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TCA cycle intermediates: biomarker evidence

TCA cycle intermediates appears in 1 entry of the OSMF biomarker atlas, covering Long COVID. Across those entries it is elevated in 1. It is currently reported in a single condition in this atlas; cross-condition comparison will be added as the dataset grows. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

Long COVID

Where TCA cycle intermediates is reported

Also listed as: Succinate, citrate, etc.

ConditionDirectionCompared againstAssociated symptomsSource
Long COVID↑ elevatedrecovered individuals without persistent symptoms (fully recovered)Mitochondrial dysfunctionPérez-Mazliah et al. 2024

Frequently asked questions

In which conditions is TCA cycle intermediates altered?

In the OSMF atlas TCA cycle intermediates is reported in Long COVID. It is elevated in 1 across 1 entries.

Is there a standard clinical test for TCA cycle intermediates?

The atlas entries for TCA cycle intermediates do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal TCA cycle intermediates result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). TCA cycle intermediates across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/tca-cycle-intermediates.html
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Last reviewed: 2026-06-29 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.