Summary
| Direction in Lyme Disease | ↕ Inconsistent — reported as both higher and lower across studies, with no consistent direction |
|---|---|
| Category | Molecular |
| Also described as | Lyme arthritis molecular |
| Compared against | Non-Lyme joint fluid |
| Associated symptoms | Persistent Lyme arthritis |
| Test type | Clinical or physiological test |
| Source | Lantos et al. 2021 — doi:10.1016/j.idc.2021.05.001 |
| Condition atlas | Lyme Disease Biomarker Atlas |
Related Molecular markers in Lyme Disease
Full list: Lyme Disease Biomarker Atlas.
Frequently asked questions
Is Anti-Bb IgG (synovial PCR) high or low in Lyme Disease?
Mixed. Some studies report higher and others lower Anti-Bb IgG (synovial PCR) in Lyme Disease compared with Non-Lyme joint fluid, so no single direction is established. Source: Lantos et al. 2021.
What symptoms is Anti-Bb IgG (synovial PCR) associated with in Lyme Disease?
The cited literature associates this marker with Persistent Lyme arthritis. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Anti-Bb IgG (synovial PCR)?
It is measured as a clinical or physiological test. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Anti-Bb IgG (synovial PCR) result diagnostic of Lyme Disease?
No. No single biomarker is diagnostic of Lyme Disease. Anti-Bb IgG (synovial PCR) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-06-29 · Page generated from lyme.json · Browse: Lyme Disease atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.