Biomarker & Intervention Discovery
Chronic Pancreatitis
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
US DALYs172.3KWHO GHE 2021 · all ages
Global DALYs4.13MWHO GHE 2021 · worldwide
US mortality5,021 deaths/yrWHO GHE 2021
Global mortality115.8K deaths/yrWHO GHE 2021 · worldwide
Spontaneous remissionProgressive exocrine and endocrine insufficiency; spontaneous improvement possible in alcoholic CP with sustained…
Best-intervention remissionAbstinence from alcohol in alcoholic CP: 30-40% pain improvement; endoscopic drainage of ductal obstruction: pain…
Gap sizeLarge — endoscopic therapy and surgery are underused in eligible patients; most are managed with analgesics indefinitely
Primary barrierpractice/access
Full remission profile →
Remission & chronicity
Spontaneous remission
Progressive exocrine and endocrine insufficiency; spontaneous improvement possible in alcoholic CP with sustained abstinence (30-40% pain improvement); structural damage (fibrosis, calcifications) is irreversible
Best-intervention remission
Abstinence from alcohol in alcoholic CP: 30-40% pain improvement; endoscopic drainage of ductal obstruction: pain relief in 65-70% at 5 years; total pancreatectomy with islet autotransplantation (TPIAT): 85-90% narcotic independence at 3 years in refractory cases; antioxidant therapy: modest evidence
Gap size
Large — endoscopic therapy and surgery are underused in eligible patients; most are managed with analgesics indefinitely
Primary barrier
practice/access
Pain management in CP often escalates to opioids without adequate trial of endoscopic decompression or TPIAT in eligible patients; TPIAT (total pancreatectomy + islet autotransplantation) for refractory pain is highly effective but available at only ~20 centres in the US; delayed referral is the dominant gap
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Chronic Pancreatitis” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."