Biomarker & Intervention Discovery
Endometriosis
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
US DALYs820.9KWHO GHE 2021 · all ages
Global DALYs27.02MWHO GHE 2021 · worldwide
Global mortality7,743 deaths/yrWHO GHE 2021 · worldwide
NIH funding$37MFY2025 · RCDC estimate
Funding levelSeverely Underfunded
Spontaneous remissionEndometriosis lesions may partially regress after menopause; spontaneous resolution of symptoms rare; recurrence rate…
Best-intervention remissionExcision surgery achieves pain relief in 60-80% at 6 months but 50% recurrence at 5 years; GnRH agonists + add-back…
Gap sizeVery large — diagnostic delay averages 7-10 years from symptom onset; no disease-modifying treatment; high recurrence…
Primary barrierbiological + practice
Full remission profile →
Remission & chronicity
Spontaneous remission
Endometriosis lesions may partially regress after menopause; spontaneous resolution of symptoms rare; recurrence rate after surgery 20-40% at 2 years and 50-60% at 5 years
Best-intervention remission
Excision surgery achieves pain relief in 60-80% at 6 months but 50% recurrence at 5 years; GnRH agonists + add-back therapy: 70-90% pain reduction but oestrogen-deprivation side effects; combined OCP: 50-60% pain reduction; elagolix (Orilissa): 43% reduction in dysmenorrhoea vs placebo (ELARIS EM-I)
Gap size
Very large — diagnostic delay averages 7-10 years from symptom onset; no disease-modifying treatment; high recurrence after surgery
Primary barrier
biological + practice
Diagnostic delay of 7-10 years is the largest modifiable factor; endometriosis dismissed as 'normal period pain'; no non-surgical diagnostic test; all medical treatments are suppressive not curative; recurrence after surgery is universal without continued medical suppression
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Endometriosis” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."