Biomarker & Intervention Discovery

Metabolic Syndrome

This page lists 10 druggable gene targets and 5 recent clinical trials for Metabolic Syndrome, with each agent ranked by the strength of its evidence (clinical, mechanistic or correlative). Sources are linked so you can check every claim.

Research Tracker Chronic Disease Interventions Metabolic Syndrome

Disease Overview

Spontaneous remission
Not established
Best-intervention remission
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Gap size
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Primary barrier
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Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: Clinical > Mechanistic > Correlative.

ACE 229AGTR1 249IL6 173INSR 256IRS1 16LEPR 6LPL 60PPARG 231PRKAA1 202TNF 277

ACE

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
SALVIANOLIC ACID B ? unclear Mechanistic DGIdb
CANDOXATRIL ? unclear Mechanistic DGIdb
CILAZAPRIL ↓ inhibits Mechanistic DGIdb
TP0556351 ↓ inhibits Mechanistic DGIdb
PRAVASTATIN SODIUM ? unclear Mechanistic DGIdb
SILDENAFIL ? unclear Mechanistic DGIdb
GEMFIBROZIL ? unclear Mechanistic DGIdb
RESCINNAMINE ? unclear Mechanistic DGIdb
SPIRAPRIL ? unclear Mechanistic DGIdb
INDOMETHACIN ? unclear Mechanistic DGIdb
HYDROCHLOROTHIAZIDE ? unclear Mechanistic DGIdb
ARGIPRESSIN ? unclear Mechanistic DGIdb
METOPROLOL ? unclear Mechanistic DGIdb
DELAPRIL ↓ inhibits Mechanistic DGIdb
ACETYLCHOLINE ? unclear Mechanistic DGIdb
THERAPEUTIC GLUCOCORTICOID ? unclear Mechanistic DGIdb
IMIDAPRIL ↓ inhibits Mechanistic DGIdb
MALATHION ↓ inhibits Mechanistic DGIdb
MOEXIPRIL ? unclear Mechanistic 56.0 nM (IC50) DGIdb
VORINOSTAT ? unclear Mechanistic DGIdb
ILEPATRIL ↓ inhibits Mechanistic DGIdb
RXP470.1 ↓ inhibits Mechanistic DGIdb
CGS-27023A ? unclear Mechanistic DGIdb
NITROPRUSSIDE ? unclear Mechanistic DGIdb
ENALAPRILAT ANHYDROUS ↓ inhibits Mechanistic 1.2 nM (IC50) DGIdb
TORSEMIDE ? unclear Mechanistic DGIdb
ATORVASTATIN CALCIUM TRIHYDRATE ? unclear Mechanistic DGIdb
FOSINOPRIL ? unclear Mechanistic DGIdb
FUROSEMIDE ? unclear Mechanistic DGIdb
TEMOCAPRIL HYDROCHLORIDE ? unclear Mechanistic DGIdb
BENAZEPRIL HYDROCHLORIDE ↓ inhibits Mechanistic DGIdb
CARBARIL ↓ inhibits Mechanistic DGIdb
BUPROPION HYDROCHLORIDE ? unclear Mechanistic DGIdb
QUINAPRIL ? unclear Mechanistic 8.3 nM (IC50) DGIdb
COMPOUND 1 [PMID: 24900526] ↓ inhibits Mechanistic DGIdb
COMPOUND 20 [PMID: 22153340] ↓ inhibits Mechanistic DGIdb
BUMETANIDE ? unclear Mechanistic DGIdb
GALLOPAMIL ? unclear Mechanistic DGIdb
FLUOXETINE HYDROCHLORIDE ? unclear Mechanistic DGIdb
AZD6605 ↓ inhibits Mechanistic DGIdb

Showing top 40 of 229 agents ranked by evidence tier.

