{
  "key": "me-cfs",
  "year": 2026,
  "condition": "ME/CFS",
  "short": "ME/CFS",
  "generated_at": "2026-10-07T23:43:14+00:00",
  "snapshot": {
    "feed_last_updated": "2026-07-06",
    "feed_file_mtime": "2026-10-07",
    "trials_last_run": "2026-10-07",
    "agents_last_updated": "2026-10-07",
    "biomarkers_date_modified": "2026-06-29",
    "cohorts_version": "2.0.0-seed"
  },
  "literature": {
    "feed_total": 75,
    "feed_range": [
      "2026-05-05",
      "2026-07-06"
    ],
    "undated": 0,
    "in_year": 75,
    "unique_pmids": 75,
    "month_precision_only": 0,
    "by_month": [
      0,
      0,
      0,
      0,
      31,
      38,
      6,
      0,
      0,
      0,
      0,
      0
    ],
    "top_journals": [
      [
        "Journal of translational medicine",
        7
      ],
      [
        "International journal of molecular sciences",
        6
      ],
      [
        "Frontiers in psychiatry",
        2
      ],
      [
        "Frontiers in neuroscience",
        2
      ],
      [
        "Frontiers in immunology",
        2
      ],
      [
        "Cureus",
        2
      ],
      [
        "Scientific reports",
        2
      ],
      [
        "European journal of pediatrics",
        2
      ],
      [
        "Frontiers in medicine",
        1
      ],
      [
        "Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis",
        1
      ]
    ],
    "journal_count": 58,
    "feed_source": "PubMed (NCBI)"
  },
  "trials": {
    "total": 146,
    "mapped": 146,
    "keyword": 0,
    "all_tracked": 629,
    "match_labels": [
      "ME/CFS"
    ],
    "match_keywords": [],
    "by_status": [
      [
        "COMPLETED",
        75
      ],
      [
        "RECRUITING",
        21
      ],
      [
        "UNKNOWN",
        21
      ],
      [
        "ACTIVE_NOT_RECRUITING",
        9
      ],
      [
        "TERMINATED",
        9
      ],
      [
        "NOT_YET_RECRUITING",
        4
      ],
      [
        "WITHDRAWN",
        4
      ],
      [
        "SUSPENDED",
        2
      ],
      [
        "ENROLLING_BY_INVITATION",
        1
      ]
    ],
    "by_phase": [
      [
        "NA",
        91
      ],
      [
        "PHASE2",
        29
      ],
      [
        "PHASE1",
        12
      ],
      [
        "PHASE4",
        8
      ],
      [
        "PHASE3",
        4
      ],
      [
        "EARLY_PHASE1",
        2
      ]
    ],
    "by_sponsor": [
      [
        "OTHER",
        125
      ],
      [
        "INDUSTRY",
        12
      ],
      [
        "NIH",
        3
      ],
      [
        "NETWORK",
        2
      ],
      [
        "OTHER_GOV",
        2
      ],
      [
        "FED",
        2
      ]
    ],
    "started_in_year": 10,
    "updated_in_year": 29,
    "active": 35,
    "median_enrollment": 55,
    "enrollment_known": 145,
    "top_agents": [
      {
        "agent": "Rituximab",
        "trials": 5,
        "active": 1
      },
      {
        "agent": "N-Acetylcysteine (NAC)",
        "trials": 3,
        "active": 1
      },
      {
        "agent": "Acupuncture",
        "trials": 3,
        "active": 1
      },
      {
        "agent": "Hydrogen Water",
        "trials": 3,
        "active": 0
      },
      {
        "agent": "Sodium Oxybate",
        "trials": 3,
        "active": 0
      },
      {
        "agent": "Low-Dose Naltrexone (LDN)",
        "trials": 2,
        "active": 2
      },
      {
        "agent": "Melatonin Plus Zinc",
        "trials": 2,
        "active": 0
      },
      {
        "agent": "Blood Test",
        "trials": 2,
        "active": 0
      },
      {
        "agent": "Actigraphy",
        "trials": 2,
        "active": 0
      },
      {
        "agent": "Maximal Effort Test",
        "trials": 2,
        "active": 0
      }
    ],
    "distinct_agents": 192,
    "recent": [
      {
        "nct_id": "NCT07724834",
        "title": "CD19-B Cell Depletion in PAIS-ME/CFS Patients",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE2",
        "start_date": "2026-12-01",
        "sponsor": "Charite University, Berlin, Germany",
        "agents": [
          "Inebilizumab"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07724834"
      },
      {
        "nct_id": "NCT07285473",
        "title": "Low-Dose Naltrexone For ME/CFS: Dose-Finding",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE2",
        "start_date": "2026-10-01",
        "sponsor": "University of Alabama at Birmingham",
        "agents": [
          "Low-Dose Naltrexone (LDN)"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07285473"
      },
      {
        "nct_id": "NCT07753122",
        "title": "Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2026-08-15",
        "sponsor": "Fred Friedberg",
        "agents": [
          "Molecular Hydrogen Produced By A Metallic Magnesium Tablet, Consumed 3X A Day Dissolved In Water. Treatment Duration Is 16 Weeks."
