Summary
| Direction in Long COVID | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Coagulation |
| Also described as | P-selectin, GP IIb/IIIa |
| Compared against | HC (healthy controls) |
| Associated symptoms | Thromboinflammation |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Pretorius et al. 2023 — doi:10.1186/s12933-023-01931-4 |
| Condition atlas | Long COVID Biomarker Atlas |
Trials, interventions and tests
In clinical-trial registrations this marker maps to the outcome term sP selectin (2 registered trials use a matching outcome measure).
Clinical trials using Platelet hyperactivation as an outcome
- NCT05890534: Pycnogenol® in Post-COVID-19 Condition (Completed)
Outcome measure: sP selectin - NCT05795816: Effectiveness of Testofen Compared to Placebo on Long COVID Symptoms (Completed)
Outcome measure: Change in Pathology results via Blood test
Related Coagulation markers in Long COVID
Full list: Long COVID Biomarker Atlas.
Frequently asked questions
Is Platelet hyperactivation high or low in Long COVID?
Elevated. Studies summarised in the OSMF atlas report higher Platelet hyperactivation in Long COVID than in healthy controls. Source: Pretorius et al. 2023.
What symptoms is Platelet hyperactivation associated with in Long COVID?
The cited literature associates this marker with Thromboinflammation. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Platelet hyperactivation?
It is measured as a blood test (serum / plasma / whole blood). Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Platelet hyperactivation result diagnostic of Long COVID?
No. No single biomarker is diagnostic of Long COVID. Platelet hyperactivation findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-29 · Page generated from long-covid.json · Browse: Long COVID atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.