Research Tracker›Biomarker Atlas›Marker Pages›Kynurenine

Kynurenine across conditions

Kynurenine appears in 2 entries of the OSMF biomarker atlas, covering Long COVID, ME/CFS. Across those entries it is elevated in 2. Because the same marker shifts in several unrelated conditions, it is best understood as a signal of shared biology such as inflammation, vascular or metabolic stress rather than as a condition-specific test. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

Long COVIDME/CFS

Where Kynurenine is reported

Also listed as: Tryptophan metabolite

ConditionDirectionCompared againstAssociated symptomsSource
Long COVID↑ elevatedhealthy controlsNeuroinflammation, fatigueSaito et al. 2024
ME/CFS↑ elevatedhealthy controlsNeuroinflammation, fatigueSaito et al. 2024

Frequently asked questions

In which conditions is Kynurenine altered?

In the OSMF atlas Kynurenine is reported in Long COVID, ME/CFS. It is elevated in 2 across 2 entries.

Does Kynurenine point to one specific diagnosis?

No. Because Kynurenine changes in several conditions (Long COVID, ME/CFS), an abnormal result cannot identify which condition, if any, is present. It must be interpreted with symptoms, history and other tests.

Is there a standard clinical test for Kynurenine?

The atlas entries for Kynurenine do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal Kynurenine result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). Kynurenine across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/kynurenine.html
Get OSMF research updates. New biomarker, trial and treatment evidence summaries by email.
Subscribe on Substack

Last reviewed: 2026-06-29 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.