        ],
        "link": "https://clinicaltrials.gov/study/NCT07753122"
      },
      {
        "nct_id": "NCT07621068",
        "title": "Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2026-07-19",
        "sponsor": "Assaf-Harofeh Medical Center",
        "agents": [
          "Hyperbaric Oxygen Therapy (HBOT)"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07621068"
      },
      {
        "nct_id": "NCT07523113",
        "title": "ME/CFS Brain Fog: Cognitive Rehabilitation Trial",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2026-06-23",
        "sponsor": "University of Alabama at Birmingham",
        "agents": [
          "Processing Speed Training",
          "In-Session Instrumental Activities Of Daily Living Training",
          "Transfer Package"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07523113"
      },
      {
        "nct_id": "NCT07546539",
        "title": "Photobiomodulation in Chronic Fatigue Syndrome",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2026-06-15",
        "sponsor": "University of Lahore",
        "agents": [
          "Photobiomodulation"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07546539"
      },
      {
        "nct_id": "NCT07317401",
        "title": "Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment",
        "status": "NOT_YET_RECRUITING",
        "phase": "NA",
        "start_date": "2026-06-01",
        "sponsor": "University of Aarhus",
        "agents": [
          "Intermittent Hypoxia-Hyperoxia Treatment"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07317401"
      },
      {
        "nct_id": "NCT07357688",
        "title": "The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome",
        "status": "NOT_YET_RECRUITING",
        "phase": "NA",
        "start_date": "2026-05",
        "sponsor": "Xi Wu",
        "agents": [
          "Acupuncture"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07357688"
      }
    ]
  },
  "agents": {
    "catalogued": 191,
    "by_evidence": [
      [
        "Preliminary",
        176
      ],
      [
        "Moderate",
        14
      ],
      [
        "Anecdotal",
        1
      ]
    ],
    "labels": [
      "ME/CFS"
    ],
    "all_catalogued": 605
  },
  "biomarkers": {
    "slug": "me-cfs",
    "total": 46,
    "by_category": [
      [
        "inflammatory",
        {
          "up": 4,
          "mixed": 6
        }
      ],
      [
        "metabolic",
        {
          "up": 5,
          "mixed": 1,
          "down": 4
        }
      ],
      [
        "autonomic",
        {
          "down": 3,
          "mixed": 1,
          "up": 2
        }
      ],
      [
        "immune",
        {
          "down": 2,
          "up": 2,
          "mixed": 1
        }
      ],
      [
        "mitochondrial",
        {
          "down": 4
        }
      ],
      [
        "functional",
        {
          "down": 4
        }
      ],
      [
        "autoimmune",
        {
          "up": 3
        }
      ],
      [
        "neurological",
        {
          "mixed": 2
        }
      ],
      [
        "urinary",
        {
          "mixed": 2
        }
      ]
    ],
    "by_direction": {
      "up": 16,
      "mixed": 13,
      "down": 17
    },
    "category_labels": {
      "inflammatory": "Inflammatory",
      "metabolic": "Metabolic",
      "mitochondrial": "Mitochondrial",
      "immune": "Immune",
      "autoimmune": "Autoimmune",
      "autonomic": "Autonomic",
      "neurological": "Neurological",
      "urinary": "Urinary",
      "functional": "Functional"
    },
    "distinct_dois": 8
  },
  "cohorts": {
    "count": 4,
    "rows": [
      {
        "id": "decodeme-mecfs-gwas",
        "name": "DecodeME ME/CFS GWAS",
        "design": "registry_linkage",
        "n_enrolled": 15579,
        "pathogen": "unknown-trigger",
        "biobank": "active",
        "registration": ""
      },
      {
        "id": "uk-me-cfs-biobank",
        "name": "UK ME/CFS Biobank (CureME, LSHTM)",
        "design": "cross_sectional",
        "n_enrolled": 632,
        "pathogen": "unknown-trigger",
        "biobank": "active",
        "registration": ""
      },
      {
        "id": "katz-2009-mononucleosis",
        "name": "Chicago adolescent post-mononucleosis cohort (Katz)",
        "design": "prospective_inception",
        "n_enrolled": 301,
        "pathogen": "epstein-barr-virus",
        "biobank": "unknown",
        "registration": ""
      },
      {
        "id": "nih-intramural-me-cfs-2024",
        "name": "NIH Intramural ME/CFS Deep-Phenotyping Study (Walitt/Nath 2024)",
        "design": "cross_sectional",
        "n_enrolled": 57,
        "pathogen": "unknown-trigger",
        "biobank": "active",
        "registration": "NCT02669212"
      }
    ],
    "all_tracked": 32,
    "match_pathogens": [
      "unknown-trigger"
    ],
    "match_case_defs": [
      "fukuda_1994",
      "canadian_consensus",
      "iom_nam_2015",
      "icc_2011",
      "ccc_2003"
    ]
  }
}