Remission & chronicity
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: Clinical > Mechanistic > Correlative.
ADRA2A
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| FADOLMIDINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| FIPAMEZOLE | ↓ inhibits | Mechanistic | DGIdb | |
| ERGOLOID MESYLATES | ↓ inhibits | Mechanistic | DGIdb | |
| BRIMONIDINE | ↑ activates | Mechanistic | DGIdb | |
| CLONIDINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| ERGOLOID MESYLATES, USP | ? unclear | Mechanistic | DGIdb | |
| SODIUM CHLORIDE | ? unclear | Mechanistic | DGIdb | |
| NICERGOLINE | ? unclear | Mechanistic | DGIdb | |
| YOHIMBINE | ↓ inhibits | Mechanistic | 0.42 nM (Ki) | DGIdb |
| DEXMEDETOMIDINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| GUANIDINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| MEPERIDINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| BRIMONIDINE TARTRATE | ↑ activates | Mechanistic | DGIdb | |
| NOREPINEPHRINE | ↑ activates | Mechanistic | 66.0 nM (Ki) | DGIdb |
| MK-912 | ↓ inhibits | Mechanistic | DGIdb | |
| LOFEXIDINE | ↑ activates | Mechanistic | DGIdb | |
| PIRIBEDIL | ↓ inhibits | Mechanistic | DGIdb | |
| BENZPHETAMINE | ? unclear | Mechanistic | DGIdb | |
| [125I]P-IODOCLONIDINE | ↑ activates | Mechanistic | DGIdb | |
| GUANFACINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| DOXAZOSIN MESYLATE | ? unclear | Mechanistic | DGIdb | |
| EPINEPHRINE | ↑ activates | Mechanistic | DGIdb | |
| DROXIDOPA | ↑ activates | Mechanistic | DGIdb | |
| PSEUDOEPHEDRINE POLISTIREX | ? unclear | Mechanistic | DGIdb | |
| RX821002 | ↓ inhibits | Mechanistic | DGIdb | |
| MUSCARINIC TOXIN 3 | ↓ inhibits | Mechanistic | DGIdb | |
| TOLAZOLINE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENTOLAMINE | ↓ inhibits | Mechanistic | 2.6 nM (Ki) | DGIdb |
| METHYLDOPATE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| TETRAHYDROZOLINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| DIPIVEFRIN HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| NAPHAZOLINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| RAUWOLFIA SERPENTINA | ↓ inhibits | Mechanistic | 8.2 nM (Ki) | DGIdb |
| GUANABENZ | ↑ activates | Mechanistic | DGIdb | |
| ASENAPINE | ? unclear | Mechanistic | DGIdb | |
| SPIROXATRINE | ↓ inhibits | Mechanistic | DGIdb | |
| GUANABENZ ACETATE | ↑ activates | Mechanistic | DGIdb | |
| BRL44408 | ↓ inhibits | Mechanistic | DGIdb | |
| BETHANIDINE | ? unclear | Mechanistic | DGIdb | |
| LOFEXIDINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb |
Showing top 40 of 281 agents ranked by evidence tier.
