Biomarker & Intervention Discovery
Alcohol Use Disorder
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
Spontaneous remission30-40% of people with AUD achieve sustained abstinence without formal treatment at 1 year (natural recovery); but…
Best-intervention remissionNaltrexone (COMBINE trial): 23% abstinence rate vs 14% placebo at 16 weeks; combined pharmacotherapy + CBT: best…
Gap sizeVery large — vast majority of people with AUD never receive pharmacotherapy; <10% receive evidence-based treatment
Primary barrieraccess/framing
Full remission profile →
Remission & chronicity
Spontaneous remission
30-40% of people with AUD achieve sustained abstinence without formal treatment at 1 year (natural recovery); but functional impairment, liver damage, and mortality risk accumulate; relapse in 50-60% within 1 year even after treatment
Best-intervention remission
Naltrexone (COMBINE trial): 23% abstinence rate vs 14% placebo at 16 weeks; combined pharmacotherapy + CBT: best outcomes (~30-40% sustained abstinence at 1 year); acamprosate: reduces relapse risk 14% (meta-analysis); liver cirrhosis reversal with abstinence: fibrosis regression in 30-40% at 5 years
Gap size
Very large — vast majority of people with AUD never receive pharmacotherapy; <10% receive evidence-based treatment
Primary barrier
access/framing
AUD is massively undertreated; only 5.7% of people with AUD in the US received any treatment in 2019 (SAMHSA); naltrexone and acamprosate are dramatically underprescribed (<1% of AUD patients); 12-step/abstinence framing excludes patients seeking harm reduction; primary care providers rarely screen or treat
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Alcohol Use Disorder” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."