Biomarker & Intervention Discovery
Acne Vulgaris
Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.
Spontaneous remissionSpontaneous resolution by adulthood in majority (persistent adult acne in 12-22% of women, 3% of men); moderate-severe…
Best-intervention remissionOral isotretinoin: 85-90% achieve sustained remission (acne-free at 5 years) after one course; relapse requiring…
Gap sizeLarge — isotretinoin is highly effective but dramatically underused due to iPLEDGE programme barriers and pregnancy…
Primary barrieraccess/framing
Full remission profile →
Remission & chronicity
Spontaneous remission
Spontaneous resolution by adulthood in majority (persistent adult acne in 12-22% of women, 3% of men); moderate-severe acne rarely self-resolves; scarring occurs in up to 95% without adequate treatment
Best-intervention remission
Oral isotretinoin: 85-90% achieve sustained remission (acne-free at 5 years) after one course; relapse requiring retreat in 15-20%; topical adapalene + benzoyl peroxide: 65-70% reduction in inflammatory lesions at 12 weeks
Gap size
Large — isotretinoin is highly effective but dramatically underused due to iPLEDGE programme barriers and pregnancy concerns; patients spend years on antibiotics instead
Primary barrier
access/framing
The iPLEDGE programme creates substantial barriers to isotretinoin access (monthly blood tests, pregnancy tests, pharmacy restrictions); this leads to years of antibiotic courses creating antibiotic resistance and allowing scarring to progress; acne is not considered a 'serious' disease despite causing significant psychological morbidity and permanent scarring
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC.
Agents ranked: ● Clinical >
● Mechanistic >
● Correlative.
Pipeline results not yet available. Run: python -m biomarker_pipeline.run_for_diseases --skip-llm
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov.
Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Acne Vulgaris” via ClinicalTrials.gov interventions and Open Targets'
disease→drug data — independent of the 0-gene target panel above.
This surfaces agents whose mechanism doesn't route through a curated gene (combination
therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."