https://research.opensourcemed.info/me-cfs.htmlClinicalTrials.gov records for ME/CFS that were newly registered or updated, as tracked by the Open Source Medicine Foundation research tracker. The 30 most recently updated trials, newest first.enFri, 09 Oct 2026 11:21:14 +0000OSMF build_condition_feeds.py1440https://opensourcemed.info/favicon.pnghttps://research.opensourcemed.info/me-cfs.htmlhttps://clinicaltrials.gov/study/NCT07546539NCT07546539:2026-10-08Thu, 08 Oct 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Photobiomodulation — The goal of this clinical trial is to evaluate whether photobiomodulation therapy (low-level laser therapy) can reduce fatigue and improve quality of life in patients with chronic fatigue syndrome (CFS). The study will include adults aged 18-60 years diagnosed with chronic fatigue syndrome. The main…https://clinicaltrials.gov/study/NCT07285473NCT07285473:2026-10-08Thu, 08 Oct 2026 08:00:00 +0000ME/CFSNot Yet RecruitingNot Yet Recruiting · Phase 2 · Low-Dose Naltrexone (LDN) — This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A remote trial approach is used, with eligibility open to the state of Alabama.https://clinicaltrials.gov/study/NCT06739720NCT06739720:2026-09-21Mon, 21 Sep 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Phase 2 · Lingzhi Capsule — The goal of this clinical trial is to test if a Lingzhi supplement (CP003) helps people with chronic fatigue or post-COVID fatigue feel better. It will also check if the supplement is safe to use. The main questions it aims to answer are: Does the Lingzhi supplement reduce fatigue symptoms? Is it sa…https://clinicaltrials.gov/study/NCT06472622NCT06472622:2026-09-18Fri, 18 Sep 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Early phase 1 · Thermal Pain Stimulation, Physical Effort Stimulation — Background: The way the brain processes rewards and punishments may play a role in some disorders of the nervous system. People with chronic overlapping pain conditions (such as myalgic encephalomyelitis/chronic fatigue syndrome \[ME/CFS\]) may have heightened responses to unpleasant, punishing sens…https://clinicaltrials.gov/study/NCT06933173NCT06933173:2026-09-09Wed, 09 Sep 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Dynamic Neural Retraining System — We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC). Our team recognizes that ME/CFS and Long COVID are serious, debilitating, biomedical conditions. ME/CFS can affect many different parts of …https://clinicaltrials.gov/study/NCT07621068NCT07621068:2026-08-21Fri, 21 Aug 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Hyperbaric Oxygen Therapy (HBOT) — This study evaluates the effects of hyperbaric oxygen therapy (HBOT) in patients with mild to moderate CFS/ME. Participants will undergo 60 HBOT sessions over 3 months with a 3-month follow-up, including physical, cognitive, imaging, and laboratory assessments.https://clinicaltrials.gov/study/NCT07523113NCT07523113:2026-08-14Fri, 14 Aug 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Processing Speed Training, In-Session Instrumental Activities Of Daily Living Training, Transfer Package, Follow Up Phone Calls, Trans-Auricular Vagus Nerve Stimulation: High Intensity — The purpose of this study is to compare two approaches to cognitive rehabilitation in adults with post-viral cognitive syndrome, which resulted in brain fog. All participants will be screened for eligibility prior to participation. Most of the procedures will take place over a phone call or secure t…https://clinicaltrials.gov/study/NCT07753122NCT07753122:2026-08-07Fri, 07 Aug 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Molecular Hydrogen Produced By A Metallic Magnesium Tablet, Consumed 3X A Day Dissolved In Water. Treatment Duration Is 16 Weeks. — This is a 16-week controlled treatment trial of an over-the -counter supplement, hydrogen water, for individuals with ME/CFS patients. An active treatment condition will be compared to a placebo-control condition. The study will also seek confirmation of heart rate variability (HRV) as a biomarker, …https://clinicaltrials.gov/study/NCT06585254NCT06585254:2026-08-03Mon, 03 Aug 2026 08:00:00 +0000ME/CFSActive Not RecruitingActive Not Recruiting · Not applicable · Transcutaneous Vagus Nerve Stimulator — A prior open label study has shown that transcutaneous vagus nerve stimulation \[tVNS\] can improve the health of some patients with postacute sequelae of SARS-CoV-2 infection (PASC), severely affected enough to also fulfill criteria for myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS).