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Toronto Chronic Post-SARS Cohort (Moldofsky)
source record (JSON) · schema v2.0.0 · CC BY 4.0
Design notes & limitations. Deliberately included as a methodologically weak but historically important study: small (22 cases, 7 controls), cross-sectional case-control with a convenience control group, but the first to characterize an ME/CFS/fibromyalgia-like chronic syndrome after a coronavirus — an early precedent for Long COVID.
Identity & trigger
- Cohort id
moldofsky-post-sars- Aliases
- chronic post-SARS syndrome case-control
- Outbreak / event
- SARS outbreak 2003 (Toronto)
- Pathogen
- SARS-CoV-1 (Virus)
- Exposure ascertainment
- clinical diagnosis
Design
- Design
- Case-control
- Denominator defined
- No
- Denominator method
- n/r
- Recruitment
- self referral
- Time zero
- Recovery from acute SARS (assessed 13–36 months later) (month)
- Control group
- Healthy convenience
Size & attrition
- Enrolled
- 29
- Analysed / enrolled
- 29/29 (100%)
- Max follow-up (months)
- 36
Biospecimens
- Specimens
- No
- Types
- none
- Acute-phase specimens
- No
- Biobank
- N/A
- External access
- closed
Observations (1)
Symptoms
measured, not reported Proportion
- Measure
- Fatigue sym:fatigue
- As worded
- “persistent fatigue among post-SARS subjects unable to return to former occupation”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=22
- Timing
- 24 mo (12-24 mo) · ref Not reported
- Method
- Unclear
- Comparator
- no comparator
- Comparability signature
- e70533efa5 — measure sym:fatigue · Unclear · ref Not reported · denom Assessed at timepoint · 12-24 mo · Proportion
- Provenance
- Results (chronic fatigue, myalgia, weakness, depression, non-restorative sleep vs healthy controls) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Moldofsky H, Patcai J (2011). Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. BMC Neurology. PMID 21435231 · DOI 10.1186/1471-2377-11-37 primary
Provenance & verification
- Registration
- n/r
- Funders
- n/r
- Related cohorts
- none
- Symptom-inventory scope
- Single domain
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)