{ "version": "https://jsonfeed.org/version/1.1", "title": "POTS clinical trials: new and updated - Open Source Medicine Foundation", "home_page_url": "https://research.opensourcemed.info/pots.html", "feed_url": "https://research.opensourcemed.info/feeds/pots.json", "description": "ClinicalTrials.gov records for Postural Orthostatic Tachycardia Syndrome (POTS) that were newly registered or updated, as tracked by the Open Source Medicine Foundation research tracker. The 30 most recently updated trials, newest first.", "language": "en", "icon": "https://opensourcemed.info/favicon.png", "favicon": "https://opensourcemed.info/favicon.png", "authors": [ { "name": "Open Source Medicine Foundation", "url": "https://opensourcemed.info" } ], "items": [ { "id": "NCT07837804:2026-09-24", "url": "https://clinicaltrials.gov/study/NCT07837804", "title": "RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome", "content_text": "Not Yet Recruiting · Not applicable · Bilateral Sequential Stellate Ganglion Block — RESET-POTS is a pilot study for adults with postural orthostatic tachycardia syndrome (POTS), a condition that can cause a rapid increase in heart rate, dizziness, weakness, fatigue and other symptoms when standing. The study has two parts. In the first part, patients with POTS and healthy volunteer…", "summary": "Not Yet Recruiting · Not applicable · Bilateral Sequential Stellate Ganglion Block — RESET-POTS is a pilot study for adults with postural orthostatic tachycardia syndrome (POTS), a condition that can cause a rapid increase in heart rate, dizziness, weakness, fatigue and other symptoms when standing.", "tags": [ "POTS", "Not Yet Recruiting", "Bilateral Sequential Stellate Ganglion Block" ], "_osmf": { "nct_id": "NCT07837804", "status": "NOT_YET_RECRUITING", "phase": "NA", "start_date": "2026-10-01", "last_updated": "2026-09-24", "agents": [ "Bilateral Sequential Stellate Ganglion Block" ] }, "date_published": "2026-09-24T08:00:00+00:00", "date_modified": "2026-09-24T08:00:00+00:00" }, { "id": "NCT05554107:2026-09-03", "url": "https://clinicaltrials.gov/study/NCT05554107", "title": "The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome", "content_text": "Recruiting · Not applicable · Training Program — Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic hypotension. In addition to the orthostatic intolerance and tachycardia, patie…", "summary": "Recruiting · Not applicable · Training Program — Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic hypotension. In addition to t", "tags": [ "POTS", "Recruiting", "Training Program" ], "_osmf": { "nct_id": "NCT05554107", "status": "RECRUITING", "phase": "NA", "start_date": "2022-11-02", "last_updated": "2026-09-03", "agents": [ "Training Program" ] }, "date_published": "2026-09-03T08:00:00+00:00", "date_modified": "2026-09-03T08:00:00+00:00" }, { "id": "NCT07757555:2026-08-12", "url": "https://clinicaltrials.gov/study/NCT07757555", "title": "Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial", "content_text": "Not Yet Recruiting · Early phase 1 · Guanfacine, Cromolyn Sodium — The goal of this clinical trial is to learn whether guanfacine or cromolyn sodium can improve symptoms and physical functioning in adults with Postural Orthostatic Tachycardia Syndrome (POTS). Both medications are FDA-approved for other conditions but are investigational for the treatment of POTS. T…", "summary": "Not Yet Recruiting · Early phase 1 · Guanfacine, Cromolyn Sodium — The goal of this clinical trial is to learn whether guanfacine or cromolyn sodium can improve symptoms and physical functioning in adults with Postural Orthostatic Tachycardia Syndrome (POTS). Both medications are FDA-approved for ot", "tags": [ "POTS", "Not Yet Recruiting", "Guanfacine", "Cromolyn Sodium" ], "_osmf": { "nct_id": "NCT07757555", "status": "NOT_YET_RECRUITING", "phase": "EARLY_PHASE1", "start_date": "2026-08-15", "last_updated": "2026-08-12", "agents": [ "Guanfacine", "Cromolyn Sodium" ] }, "date_published": "2026-08-12T08:00:00+00:00", "date_modified": "2026-08-12T08:00:00+00:00" }, { "id": "NCT06593600:2026-07-21", "url": "https://clinicaltrials.gov/study/NCT06593600", "title": "Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)", "content_text": "Completed · Phase 2 · Regn7544 — This study is researching