{
  "key": "long-covid",
  "year": 2026,
  "condition": "Long COVID (PASC)",
  "short": "Long COVID",
  "generated_at": "2026-10-07T23:43:14+00:00",
  "snapshot": {
    "feed_last_updated": "2026-07-07",
    "feed_file_mtime": "2026-10-07",
    "trials_last_run": "2026-10-07",
    "agents_last_updated": "2026-10-07",
    "biomarkers_date_modified": "2026-06-29",
    "cohorts_version": "2.0.0-seed"
  },
  "literature": {
    "feed_total": 75,
    "feed_range": [
      "2026-06-27",
      "2026-07-07"
    ],
    "undated": 0,
    "in_year": 75,
    "unique_pmids": 75,
    "month_precision_only": 0,
    "by_month": [
      0,
      0,
      0,
      0,
      0,
      28,
      47,
      0,
      0,
      0,
      0,
      0
    ],
    "top_journals": [
      [
        "Frontiers in immunology",
        3
      ],
      [
        "JAMA network open",
        2
      ],
      [
        "Scientific reports",
        2
      ],
      [
        "Pediatrics and neonatology",
        1
      ],
      [
        "The Journal of biological chemistry",
        1
      ],
      [
        "Brain, behavior, and immunity",
        1
      ],
      [
        "Phytomedicine : international journal of phytotherapy and phytopharmacology",
        1
      ],
      [
        "Journal of medical economics",
        1
      ],
      [
        "Cardiology in the young",
        1
      ],
      [
        "Physiotherapy research international : the journal for researchers and clinicians in physical therapy",
        1
      ]
    ],
    "journal_count": 71,
    "feed_source": "PubMed (NCBI)"
  },
  "trials": {
    "total": 341,
    "mapped": 341,
    "keyword": 0,
    "all_tracked": 629,
    "match_labels": [
      "Long COVID / PASC"
    ],
    "match_keywords": [],
    "by_status": [
      [
        "COMPLETED",
        150
      ],
      [
        "UNKNOWN",
        57
      ],
      [
        "RECRUITING",
        53
      ],
      [
        "ACTIVE_NOT_RECRUITING",
        26
      ],
      [
        "NOT_YET_RECRUITING",
        25
      ],
      [
        "WITHDRAWN",
        14
      ],
      [
        "TERMINATED",
        10
      ],
      [
        "ENROLLING_BY_INVITATION",
        3
      ],
      [
        "SUSPENDED",
        3
      ]
    ],
    "by_phase": [
      [
        "NA",
        218
      ],
      [
        "PHASE2",
        75
      ],
      [
        "PHASE3",
        21
      ],
      [
        "PHASE1",
        14
      ],
      [
        "PHASE4",
        7
      ],
      [
        "EARLY_PHASE1",
        6
      ]
    ],
    "by_sponsor": [
      [
        "OTHER",
        288
      ],
      [
        "INDUSTRY",
        38
      ],
      [
        "FED",
        7
      ],
      [
        "OTHER_GOV",
        6
      ],
      [
        "NIH",
        1
      ],
      [
        "NETWORK",
        1
      ]
    ],
    "started_in_year": 28,
    "updated_in_year": 127,
    "active": 107,
    "median_enrollment": 59,
    "enrollment_known": 341,
    "top_agents": [
      {
        "agent": "Paxlovid (Nirmatrelvir/Ritonavir)",
        "trials": 8,
        "active": 3
      },
      {
        "agent": "Acupuncture",
        "trials": 6,
        "active": 3
      },
      {
        "agent": "Hyperbaric Oxygen Therapy (HBOT)",
        "trials": 4,
        "active": 1
      },
      {
        "agent": "Fluvoxamine",
        "trials": 3,
        "active": 1
      },
      {
        "agent": "Metformin",
        "trials": 3,
        "active": 0
      },
      {
        "agent": "Ritonavir",
        "trials": 3,
        "active": 0
      },
      {
        "agent": "Exercise",
        "trials": 3,
        "active": 1
      },
      {
        "agent": "Structured Pacing",
        "trials": 2,
        "active": 0
      },
      {
        "agent": "Taurine",
        "trials": 2,
        "active": 2
      },
      {
        "agent": "Pasc Core",
        "trials": 2,
        "active": 0
      }
    ],
    "distinct_agents": 426,
    "recent": [
      {
        "nct_id": "NCT07724834",
        "title": "CD19-B Cell Depletion in PAIS-ME/CFS Patients",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE2",
        "start_date": "2026-12-01",
        "sponsor": "Charite University, Berlin, Germany",
        "agents": [
          "Inebilizumab"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07724834"
      },
      {
        "nct_id": "NCT07697261",
        "title": "Fatigue in Long COVID",
        "status": "NOT_YET_RECRUITING",
        "phase": "NA",
        "start_date": "2026-11",
        "sponsor": "McMaster University",
        "agents": [
          "Lightning Process",
          "Activity Pacing"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07697261"
      },
      {
        "nct_id": "NCT07388550",
        "title": "Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE1",
        "start_date": "2026-10-12",
        "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
        "agents": [
          "Keytruda"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07388550"
      },
      {
        "nct_id": "NCT07714213",
        "title": "Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE)",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE2",
        "start_date": "2026-10-01",
        "sponsor": "Christiana Franke",
        "agents": [
          "Aripiprazole"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07714213"
      },
      {
        "nct_id": "NCT07682402",
