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AST across conditions

AST appears in 2 entries of the OSMF biomarker atlas, covering Hepatitis C, NAFLD / MASH (Metabolic-Associated Steatohepatitis). Across those entries it is elevated in 2. Because the same marker shifts in several unrelated conditions, it is best understood as a signal of shared biology such as inflammation, vascular or metabolic stress rather than as a condition-specific test. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

Hepatitis CNAFLD / MASH (Metabolic-Associated Steatohepatitis)

Where AST is reported

ConditionDirectionCompared againstAssociated symptomsSource
Hepatitis C↑ elevatedchronic HCV (CHC) patients vs healthy controls—Al-Rawaf et al. 2024
NAFLD / MASH (Metabolic-Associated Steatohepatitis)↑ elevatedNAFLD vs without NAFLD—Liu et al. 2023

Frequently asked questions

In which conditions is AST altered?

In the OSMF atlas AST is reported in Hepatitis C, NAFLD / MASH (Metabolic-Associated Steatohepatitis). It is elevated in 2 across 2 entries.

Does AST point to one specific diagnosis?

No. Because AST changes in several conditions (Hepatitis C, NAFLD / MASH (Metabolic-Associated Steatohepatitis)), an abnormal result cannot identify which condition, if any, is present. It must be interpreted with symptoms, history and other tests.

Is there a standard clinical test for AST?

The atlas entries for AST do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal AST result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). AST across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/ast.html
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Last reviewed: 2026-07-03 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.