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Muscarinic cholinergic autoantibodies: biomarker evidence

Muscarinic cholinergic autoantibodies appears in 1 entry of the OSMF biomarker atlas, covering ME/CFS. Across those entries it is elevated in 1. It is currently reported in a single condition in this atlas; cross-condition comparison will be added as the dataset grows. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

ME/CFS

Where Muscarinic cholinergic autoantibodies is reported

Also listed as: Anti-M3/M4

ConditionDirectionCompared againstAssociated symptomsSource
ME/CFS↑ elevatedhealthy controlsAutonomic, GI symptomsMaksoud et al. 2023

Frequently asked questions

In which conditions is Muscarinic cholinergic autoantibodies altered?

In the OSMF atlas Muscarinic cholinergic autoantibodies is reported in ME/CFS. It is elevated in 1 across 1 entries.

Is there a standard clinical test for Muscarinic cholinergic autoantibodies?

The atlas entries for Muscarinic cholinergic autoantibodies do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal Muscarinic cholinergic autoantibodies result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). Muscarinic cholinergic autoantibodies across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/muscarinic-cholinergic-autoantibodies.html
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Last reviewed: 2026-06-29 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.