Neglected tropical disease intelligence: burden, top therapeutic hits, and documented
post-infectious syndrome with literature persistence rates. Pathogen: virus.
Documented post-infectious syndrome
Chronic chikungunya arthritis / chronic inflammatory rheumatism
~40%
persistent symptoms — of symptomatic cases
Summary
Persistent arthralgia >=3 months in a pooled ~40% (95% CI 31-49%); cohort range 7-79%; Americas meta-analyses up to 52%.
Timeframe
months to years post-acute
Evidence strength
strong (multiple meta-analyses)
Classification
Post-infectious syndrome
Sources: Rodriguez-Morales 2016 (pooled 40%); Bonifay 2024 Lancet Infect Dis; Paixao 2018 (43% >3 mo); Webb 2024 PLoS Negl Trop Dis (44% chronic)