AGTR1

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
CANDESARTAN CILEXETIL ↓ inhibits Mechanistic DGIdb
CHEMBL:CHEMBL586135 ? unclear Mechanistic DGIdb
VALSARTAN ↓ inhibits Mechanistic 4700.0 nM (Ki) DGIdb
EPROSARTAN MESYLATE ↓ inhibits Mechanistic DGIdb
FIMASARTAN ↓ inhibits Mechanistic DGIdb
ASCORBIC ACID ? unclear Mechanistic DGIdb
OLMESARTAN MEDOXOMIL ↓ inhibits Mechanistic DGIdb
AZILSARTAN MEDOXOMIL ↓ inhibits Mechanistic DGIdb
THERAPEUTIC ANDROSTANOLONE ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL347610 ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL421088 ? unclear Mechanistic DGIdb
LOSARTAN POTASSIUM ↓ inhibits Mechanistic 5.5 nM (IC50) DGIdb
CHEMBL:CHEMBL1492017 ? unclear Mechanistic DGIdb
SPARSENTAN ↓ inhibits Mechanistic DGIdb
SODIUM CHLORIDE ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL261693 ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL1972216 ? unclear Mechanistic DGIdb
EPROSARTAN ? unclear Mechanistic 7.3 nM (IC50) DGIdb
C-FOS ANTISENSE ? unclear Mechanistic DGIdb
SARALASIN ACETATE ↓ inhibits Mechanistic DGIdb
IRBESARTAN ↓ inhibits Mechanistic 1.1 nM (Ki) DGIdb
DISULFIRAM ? unclear Mechanistic DGIdb
SAPRISARTAN ? unclear Mechanistic DGIdb
H2O2 ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL591834 ? unclear Mechanistic DGIdb
CAPTOPRIL ? unclear Mechanistic DGIdb
ANGIOTENSIN II ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL400912 ? unclear Mechanistic DGIdb
ATORVASTATIN CALCIUM TRIHYDRATE ? unclear Mechanistic DGIdb
IDOXIFENE ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL528694 ? unclear Mechanistic DGIdb
IL-6 ? unclear Mechanistic DGIdb
ANGIOTENSIN II ACETATE ↑ activates Mechanistic DGIdb
LEVODOPA ? unclear Mechanistic DGIdb
GAMMA-INTERFERON ? unclear Mechanistic DGIdb
AZILSARTAN KAMEDOXOMIL ↓ inhibits Mechanistic DGIdb
HYDROCHLOROTHIAZIDE ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL1445650 ? unclear Mechanistic DGIdb
MUSCLE RELAXANT ? unclear Mechanistic DGIdb
CL-329167 ? unclear Mechanistic DGIdb

Showing top 40 of 249 agents ranked by evidence tier.

IL6

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
CISPLATIN ? unclear Mechanistic DGIdb
ZILTIVEKIMAB ~ modulates Mechanistic DGIdb
CHINESE HERBS ? unclear Mechanistic DGIdb
PF-04236921 ↓ inhibits Mechanistic DGIdb
MRA 003 US ↓ inhibits Mechanistic DGIdb
SIGNAL TRANSDUCTION INHIBITOR ? unclear Mechanistic DGIdb
BINETRAKIN ? unclear Mechanistic DGIdb
IBUDILAST ? unclear Mechanistic DGIdb
INSULIN, REGULAR, HUMAN ? unclear Mechanistic DGIdb
SILTUXIMAB ↓ inhibits Mechanistic DGIdb
METRONIDAZOLE ? unclear Mechanistic DGIdb
CLAZAKIZUMAB ↓ inhibits Mechanistic DGIdb
GALLIUM NITRATE ? unclear Mechanistic DGIdb
INTERFERON ALFA-2B ? unclear Mechanistic DGIdb
DULOXETINE HYDROCHLORIDE ? unclear Mechanistic DGIdb
MEDI-5117 ↓ inhibits Mechanistic DGIdb
GEMFIBROZIL ? unclear Mechanistic DGIdb
BIAFINE CREAM ? unclear Mechanistic DGIdb
ETANERCEPT ? unclear Mechanistic DGIdb
ELSILIMOMAB ↓ inhibits Mechanistic DGIdb
SAQUINAVIR ? unclear Mechanistic DGIdb
INFLIXIMAB ? unclear Mechanistic DGIdb
LINEZOLID ? unclear Mechanistic DGIdb
IFOSFAMIDE ? unclear Mechanistic DGIdb
OLOKIZUMAB ↓ inhibits Mechanistic DGIdb
HMG-COA REDUCTASE INHIBITOR ? unclear Mechanistic DGIdb
MIDOSTAURIN ? unclear Mechanistic DGIdb
SELENIUM ? unclear Mechanistic DGIdb
SIRUKUMAB ↓ inhibits Mechanistic DGIdb
PEGINTERFERON ALFA-2B ? unclear Mechanistic DGIdb
ECHINACEA PREPARATION ? unclear Mechanistic DGIdb
ENZYME INHIBITOR ? unclear Mechanistic DGIdb
FENOFIBRATE MICRONIZED ? unclear Mechanistic DGIdb
VITAMIN K ? unclear Mechanistic DGIdb
PEGINTERFERON ALFA-2A ? unclear Mechanistic DGIdb
RIBAVIRIN ? unclear Mechanistic DGIdb
VITAMIN A PALMITATE ? unclear Mechanistic DGIdb
ARSENIC TRIOXIDE ? unclear Mechanistic DGIdb
DIHYDROSPHINGOSINE ? unclear Mechanistic DGIdb
LEVOFLOXACIN ANHYDROUS ? unclear Mechanistic DGIdb

