Summary
| Direction in Lyme Disease | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Co-infection |
| Also described as | Tick-borne encephalitis virus |
| Compared against | Uninfected |
| Associated symptoms | Neurological co-infection |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Swanson et al. 2022 — doi:10.1016/j.ttbdis.2022.101987 |
| Condition atlas | Lyme Disease Biomarker Atlas |
Related Co-infection markers in Lyme Disease
- Ehrlichia / Ehrlichiosis panel ↑
- Babesia microti serology / PCR ↑
- Anaplasma phagocytophilum serology ↑
Full list: Lyme Disease Biomarker Atlas.
Frequently asked questions
Is Powassan virus serology high or low in Lyme Disease?
Elevated. Studies summarised in the OSMF atlas report higher Powassan virus serology in Lyme Disease than in Uninfected. Source: Swanson et al. 2022.
What symptoms is Powassan virus serology associated with in Lyme Disease?
The cited literature associates this marker with Neurological co-infection. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Powassan virus serology?
It is measured as a blood test (serum / plasma / whole blood). Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Powassan virus serology result diagnostic of Lyme Disease?
No. No single biomarker is diagnostic of Lyme Disease. Powassan virus serology findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-29 · Page generated from lyme.json · Browse: Lyme Disease atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.