an experimental drug called REGN7544 (called \"study drug\"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research questions, including: * How the st…", "summary": "Completed · Phase 2 · Regn7544 — This study is researching an experimental drug called REGN7544 (called \"study drug\"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research q", "tags": [ "POTS", "Completed", "Regn7544" ], "_osmf": { "nct_id": "NCT06593600", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2024-11-13", "last_updated": "2026-07-21", "agents": [ "Regn7544" ] }, "date_published": "2026-07-21T08:00:00+00:00", "date_modified": "2026-07-21T08:00:00+00:00" }, { "id": "NCT05877534:2026-07-15", "url": "https://clinicaltrials.gov/study/NCT05877534", "title": "Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study", "content_text": "Active Not Recruiting · Not applicable · Individual Tailored Exercise — Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms. The term post COVID-19 condition (defined by WHO) is used to describe the wide range of prolong…", "summary": "Active Not Recruiting · Not applicable · Individual Tailored Exercise — Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms. The term post COVID-19 ", "tags": [ "POTS", "Active Not Recruiting", "Individual Tailored Exercise" ], "_osmf": { "nct_id": "NCT05877534", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "start_date": "2023-05-25", "last_updated": "2026-07-15", "agents": [ "Individual Tailored Exercise" ] }, "date_published": "2026-07-15T08:00:00+00:00", "date_modified": "2026-07-15T08:00:00+00:00" }, { "id": "NCT05421208:2026-07-15", "url": "https://clinicaltrials.gov/study/NCT05421208", "title": "Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome", "content_text": "Active Not Recruiting · Not applicable · Effect On Inflammation After Chronic Pns Stimulation — The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable caus…", "summary": "Active Not Recruiting · Not applicable · Effect On Inflammation After Chronic Pns Stimulation — The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\\~80%), pre", "tags": [ "POTS", "Active Not Recruiting", "Effect On Inflammation After Chronic Pns Stimulation" ], "_osmf": { "nct_id": "NCT05421208", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "start_date": "2022-06-01", "last_updated": "2026-07-15", "agents": [ "Effect On Inflammation After Chronic Pns Stimulation" ] }, "date_published": "2026-07-15T08:00:00+00:00", "date_modified": "2026-07-15T08:00:00+00:00" }, { "id": "NCT03124355:2026-07-13", "url": "https://clinicaltrials.gov/study/NCT03124355", "title": "Vagal Stimulation in POTS", "content_text": "Active Not Recruiting · Phase 1 · Pyridostigmine Pill, Galantamine Pill, Vagal Stimulation — The purpose of this study is to investigate how the electrical stimulation of a nerve in the skin of the earlobe (transcutaneous vagal nerve stimulation), alone or in combination with two medications (galantamine and pyridostigmine), affects the way the autonomic (involuntary) nervous system control…", "summary": "Active Not Recruiting · Phase 1 · Pyridostigmine Pill, Galantamine Pill, Vagal Stimulation — The purpose of this study is to investigate how the electrical stimulation of a nerve in the skin of the earlobe (transcutaneous vagal nerve stimulation), alone or in combination with two medications (galant", "tags": [ "POTS", "Active Not Recruiting", "Pyridostigmine Pill", "Galantamine Pill", "Vagal Stimulation" ], "_osmf": { "nct_id": "NCT03124355", "status": "ACTIVE_NOT_RECRUITING", "phase": "PHASE1", "start_date": "2017-09-30", "last_updated": "2026-07-13", "agents": [ "Pyridostigmine Pill", "Galantamine Pill", "Vagal Stimulation" ] }, "date_published": "2026-07-13T08:00:00+00:00", "date_modified": "2026-07-13T08:00:00+00:00" }, { "id": "NCT07585513:2026-05-13", "url": "https://clinicaltrials.gov/study/NCT07585513", "title": "Beta-3 Enhanced Autonomic Therapy for POTS", "content_text": "Not Yet Recruiting · Phase 2 · Mirabegron — The study will test the hypothesis that mirabegron is more effective than a placebo in alleviating postural orthostatic tachycardia (POTS) symptoms.", "summary": "Not Yet Recruiting · Phase 2 · Mirabegron — The study will test the hypothesis that mirabegron is more effective than a placebo