Showing top 40 of 173 agents ranked by evidence tier.

INSR

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
TESOFENSINE ? unclear Mechanistic DGIdb
INSULIN SUSP ISOPHANE SEMISYNTHETIC PURIFIED HUMAN ↑ activates Mechanistic DGIdb
GO-6976 ? unclear Mechanistic DGIdb
INSULIN ZINC, PROMPT ↑ activates Mechanistic DGIdb
INSULIN PURIFIED PORK ↑ activates Mechanistic DGIdb
INSULIN ZINC SUSP EXTENDED PURIFIED BEEF ↑ activates Mechanistic DGIdb
INSULIN ZINC, EXTENDED ↑ activates Mechanistic DGIdb
INSULIN ZINC SUSP EXTENDED BEEF ↑ activates Mechanistic DGIdb
INSULIN ZINC SUSP BEEF ↑ activates Mechanistic DGIdb
INSULIN SENSITIZER S-707106 ? unclear Mechanistic DGIdb
SP-600125 ? unclear Mechanistic DGIdb
CYCLOPHOSPHAMIDE ANHYDROUS ? unclear Mechanistic DGIdb
INSULIN DETEMIR ↑ activates Mechanistic DGIdb
INSULIN DEGLUDEC ↑ activates Mechanistic DGIdb
AEW-541 ? unclear Mechanistic 2300.0 nM (IC50) DGIdb
ILORASERTIB ? unclear Mechanistic DGIdb
NVP-TAE684 ? unclear Mechanistic DGIdb
INSULIN ASPART PROTAMINE RECOMBINANT ↑ activates Mechanistic DGIdb
INSULIN SUSP PROTAMINE ZINC PURIFIED BEEF ↑ activates Mechanistic DGIdb
INSULIN, PROTAMINE ZINC ↑ activates Mechanistic DGIdb
INSULIN TREGOPIL ↑ activates Mechanistic DGIdb
INSULIN, REGULAR, HUMAN ↑ activates Mechanistic DGIdb
PF-562271 ? unclear Mechanistic DGIdb
INSULIN SUSP PROTAMINE ZINC PURIFIED PORK ↑ activates Mechanistic DGIdb
RECOMBINANT HUMAN KALLIKREIN-1 ? unclear Mechanistic DGIdb
LINIFANIB ? unclear Mechanistic DGIdb
INSULIN [INJECTION], BIPHASIC ↑ activates Mechanistic DGIdb
INSULIN HUMAN, ISOPHANE ↑ activates Mechanistic DGIdb
INSULIN SUSP ISOPHANE PURIFIED PORK ↑ activates Mechanistic DGIdb
INSULIN ZINC SUSP PURIFIED PORK ↑ activates Mechanistic DGIdb
RG-1530 ? unclear Mechanistic DGIdb
EPIRUBICIN ? unclear Mechanistic DGIdb
INSULIN ASPART PROTAMINE, HUMAN ↑ activates Mechanistic DGIdb
TOZASERTIB ? unclear Mechanistic 506.0 nM (Kd) DGIdb
TOPIRAMATE ? unclear Mechanistic DGIdb
LINSITINIB ↓ inhibits Mechanistic DGIdb
INSULIN LISPRO ↑ activates Mechanistic DGIdb
INSULIN LISPRO PROTAMINE RECOMBINANT ↑ activates Mechanistic DGIdb
INSULIN SUSP ISOPHANE BEEF/PORK ↑ activates Mechanistic DGIdb
MITOGLITAZONE ? unclear Mechanistic DGIdb

Showing top 40 of 256 agents ranked by evidence tier.