COMT
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| ENTACAPONE | ↓ inhibits | Mechanistic | 386.0 nM (IC50) | DGIdb |
| TOLCAPONE | ↓ inhibits | Mechanistic | 127.0 nM (IC50) | DGIdb |
| HYDROCODONE POLISTIREX | ? unclear | Mechanistic | DGIdb | |
| SUMATRIPTAN | ? unclear | Mechanistic | DGIdb | |
| QUETIAPINE FUMARATE | ? unclear | Mechanistic | DGIdb | |
| RASAGILINE | ? unclear | Mechanistic | DGIdb | |
| PREGABALIN | ? unclear | Mechanistic | DGIdb | |
| NALTREXONE | ? unclear | Mechanistic | DGIdb | |
| HALOPERIDOL DECANOATE | ? unclear | Mechanistic | DGIdb | |
| PROPRANOLOL HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| ACETAMINOPHEN | ? unclear | Mechanistic | DGIdb | |
| CODEINE ANHYDROUS | ? unclear | Mechanistic | DGIdb | |
| MERCAPTOPURINE | ? unclear | Mechanistic | DGIdb | |
| OPICAPONE | ↓ inhibits | Mechanistic | 1.0 nM (Ki) | DGIdb |
| PAROXETINE HYDROCHLORIDE, HEMIHYDRATE | ? unclear | Mechanistic | DGIdb | |
| RALOXIFENE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| NEBICAPONE | ↓ inhibits | Mechanistic | DGIdb | |
| ANALGESIC AGENT | ? unclear | Mechanistic | DGIdb | |
| ANHYDROUS DEXTROSE | ? unclear | Mechanistic | DGIdb | |
| GALCANEZUMAB | ? unclear | Mechanistic | DGIdb | |
| REMIFENTANIL HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| FLUVOXAMINE | ? unclear | Mechanistic | DGIdb | |
| ERGOT ALKALOIDS | ? unclear | Mechanistic | DGIdb | |
| IBUPROFEN, SODIUM SALT | ? unclear | Mechanistic | DGIdb | |
| ERENUMAB | ? unclear | Mechanistic | DGIdb | |
| METHADONE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| FREMANEZUMAB | ? unclear | Mechanistic | DGIdb | |
| ALFENTANIL | ? unclear | Mechanistic | DGIdb | |
| BUPROPION HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| NALOXONE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| DULOXETINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL1091983 | ↓ inhibits | Mechanistic | 1.6 nM (Ki) | ChEMBL |
| CHEMBL1091982 | ↓ inhibits | Mechanistic | 6.0 nM (Ki) | ChEMBL |
| CHEMBL1091981 | ↓ inhibits | Mechanistic | 16.6 nM (Ki) | ChEMBL |
| CHEMBL1089539 | ↓ inhibits | Mechanistic | 10.6 nM (Ki) | ChEMBL |
| CHEMBL1089538 | ↓ inhibits | Mechanistic | 17.0 nM (Ki) | ChEMBL |
| CHEMBL1089537 | ↓ inhibits | Mechanistic | 17.0 nM (Ki) | ChEMBL |
| CHEMBL1089536 | ↓ inhibits | Mechanistic | 10.2 nM (Ki) | ChEMBL |
| CHEMBL1091204 | ↓ inhibits | Mechanistic | 1.1 nM (Ki) | ChEMBL |
| CHEMBL1089630 | ↓ inhibits | Mechanistic | 1.3 nM (Ki) | ChEMBL |
Showing top 40 of 176 agents ranked by evidence tier.
DRD2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| LOXAPINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| MINAPRINE | ↑ activates | Mechanistic | DGIdb | |
| SULPIRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| HALOPERIDOL DECANOATE | ↓ inhibits | Mechanistic | DGIdb | |
| ZIPRASIDONE MESYLATE | ↓ inhibits | Mechanistic | DGIdb | |
| METHYLDOPA ANHYDROUS | ? unclear | Mechanistic | DGIdb | |
| BENPERIDOL | ↓ inhibits | Mechanistic | DGIdb | |
| FLUSPIRILENE | ↓ inhibits | Mechanistic | DGIdb | |
| VERALIPRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CAFFEINE | ? unclear | Mechanistic | DGIdb | |
| SUMANIROLE | ↑ activates | Mechanistic | 9.0 nM (Ki) | DGIdb |
| ZIPRASIDONE | ↓ inhibits | Mechanistic | DGIdb | |
| METOCLOPRAMIDE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| LUMATEPERONE | ↓ inhibits | Mechanistic | DGIdb | |
| FLUPENTHIXOL | ↓ inhibits | Mechanistic | DGIdb | |
| PROCHLORPERAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| PERAZINE | ? unclear | Mechanistic | DGIdb | |
| FLUPHENAZINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ROPINIROLE | ↑ activates | Mechanistic | DGIdb | |
| RACLOPRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROMAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| [3H]PD128907 | ↑ activates | Mechanistic | DGIdb | |
| MORPHINE SULFATE | ? unclear | Mechanistic | DGIdb | |
| ALIZAPRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENYLTOLOXAMINE | ? unclear | Mechanistic | DGIdb | |
| LOXAPINE | ↓ inhibits | Mechanistic | DGIdb | |
| CABERGOLINE | ↑ activates | Mechanistic | DGIdb | |
| BREXPIPRAZOLE | ↑ activates | Mechanistic | DGIdb | |
| PALIPERIDONE | ↓ inhibits | Mechanistic | DGIdb | |
| APLINDORE FUMARATE | ↑ activates | Mechanistic | DGIdb | |
| APOMORPHINE | ↑ activates | Mechanistic | DGIdb | |
| CARIPRAZINE | ↑ activates | Mechanistic | DGIdb | |
| MOLINDONE | ? unclear | Mechanistic | DGIdb | |
| TIAPRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ZOTEPINE | ↓ inhibits | Mechanistic | DGIdb | |
| DOPAMINE | ↑ activates | Mechanistic | DGIdb | |
| XP21279 | ? unclear | Mechanistic | DGIdb | |
| PROMAZINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| VILAZODONE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| TRIFLUPROMAZINE | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 372 agents ranked by evidence tier.
