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Mitochondrial membrane potential: biomarker evidence

Mitochondrial membrane potential appears in 1 entry of the OSMF biomarker atlas, covering ME/CFS. Across those entries it is reduced in 1. It is currently reported in a single condition in this atlas; cross-condition comparison will be added as the dataset grows. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

ME/CFS

Where Mitochondrial membrane potential is reported

Also listed as: ΔΨm

ConditionDirectionCompared againstAssociated symptomsSource
ME/CFS↓ reducedhealthy controlsMitochondrial dysfunctionHolden et al. 2020

Frequently asked questions

In which conditions is Mitochondrial membrane potential altered?

In the OSMF atlas Mitochondrial membrane potential is reported in ME/CFS. It is reduced in 1 across 1 entries.

Is there a standard clinical test for Mitochondrial membrane potential?

The atlas entries for Mitochondrial membrane potential do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal Mitochondrial membrane potential result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). Mitochondrial membrane potential across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/mitochondrial-membrane-potential.html
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Last reviewed: 2026-06-29 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.