IRS1

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
AGANIRSEN ? unclear Mechanistic DGIdb
CYCLOPHOSPHAMIDE ANHYDROUS ? unclear Mechanistic DGIdb
FLUOROURACIL ? unclear Mechanistic DGIdb
DEHYDRATED ALCOHOL ? unclear Mechanistic DGIdb
PRASTERONE ? unclear Mechanistic DGIdb
EPIRUBICIN ? unclear Mechanistic DGIdb
INOSITOL ? unclear Mechanistic DGIdb
GLIMEPIRIDE ? unclear Mechanistic DGIdb
CHEMBL1685056 ↓ inhibits Mechanistic 50.0 nM (Kd) ChEMBL
CHEMBL1685055 ↓ inhibits Mechanistic 150.0 nM (Kd) ChEMBL
CHEMBL1681823 ↓ inhibits Mechanistic 50.0 nM (Kd) ChEMBL
CHEMBL4536878 ↓ inhibits Mechanistic 120.0 nM (Kd) ChEMBL
CHEMBL4591779 ↓ inhibits Mechanistic 16200.0 nM (Kd) ChEMBL
CHEMBL4530453 ↓ inhibits Mechanistic 1600.0 nM (Kd) ChEMBL
CHEMBL1572640 ↓ inhibits Mechanistic 3300.0 nM (Kd) ChEMBL
CHEMBL4576057 ↓ inhibits Mechanistic 16400.0 nM (Kd) ChEMBL

LEPR

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
MIBAVADEMAB ↑ activates Mechanistic DGIdb
SIMVASTATIN ? unclear Mechanistic DGIdb
VALPROIC ACID ? unclear Mechanistic DGIdb
METRELEPTIN ↑ activates Mechanistic DGIdb
ATORVASTATIN CALCIUM TRIHYDRATE ? unclear Mechanistic DGIdb
SETMELANOTIDE ? unclear Mechanistic DGIdb

LPL

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
INOSITOL ? unclear Mechanistic DGIdb
DEXTRAN SULFATE ? unclear Mechanistic DGIdb
ASPARAGINASE ? unclear Mechanistic DGIdb
RETINYL ACETATE ? unclear Mechanistic DGIdb
RECOMBINANT INTERLEUKIN ? unclear Mechanistic DGIdb
ANABOLIC STEROID ? unclear Mechanistic DGIdb
OXIDOPAMINE ? unclear Mechanistic DGIdb
ISOTRETINOIN ? unclear Mechanistic DGIdb
FOLIC ACID ? unclear Mechanistic DGIdb
LYMPHOKINE-ACTIVATED KILLER CELLS ? unclear Mechanistic DGIdb
MIFEPRISTONE ? unclear Mechanistic DGIdb
ACARBOSE ? unclear Mechanistic DGIdb
H2O2 ? unclear Mechanistic DGIdb
GEMFIBROZIL ? unclear Mechanistic DGIdb
RECOMBINANT LYMPHOKINE ? unclear Mechanistic DGIdb
CLOFIBRATE ? unclear Mechanistic DGIdb
TRIAMCINOLONE ? unclear Mechanistic DGIdb
ADRIAMYCIN ? unclear Mechanistic DGIdb
LABETALOL ? unclear Mechanistic DGIdb
LOVASTATIN ? unclear Mechanistic DGIdb
INSULIN, REGULAR, HUMAN ? unclear Mechanistic DGIdb
DIAZOXIDE ? unclear Mechanistic DGIdb
PIOGLITAZONE HYDROCHLORIDE ? unclear Mechanistic DGIdb
PRAVASTATIN SODIUM ? unclear Mechanistic DGIdb
RESERPINE ? unclear Mechanistic DGIdb
ORLISTAT ? unclear Mechanistic 66.0 nM (IC50) DGIdb
NADOLOL ? unclear Mechanistic DGIdb
IBROLIPIM ? unclear Mechanistic DGIdb
CHEMBL339297 ↓ inhibits Mechanistic 200.0 nM (IC50) ChEMBL
TOLYL BORONIC ACID ↓ inhibits Mechanistic 9000.0 nM (IC50) ChEMBL
CHEMBL1952294 ↓ inhibits Mechanistic 9000.0 nM (IC50) ChEMBL
CHEMBL1952295 ↓ inhibits Mechanistic 8000.0 nM (IC50) ChEMBL
CHEMBL1952296 ↓ inhibits Mechanistic 15000.0 nM (IC50) ChEMBL
CHEMBL1952297 ↓ inhibits Mechanistic 30000.0 nM (IC50) ChEMBL
CHEMBL485946 ↓ inhibits Mechanistic 42000.0 nM (IC50) ChEMBL
CHEMBL1952298 ↓ inhibits Mechanistic 50000.0 nM (IC50) ChEMBL
CHEMBL1952299 ↓ inhibits Mechanistic 50000.0 nM (IC50) ChEMBL
CHEMBL1952302 ↓ inhibits Mechanistic 25000.0 nM (IC50) ChEMBL
CHEMBL1952303 ↓ inhibits Mechanistic 50000.0 nM (IC50) ChEMBL
CHEMBL1952304 ↓ inhibits Mechanistic 55000.0 nM (IC50) ChEMBL

