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Interferon-γ (IFN-γ) across conditions

Interferon-γ (IFN-γ) appears in 2 entries of the OSMF biomarker atlas, covering Gulf War Illness, Lyme Disease. Across those entries it is elevated in 2. Because the same marker shifts in several unrelated conditions, it is best understood as a signal of shared biology such as inflammation, vascular or metabolic stress rather than as a condition-specific test. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

Gulf War IllnessLyme Disease

Where Interferon-γ (IFN-γ) is reported

Also listed as: Th1 cytokine

ConditionDirectionCompared againstAssociated symptomsSource
Gulf War Illness↑ elevatedhealthy Gulf War veteran controlsImmune activationMaury & Holton 2024
Lyme Disease↑ elevatedhealthy controlsCell-mediated immune responseLantos et al. 2021

Frequently asked questions

In which conditions is Interferon-γ (IFN-γ) altered?

In the OSMF atlas Interferon-γ (IFN-γ) is reported in Gulf War Illness, Lyme Disease. It is elevated in 2 across 2 entries.

Does Interferon-γ (IFN-γ) point to one specific diagnosis?

No. Because Interferon-γ (IFN-γ) changes in several conditions (Gulf War Illness, Lyme Disease), an abnormal result cannot identify which condition, if any, is present. It must be interpreted with symptoms, history and other tests.

What is the LOINC code for Interferon-γ (IFN-γ)?

Entries in this atlas use LOINC 14477-8. LOINC codes identify the laboratory observation so results can be compared across systems.

Is one abnormal Interferon-γ (IFN-γ) result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). Interferon-γ (IFN-γ) across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/interferon-gamma-ifn-gamma.html
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Last reviewed: 2026-06-29 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.