Summary
| Direction in Lyme Disease | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | CSF |
| Also described as | Intrathecal antibody production |
| Compared against | Serum/CSF ratio |
| Associated symptoms | Neuroborreliosis confirmation |
| Test type | Tissue / pathology test |
| Source | Lantos et al. 2021 — doi:10.1016/j.idc.2021.05.001 |
| Condition atlas | Lyme Disease Biomarker Atlas |
Related CSF markers in Lyme Disease
- CSF CXCL13 ↑
- CSF lymphocytic pleocytosis ↑
- CSF protein elevation ↑
- CSF oligoclonal bands ↕
- CSF glucose ↕
Full list: Lyme Disease Biomarker Atlas.
Frequently asked questions
Is CSF anti-Bb antibody index high or low in Lyme Disease?
Elevated. Studies summarised in the OSMF atlas report higher CSF anti-Bb antibody index in Lyme Disease than in Serum/CSF ratio. Source: Lantos et al. 2021.
What symptoms is CSF anti-Bb antibody index associated with in Lyme Disease?
The cited literature associates this marker with Neuroborreliosis confirmation. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures CSF anti-Bb antibody index?
It is measured as a tissue / pathology test. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal CSF anti-Bb antibody index result diagnostic of Lyme Disease?
No. No single biomarker is diagnostic of Lyme Disease. CSF anti-Bb antibody index findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-29 · Page generated from lyme.json · Browse: Lyme Disease atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.