Summary
| Direction in ME/CFS | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Functional |
| Also described as | CPET parameter |
| Compared against | HC (healthy controls) |
| Associated symptoms | Reduced exercise capacity |
| Test type | Clinical or physiological test |
| Source | Holden et al. 2020 — doi:10.1186/s12967-020-02477-4 |
| Condition atlas | ME/CFS Biomarker Atlas |
Related Functional markers in ME/CFS
Full list: ME/CFS Biomarker Atlas.
Frequently asked questions
Is Workload at anaerobic threshold high or low in ME/CFS?
Reduced. Studies summarised in the OSMF atlas report lower Workload at anaerobic threshold in ME/CFS than in healthy controls. Source: Holden et al. 2020.
What symptoms is Workload at anaerobic threshold associated with in ME/CFS?
The cited literature associates this marker with Reduced exercise capacity. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Workload at anaerobic threshold?
It is measured as a clinical or physiological test. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Workload at anaerobic threshold result diagnostic of ME/CFS?
No. No single biomarker is diagnostic of ME/CFS. Workload at anaerobic threshold findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-29 · Page generated from me-cfs.json · Browse: ME/CFS atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.