Summary
| Direction in Lyme Disease | ↕ Inconsistent — reported as both higher and lower across studies, with no consistent direction |
|---|---|
| Category | Chronic/PTLDS |
| Also described as | Autoimmune neurological |
| Compared against | HC (healthy controls) |
| Associated symptoms | Cognitive, neuropathic symptoms |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Aucott et al. 2014 — doi:10.1016/j.amjmed.2014.02.016 |
| Condition atlas | Lyme Disease Biomarker Atlas |
Related Chronic/PTLDS markers in Lyme Disease
Full list: Lyme Disease Biomarker Atlas.
Frequently asked questions
Is Anti-neuronal antibodies (PTLDS) high or low in Lyme Disease?
Mixed. Some studies report higher and others lower Anti-neuronal antibodies (PTLDS) in Lyme Disease compared with healthy controls, so no single direction is established. Source: Aucott et al. 2014.
What symptoms is Anti-neuronal antibodies (PTLDS) associated with in Lyme Disease?
The cited literature associates this marker with Cognitive, neuropathic symptoms. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Anti-neuronal antibodies (PTLDS)?
It is measured as a blood test (serum / plasma / whole blood). Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Anti-neuronal antibodies (PTLDS) result diagnostic of Lyme Disease?
No. No single biomarker is diagnostic of Lyme Disease. Anti-neuronal antibodies (PTLDS) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-29 · Page generated from lyme.json · Browse: Lyme Disease atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.