DRD4
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CHLORPROMAZINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| L741742 | ↓ inhibits | Mechanistic | DGIdb | |
| ERGOLOID MESYLATES | ↑ activates | Mechanistic | DGIdb | |
| BENPERIDOL | ↓ inhibits | Mechanistic | DGIdb | |
| ROTIGOTINE | ↑ activates | Mechanistic | DGIdb | |
| ABT-670 | ↑ activates | Mechanistic | DGIdb | |
| CHLORPROMAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| METHOTRIMEPRAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| PRAMIPEXOLE | ? unclear | Mechanistic | DGIdb | |
| DOPAMINE | ↑ activates | Mechanistic | DGIdb | |
| PROMAZINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PROPIOMAZINE | ? unclear | Mechanistic | DGIdb | |
| TERGURIDE | ↓ inhibits | Mechanistic | DGIdb | |
| PRAMIPEXOLE DIHYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| LOXAPINE | ↓ inhibits | Mechanistic | DGIdb | |
| NEMONAPRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CLOTHIAPINE | ↓ inhibits | Mechanistic | DGIdb | |
| PF-592379 | ↑ activates | Mechanistic | DGIdb | |
| THIETHYLPERAZINE | ? unclear | Mechanistic | DGIdb | |
| A-381393 | ↓ inhibits | Mechanistic | DGIdb | |
| ETICLOPRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| APOMORPHINE | ↑ activates | Mechanistic | DGIdb | |
| APOMORPHINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| ZIPRASIDONE | ? unclear | Mechanistic | DGIdb | |
| AMOXAPINE | ↓ inhibits | Mechanistic | DGIdb | |
| BROMOCRIPTINE MESYLATE | ↑ activates | Mechanistic | DGIdb | |
| L745870 | ↓ inhibits | Mechanistic | DGIdb | |
| SULPIRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| HALOPERIDOL DECANOATE | ↓ inhibits | Mechanistic | DGIdb | |
| ROPINIROLE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| PERGOLIDE | ↑ activates | Mechanistic | DGIdb | |
| U101958 | ↓ inhibits | Mechanistic | DGIdb | |
| HALOPERIDOL LACTATE | ↓ inhibits | Mechanistic | DGIdb | |
| PROCHLORPERAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| OLANZAPINE | ↓ inhibits | Mechanistic | DGIdb | |
| ETILEVODOPA | ? unclear | Mechanistic | DGIdb | |
| SERTINDOLE | ↓ inhibits | Mechanistic | DGIdb | |
| [3H]NGD941 | ↓ inhibits | Mechanistic | DGIdb | |
| PIMOZIDE | ↓ inhibits | Mechanistic | DGIdb | |
| TRIFLUOPERAZINE | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 247 agents ranked by evidence tier.
