{
  "key": "pacvs",
  "year": 2026,
  "condition": "Post-Acute COVID-19 Vaccination Syndrome (PACVS)",
  "short": "PACVS",
  "generated_at": "2026-10-07T23:43:14+00:00",
  "snapshot": {
    "feed_last_updated": "2026-10-07",
    "feed_file_mtime": "2026-10-07",
    "trials_last_run": "2026-10-07",
    "agents_last_updated": "2026-10-07",
    "biomarkers_date_modified": "2026-06-30",
    "cohorts_version": "2.0.0-seed"
  },
  "literature": {
    "feed_total": 15,
    "feed_range": [
      "2026-04-17",
      "2026-09-24"
    ],
    "undated": 0,
    "in_year": 15,
    "unique_pmids": 15,
    "month_precision_only": 0,
    "by_month": [
      0,
      0,
      0,
      2,
      1,
      4,
      3,
      2,
      3,
      0,
      0,
      0
    ],
    "top_journals": [
      [
        "Scientific reports",
        2
      ],
      [
        "Diseases (Basel, Switzerland)",
        1
      ],
      [
        "Frontiers in public health",
        1
      ],
      [
        "Cureus",
        1
      ],
      [
        "Public health",
        1
      ],
      [
        "Pediatrics and neonatology",
        1
      ],
      [
        "World journal of nephrology",
        1
      ],
      [
        "Viruses",
        1
      ],
      [
        "European journal of translational myology",
        1
      ],
      [
        "World journal of transplantation",
        1
      ]
    ],
    "journal_count": 14,
    "feed_source": "PubMed (NCBI)"
  },
  "trials": {
    "total": 2,
    "mapped": 0,
    "keyword": 2,
    "all_tracked": 629,
    "match_labels": [],
    "match_keywords": [
      "\\bpacvs\\b",
      "post[- ]?vac",
      "vaccin\\w*\\s+(injur|syndrome|adverse|sequel)",
      "post-vaccination"
    ],
    "by_status": [
      [
        "ENROLLING_BY_INVITATION",
        1
      ],
      [
        "NOT_YET_RECRUITING",
        1
      ]
    ],
    "by_phase": [
      [
        "PHASE2",
        2
      ]
    ],
    "by_sponsor": [
      [
        "OTHER",
        2
      ]
    ],
    "started_in_year": 1,
    "updated_in_year": 1,
    "active": 2,
    "median_enrollment": 100,
    "enrollment_known": 2,
    "top_agents": [
      {
        "agent": "N-Acetylcysteine (NAC)",
        "trials": 1,
        "active": 1
      },
      {
        "agent": "Dmso-Based Otic Solution With Betahistine, Dexamethasone, And Lidocaine",
        "trials": 1,
        "active": 1
      },
      {
        "agent": "Rice Protein Powder With Vitamin C",
        "trials": 1,
        "active": 1
      },
      {
        "agent": "Combined Metabolic Modulator",
        "trials": 1,
        "active": 1
      }
    ],
    "distinct_agents": 4,
    "recent": [
      {
        "nct_id": "NCT07567274",
        "title": "DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury",
        "status": "ENROLLING_BY_INVITATION",
        "phase": "PHASE2",
        "start_date": "2026-05-15",
        "sponsor": "Leading Edge Clinic",
        "agents": [
          "Dmso-Based Otic Solution With Betahistine, Dexamethasone, And Lidocaine",
          "N-Acetylcysteine (NAC)"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07567274"
      }
    ]
  },
  "agents": {
    "catalogued": 4,
    "by_evidence": [
      [
        "Anecdotal",
        3
      ],
      [
        "Moderate",
        1
      ]
    ],
    "labels": [
      "PACVS"
    ],
    "all_catalogued": 605
  },
  "biomarkers": {
    "slug": "pacvs",
    "total": 32,
    "by_category": [
      [
        "autoimmune",
        {
          "up": 5,
          "down": 1,
          "mixed": 2
        }
      ],
      [
        "functional",
        {
          "down": 6,
          "up": 2
        }
      ],
      [
        "spike",
        {
          "up": 4
        }
      ],
      [
        "molecular",
        {
          "up": 1,
          "down": 1,
          "mixed": 2
        }
      ],
      [
        "metabolic",
        {
          "down": 2,
          "up": 1
        }
      ],
      [
        "serologic",
        {
          "up": 1,
          "down": 1
        }
      ],
      [
        "inflammatory",
        {
          "up": 2
        }
      ],
      [
        "proteomic",
        {
          "mixed": 1
        }
      ]
    ],
    "by_direction": {
      "up": 16,
      "down": 11,
      "mixed": 5
    },
    "category_labels": {
      "spike": "Spike Antigen",
      "serologic": "Serologic",
      "autoimmune": "Autoimmune",
      "metabolic": "Metabolic",
      "molecular": "Molecular",
      "proteomic": "Proteomic",
      "inflammatory": "Inflammatory",
      "functional": "Functional"
    },
    "distinct_dois": 11
  },
  "cohorts": {
    "count": 4,
    "rows": [
      {
        "id": "postvac-germany-survey",
        "name": "Post-Vac-Syndrom Deutschland patient survey",
        "design": "survey",
        "n_enrolled": 777,
        "pathogen": "covid-19-vaccine",
        "biobank": "not_applicable",
        "registration": ""
      },
      {
        "id": "vitae-survey",
        "name": "VITAE vaccine-injury survey (Halma & Varon)",
        "design": "survey",
        "n_enrolled": 706,
        "pathogen": "covid-19-vaccine",
        "biobank": "not_applicable",
        "registration": ""
      },
      {
        "id": "yale-listen-pvs",
        "name": "Yale LISTEN post-vaccination syndrome cohort (Krumholz)",
        "design": "survey",
        "n_enrolled": 241,
        "pathogen": "covid-19-vaccine",
        "biobank": "active",
        "registration": ""
      },
      {
        "id": "marburg-pacvs",
        "name": "PACVS registry cohort (Semmler/Mundorf)",
        "design": "cross_sectional",
        "n_enrolled": 191,
        "pathogen": "covid-19-vaccine",
        "biobank": "unknown",
        "registration": ""
      }
    ],
    "all_tracked": 32,
    "match_pathogens": [
      "covid-19-vaccine"
    ],
    "match_case_defs": []
  }
}