50)	ChEMBL
CHEMBL439465	↑ activates	Mechanistic	30.11 nM (EC50)	ChEMBL
CHEMBL414517	↑ activates	Mechanistic	65.85 nM (EC50)	ChEMBL
CHEMBL385216	↑ activates	Mechanistic	176.99 nM (EC50)	ChEMBL
CHEMBL413653	↑ activates	Mechanistic	107.95 nM (EC50)	ChEMBL
CHEMBL408343	↑ activates	Mechanistic	198.41 nM (EC50)	ChEMBL
CHEMBL294263	↓ inhibits	Mechanistic	0.3 nM (Ki)	ChEMBL
CHEMBL405854	↓ inhibits	Mechanistic	0.65 nM (Ki)	ChEMBL
CHEMBL415133	↓ inhibits	Mechanistic	87.0 nM (Ki)	ChEMBL
CHEMBL412793	↓ inhibits	Mechanistic	360.0 nM (Ki)	ChEMBL
CHEMBL294262	↓ inhibits	Mechanistic	680.0 nM (Ki)	ChEMBL
CHEMBL434023	↓ inhibits	Mechanistic	2600.0 nM (Ki)	ChEMBL
CHEMBL61413	↓ inhibits	Mechanistic	2900.0 nM (Ki)	ChEMBL
CHEMBL59028	↓ inhibits	Mechanistic	62.0 nM (Ki)	ChEMBL
CHEMBL304191	↓ inhibits	Mechanistic	65.0 nM (Ki)	ChEMBL
CHEMBL264744	↓ inhibits	Mechanistic	0.49 nM (Ki)	ChEMBL
CHEMBL435181	↓ inhibits	Mechanistic	539.0 nM (Ki)	ChEMBL
CHEMBL61383	↓ inhibits	Mechanistic	0.4 nM (Ki)	ChEMBL
CHEMBL411542	↓ inhibits	Mechanistic	0.1 nM (Ki)	ChEMBL
CHEMBL507122	↓ inhibits	Mechanistic	36.0 nM (IC50)	ChEMBL
CHEMBL1643388	↓ inhibits	Mechanistic	6.0 nM (IC50)	ChEMBL
CHEMBL1643389	↓ inhibits	Mechanistic	60.0 nM (IC50)	ChEMBL
CHEMBL1643390	↓ inhibits	Mechanistic	240.0 nM (IC50)	ChEMBL

Showing top 40 of 104 agents ranked by evidence tier.

NR3C2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
SPIRONOLACTONE	↓ inhibits	Mechanistic	2.323 nM (Ki)	DGIdb
EPLERENONE	↓ inhibits	Mechanistic		DGIdb
CORTICOSTERONE	↑ activates	Mechanistic		DGIdb
DROSPIRENONE	↓ inhibits	Mechanistic		DGIdb
BENZODROCORTISONE	↑ activates	Mechanistic		DGIdb
NIMODIPINE	↓ inhibits	Mechanistic		DGIdb
FLUDROCORTISONE ACETATE	↑ activates	Mechanistic		DGIdb
VAMOROLONE	↓ inhibits	Mechanistic		DGIdb
BUDESONIDE	↑ activates	Mechanistic		DGIdb
DESOXYCORTICOSTERONE	↑ activates	Mechanistic		DGIdb
DESOXYCORTICOSTERONE ACETATE	↑ activates	Mechanistic		DGIdb
LY-2623091	? unclear	Mechanistic		DGIdb
ESAXERENONE	↓ inhibits	Mechanistic		DGIdb
APARARENONE	↓ inhibits	Mechanistic		DGIdb
AZD-9977	↓ inhibits	Mechanistic		DGIdb
FLUDROCORTISONE	↑ activates	Mechanistic		DGIdb
CANRENONE	↓ inhibits	Mechanistic		DGIdb
HYDROCORTISONE BUTYRATE	↑ activates	Mechanistic		DGIdb
CANRENOATE POTASSIUM	↓ inhibits	Mechanistic		DGIdb
FELODIPINE	↓ inhibits	Mechanistic		DGIdb
AZD9567	↑ activates	Mechanistic		DGIdb
BALCINRENONE	~ modulates	Mechanistic		DGIdb
DEXAMETHASONE	↑ activates	Mechanistic	33.0 nM (IC50)	DGIdb
RU28318	↓ inhibits	Mechanistic		DGIdb
XL550	↓ inhibits	Mechanistic		DGIdb
ONAPRISTONE	↓ inhibits	Mechanistic	470.0 nM (IC50)	DGIdb
FLUTICASONE	↑ activates	Mechanistic		DGIdb
ZK112993	↓ inhibits	Mechanistic		DGIdb
PROGESTERONE	↓ inhibits	Mechanistic	14.0 nM (IC50)	DGIdb
ALDOSTERONE	↑ activates	Mechanistic		DGIdb
PF-03882845	↓ inhibits	Mechanistic		DGIdb
DESOXYCORTICOSTERONE PIVALATE	↑ activates	Mechanistic		DGIdb
FINERENONE	↓ inhibits	Mechanistic		DGIdb
LY2623091	↓ inhibits	Mechanistic		DGIdb
PREDNISOLONE	↑ activates	Mechanistic	37.0 nM (Ki)	DGIdb
OCEDURENONE	↓ inhibits	Mechanistic		DGIdb
MT-3995	? unclear	Mechanistic		Open Targets
CHEMBL134277	↓ inhibits	Mechanistic	1900.0 nM (IC50)	ChEMBL
CHEMBL415524	↓ inhibits	Mechanistic	334.0 nM (IC50)	ChEMBL
MEDROXYPROGESTERONE ACETATE	↓ inhibits	Mechanistic	1197.0 nM (IC50)	ChEMBL

