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PON1 (paraoxonase 1) activity: biomarker evidence

PON1 (paraoxonase 1) activity appears in 1 entry of the OSMF biomarker atlas, covering Gulf War Illness. Across those entries it is reduced in 1. It is currently reported in a single condition in this atlas; cross-condition comparison will be added as the dataset grows. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

Gulf War Illness

Where PON1 (paraoxonase 1) activity is reported

Also listed as: OP pesticide detoxification

ConditionDirectionCompared againstAssociated symptomsSource
Gulf War Illness↓ reducedhealthy Gulf War veteran controlsOrganophosphate sensitivityGean et al. 2021

Frequently asked questions

In which conditions is PON1 (paraoxonase 1) activity altered?

In the OSMF atlas PON1 (paraoxonase 1) activity is reported in Gulf War Illness. It is reduced in 1 across 1 entries.

Is there a standard clinical test for PON1 (paraoxonase 1) activity?

The atlas entries for PON1 (paraoxonase 1) activity do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal PON1 (paraoxonase 1) activity result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). PON1 (paraoxonase 1) activity across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/pon1-paraoxonase-1-activity.html
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Last reviewed: 2026-06-29 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.