HTR1B
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| ROXINDOLE | ↑ activates | Mechanistic | DGIdb | |
| SUMATRIPTAN | ↑ activates | Mechanistic | 7.7 nM (Ki) | DGIdb |
| OXYMETAZOLINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| [3H]ELETRIPTAN | ↑ activates | Mechanistic | DGIdb | |
| RITANSERIN | ↓ inhibits | Mechanistic | DGIdb | |
| NEFAZODONE | ? unclear | Mechanistic | DGIdb | |
| METHYSERGIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ELETRIPTAN | ↑ activates | Mechanistic | DGIdb | |
| DIPROPYL-5-CT | ↑ activates | Mechanistic | DGIdb | |
| NARATRIPTAN | ↑ activates | Mechanistic | DGIdb | |
| LISURIDE | ↑ activates | Mechanistic | DGIdb | |
| ZOLMITRIPTAN | ↑ activates | Mechanistic | 6.166 nM (IC50) | DGIdb |
| DIHYDROERGOTAMINE MESYLATE | ↑ activates | Mechanistic | DGIdb | |
| TERGURIDE | ↑ activates | Mechanistic | DGIdb | |
| [3H]SUMATRIPTAN | ↑ activates | Mechanistic | DGIdb | |
| SB 224289 | ↓ inhibits | Mechanistic | DGIdb | |
| (R)-FLUROCARAZOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| 5-(NONYLOXY)-TRYPTAMINE | ↑ activates | Mechanistic | DGIdb | |
| BMS 181,101 | ↑ activates | Mechanistic | DGIdb | |
| RIZATRIPTAN BENZOATE | ↑ activates | Mechanistic | DGIdb | |
| ALNIDITAN | ↑ activates | Mechanistic | DGIdb | |
| ELZASONAN HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CABERGOLINE | ↑ activates | Mechanistic | DGIdb | |
| [3H]GR 125,743 | ↓ inhibits | Mechanistic | DGIdb | |
| SB 649915 | ↓ inhibits | Mechanistic | DGIdb | |
| SERTINDOLE | ↓ inhibits | Mechanistic | DGIdb | |
| AVITRIPTAN | ↑ activates | Mechanistic | DGIdb | |
| RISPERIDONE | ↓ inhibits | Mechanistic | DGIdb | |
| DEXFENFLURAMINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| OCAPERIDONE | ↓ inhibits | Mechanistic | DGIdb | |
| ELETRIPTAN HYDROBROMIDE | ↑ activates | Mechanistic | DGIdb | |
| DONITRIPTAN | ↑ activates | Mechanistic | DGIdb | |
| SB236057 | ↓ inhibits | Mechanistic | DGIdb | |
| TFMPP | ↑ activates | Mechanistic | DGIdb | |
| SB 714786 | ↓ inhibits | Mechanistic | DGIdb | |
| CLOZAPINE | ↑ activates | Mechanistic | DGIdb | |
| ALMOTRIPTAN | ↑ activates | Mechanistic | DGIdb | |
| CP94253 | ↑ activates | Mechanistic | DGIdb | |
| RU 24969 | ↑ activates | Mechanistic | DGIdb | |
| 1-NAPHTHYLPIPERAZINE | ↑ activates | Mechanistic | DGIdb |
Showing top 40 of 266 agents ranked by evidence tier.
MAOA
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CX157 | ? unclear | Mechanistic | DGIdb | |
| MOCLOBEMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LADOSTIGIL | ? unclear | Mechanistic | 85000.0 nM (IC50) | DGIdb |
| BIFEMELANE | ↓ inhibits | Mechanistic | DGIdb | |
| METHAMPHETAMINE | ? unclear | Mechanistic | DGIdb | |
| MINAPRINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL2088303 | ? unclear | Mechanistic | DGIdb | |
| PARGYLINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ISOCARBOXAZID | ↓ inhibits | Mechanistic | DGIdb | |
| TRANYLCYPROMINE SULFATE | ↓ inhibits | Mechanistic | DGIdb | |
| CR4056 | ↓ inhibits | Mechanistic | DGIdb | |
| TRANYLCYPROMINE | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1927670 | ? unclear | Mechanistic | DGIdb | |
| INDANTADOL | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL2088301 | ? unclear | Mechanistic | DGIdb | |
| PSORALEN | ? unclear | Mechanistic | DGIdb | |
| CLORGILINE | ↓ inhibits | Mechanistic | DGIdb | |
| VITAMIN K3 | ? unclear | Mechanistic | DGIdb | |
| IPRONIAZID | ↓ inhibits | Mechanistic | DGIdb | |
| MINAPRINE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENELZINE | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1642672 | ? unclear | Mechanistic | DGIdb | |
| 1-PHENETHYLPIPERIDINE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL602466 | ? unclear | Mechanistic | DGIdb | |
| MEBANAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| SELEGILINE | ↓ inhibits | Mechanistic | 1200.0 nM (IC50) | DGIdb |
| ACACETIN | ↓ inhibits | Mechanistic | DGIdb | |
| HARMINE | ? unclear | Mechanistic | DGIdb | |
| LINEZOLID | ↓ inhibits | Mechanistic | 20000.0 nM (Ki) | DGIdb |
| HARMALINE | ↓ inhibits | Mechanistic | DGIdb | |
| NICOTINE POLACRILEX | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1927684 | ? unclear | Mechanistic | DGIdb | |
| PHENELZINE SULFATE | ↓ inhibits | Mechanistic | DGIdb | |
| PIPERINE | ? unclear | Mechanistic | DGIdb | |
| ANTIDEPRESSANT AGENT | ? unclear | Mechanistic | DGIdb | |
| PROXIBARBAL | ↑ activates | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1813518 | ? unclear | Mechanistic | DGIdb | |
| NIALAMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| BEFLOXATONE | ↓ inhibits | Mechanistic | DGIdb | |
| TRYPTAMINE | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 233 agents ranked by evidence tier.