Showing top 40 of 213 agents ranked by evidence tier.

REN

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
MURAGLITAZAR	? unclear	Mechanistic	DGIdb
HYDROCHLOROTHIAZIDE	? unclear	Mechanistic	DGIdb
IMARIKIREN HYDROCHLORIDE	↓ inhibits	Mechanistic	DGIdb
1.ALPHA.-HYDROXYVITAMIN D5	? unclear	Mechanistic	DGIdb
ALISKIREN FUMARATE	↓ inhibits	Mechanistic	DGIdb
TERLAKIREN	? unclear	Mechanistic	DGIdb
SITOKIREN	↓ inhibits	Mechanistic	DGIdb
REMIKIREN	? unclear	Mechanistic	DGIdb
ALISKIREN	? unclear	Mechanistic	DGIdb
VTP-27999	? unclear	Mechanistic	DGIdb

SLC12A3

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
HYDROCHLOROTHIAZIDE	↓ inhibits	Mechanistic	DGIdb
CHLOROTHIAZIDE SODIUM	↓ inhibits	Mechanistic	DGIdb
POLYTHIAZIDE	↓ inhibits	Mechanistic	DGIdb
QUINETHAZONE	↓ inhibits	Mechanistic	DGIdb
METOLAZONE	↓ inhibits	Mechanistic	DGIdb
CHLOROTHIAZIDE	↓ inhibits	Mechanistic	DGIdb
FUROSEMIDE	? unclear	Mechanistic	DGIdb
BENDROFLUMETHIAZIDE	↓ inhibits	Mechanistic	DGIdb
DIAZOXIDE	? unclear	Mechanistic	DGIdb
METHYCLOTHIAZIDE	↓ inhibits	Mechanistic	DGIdb
CHLORTHALIDONE	↓ inhibits	Mechanistic	DGIdb
INDAPAMIDE	↓ inhibits	Mechanistic	DGIdb
TRICHLORMETHIAZIDE	↓ inhibits	Mechanistic	DGIdb
CYCLOTHIAZIDE	↓ inhibits	Mechanistic	DGIdb
HYDROFLUMETHIAZIDE	↓ inhibits	Mechanistic	DGIdb
TORSEMIDE	? unclear	Mechanistic	DGIdb
BUMETANIDE	? unclear	Mechanistic	DGIdb
BENZTHIAZIDE	↓ inhibits	Mechanistic	DGIdb

Clinical Trials

Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-06.

No recent clinical trials found on ClinicalTrials.gov for this condition.

Agents Found By Disease-Level Search

Searched directly from “Hypertension” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 13-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

60 agents shown (approved or with trial evidence) — 53 not found by the gene-target search above.

Azilsartan

Approved · 2 trials · source: ClinicalTrials.gov, Open Targets
NCT02079805 NCT02100319

sibutramineNOT in gene-target list

· 2 trials · source: ClinicalTrials.gov
NCT00679653 NCT00679653

Postpartum follow up cardNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06054841

Telmisartan

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT02079805

Intervention on DCP3 based strategies for Hypertension Management and ControlNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04336631

Nicotinamide RibosideNOT in gene-target list

Phase 1 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT06991712

NicotinamideNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06991712

Nicotinamide MononucleotideNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06991712

Nicotinic AcidNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06991712

Treprostinil Palmitil Inhalation PowderNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07481981

HCP1904-3NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05199129

RLD2001-1NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05199129

ALT-711NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00045981

Counseling letterNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03077373

Ali/Amlo 150/2.5 mgNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01237873

Qishen Yiqi Dropping Pills 0.5g Oral Three Times Daily + Targeted Therapy for Pulmonary Arterial HypertensionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07604805

Standard Pulmonary Arterial Hypertension (PAH)-Targeted Therapy AloneNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07604805

Estimation of Protein 13NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05517512

Artificial Intelligence model to detect glaucomaNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07243665

AGV implantationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00628173

Paul glaucoma drainage device (GDD)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05500469

Dietary supplement intervention Goodphyte IB DefenseNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07380022

Dietary supplement intervention Goodphyte ImmunityNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07380022

Wearable BP deviceNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05866445

24-hour ambulatory blood pressure monitorNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05866445

