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DecodeME ME/CFS GWAS
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Flags: preprint not peer-reviewed — read the observations and design fields with these caveats in mind.
Design notes & limitations. The largest ME/CFS genome-wide association study (15,579 cases). Included as the anchor host-genetic susceptibility cohort for an idiopathic syndrome: eight genome-wide signals, of which four (RABGAP1L, FBXL4, OLFM4, CA10) replicated in independent post-exertional-malaise/fatigue samples. Genetic factors are temporality-valid by construction (fixed at conception). Initial findings are a 2025 preprint — flagged accordingly.
Identity & trigger
- Cohort id
decodeme-mecfs-gwas- Aliases
- DecodeME genome-wide association study
- Outbreak / event
- n/r
- Pathogen
- Unknown / idiopathic trigger (Unknown)
- Exposure ascertainment
- not reported
Design
- Design
- Registry linkage
- Denominator defined
- Yes
- Denominator method
- Genotyped case-control sample: 15,579 people with ME/CFS vs 259,909 population controls of European descent, recruited via a dedicated UK study plus biobank linkage (UK Biobank, Lifelines).
- Recruitment
- population registry
- Time zero
- Germline genotype (fixed at conception); ME/CFS caseness ascertained cross-sectionally (undefined)
- Control group
- Unexposed (unmatched)
Size & attrition
- Enrolled
- 15579
- Analysed / enrolled
- 15579/15579 (100%)
- Max follow-up (months)
- n/r
Biospecimens
- Specimens
- Yes
- Types
- saliva
- Acute-phase specimens
- No
- Biobank
- active
- External access
- collaboration only
Harmonized estimate layer
Curation status: none · 0 estimate(s). Download core estimates
Observations (0)
No observations recorded yet — contributions welcome via pull request.
Publications
- DecodeME Collaboration. (2025). Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome. medRxiv (preprint). DOI 10.1101/2025.08.06.25333109 preprint primary
Provenance & verification
- Registration
- n/r
- Funders
- Medical Research Council (UK), National Institute for Health and Care Research (NIHR)
- Related cohorts
- uk-me-cfs-biobank (Sibling analysis), nih-intramural-me-cfs-2024 (Sibling analysis)
- Symptom-inventory scope
- None
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)