SLC6A2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| GUANETHIDINE | ? unclear | Mechanistic | DGIdb | |
| BUPROPION HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| TRIMIPRAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| DIETHYLPROPION | ? unclear | Mechanistic | DGIdb | |
| LEVOMILNACIPRAN | ↓ inhibits | Mechanistic | DGIdb | |
| DOXEPIN HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DULOXETINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DASOTRALINE | ↓ inhibits | Mechanistic | DGIdb | |
| SERDEXMETHYLPHENIDATE | ↓ inhibits | Mechanistic | DGIdb | |
| ZOTEPINE | ↓ inhibits | Mechanistic | DGIdb | |
| LOFEPRAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| LISDEXAMFETAMINE DIMESYLATE | ? unclear | Mechanistic | DGIdb | |
| NEFAZODONE | ↓ inhibits | Mechanistic | 360.0 nM (Kd) | DGIdb |
| 3-IODOBENZYLGUANIDINE | ? unclear | Mechanistic | DGIdb | |
| PHENTERMINE RESIN | ? unclear | Mechanistic | DGIdb | |
| REBOXETINE | ↓ inhibits | Mechanistic | 1.1 nM (Ki) | DGIdb |
| NORZOTEPINE | ↓ inhibits | Mechanistic | DGIdb | |
| ATOMOXETINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| SERDEXMETHYLPHENIDATE CHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| SOLRIAMFETOL | ↓ inhibits | Mechanistic | DGIdb | |
| DESIPRAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| METHYLPHENIDATE | ↓ inhibits | Mechanistic | DGIdb | |
| AMPRELOXETINE | ↓ inhibits | Mechanistic | DGIdb | |
| MILNACIPRAN | ↓ inhibits | Mechanistic | DGIdb | |
| ORPHENADRINE CITRATE | ↓ inhibits | Mechanistic | DGIdb | |
| AMITRIPTYLINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| [3H]NISOXETINE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENDIMETRAZINE TARTRATE | ↓ inhibits | Mechanistic | DGIdb | |
| LEVOMILNACIPRAN HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| METHAMPHETAMINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| AMITIFADINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| AMOXAPINE | ↓ inhibits | Mechanistic | DGIdb | |
| QUETIAPINE FUMARATE | ↓ inhibits | Mechanistic | DGIdb | |
| AMITIFADINE | ? unclear | Mechanistic | DGIdb | |
| VENLAFAXINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| HINOKININ | ? unclear | Mechanistic | DGIdb | |
| TESOFENSINE | ? unclear | Mechanistic | DGIdb | |
| TEDATIOXETINE | ? unclear | Mechanistic | DGIdb | |
| MAZINDOL | ↓ inhibits | Mechanistic | 18.0 nM (Ki) | DGIdb |
| AMPHETAMINE ASPARTATE | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 281 agents ranked by evidence tier.
