Biomarker & Intervention Discovery
Chronic Venous Insufficiency / Venous Leg Ulcers
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
Spontaneous remissionVenous leg ulcers: spontaneous healing in 20-30% at 6 months without compression; recurrence in 70% within 1 year even…
Best-intervention remissionCompression therapy (graduated 40 mmHg): 70-80% healing at 24 weeks; venous ablation (EVLA, RFA) of incompetent veins…
Gap sizeLarge — venous ablation is significantly underused; compression adherence is the primary barrier in healed ulcers
Primary barrierpractice/access
Full remission profile →
Remission & chronicity
Spontaneous remission
Venous leg ulcers: spontaneous healing in 20-30% at 6 months without compression; recurrence in 70% within 1 year even after healing; CVI is progressive without intervention
Best-intervention remission
Compression therapy (graduated 40 mmHg): 70-80% healing at 24 weeks; venous ablation (EVLA, RFA) of incompetent veins + compression: 57% ulcer healing at 6 months vs 36% compression alone (VenUS IV); early intervention (within 6 months of ulcer onset) dramatically improves outcomes
Gap size
Large — venous ablation is significantly underused; compression adherence is the primary barrier in healed ulcers
Primary barrier
practice/access
The Early Venous Reflux Ablation (EVRA) trial showed early ablation superior to compression-first strategy but most patients still wait 6+ months; compression stocking adherence is extremely poor without adequate education; many patients receive only wound dressings without compression or vascular assessment
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Chronic Venous Insufficiency / Venous Leg Ulcers” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."