Biomarker & Intervention Discovery
Coeliac Disease (Refractory / RCD)
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
Spontaneous remissionNo spontaneous remission — autoimmune injury continues as long as gluten is consumed; villous atrophy persists in…
Best-intervention remissionStrict gluten-free diet: histological remission (Marsh 0-1) in 60-70% at 2 years; mucosal healing complete in only…
Gap sizeModerate — GFD is effective but imperfect; adherence is the primary barrier; and no pharmacotherapy exists for GFD…
Primary barrierframing/biological
Full remission profile →
Remission & chronicity
Spontaneous remission
No spontaneous remission — autoimmune injury continues as long as gluten is consumed; villous atrophy persists in 30-40% at 5 years even on gluten-free diet (GFD) due to cross-contamination
Best-intervention remission
Strict gluten-free diet: histological remission (Marsh 0-1) in 60-70% at 2 years; mucosal healing complete in only ~40% at 5 years; non-responsive celiac in 7-30% (defined as persistent symptoms/histology on strict GFD)
Gap size
Moderate — GFD is effective but imperfect; adherence is the primary barrier; and no pharmacotherapy exists for GFD non-responders
Primary barrier
framing/biological
The GFD is the only treatment and no pharmacotherapy is approved, leaving 7-30% of non-responsive/refractory patients without additional options; even 'strict' adherence fails to achieve mucosal healing in a large minority due to food labelling gaps and cross-contamination; quality of life impact of GFD is substantial; refractory celiac disease Type II (RCDII) has very poor prognosis
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Coeliac Disease (Refractory / RCD)” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."