…https://clinicaltrials.gov/study/NCT07724834NCT07724834:2026-07-24Fri, 24 Jul 2026 08:00:00 +0000ME/CFSNot Yet RecruitingNot Yet Recruiting · Phase 2 · Inebilizumab — Post-acute infection syndromes (PAIS) are long-lasting health problems that can develop after an infection. They include post-COVID-19 syndrome and similar illnesses following other infections. Some people with PAIS develop myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a serious and d…https://clinicaltrials.gov/study/NCT04542161NCT04542161:2026-06-22Mon, 22 Jun 2026 08:00:00 +0000ME/CFSActive Not RecruitingActive Not Recruiting · Phase 2 · N-Acetylcysteine (NAC) — Chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) is an unexplained multisymptom/multisystem disorder for which there are currently no validated treatments. The present exploratory clinical trial aims to advance our understand of the mechanisms of in situ GSH synthesis control through asse…https://clinicaltrials.gov/study/NCT05967052NCT05967052:2026-06-17Wed, 17 Jun 2026 08:00:00 +0000ME/CFSTerminatedTerminated · Phase 2 · Pregabalin, Independent Walking Training, Gradual Movement Therapy In The Ward, Telerehabilitation, Psychotherapy — This is a single-center, prospective, randomized, double-blind (pharmacotherapy), placebo-controlled, and comprehensive rehabilitation phase II clinical trial to determine the usefulness of pregabalin in a new indication (post-COVID chronic fatigue syndrome). Patients will be randomized in a 1:1:1:1…https://clinicaltrials.gov/study/NCT07491315NCT07491315:2026-06-08Mon, 08 Jun 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Exercise Test On Ergocycle, Near Infrared Spectroscopy — Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is a disease characterized by persistent and unexplained fatigue associated with diffuse pain, sleep disorders, neurocognitive and autonomic symptoms, musculoskeletal manifestations and digestive symptoms. A central feature of this diseas…https://clinicaltrials.gov/study/NCT03807973NCT03807973:2026-06-02Tue, 02 Jun 2026 08:00:00 +0000ME/CFSSuspendedSuspended · Phase 1 · [Zr-89]Oxine-Labeled Leukocytes Pet/Mri — This study will use brain Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and an investigational radioactive drug called \[Zr-89\]oxine to track the location of white blood cells (also called leukocytes) in the body. PET/MRI will be used to visualize labeled white blood cells and …https://clinicaltrials.gov/study/NCT03759522NCT03759522:2026-06-02Tue, 02 Jun 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Phase 1 · Dpa-714 Pet/Mri — The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET t…https://clinicaltrials.gov/study/NCT07317401NCT07317401:2026-05-22Fri, 22 May 2026 08:00:00 +0000ME/CFSNot Yet RecruitingNot Yet Recruiting · Not applicable · Intermittent Hypoxia-Hyperoxia Treatment — This study is testing a new treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and long-term symptoms after COVID-19. Both conditions cause extreme fatigue, muscle pain, "brain fog," and trouble concentrating, which often get worse after physical or mental activity…https://clinicaltrials.gov/study/NCT07573709NCT07573709:2026-05-07Thu, 07 May 2026 08:00:00 +0000ME/CFSTerminatedTerminated · Not applicable · Transcraneal Direct Current Electric Stimulation, Transcranial Direct Current Electric Stimulation — Functional and Affective Effects of a brief tDCS Intervention in Fibromyalgia and Chronic Fatigue Syndrome Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are characterized by persistent, multidimensional symptoms arising from complex brain-body interactions that impair functioning and quality …https://clinicaltrials.gov/study/NCT06170645NCT06170645:2026-05-06Wed, 06 May 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Apa Program, Active Transcutaneous Vns — Chronic fatigue is enhanced by adapted physical activity (APA) programs. Patients consulting on St Etienne hospital and suffering from fibromyalgia and long Covid benefit from a 4-6 week APA program, with 2 sessions per week. While most patients are improved by these exercise-training programs, for …https://clinicaltrials.gov/study/NCT06978582NCT06978582:2026-04-28Tue, 28 Apr 2026 08:00:00 +0000ME/CFSActive Not RecruitingActive Not Recruiting · Not applicable · Mindful And Conscious Movement-Based Exercise, Conventional Exercise — This is a randomized, single-blind clinical trial that aims to evaluate the effectiveness of a tele-rehabilitation program based on mindful and conscious movement-based exercise (including adapted yoga, breathing