        "title": "Taurine Supplementation in Adolescents With Post-COVID Condition",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE1",
        "start_date": "2026-09-30",
        "sponsor": "University of Alberta",
        "agents": [
          "Taurine"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07682402"
      },
      {
        "nct_id": "NCT07709234",
        "title": "Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue",
        "status": "NOT_YET_RECRUITING",
        "phase": "NA",
        "start_date": "2026-09-15",
        "sponsor": "University of Las Palmas de Gran Canaria",
        "agents": [
          "Transcranial Direct Current Stimulation"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07709234"
      },
      {
        "nct_id": "NCT07798570",
        "title": "Observational Study With CICR-NAM as a Food for Special Medicinal Purposes in Post-COVID Syndrome (PCS)",
        "status": "NOT_YET_RECRUITING",
        "phase": "NA",
        "start_date": "2026-09-06",
        "sponsor": "University Hospital Schleswig-Holstein",
        "agents": [
          "Cicr-Nam"
        ],
        "link": "https://clinicaltrials.gov/study/NCT07798570"
      },
      {
        "nct_id": "NCT06907251",
        "title": "Dapagliflozin for Long COVID Syndrome",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE3",
        "start_date": "2026-09-01",
        "sponsor": "Ottawa Heart Institute Research Corporation",
        "agents": [
          "Dapagliflozin"
        ],
        "link": "https://clinicaltrials.gov/study/NCT06907251"
      }
    ]
  },
  "agents": {
    "catalogued": 434,
    "by_evidence": [
      [
        "Preliminary",
        380
      ],
      [
        "Moderate",
        40
      ],
      [
        "Anecdotal",
        14
      ]
    ],
    "labels": [
      "Long COVID"
    ],
    "all_catalogued": 605
  },
  "biomarkers": {
    "slug": "long-covid",
    "total": 77,
    "by_category": [
      [
        "metabolic",
        {
          "down": 10,
          "up": 11,
          "mixed": 2
        }
      ],
      [
        "inflammatory",
        {
          "up": 11,
          "down": 1,
          "mixed": 2
        }
      ],
      [
        "vascular",
        {
          "up": 8
        }
      ],
      [
        "immune",
        {
          "up": 6,
          "mixed": 1
        }
      ],
      [
        "coagulation",
        {
          "up": 6
        }
      ],
      [
        "proteomic",
        {
          "up": 3,
          "mixed": 2
        }
      ],
      [
        "lipidomic",
        {
          "down": 1,
          "mixed": 3
        }
      ],
      [
        "neurological",
        {
          "up": 4
        }
      ],
      [
        "microbiome",
        {
          "down": 2,
          "mixed": 1,
          "up": 1
        }
      ],
      [
        "viral",
        {
          "mixed": 2
        }
      ]
    ],
    "by_direction": {
      "up": 50,
      "down": 14,
      "mixed": 13
    },
    "category_labels": {
      "inflammatory": "Inflammatory",
      "metabolic": "Metabolic",
      "coagulation": "Coagulation",
      "vascular": "Vascular",
      "neurological": "Neurological",
      "immune": "Immune",
      "proteomic": "Proteomic",
      "lipidomic": "Lipidomic",
      "microbiome": "Microbiome",
      "viral": "Viral"
    },
    "distinct_dois": 8
  },
  "cohorts": {
    "count": 7,
    "rows": [
      {
        "id": "recover-adult-long-covid",
        "name": "NIH RECOVER-Adult Cohort",
        "design": "prospective_non_inception",
        "n_enrolled": 15000,
        "pathogen": "sars-cov-2",
        "biobank": "active",
        "registration": "NCT05172024"
      },
      {
        "id": "long-covid-host-genetics",
        "name": "Long COVID Host Genetics Initiative GWAS",
        "design": "registry_linkage",
        "n_enrolled": 6450,
        "pathogen": "sars-cov-2",
        "biobank": "active",
        "registration": ""
      },
      {
        "id": "davis-2021-longcovid",
        "name": "Patient-Led Long COVID international cohort (Davis 2021)",
        "design": "survey",
        "n_enrolled": 3762,
        "pathogen": "sars-cov-2",
        "biobank": "not_applicable",
        "registration": ""
      },
      {
        "id": "phosp-covid",
        "name": "PHOSP-COVID (UK post-hospitalisation COVID-19)",
        "design": "prospective_non_inception",
        "n_enrolled": 2320,
        "pathogen": "sars-cov-2",
        "biobank": "active",
        "registration": "ISRCTN10980107"
      },
      {
        "id": "huang-2021-wuhan",
        "name": "Jinyintan (Wuhan) COVID-19 discharge cohort (Huang)",
        "design": "prospective_non_inception",
        "n_enrolled": 1733,
        "pathogen": "sars-cov-2",
        "biobank": "unknown",
        "registration": ""
      },
      {
        "id": "blomberg-2021-bergen-covid",
        "name": "Bergen COVID-19 home-isolated cohort (Blomberg)",
        "design": "prospective_inception",
        "n_enrolled": 312,
        "pathogen": "sars-cov-2",
        "biobank": "active",
        "registration": ""
      },
      {
        "id": "appelman-2024-lc-muscle",
        "name": "Amsterdam Long COVID muscle-biopsy PEM cohort (Appelman)",
        "design": "case_control",
        "n_enrolled": 46,
        "pathogen": "sars-cov-2",
        "biobank": "unknown",
        "registration": "NCT05225688"
      }
    ],
    "all_tracked": 32,
    "match_pathogens": [
      "sars-cov-2"
    ],
    "match_case_defs": []
  }
}