SLC6A3
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| DASOTRALINE | ↓ inhibits | Mechanistic | DGIdb | |
| MAZINDOL | ↓ inhibits | Mechanistic | 42.6 nM (IC50) | DGIdb |
| BUPROPION HYDROBROMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| SIBUTRAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| METHYLPHENIDATE | ↓ inhibits | Mechanistic | DGIdb | |
| 3,4-METHYLENEDIOXYMETHAMPHETAMINE | ? unclear | Mechanistic | DGIdb | |
| LISDEXAMFETAMINE DIMESYLATE | ? unclear | Mechanistic | DGIdb | |
| TESOFENSINE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENDIMETRAZINE TARTRATE | ↓ inhibits | Mechanistic | DGIdb | |
| LEVOMILNACIPRAN | ↓ inhibits | Mechanistic | DGIdb | |
| BUPROPION HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| AMPHETAMINE ADIPATE | ? unclear | Mechanistic | DGIdb | |
| ANESTHETIC AGENT | ? unclear | Mechanistic | DGIdb | |
| TRIMIPRAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| AMPHETAMINE ASPARTATE | ? unclear | Mechanistic | DGIdb | |
| RTI-336 | ? unclear | Mechanistic | DGIdb | |
| HINOKININ | ? unclear | Mechanistic | DGIdb | |
| [3H]GBR12935 | ↓ inhibits | Mechanistic | DGIdb | |
| METYROSINE | ? unclear | Mechanistic | DGIdb | |
| DIETHYLPROPION HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CLOMIPRAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| SERDEXMETHYLPHENIDATE CHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| METHYLPHENIDATE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| PHENMETRAZINE | ? unclear | Mechanistic | DGIdb | |
| CLOZAPINE | ? unclear | Mechanistic | DGIdb | |
| COMPOUND 58 [PMID: 25037917] | ↓ inhibits | Mechanistic | DGIdb | |
| SOLRIAMFETOL | ↓ inhibits | Mechanistic | DGIdb | |
| ALTROPANE | ? unclear | Mechanistic | DGIdb | |
| TOLUDESVENLAFAXINE | ↓ inhibits | Mechanistic | DGIdb | |
| DEXTROAMPHETAMINE SACCHARATE | ? unclear | Mechanistic | DGIdb | |
| PYROVALERONE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DESVENLAFAXINE SUCCINATE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENTERMINE RESIN | ? unclear | Mechanistic | DGIdb | |
| AMITIFADINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| PHENELZINE | ↓ inhibits | Mechanistic | DGIdb | |
| BICIFADINE | ↓ inhibits | Mechanistic | DGIdb | |
| PSEUDOEPHEDRINE POLISTIREX | ? unclear | Mechanistic | DGIdb | |
| PHENMETRAZINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DEXTROAMPHETAMINE ADIPATE | ? unclear | Mechanistic | DGIdb | |
| NOMIFENSINE | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 187 agents ranked by evidence tier.
SNAP25
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| INCOBOTULINUMTOXINA | ↓ inhibits | Mechanistic | DGIdb | |
| PRABOTULINUMTOXIN A | ? unclear | Mechanistic | DGIdb | |
| THERAPEUTIC STEROID HORMONE | ? unclear | Mechanistic | DGIdb | |
| AMISULPRIDE | ? unclear | Mechanistic | DGIdb | |
| DAXIBOTULINUMTOXINA | ↓ inhibits | Mechanistic | DGIdb | |
| TRENIBOTULINUMTOXINE | ? unclear | Mechanistic | DGIdb | |
| LETIBOTULINUMTOXINA | ? unclear | Mechanistic | DGIdb | |
| ONABOTULINUMTOXINA | ↓ inhibits | Mechanistic | DGIdb | |
| BOTULINUM TOXIN TYPE A | ? unclear | Mechanistic | DGIdb | |
| DIAZOXIDE | ? unclear | Mechanistic | DGIdb | |
| ABOBOTULINUMTOXINA | ? unclear | Clinical | Open Targets |
Clinical Trials
Drug, biologic and supplement trials (treatment or prevention) from ClinicalTrials.gov whose main condition is ADHD: recruiting, active or completed, most recently updated first. Data retrieved 2026-10-28.
The purpose of this study is to evaluate the efficacy and examine the safety of two doses of EB-1020 QD XR capsule administered once daily orally in adult ADHD patients.
The purpose of this study is to evaluate the safety of long-term administration of mainly high doses of EB-1020 over 52 weeks in patients who have completed the double-blind trial (405-102-00112) conducted in Japan
This study is a Phase 3, multi-center, randomized, 6-week, double-blind, placebo-controlled, parallel-group trial to assess the efficacy and safety of solriamfetol in children aged 6 to \<12 years with ADHD.
This study is a Phase 3, multi-center, randomized, 6-week, double-blind, placebo-controlled, parallel-group trial to assess the efficacy and safety of solriamfetol in adolescents aged 12 to \<18 years with ADHD.
