Leptin: biomarker evidence

Leptin appears in 1 entry of the OSMF biomarker atlas, covering ME/CFS. Across those entries it is elevated in 1. It is currently reported in a single condition in this atlas; cross-condition comparison will be added as the dataset grows. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

ME/CFS

Where Leptin is reported

Also listed as: Adipokine

ConditionDirectionCompared againstAssociated symptomsSource
ME/CFS↑ elevatedhealthy controlsInflammatory signalingStrawbridge et al. 2019

Frequently asked questions

In which conditions is Leptin altered?

In the OSMF atlas Leptin is reported in ME/CFS. It is elevated in 1 across 1 entries.

What is the LOINC code for Leptin?

Entries in this atlas use LOINC 21365-2. LOINC codes identify the laboratory observation so results can be compared across systems.

Is one abnormal Leptin result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). Leptin across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/leptin.html
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Last reviewed: 2026-06-29 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.