Summary
| Direction in Lyme Disease | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Serologic |
| Also described as | VlsE invariant region C6 |
| Compared against | Uninfected |
| Associated symptoms | High sensitivity in later stages |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Bacon et al. 2003 — doi:10.1086/376905 |
| Condition atlas | Lyme Disease Biomarker Atlas |
Trials, interventions and tests
Commercial test availability
Lyme C6 Peptide ELISA — commercial laboratory test. LabCorp tickborne profile includes C6 peptide IgG/IgM.
Links are for reference only; availability, specimen requirements and coverage vary by location.
Related Serologic markers in Lyme Disease
- IgM immunoblot (≥2 of 3 bands) ↑
- Anti-VlsE antibodies ↑
- IgG immunoblot (≥5 of 10 bands) ↑
- Anti-OspC antibodies ↑
- B. burgdorferi EIA (screening) ↑
- Anti-OspA antibodies ↑
- Anti-p41 (flagellin) antibodies ↑
- Synovial fluid anti-Bb antibodies ↑
Full list: Lyme Disease Biomarker Atlas.
Frequently asked questions
Is C6 peptide ELISA (VisE) high or low in Lyme Disease?
Elevated. Studies summarised in the OSMF atlas report higher C6 peptide ELISA (VisE) in Lyme Disease than in Uninfected. Source: Bacon et al. 2003.
What symptoms is C6 peptide ELISA (VisE) associated with in Lyme Disease?
The cited literature associates this marker with High sensitivity in later stages. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures C6 peptide ELISA (VisE)?
It is measured as a blood test (serum / plasma / whole blood). Commercial laboratories such as Quest Diagnostics, LabCorp list an orderable assay.
Is one abnormal C6 peptide ELISA (VisE) result diagnostic of Lyme Disease?
No. No single biomarker is diagnostic of Lyme Disease. C6 peptide ELISA (VisE) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-29 · Page generated from lyme.json · Browse: Lyme Disease atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.