in alleviating postural orthostatic tachycardia (POTS) symptoms.", "tags": [ "POTS", "Not Yet Recruiting", "Mirabegron" ], "_osmf": { "nct_id": "NCT07585513", "status": "NOT_YET_RECRUITING", "phase": "PHASE2", "start_date": "2026-05", "last_updated": "2026-05-13", "agents": [ "Mirabegron" ] }, "date_published": "2026-05-13T08:00:00+00:00", "date_modified": "2026-05-13T08:00:00+00:00" }, { "id": "NCT07579026:2026-05-11", "url": "https://clinicaltrials.gov/study/NCT07579026", "title": "Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.", "content_text": "Recruiting · Not applicable · Diaphragmatic Breathing Exercise — Postural orthostatic tachycardia POTS is characterized by excessive increase in heart rate when moving from lying to standing position, often accompanied by symptoms such as dizziness, fatigue, brain fog, lightheadedness, rapid heartbeat and palpitation.it most commonly effects the females of reprod…", "summary": "Recruiting · Not applicable · Diaphragmatic Breathing Exercise — Postural orthostatic tachycardia POTS is characterized by excessive increase in heart rate when moving from lying to standing position, often accompanied by symptoms such as dizziness, fatigue, brain fog, lightheadedness, rapid heartbe", "tags": [ "POTS", "Recruiting", "Diaphragmatic Breathing Exercise" ], "_osmf": { "nct_id": "NCT07579026", "status": "RECRUITING", "phase": "NA", "start_date": "2025-08-31", "last_updated": "2026-05-11", "agents": [ "Diaphragmatic Breathing Exercise" ] }, "date_published": "2026-05-11T08:00:00+00:00", "date_modified": "2026-05-11T08:00:00+00:00" }, { "id": "NCT05924646:2026-05-07", "url": "https://clinicaltrials.gov/study/NCT05924646", "title": "CAlgary SAlt for POTS", "content_text": "Recruiting · Not applicable · Microcystalline Cellulose Capsules — Many patients with postural orthostatic tachycardia syndrome (POTS) have decreased plasma volume. Current POTS guidelines recommend \\~10 g of salt and 2-3 L of fluid per day. Despite this recommendation, there is no long term data evaluating the use of salt in POTS. This randomized, placebo-controll…", "summary": "Recruiting · Not applicable · Microcystalline Cellulose Capsules — Many patients with postural orthostatic tachycardia syndrome (POTS) have decreased plasma volume. Current POTS guidelines recommend \\~10 g of salt and 2-3 L of fluid per day. Despite this recommendation, there is no long term data ev", "tags": [ "POTS", "Recruiting", "Microcystalline Cellulose Capsules" ], "_osmf": { "nct_id": "NCT05924646", "status": "RECRUITING", "phase": "NA", "start_date": "2024-05-07", "last_updated": "2026-05-07", "agents": [ "Microcystalline Cellulose Capsules" ] }, "date_published": "2026-05-07T08:00:00+00:00", "date_modified": "2026-05-07T08:00:00+00:00" }, { "id": "NCT05914649:2026-05-07", "url": "https://clinicaltrials.gov/study/NCT05914649", "title": "NC Testing in LC & POTS", "content_text": "Recruiting · Not applicable · Iv Normal Saline — Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or \"Long COVID\") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared …", "summary": "Recruiting · Not applicable · Iv Normal Saline — Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or \"Long COVID\") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive functi", "tags": [ "POTS", "Recruiting", "Iv Normal Saline" ], "_osmf": { "nct_id": "NCT05914649", "status": "RECRUITING", "phase": "NA", "start_date": "2024-09-19", "last_updated": "2026-05-07", "agents": [ "Iv Normal Saline" ] }, "date_published": "2026-05-07T08:00:00+00:00", "date_modified": "2026-05-07T08:00:00+00:00" }, { "id": "NCT04881318:2026-05-07", "url": "https://clinicaltrials.gov/study/NCT04881318", "title": "Compression Garments in the Community With POTS", "content_text": "Recruiting · Not applicable · Waist-High Compression Tights, Abdominal Compression Garments, Medications That Modulate Heart Rate And Blood Pressure — Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept compression garment has been demonstrated in an acute laboratory setting. It is not known if commercially available compression garments that particip…", "summary": "Recruiting · Not applicable · Waist-High Compression Tights, Abdominal Compression Garments, Medications That Modulate Heart Rate And Blood Pressure — Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept", "tags": [ "POTS", "Recruiting", "Waist-High Compression Tights", "Abdominal Compression Garments", "Medications That Modulate Heart Rate And Blood Pressure" ], "_osmf": { "nct_id": "NCT04881318", "status": "RECRUITING", "phase": "NA", "start_date": "2021-05-17", "last_updated": "2026-05-07", "agents": [ "Waist-High Compression Tights", "Abdominal Compression Garments", "Medications That Modulate Heart Rate And Blood Pressure" ] }, "date_published": "2026-05-07T08:00:00+00:00", "date_modified": "2026-05-07T08:00:00+00:00" }, { "id": "NCT04271878:2026-05-07", "url": "https://clinicaltrials.gov/study/NCT04271878", "title": "Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome", "content_text": "Recruiting · Not applicable · Respiract™ System — The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem. Blood gases, like carbon dioxide (CO2), have an important effect on sympathetic activation. The purpose of this research study is to determine if higher CO2 leve…", "summary": "Recruiting · Not applicable · Respiract™ System — The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem. Blood gases, like carbon dioxide (CO2), have an important effect on sympathetic activation. The purpose of this", "tags": [ "POTS", "Recruiting", "Respiract™ System" ], "_osmf": { "nct_id": "NCT04271878", "status": "RECRUITING", "phase": "NA", "start_date": "2022-02-02", "last_updated": "2026-05-07", "agents": [ "Respiract™ System" ] }, "date_published": "2026-05-07T08:00:00+00:00", "date_modified": "2026-05-07T08:00:00+00:00" }, { "id": "NCT05363514:2026-05-01", "url": "https://clinicaltrials.gov/study/NCT05363514", "title": "Low Dose Naltrexone Use in Patients With POTS", "content_text": "Not Yet Recruiting · Phase 4 · Low Dose Naltrexone, Microcrystalline Cellulose — Many patients with Postural Orthostatic Tachycardia Syndrome (POTS) experience debilitating fatigue and this significantly impacts their daily lives. Unfortunately, there are no treatments to help POTS patients with their fatigue. One medication, called low dose naltrexone (LDN), has been tested as …", "summary": "Not Yet Recruiting · Phase 4 · Low Dose Naltrexone, Microcrystalline Cellulose — Many patients with Postural Orthostatic Tachycardia Syndrome (POTS) experience debilitating fatigue and this significantly impacts their daily lives. Unfortunately, there are no treatments to help POTS patients with the", "tags": [ "POTS", "Not Yet Recruiting", "Low Dose Naltrexone", "Microcrystalline Cellulose" ], "_osmf": { "nct_id": "NCT05363514", "status": "NOT_YET_RECRUITING", "phase": "PHASE4", "start_date": "2026-07", "last_updated": "2026-05-01", "agents": [ "Low Dose Naltrexone", "Microcrystalline Cellulose" ] }, "date_published": "2026-05-01T08:00:00+00:00", "date_modified": "2026-05-01T08:00:00+00:00" }, { "id": "NCT05633693:2026-04-23", "url": "https://clinicaltrials.gov/study/NCT05633693", "title": "Postural Sway and Counterpressure Maneuvers for Pediatric Syncope", "content_text": "Recruiting · Not applicable · Counterpressure Maneuvers, Baseline Stand — The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular responses to maneuvers of exaggerated sway, leg crossing, crouching, and gl…", "summary": "Recruiting · Not applicable · Counterpressure Maneuvers, Baseline Stand — The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular r", "tags": [ "POTS", "Recruiting", "Counterpressure Maneuvers", "Baseline Stand" ], "_osmf": { "nct_id": "NCT05633693", "status": "RECRUITING", "phase": "NA", "start_date": "2023-04-17", "last_updated": "2026-04-23", "agents": [ "Counterpressure Maneuvers", "Baseline Stand" ] }, "date_published": "2026-04-23T08:00:00+00:00", "date_modified": "2026-04-23T08:00:00+00:00" }, { "id": "NCT05555771:2026-04-23", "url": "https://clinicaltrials.gov/study/NCT05555771", "title": "Paediatric Syncope in the Emergency Department", "content_text": "Recruiting · Not applicable · Counterpressure Maneuvers — The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients. Participants presenting to the emergency department (ED) will first provide written informed consent. In stage I, they will be asked to complete a brief…", "summary": "Recruiting · Not applicable · Counterpressure Maneuvers — The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients. Participants presenting to the emergency department (ED) will first provide written informed c", "tags": [ "POTS", "Recruiting", "Counterpressure Maneuvers" ], "_osmf": { "nct_id": "NCT05555771", "status": "RECRUITING", "phase": "NA", "start_date": "2022-09-03", "last_updated": "2026-04-23", "agents": [ "Counterpressure Maneuvers" ] }, "date_published": "2026-04-23T08:00:00+00:00", "date_modified": "2026-04-23T08:00:00+00:00" }, { "id": "NCT06524739:2026-04-13", "url": "https://clinicaltrials.gov/study/NCT06524739", "title": "Double-blind, Randomized, Placebo-controlled Study Evaluating Efficacy and Safety of IgPro20 in Post-COVID-19 POTS", "content_text": "Terminated · Phase 3 · Igpro20 — This is a prospective, phase 3, multicenter, double-blind, randomized placebo-controlled study to investigate the efficacy, safety, and pharmacokinetics (PK) of repeat doses of IgPro20 in participants with post SARS-CoV-2 infection 2019 postural orthostatic tachycardia syndrome (post-Coronavirus Dis…", "summary": "Terminated · Phase 3 · Igpro20 — This is a prospective, phase 3, multicenter, double-blind, randomized placebo-controlled study to investigate the efficacy, safety, and pharmacokinetics (PK) of repeat doses of IgPro20 in participants with post SARS-CoV-2 infection 2019 postural orthostatic tachycard", "tags": [ "POTS", "Terminated", "Igpro20" ], "_osmf": { "nct_id": "NCT06524739", "status": "TERMINATED", "phase": "PHASE3", "start_date": "2024-08-28", "last_updated": "2026-04-13", "agents": [ "Igpro20" ] }, "date_published": "2026-04-13T08:00:00+00:00", "date_modified": "2026-04-13T08:00:00+00:00" }, { "id": "NCT06133075:2026-04-08", "url": "https://clinicaltrials.gov/study/NCT06133075", "title": "Using Mirabegron to Increase BP in Patients With POTS", "content_text": "Completed · Phase 2 · Mirabegron 50 Mg, Mirabegron 25 Mg — This is a pilot dose-finding study to test the hypothesis that mirabegron increases systolic blood pressure (BP), prevents syncope/presyncope, and improves the quality of life (QOL), functional capacity, chest pain, and overactive bladder (OAB) symptoms in patients with postural orthostatic tachycar…", "summary": "Completed · Phase 2 · Mirabegron 50 Mg, Mirabegron 25 Mg — This is a pilot dose-finding study to test the hypothesis that mirabegron increases systolic blood pressure (BP), prevents syncope/presyncope, and improves the quality of life (QOL), functional capacity, chest pain, and overactive bladder (O", "tags": [ "POTS", "Completed", "Mirabegron 50 Mg", "Mirabegron 25 Mg" ], "_osmf": { "nct_id": "NCT06133075", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2023-12-22", "last_updated": "2026-04-08", "agents": [ "Mirabegron 50 Mg", "Mirabegron 25 Mg" ] }, "date_published": "2026-04-08T08:00:00+00:00", "date_modified": "2026-04-08T08:00:00+00:00" }, { "id": "NCT07182578:2026-04-03", "url": "https://clinicaltrials.gov/study/NCT07182578", "title": "Programming Aquatic Therapy for POTS", "content_text": "Completed · Not applicable · Aquatic Occupational Therapy — The goal of this pilot study is to create, implement, and evaluate an aquatic therapy for Postural Orthostatic Tachycardia Syndrome (POTS) program feasibility and ability to improve quality of life as determined by reduced orthostatic tachycardia, reduced POTS symptoms, and improved quality of life …", "summary": "Completed · Not applicable · Aquatic Occupational Therapy — The goal of this pilot study is to create, implement, and evaluate an aquatic therapy for Postural Orthostatic Tachycardia Syndrome (POTS) program feasibility and ability to improve quality of life as determined by reduced orthostatic tachy", "tags": [ "POTS", "Completed", "Aquatic Occupational Therapy" ], "_osmf": { "nct_id": "NCT07182578", "status": "COMPLETED", "phase": "NA", "start_date": "2025-09-12", "last_updated": "2026-04-03", "agents": [ "Aquatic Occupational Therapy" ] }, "date_published": "2026-04-03T08:00:00+00:00", "date_modified": "2026-04-03T08:00:00+00:00" }, { "id": "NCT07454395:2026-03-30", "url": "https://clinicaltrials.gov/study/NCT07454395", "title": "Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome?", "content_text": "Suspended · Not applicable · Swimming, Cycling — Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people