Showing top 40 of 60 agents ranked by evidence tier.

PPARG

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
METHOXYCHLOR ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL2208197 ? unclear Mechanistic DGIdb
PROPYLPYRAZOLETRIOL ? unclear Mechanistic DGIdb
LANIFIBRANOR ↑ activates Mechanistic DGIdb
PROPYLPARABEN ? unclear Mechanistic DGIdb
ABIETIC ACID ? unclear Mechanistic DGIdb
KEPONE ? unclear Mechanistic DGIdb
SPIRONOLACTONE ? unclear Mechanistic DGIdb
FLUOXASTROBIN ? unclear Mechanistic DGIdb
ROSIGLITAZONE MALEATE ↑ activates Mechanistic DGIdb
CHEMBL:CHEMBL2178583 ? unclear Mechanistic DGIdb
NAVEGLITAZAR ↑ activates Mechanistic DGIdb
CELECOXIB ? unclear Mechanistic DGIdb
SHINPTEROCARPIN ? unclear Mechanistic DGIdb
PSAMMAPLIN A ? unclear Mechanistic DGIdb
TECNAZENE ? unclear Mechanistic DGIdb
MYCOPHENOLATE ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL1833984 ? unclear Mechanistic DGIdb
IMIGLITAZAR ↑ activates Mechanistic DGIdb
ROSIGLITAZONE ? unclear Mechanistic 250.0 nM (IC50) DGIdb
CLX-0921 ↑ activates Mechanistic DGIdb
AVE0847 ↑ activates Mechanistic DGIdb
CHLORFENAPYR ? unclear Mechanistic DGIdb
PIOGLITAZONE HYDROCHLORIDE ↑ activates Mechanistic DGIdb
PROCHLORAZ ? unclear Mechanistic DGIdb
MESALAMINE ↑ activates Mechanistic DGIdb
BEZAFIBRATE ↑ activates Mechanistic DGIdb
CHEMBL:CHEMBL312032 ? unclear Mechanistic DGIdb
ISOSILYBIN A ? unclear Mechanistic DGIdb
AMORFRUTIN A ? unclear Mechanistic DGIdb
NALED ? unclear Mechanistic DGIdb
TROGLITAZONE ↑ activates Mechanistic 302.0 nM (Ki) DGIdb
PROSTAGLANDIN D2 ? unclear Mechanistic DGIdb
INT131 ~ modulates Mechanistic DGIdb
EFATUTAZONE HYDROCHLORIDE ↑ activates Mechanistic DGIdb
FLUORODIFEN ? unclear Mechanistic DGIdb
FLUDIOXONIL ? unclear Mechanistic DGIdb
ESTRADIOL VALERATE ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL166112 ? unclear Mechanistic DGIdb
BENSULIDE ? unclear Mechanistic DGIdb

Showing top 40 of 231 agents ranked by evidence tier.

