Summary
| Direction in Long COVID | ↕ Inconsistent — reported as both higher and lower across studies, with no consistent direction |
|---|---|
| Category | Lipidomic |
| Also described as | 447 lipids profiled |
| Compared against | R (recovered individuals without persistent symptoms) |
| Associated symptoms | Lipidomic discrimination of LC |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Pérez-Mazliah et al. 2024 — doi:10.1021/acs.jproteome.3c00706 |
| Condition atlas | Long COVID Biomarker Atlas |
Related Lipidomic markers in Long COVID
Full list: Long COVID Biomarker Atlas.
Frequently asked questions
Is Sphingolipid species high or low in Long COVID?
Mixed. Some studies report higher and others lower Sphingolipid species in Long COVID compared with recovered individuals without persistent symptoms, so no single direction is established. Source: Pérez-Mazliah et al. 2024.
What symptoms is Sphingolipid species associated with in Long COVID?
The cited literature associates this marker with Lipidomic discrimination of LC. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Sphingolipid species?
It is measured as a blood test (serum / plasma / whole blood). Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Sphingolipid species result diagnostic of Long COVID?
No. No single biomarker is diagnostic of Long COVID. Sphingolipid species findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Cite this page
Subscribe on Substack
Last reviewed: 2026-06-29 · Page generated from long-covid.json · Browse: Long COVID atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.