with ME/CFS and related conditions, due to the distinct physiological ef…", "summary": "Suspended · Not applicable · Swimming, Cycling — Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people with ME/CFS and related", "tags": [ "POTS", "Suspended", "Swimming", "Cycling" ], "_osmf": { "nct_id": "NCT07454395", "status": "SUSPENDED", "phase": "NA", "start_date": "2026-02-20", "last_updated": "2026-03-30", "agents": [ "Swimming", "Cycling" ] }, "date_published": "2026-03-30T08:00:00+00:00", "date_modified": "2026-03-30T08:00:00+00:00" }, { "id": "NCT04140721:2026-03-27", "url": "https://clinicaltrials.gov/study/NCT04140721", "title": "Autonomic Determinants of POTS - Pilot 2", "content_text": "Active Not Recruiting · Early phase 1 · Moxonidine Pill — Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. These patients have high heart rate and disabling symptoms during standing. Quality of life may be poor. The sympathetic nerves in the autonomic nervous system help to maintain norma…", "summary": "Active Not Recruiting · Early phase 1 · Moxonidine Pill — Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. These patients have high heart rate and disabling symptoms during standing. Quality of life may be poor. The sympathetic ner", "tags": [ "POTS", "Active Not Recruiting", "Moxonidine Pill" ], "_osmf": { "nct_id": "NCT04140721", "status": "ACTIVE_NOT_RECRUITING", "phase": "EARLY_PHASE1", "start_date": "2021-08-31", "last_updated": "2026-03-27", "agents": [ "Moxonidine Pill" ] }, "date_published": "2026-03-27T08:00:00+00:00", "date_modified": "2026-03-27T08:00:00+00:00" }, { "id": "NCT04050410:2026-03-27", "url": "https://clinicaltrials.gov/study/NCT04050410", "title": "Autonomic Determinants of POTS - Pilot1", "content_text": "Active Not Recruiting · Early phase 1 · Moxonidine — Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. It is the cause of significant disability and an impairment in quality of life. These patients have high heart rate and symptoms during standing. Many of these patients are disabled …", "summary": "Active Not Recruiting · Early phase 1 · Moxonidine — Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. It is the cause of significant disability and an impairment in quality of life. These patients have high heart rate and symptoms ", "tags": [ "POTS", "Active Not Recruiting", "Moxonidine" ], "_osmf": { "nct_id": "NCT04050410", "status": "ACTIVE_NOT_RECRUITING", "phase": "EARLY_PHASE1", "start_date": "2019-08-27", "last_updated": "2026-03-27", "agents": [ "Moxonidine" ] }, "date_published": "2026-03-27T08:00:00+00:00", "date_modified": "2026-03-27T08:00:00+00:00" }, { "id": "NCT02281097:2026-03-27", "url": "https://clinicaltrials.gov/study/NCT02281097", "title": "Transdermal Vagal Stimulation for POTS", "content_text": "Active Not Recruiting · Not applicable · Stimulation — Some patients experience high heart rates and symptoms of light-headedness, fatigue, headache during standing despite well maintained blood pressure. These patient are disabled and can't be in upright position for a longer time. The purpose of this study is to test whether electrical stimulation of …", "summary": "Active Not Recruiting · Not applicable · Stimulation — Some patients experience high heart rates and symptoms of light-headedness, fatigue, headache during standing despite well maintained blood pressure. These patient are disabled and can't be in upright position for a longer time. The purpose of t", "tags": [ "POTS", "Active Not Recruiting", "Stimulation" ], "_osmf": { "nct_id": "NCT02281097", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "start_date": "2013-06", "last_updated": "2026-03-27", "agents": [ "Stimulation" ] }, "date_published": "2026-03-27T08:00:00+00:00", "date_modified": "2026-03-27T08:00:00+00:00" }, { "id": "NCT07478172:2026-03-17", "url": "https://clinicaltrials.gov/study/NCT07478172", "title": "Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease", "content_text": "Recruiting · Not applicable · Whole-Body Electrical Muscle Stimulation Exercise — This single-arm pilot study evaluates the effects of whole-body electrical muscle stimulation (WB-EMS) exercise on neuromuscular and physical function in adults with neuromuscular disease (NMD). Due to motor unit impairments, NMD patients often