ESR across conditions

ESR appears in 3 entries of the OSMF biomarker atlas, covering Inflammatory Bowel Disease (Crohn's/UC), Lyme Disease, Rheumatoid Arthritis. Across those entries it is elevated in 2, mixed in 1. Because the same marker shifts in several unrelated conditions, it is best understood as a signal of shared biology such as inflammation, vascular or metabolic stress rather than as a condition-specific test. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

Inflammatory Bowel Disease (Crohn's/UC)Lyme DiseaseRheumatoid Arthritis

Where ESR is reported

Also listed as: ESR (erythrocyte sedimentation rate); Non-specific inflammation

ConditionDirectionCompared againstAssociated symptomsSource
Inflammatory Bowel Disease (Crohn's/UC)↑ elevatedactive IBD vs quiescent/baseline disease—Ondrejčáková et al. 2024
Lyme Disease↕ inconsistenthealthy controlsOften normal in LymeLantos et al. 2021
Rheumatoid Arthritis↑ elevatedRA disease activity marker vs healthy baseline—Inciarte-Mundo et al. 2022

Frequently asked questions

In which conditions is ESR altered?

In the OSMF atlas ESR is reported in Inflammatory Bowel Disease (Crohn's/UC), Lyme Disease, Rheumatoid Arthritis. It is elevated in 2, mixed in 1 across 3 entries.

Does ESR point to one specific diagnosis?

No. Because ESR changes in several conditions (Inflammatory Bowel Disease (Crohn's/UC), Lyme Disease, Rheumatoid Arthritis), an abnormal result cannot identify which condition, if any, is present. It must be interpreted with symptoms, history and other tests.

Is there a standard clinical test for ESR?

The atlas entries for ESR do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal ESR result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). ESR across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/esr.html
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Last reviewed: 2026-07-03 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.