Nifedipine

Phase 3 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT01912677

Labetalol

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT01912677

MethyldopaNOT in gene-target list

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT01912677

Carvedilol

Unknown · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT00827775

Iyengar yogaNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00328666

Enhanced nutritional care classesNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00328666

Variceal band ligationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00799851

cyanoacrylate injectionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00799851

cilnidipine

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT00325637

Community health worker delivered multicomponent interventionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05068505

CJ-30061NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03657472

Exforge® 5/160mg & Lipitor® 20mgNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03657472

ION904NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05314439

Occupational therapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00229957

PhysiotherapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00229957

Self-managementNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00229957

DE-117 ophthalmic solutionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02822742

Latanoprost ophthalmic solution 0.005%NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02822742

Veno-veno-arterial ECMONOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02859194

Aliskiren/AmlodipineNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00942994

Aliskiren/Amlodipine and Hydrochlorothiazide (HCTZ)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00942994

Lowering salt in dietNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01628302

verapamil/trandolaprilNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00679653

metoprolol/HCTNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00679653

felodipine/ramiprilNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00679653

AllopurinolNOT in gene-target list

Phase 3 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT00241839

Chlorthalidone

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT00241839

Potassium chlorideNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00241839

AR-assisted EVD placementNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06571539

Freehand EVD placementNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06571539

CoachingNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02653573

1 dose of Beetroot juice intakeNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06584331

2 doses of Beetroot juice intakeNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06584331

health educationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00123045

"model 1000 PNT vacuum controller" (the vacuum device for ocular suction)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01540331

Hypertension

Remission & chronicity

ACE

ADRB1

ADRB2

AGT

AGTR1

AGTR2

CACNA1C

EDN1

NOS3

NPR1

NR3C2

REN

SLC12A3

Azilsartan

sibutramineNOT in gene-target list

Postpartum follow up cardNOT in gene-target list

Telmisartan

Intervention on DCP3 based strategies for Hypertension Management and ControlNOT in gene-target list

Nicotinamide RibosideNOT in gene-target list

NicotinamideNOT in gene-target list

Nicotinamide MononucleotideNOT in gene-target list

Nicotinic AcidNOT in gene-target list

Treprostinil Palmitil Inhalation PowderNOT in gene-target list

HCP1904-3NOT in gene-target list

RLD2001-1NOT in gene-target list

ALT-711NOT in gene-target list

Counseling letterNOT in gene-target list

Ali/Amlo 150/2.5 mgNOT in gene-target list

Qishen Yiqi Dropping Pills 0.5g Oral Three Times Daily + Targeted Therapy for Pulmonary Arterial HypertensionNOT in gene-target list

Standard Pulmonary Arterial Hypertension (PAH)-Targeted Therapy AloneNOT in gene-target list

Estimation of Protein 13NOT in gene-target list

Artificial Intelligence model to detect glaucomaNOT in gene-target list

AGV implantationNOT in gene-target list

Paul glaucoma drainage device (GDD)NOT in gene-target list

Dietary supplement intervention Goodphyte IB DefenseNOT in gene-target list

Dietary supplement intervention Goodphyte ImmunityNOT in gene-target list

Wearable BP deviceNOT in gene-target list

24-hour ambulatory blood pressure monitorNOT in gene-target list

Nifedipine

Labetalol

MethyldopaNOT in gene-target list

Carvedilol

Iyengar yogaNOT in gene-target list

Enhanced nutritional care classesNOT in gene-target list

Variceal band ligationNOT in gene-target list

cyanoacrylate injectionNOT in gene-target list

cilnidipine

Community health worker delivered multicomponent interventionNOT in gene-target list

CJ-30061NOT in gene-target list

Exforge® 5/160mg & Lipitor® 20mgNOT in gene-target list

ION904NOT in gene-target list

Occupational therapyNOT in gene-target list

PhysiotherapyNOT in gene-target list

Self-managementNOT in gene-target list

DE-117 ophthalmic solutionNOT in gene-target list

Latanoprost ophthalmic solution 0.005%NOT in gene-target list

Veno-veno-arterial ECMONOT in gene-target list

Aliskiren/AmlodipineNOT in gene-target list

Aliskiren/Amlodipine and Hydrochlorothiazide (HCTZ)NOT in gene-target list

Lowering salt in dietNOT in gene-target list

verapamil/trandolaprilNOT in gene-target list

metoprolol/HCTNOT in gene-target list

felodipine/ramiprilNOT in gene-target list

AllopurinolNOT in gene-target list

Chlorthalidone

Potassium chlorideNOT in gene-target list

AR-assisted EVD placementNOT in gene-target list

Freehand EVD placementNOT in gene-target list

CoachingNOT in gene-target list

1 dose of Beetroot juice intakeNOT in gene-target list

2 doses of Beetroot juice intakeNOT in gene-target list

health educationNOT in gene-target list

"model 1000 PNT vacuum controller" (the vacuum device for ocular suction)NOT in gene-target list

Part of the Open Source Medicine Foundation Network