cannot tolerate traditional exercise. WB-EMS bypasses v…", "summary": "Recruiting · Not applicable · Whole-Body Electrical Muscle Stimulation Exercise — This single-arm pilot study evaluates the effects of whole-body electrical muscle stimulation (WB-EMS) exercise on neuromuscular and physical function in adults with neuromuscular disease (NMD). Due to motor unit impai", "tags": [ "POTS", "Recruiting", "Whole-Body Electrical Muscle Stimulation Exercise" ], "_osmf": { "nct_id": "NCT07478172", "status": "RECRUITING", "phase": "NA", "start_date": "2026-03-10", "last_updated": "2026-03-17", "agents": [ "Whole-Body Electrical Muscle Stimulation Exercise" ] }, "date_published": "2026-03-17T08:00:00+00:00", "date_modified": "2026-03-17T08:00:00+00:00" }, { "id": "NCT05212129:2026-02-13", "url": "https://clinicaltrials.gov/study/NCT05212129", "title": "Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome", "content_text": "Recruiting · Not applicable · Percutaneous Vagal Nerve Stimulation (Pvns) Device, Acoustic Vagal Nerve Stimulation (Avns) Treatment — Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue manifestations. For unclear reasons, hEDS is associated with many gastrointestinal (GI) and autonomic nervous system (ANS) complaints …", "summary": "Recruiting · Not applicable · Percutaneous Vagal Nerve Stimulation (Pvns) Device, Acoustic Vagal Nerve Stimulation (Avns) Treatment — Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue ", "tags": [ "POTS", "Recruiting", "Percutaneous Vagal Nerve Stimulation (Pvns) Device", "Acoustic Vagal Nerve Stimulation (Avns) Treatment" ], "_osmf": { "nct_id": "NCT05212129", "status": "RECRUITING", "phase": "NA", "start_date": "2021-04-05", "last_updated": "2026-02-13", "agents": [ "Percutaneous Vagal Nerve Stimulation (Pvns) Device", "Acoustic Vagal Nerve Stimulation (Avns) Treatment" ] }, "date_published": "2026-02-13T08:00:00+00:00", "date_modified": "2026-02-13T08:00:00+00:00" }, { "id": "NCT07189936:2026-01-22", "url": "https://clinicaltrials.gov/study/NCT07189936", "title": "Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS", "content_text": "Recruiting · Phase 2 · To Measure Levels Of Circulating Monocyte/ T Cell Doublets At Baseline, To Measure Levels Of Circulating Monocyte/ T Cell Doublets After 28 Days Of 2 Hoba Treatment, To Measure Splanchnic Venous Capacitance After 28 Days Of Treatment With 2Hoba, To Measure Orthostatic Tachycardia After 28 Days Of Treatment With 2Hoba — Long COVID is defined by a range of symptoms affecting multiple organs that persist for more than three months following an acute SARS-CoV-2 infection. Approximately 7% of individuals who recover from SARS-Cov-2 infection develop Long COVID. Long COVID Postural Orthostatic Tachycardia Syndrome (LCPO…", "summary": "Recruiting · Phase 2 · To Measure Levels Of Circulating Monocyte/ T Cell Doublets At Baseline, To Measure Levels Of Circulating Monocyte/ T Cell Doublets After 28 Days Of 2 Hoba Treatment, To Measure Splanchnic Venous Capacitance After 28 Days Of Treatment With 2Hoba, To Measure Orthostatic Tachycar", "tags": [ "POTS", "Recruiting", "To Measure Levels Of Circulating Monocyte/ T Cell Doublets At Baseline", "To Measure Levels Of Circulating Monocyte/ T Cell Doublets After 28 Days Of 2 Hoba Treatment", "To Measure Splanchnic Venous Capacitance After 28 Days Of Treatment With 2Hoba", "To Measure Orthostatic Tachycardia After 28 Days Of Treatment With 2Hoba" ], "_osmf": { "nct_id": "NCT07189936", "status": "RECRUITING", "phase": "PHASE2", "start_date": "2025-12-18", "last_updated": "2026-01-22", "agents": [ "To Measure Levels Of Circulating Monocyte/ T Cell Doublets At Baseline", "To Measure Levels Of Circulating Monocyte/ T Cell Doublets After 28 Days Of 2 Hoba Treatment", "To Measure Splanchnic Venous Capacitance After 28 Days Of Treatment With 2Hoba", "To Measure Orthostatic Tachycardia After 28 Days Of Treatment With 2Hoba" ] }, "date_published": "2026-01-22T08:00:00+00:00", "date_modified": "2026-01-22T08:00:00+00:00" }, { "id": "NCT01988883:2026-01-15", "url": "https://clinicaltrials.gov/study/NCT01988883", "title": "Modafinil and Cognitive Function in POTS", "content_text": "Active Not Recruiting · Early phase 1 · Modafinil, Propranolol — A common complaint among patients with Postural Tachycardia