Research Tracker›Biomarker Atlas›Atrial Fibrillation›D-dimer

D-dimer in Atrial Fibrillation

D-dimer belongs to the cardiac group of Atrial Fibrillation markers and is reported to be raised relative to the reference group of the cited comparison (AF vs healthy/non-AF). The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The evidence summarised here comes from Rafaqat et al. 2024 and reflects averages across cohorts rather than any single patient's result.

↑ ElevatedCardiacLOINC 48065-7

Summary

Direction in Atrial Fibrillation↑ Elevated — higher than in the comparison group
CategoryCardiac
Compared againstAF vs healthy/non-AF
Test typeBlood test (serum / plasma / whole blood)
LOINC code48065-7
SourceRafaqat et al. 2024 — doi:10.3390/biomedicines12020274
Condition atlasAtrial Fibrillation Biomarker Atlas

Other conditions where D-dimer is reported

See the cross-condition hub: D-dimer across conditions.

Related Cardiac markers in Atrial Fibrillation

Full list: Atrial Fibrillation Biomarker Atlas.

Frequently asked questions

Is D-dimer high or low in Atrial Fibrillation?

Elevated. Studies summarised in the OSMF atlas report higher D-dimer in Atrial Fibrillation than in the reference group of the cited comparison (AF vs healthy/non-AF). Source: Rafaqat et al. 2024.

Which test measures D-dimer?

It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 48065-7. Many of the cited studies used research-grade assays, so clinical availability may vary.

Is one abnormal D-dimer result diagnostic of Atrial Fibrillation?

No. No single biomarker is diagnostic of Atrial Fibrillation. D-dimer findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Is D-dimer specific to Atrial Fibrillation?

No. The same marker is also reported in Long COVID in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.

Cite this page

Open Source Medicine Foundation. (2026). D-dimer in Atrial Fibrillation: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/atrial-fibrillation/d-dimer.html
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Last reviewed: 2026-07-03 · Page generated from atrial-fibrillation.json · Browse: Atrial Fibrillation atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.