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Sejvar West Nile Neuroinvasive Disease Cohort
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Design notes & limitations. Small prospective inception cohort of confirmed neuroinvasive disease with structured serial assessment to 90 days. Short follow-up and no control group; captures acute-to-subacute neurological recovery.
Identity & trigger
- Cohort id
sejvar-wnv-neuroinvasive- Aliases
- WNV neuroinvasive prospective cohort
- Outbreak / event
- n/r
- Pathogen
- West Nile virus (Virus)
- Exposure ascertainment
- serology
Design
- Design
- Prospective (inception)
- Denominator defined
- Yes
- Denominator method
- Patients with West Nile virus neuroinvasive disease confirmed by CSF IgM, enrolled during acute illness.
- Recruitment
- hospital
- Time zero
- Acute West Nile neuroinvasive disease presentation (week)
- Control group
- None
Size & attrition
- Enrolled
- 55
- Analysed / enrolled
- 55/55 (100%)
- Max follow-up (months)
- 3
Biospecimens
- Specimens
- Yes
- Types
- serum, csf
- Acute-phase specimens
- Yes
- Biobank
- Unknown
- External access
- Unknown
Observations (1)
Functional outcomes
49% Proportion
- Measure
- Any persistent symptom func:any-persistent-symptom
- As worded
- “limb weakness at initial clinical presentation”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=55
- Timing
- 0 mo (Acute) · ref Not reported
- Method
- Unclear
- Comparator
- no comparator
- Comparability signature
- 8782bfb51f — measure func:any-persistent-symptom · Unclear · ref Not reported · denom Assessed at timepoint · Acute · Proportion
- Provenance
- Results (49% weakness, 35% tremor, 16% cranial neuropathy at presentation) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Sejvar JJ, et al. (2014). West Nile virus neuroinvasive disease: neurological manifestations and prospective longitudinal outcomes. BMC Infectious Diseases. PMID 24884681 primary
Provenance & verification
- Registration
- NCT00138463
- Funders
- National Institutes of Health (USA)
- Related cohorts
- none
- Symptom-inventory scope
- Targeted panel
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)