The purpose of this study is to measure safety and the improvement in symptoms in subjects with ADHD when taking ALKS 7290 tablets compared with placebo tablets.
The indication of attention-deficit/hyperactivity disorder (ADHD) to be examined often occurs with other psychiatric disorders, and the majority of adults with ADHD have at least one psychiatric comorbidity in their lives. Depression is one of the most common comorbidities in patients with ADHD. The...
Attention deficit hyperactivity disorder (ADHD) is characterized by difficulties paying attention, poor impulse control, and hyperactive behaviors. It is associated with several health and social detrimental outcomes and leads to increased risks of criminality and recidivism. However, to date, ADHD ...
This study will compare the effectiveness of combined parental stimulant medication and behavioral parent training (BPT) versus BPT alone on child ADHD-related impairment (primary outcome), child ADHD and externalizing symptoms, time to child stimulant prescription (secondary child outcomes) and par...
This project will evaluate the effectiveness of Methylphenidate versus Guanfacine in treating Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 3 through 5 years (inclusive), as measured by clinician rating of global improvement.
The aim of this project is to look at the impact of 5-Hydroxytryptophan (5-HTP) on distractibility. 5-HTP is the precursor to the neurotransmitter serotonin and is a chemical that the body produces naturally. There is evidence that distractibility is associated with a decreased level of serotonin. T...
This is an observational study assessing the usage of stimulant medication for ADHD in the context of pediatric epilepsy.
The effect of probiotics on the gut-brain axis in children with attention deficit hyperactivity disorder will be studied.
The goal of this clinical trial is to evaluate the efficacy and safety of CTx-1301 in adults with ADHD in a laboratory classroom setting.
This study is a Phase 3, multicenter, dose-optimized, double-blind, randomized, placebo-controlled study designed to evaluate the efficacy, safety, and tolerability of oral AK0901 capsules in children 6 to 12 years old with Attention Deficit Hyperactivity Disorder(ADHD).
This study aims to evaluate the potential effects of full-spectrum cannabigerol (CBG) oil on cognitive and behavioral symptoms in adolescents diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD). ADHD is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsi...
Agents Found By Disease-Level Search
Searched directly from “ADHD” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 9-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).
37 agents shown (approved or with trial evidence) — 33 not found by the gene-target search above.
Atomoxetine
Methylphenidate
OROS methylphenidate HClNOT in gene-target list
RitalinNOT in gene-target list
Lisdexamfetamine
ConcertaNOT in gene-target list
Centanafadine SRNOT in gene-target list
Coping PowerNOT in gene-target list
Individualized TreatmentNOT in gene-target list
BCINOT in gene-target list
viloxazine (SPN-812)NOT in gene-target list
FRx-001NOT in gene-target list
FRx-003NOT in gene-target list
FRx-004NOT in gene-target list
GABANOT in gene-target list
fasoracetam (AEVI-001)NOT in gene-target list
Clinical evaluationNOT in gene-target list
Neuropsychological evaluationNOT in gene-target list
Neurophysiological evaluationNOT in gene-target list
Genetic evaluationNOT in gene-target list
Stimulant Diversion Prevention (SDP)NOT in gene-target list
QbTestNOT in gene-target list
EB-1020 (Centanafadine) 164.4 mgNOT in gene-target list
EB-1020 (Centanafadine) 328.8 mgNOT in gene-target list
HLD200 methylphenidate hydrochloride (MPH) CapsulesNOT in gene-target list
Spanish-Language Unstuck and On Target (SL-Unstuck)NOT in gene-target list
Drive funNOT in gene-target list
Concerta AG formulationNOT in gene-target list
Concerta EG formulationNOT in gene-target list
Usual treatment for ADHDNOT in gene-target list
dasotraline
Mindful Awareness Practices (MAPs)NOT in gene-target list
Stimulant medication therapyNOT in gene-target list
Community-based psychosocial treatmentNOT in gene-target list
Motor Proficiency in School Age ADHD: Contribution of Different ComorbiditiesNOT in gene-target list
Serdexmethylphenidate/dexmethylphenidateNOT in gene-target list
CLS-FUERTENOT in gene-target list
Generated by the Open Source Medicine Foundation Biomarker Pipeline — 2026-10-08. Data sources: DGIdb, Open Targets, ChEMBL, PubMed, ClinicalTrials.gov. Not medical advice.