PRKAA1

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
GW441756X ? unclear Mechanistic DGIdb
PD-0166285 ? unclear Mechanistic 316.23 nM (Ki) DGIdb
CENISERTIB ? unclear Mechanistic DGIdb
CYC-116 ? unclear Mechanistic 501.19 nM (Ki) DGIdb
PENTOSTATIN ? unclear Mechanistic DGIdb
PALBOCICLIB ? unclear Mechanistic DGIdb
JNJ-7706621 ? unclear Mechanistic 1700.0 nM (Kd) DGIdb
PF-562271 ? unclear Mechanistic DGIdb
TOZASERTIB ? unclear Mechanistic 1100.0 nM (Kd) DGIdb
STREPTOZOCIN ? unclear Mechanistic DGIdb
DOVITINIB ? unclear Mechanistic 520.0 nM (Kd) DGIdb
TYROSINE KINASE INHIBITOR ? unclear Mechanistic DGIdb
METFORMIN ? unclear Mechanistic DGIdb
RG-1530 ? unclear Mechanistic DGIdb
LY-2090314 ? unclear Mechanistic 630.96 nM (Ki) DGIdb
ADENOSINE DEAMINASE INHIBITOR ? unclear Mechanistic DGIdb
SAPONARIN ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL587615 ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL1997335 ? unclear Mechanistic DGIdb
ENTRECTINIB ? unclear Mechanistic 251.19 nM (Ki) DGIdb
SIROLIMUS ? unclear Mechanistic DGIdb
ILORASERTIB ? unclear Mechanistic DGIdb
TETRADECANOYLPHORBOL ACETATE ? unclear Mechanistic DGIdb
CHEMBL:CHEMBL379975 ? unclear Mechanistic DGIdb
HESPERADIN ↓ inhibits Mechanistic 19.0 nM (Kd) DGIdb
PHENFORMIN ? unclear Mechanistic DGIdb
THYROXINE ? unclear Mechanistic DGIdb
ACADESINE ↑ activates Mechanistic DGIdb
CHEMOPREVENTIVE AGENT ? unclear Mechanistic DGIdb
SOTRASTAURIN ? unclear Mechanistic 630.96 nM (Ki) DGIdb
NVP-TAE684 ? unclear Mechanistic DGIdb
METFORMIN HYDROCHLORIDE ↑ activates Mechanistic DGIdb
SUNITINIB ↓ inhibits Mechanistic 52.0 nM (Kd) ChEMBL
ALVOCIDIB ↓ inhibits Mechanistic 6600.0 nM (Kd) ChEMBL
STAUROSPORINE ↓ inhibits Mechanistic 9.0 nM (Kd) ChEMBL
VANDETANIB ↓ inhibits Mechanistic 10000.0 nM (Kd) ChEMBL
AST-487 ↓ inhibits Mechanistic 1400.0 nM (Kd) ChEMBL
RAF-265 ↓ inhibits Mechanistic 4500.0 nM (Kd) ChEMBL
MIDOSTAURIN ↓ inhibits Mechanistic 180.0 nM (Kd) ChEMBL
SU-014813 ↓ inhibits Mechanistic 100.0 nM (Kd) ChEMBL

Showing top 40 of 202 agents ranked by evidence tier.