Syndrome (POTS) is \"brain fog\" or difficulty concentrating. This problem is poorly understood. The purpose of this study is to better understand the cognitive dysfunction associated POTS, and to determine optimal treatment strategies for th…", "summary": "Active Not Recruiting · Early phase 1 · Modafinil, Propranolol — A common complaint among patients with Postural Tachycardia Syndrome (POTS) is \"brain fog\" or difficulty concentrating. This problem is poorly understood. The purpose of this study is to better understand the cognitive dysfunction asso", "tags": [ "POTS", "Active Not Recruiting", "Modafinil", "Propranolol" ], "_osmf": { "nct_id": "NCT01988883", "status": "ACTIVE_NOT_RECRUITING", "phase": "EARLY_PHASE1", "start_date": "2014-10", "last_updated": "2026-01-15", "agents": [ "Modafinil", "Propranolol" ] }, "date_published": "2026-01-15T08:00:00+00:00", "date_modified": "2026-01-15T08:00:00+00:00" }, { "id": "NCT00962728:2025-12-22", "url": "https://clinicaltrials.gov/study/NCT00962728", "title": "Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)", "content_text": "Active Not Recruiting · Not applicable · Inspiratory Threshold Device — The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease heart rate increases on standing in patients with postural tachycardia syndrome.", "summary": "Active Not Recruiting · Not applicable · Inspiratory Threshold Device — The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease heart rate increases on standing in patients with postural tachycardia syndrome.", "tags": [ "POTS", "Active Not Recruiting", "Inspiratory Threshold Device" ], "_osmf": { "nct_id": "NCT00962728", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "start_date": "2009-07", "last_updated": "2025-12-22", "agents": [ "Inspiratory Threshold Device" ] }, "date_published": "2025-12-22T08:00:00+00:00", "date_modified": "2025-12-22T08:00:00+00:00" }, { "id": "NCT07197905:2025-12-11", "url": "https://clinicaltrials.gov/study/NCT07197905", "title": "Restoring Iron Deficiency in POTS", "content_text": "Recruiting · Phase 2 · Intravenous Iron — People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body). The purpose of this pilot study is to investigate whether giving iron to people with POTS who have low ferritin levels will incre…", "summary": "Recruiting · Phase 2 · Intravenous Iron — People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body). The purpose of this pilot study is to investigate whether giving iron to people with PO", "tags": [ "POTS", "Recruiting", "Intravenous Iron" ], "_osmf": { "nct_id": "NCT07197905", "status": "RECRUITING", "phase": "PHASE2", "start_date": "2025-11-24", "last_updated": "2025-12-11", "agents": [ "Intravenous Iron" ] }, "date_published": "2025-12-11T08:00:00+00:00", "date_modified": "2025-12-11T08:00:00+00:00" }, { "id": "NCT05375968:2025-12-05", "url": "https://clinicaltrials.gov/study/NCT05375968", "title": "Splanchnic Venous Capacitance in Postural Tachycardia Syndrome", "content_text": "Recruiting · Phase 2 · Compare Change Is Svc And Sma Flow Due To Gip Antagonist Gip(3-30)Nh2, Compare Change Is Svc And Sma Flow Due To Saline — Postural tachycardia syndrome (POTS) affects ≈3 million young people, characterized by chronic presyncopal symptoms characterized by dizziness, lightheadedness, and orthostatic tachycardia that occur while standing. Across-sectional survey found that 25% of these patients complains that meals rich i…", "summary": "Recruiting · Phase 2 · Compare Change Is Svc And Sma Flow Due To Gip Antagonist Gip(3-30)Nh2, Compare Change Is Svc And Sma Flow Due To Saline — Postural tachycardia syndrome (POTS) affects ≈3 million young people, characterized by chronic presyncopal symptoms characterized by dizziness, lightheaded", "tags": [ "POTS", "Recruiting", "Compare Change Is Svc And Sma Flow Due To Gip Antagonist Gip(3-30)Nh2", "Compare Change Is Svc And Sma Flow Due To Saline" ], "_osmf": { "nct_id": "NCT05375968", "status": "RECRUITING", "phase": "PHASE2", "start_date": "2023-02-25", "last_updated": "2025-12-05", "agents": [ "Compare Change Is Svc And Sma Flow Due To Gip Antagonist Gip(3-30)Nh2", "Compare Change Is Svc And Sma Flow Due To Saline" ] }, "date_published": "2025-12-05T08:00:00+00:00", "date_modified": "2025-12-05T08:00:00+00:00" } ] }