exercises, and body awareness) compared to conventional exercise (low-intensity strengt…https://clinicaltrials.gov/study/NCT06128967NCT06128967:2026-04-13Mon, 13 Apr 2026 08:00:00 +0000ME/CFSCompletedCompleted · Phase 3 · Fluvoxamine Maleate 100 Mg, Metformin — IRB approval date 14-APR-2024 and public at https://plataformabrasil.saude.gov.br/login.jsf since IURB approval Long COVID is a multi-systemic condition comprising often severe and persistent symptoms (longer than 12 weeks) that follow a known episode of COVID-19 and cannot be explained by another m…https://clinicaltrials.gov/study/NCT07454395NCT07454395:2026-03-30Mon, 30 Mar 2026 08:00:00 +0000ME/CFSSuspendedSuspended · Not applicable · Swimming, Cycling — Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people with ME/CFS and related conditions, due to the distinct physiological ef…https://clinicaltrials.gov/study/NCT03844412NCT03844412:2026-03-19Thu, 19 Mar 2026 08:00:00 +0000ME/CFSCompletedCompleted · Phase 2 · Nortriptyline — Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States. Here, the investigators plan to conduct a randomized, double-blinded, placebo-controlled clinical trial to 1) compare th…https://clinicaltrials.gov/study/NCT06511050NCT06511050:2026-03-13Fri, 13 Mar 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Phase 1 · Lumbrokinase — This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: * Long Covid (LC) * Post-treatment Lyme disease syndrome (PTLDS) * Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)https://clinicaltrials.gov/study/NCT07242573NCT07242573:2026-02-24Tue, 24 Feb 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Physical Training Program, Nesa X-Signal, Conventional Physiotherapy — Fibromyalgia (FMS) is a chronic, multifactorial syndrome characterized by widespread pain, fatigue, and cognitive disturbances. This interventional study evaluates the impact of structured physical training using diagnostic-training devices (Zebris treadmill and Alfa balance platform) and transcutan…https://clinicaltrials.gov/study/NCT07363655NCT07363655:2026-01-28Wed, 28 Jan 2026 08:00:00 +0000ME/CFSCompletedCompleted · Not applicable · Intervention Group — The study focuses on rehabilitation nursing care for adults diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a home setting. The objective is to evaluate the effects of an individualised rehabilitation programme, which aims to empower participants to manage their energy effective…https://clinicaltrials.gov/study/NCT05697640NCT05697640:2026-01-28Wed, 28 Jan 2026 08:00:00 +0000ME/CFSActive Not RecruitingActive Not Recruiting · Phase 2 · Vericiguat Oral Tablet — The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main questions it aims to answer are: • Does Vericiguat relieve fatigue and/or othe…https://clinicaltrials.gov/study/NCT07357688NCT07357688:2026-01-22Thu, 22 Jan 2026 08:00:00 +0000ME/CFSNot Yet RecruitingNot Yet Recruiting · Not applicable · Acupuncture — Background of study: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a common sequela after SARS-CoV-2 infection(COVID-19). Cognitive dysfunction is one of the most common debilitating symptoms in ME/CFS. Currently, standardized therapy for ME/CFS has not been established. Some treatm…https://clinicaltrials.gov/study/NCT07352254NCT07352254:2026-01-21Wed, 21 Jan 2026 08:00:00 +0000ME/CFSRecruitingRecruiting · Not applicable · Online Visit — The significance of the Post-COVID Syndrome (PCS) has been widely acknowledged. Various efforts are made to find out about the pathomechanisms behind PCS and to establish therapies. One sub-group of PCS-patients, however, is generally excluded from any studies, and that are those who are unable to v…https://clinicaltrials.gov/study/NCT05710770NCT05710770:2026-01-16Fri, 16 Jan 2026 08:00:00 +0000ME/CFSCompletedCompleted · Not applicable · Immunoadsorption — The goal of this clinical trial is to learn about the effectiveness of repeated immunoadsorption intervention in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS). The main questions it aims to answer are: (1) Does repeated immunoadsorption relie…https://clinicaltrials.gov/study/NCT04740736NCT04740736:2025-12-18Thu, 18 Dec 2025 08:00:00 +0000ME/CFSCompletedCompleted · Not applicable · Saline Infusion — The purpose of this study is to examine cardiopulmonary function in Chronic Fatigue Syndrome (CFS) patients and determine how it relates to the common symptom of Post-exertional malaise (PEM). Subjects will complete a maximal exercise test on 2 subsequent days. Total blood volume will be measured pr…