TNF

UniProt Ensembl DGIdb Open Targets
Therapeutic Agent Effect Direction Evidence Tier Potency Source
NERELIMOMAB ↓ inhibits Mechanistic DGIdb
CROMOLYN SODIUM ? unclear Mechanistic DGIdb
PLACULUMAB ↓ inhibits Mechanistic DGIdb
METHYLENE BLUE ? unclear Mechanistic DGIdb
ALTEPLASE ? unclear Mechanistic DGIdb
CARBOPLATIN ? unclear Mechanistic DGIdb
GENTAMICIN ? unclear Mechanistic DGIdb
GOLIMUMAB ↓ inhibits Mechanistic DGIdb
BUPIVACAINE ? unclear Mechanistic DGIdb
PENTOXIFYLLINE ? unclear Mechanistic 85000.0 nM (IC50) DGIdb
BENZO[E]PYRENE ? unclear Mechanistic DGIdb
THALIDOMIDE ? unclear Mechanistic DGIdb
PYRAZINAMIDE ? unclear Mechanistic DGIdb
GLIMEPIRIDE ? unclear Mechanistic DGIdb
OMEPRAZOLE ? unclear Mechanistic DGIdb
LENERCEPT ↓ inhibits Mechanistic DGIdb
ADALIMUMAB ↓ inhibits Mechanistic DGIdb
PRAZOSIN HYDROCHLORIDE ? unclear Mechanistic DGIdb
REMTOLUMAB ? unclear Mechanistic DGIdb
MIDOSTAURIN ? unclear Mechanistic DGIdb
LENABASUM ? unclear Mechanistic DGIdb
MAGNESIUM SULFATE ANHYDROUS ? unclear Mechanistic DGIdb
PICIBANIL ? unclear Mechanistic DGIdb
FLUOCINOLONE ACETONIDE ? unclear Mechanistic DGIdb
MILTEFOSINE ? unclear Mechanistic DGIdb
HOMIDIUM BROMIDE ? unclear Mechanistic DGIdb
OZORALIZUMAB ↓ inhibits Mechanistic DGIdb
PEGSUNERCEPT ↓ inhibits Mechanistic DGIdb
CERTOLIZUMAB PEGOL ↓ inhibits Mechanistic DGIdb
THERAPEUTIC HORMONE ? unclear Mechanistic DGIdb
NAFAMOSTAT ? unclear Mechanistic DGIdb
FOLIC ACID ? unclear Mechanistic DGIdb
ABBV-257 ? unclear Mechanistic DGIdb
RISPERIDONE ? unclear Mechanistic DGIdb
COVA322 ? unclear Mechanistic DGIdb
HYDROXYCHLOROQUINE ? unclear Mechanistic DGIdb
CERTOLIZUMAB ? unclear Mechanistic DGIdb
AN0128 ? unclear Mechanistic DGIdb
5,7-DIHYDROXY-4-METHYLCOUMARIN ? unclear Mechanistic DGIdb
SORAFENIB ? unclear Mechanistic DGIdb

Showing top 40 of 277 agents ranked by evidence tier.

Clinical Trials

Drug, biologic and supplement trials (treatment or prevention) from ClinicalTrials.gov whose main condition is Metabolic Syndrome: recruiting, active or completed, most recently updated first. Data retrieved 2026-10-28.

Effects of Peppermint Oil in Pre-metabolic Syndrome Completed
NCT07815899 Phase: N/A Started: 2025-01-01

Cardiovascular and metabolic diseases are leading causes of morbidity and mortality worldwide; therefore, the development of effective preventive interventions is paramount. Pre-metabolic syndrome, characterised by the presence of cardiometabolic risk factors without meeting the full diagnostic crit...

Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity Completed
NCT04519164 Phase: 4 Started: 2020-12-01

This study will evaluate whether the mineralocorticoid receptor antagonist eplerenone, when compared to chlorthalidone plus potassium chloride, can improve cardiac MRI-derived myocardial perfusion reserve and fibrosis, independent of blood pressure, and proportionately to the severity of autonomous ...

Effects of Oral Fruit Concentrate Supplementation in Pre-Metabolic Syndrome. Completed
NCT07815847 Phase: N/A Started: 2021-05-01

Cardiovascular disease, type 2 diabetes mellitus and associated metabolic diseases are leading causes of morbidity and mortality worldwide; therefore, effective preventive interventions are required. Pre-metabolic syndrome, characterised by the presence of two metabolic syndrome components, represen...

Effects of Quercetin on Cardiometabolic Outcomes Recruiting
NCT06230861 Phase: N/A Started: 2024-03-01

Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. Dietary interventions to improve cardiometabolic health are highly sought after as they possess...

Effects of Cornelian Cherry Supplementation in Patients With Metabolic Syndrome Completed
NCT07739602 Phase: N/A Started: 2019-01-17

This randomized, double-blind, placebo-controlled, parallel-group study evaluated the effects of six-month oral supplementation with Cornus mas fruit lyophilizate in patients with metabolic syndrome. Participants were assigned to receive either 8 g of Cornus mas fruit lyophilizate once daily or a ma...

Agents Found By Disease-Level Search

Searched directly from “Metabolic Syndrome” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 10-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."