{
  "key": "lyme",
  "year": 2026,
  "condition": "Chronic Lyme / Post-Treatment Lyme Disease Syndrome",
  "short": "Lyme / PTLDS",
  "generated_at": "2026-10-07T23:43:14+00:00",
  "snapshot": {
    "feed_last_updated": "2026-07-08",
    "feed_file_mtime": "2026-10-07",
    "trials_last_run": "2026-10-07",
    "agents_last_updated": "2026-10-07",
    "biomarkers_date_modified": "2026-06-29",
    "cohorts_version": "2.0.0-seed"
  },
  "literature": {
    "feed_total": 75,
    "feed_range": [
      "2025-01-01",
      "2026-07-05"
    ],
    "undated": 0,
    "in_year": 39,
    "unique_pmids": 39,
    "month_precision_only": 0,
    "by_month": [
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      8,
      8,
      6,
      4,
      4,
      2,
      0,
      0,
      0,
      0,
      0
    ],
    "top_journals": [
      [
        "Pathogens (Basel, Switzerland)",
        3
      ],
      [
        "Infection and immunity",
        2
      ],
      [
        "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",
        2
      ],
      [
        "Parasites & vectors",
        2
      ],
      [
        "Scientific reports",
        2
      ],
      [
        "bioRxiv : the preprint server for biology",
        2
      ],
      [
        "Cureus",
        2
      ],
      [
        "Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis",
        1
      ],
      [
        "Annals of agricultural and environmental medicine : AAEM",
        1
      ],
      [
        "Frontiers in public health",
        1
      ]
    ],
    "journal_count": 31,
    "feed_source": "PubMed (NCBI)"
  },
  "trials": {
    "total": 1,
    "mapped": 0,
    "keyword": 1,
    "all_tracked": 629,
    "match_labels": [],
    "match_keywords": [
      "\\blyme\\b",
      "borreli",
      "\\bptlds\\b"
    ],
    "by_status": [
      [
        "RECRUITING",
        1
      ]
    ],
    "by_phase": [
      [
        "PHASE1",
        1
      ]
    ],
    "by_sponsor": [
      [
        "OTHER",
        1
      ]
    ],
    "started_in_year": 0,
    "updated_in_year": 1,
    "active": 1,
    "median_enrollment": 120,
    "enrollment_known": 1,
    "top_agents": [
      {
        "agent": "Lumbrokinase",
        "trials": 1,
        "active": 1
      }
    ],
    "distinct_agents": 1,
    "recent": []
  },
  "agents": {
    "catalogued": 4,
    "by_evidence": [
      [
        "Moderate",
        3
      ],
      [
        "Anecdotal",
        1
      ]
    ],
    "labels": [
      "Lyme"
    ],
    "all_catalogued": 605
  },
  "biomarkers": {
    "slug": "lyme",
    "total": 36,
    "by_category": [
      [
        "serologic",
        {
          "up": 9
        }
      ],
      [
        "csf",
        {
          "up": 4,
          "mixed": 2
        }
      ],
      [
        "inflammatory",
        {
          "up": 4,
          "mixed": 2
        }
      ],
      [
        "molecular",
        {
          "mixed": 3,
          "up": 1
        }
      ],
      [
        "coinfection",
        {
          "up": 4
        }
      ],
      [
        "chronic",
        {
          "mixed": 3,
          "down": 1
        }
      ],
      [
        "functional",
        {
          "mixed": 1,
          "up": 1,
          "down": 1
        }
      ]
    ],
    "by_direction": {
      "up": 23,
      "mixed": 11,
      "down": 2
    },
    "category_labels": {
      "serologic": "Serologic",
      "csf": "CSF",
      "inflammatory": "Inflammatory",
      "molecular": "Molecular",
      "coinfection": "Co-infection",
      "chronic": "Chronic/PTLDS",
      "functional": "Functional"
    },
    "distinct_dois": 5
  },
  "cohorts": {
    "count": 1,
    "rows": [
      {
        "id": "aucott-slice-ptlds",
        "name": "Johns Hopkins SLICE early-Lyme cohort (Aucott/Rebman)",
        "design": "prospective_inception",
        "n_enrolled": 234,
        "pathogen": "borrelia-burgdorferi",
        "biobank": "active",
        "registration": ""
      }
    ],
    "all_tracked": 32,
    "match_pathogens": [
      "borrelia-burgdorferi"
    ],
    "match_case_defs": []
  }
}