{
  "version": "https://jsonfeed.org/version/1.1",
  "title": "Long COVID clinical trials: new and updated - Open Source Medicine Foundation",
  "home_page_url": "https://research.opensourcemed.info/long-covid.html",
  "feed_url": "https://research.opensourcemed.info/feeds/long-covid.json",
  "description": "ClinicalTrials.gov records for Long COVID (PASC) that were newly registered or updated, as tracked by the Open Source Medicine Foundation research tracker. The 30 most recently updated trials, newest first.",
  "language": "en",
  "icon": "https://opensourcemed.info/favicon.png",
  "favicon": "https://opensourcemed.info/favicon.png",
  "authors": [
    {
      "name": "Open Source Medicine Foundation",
      "url": "https://opensourcemed.info"
    }
  ],
  "items": [
    {
      "id": "NCT07388550:2026-10-08",
      "url": "https://clinicaltrials.gov/study/NCT07388550",
      "title": "Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)",
      "content_text": "Not Yet Recruiting · Phase 1 · Keytruda — Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from an acute COVID-19 infection may continue to have symptoms that persist for months or years. These can include neurological symptoms, such as headaches, loss of taste or smell, dizziness, or trouble walking. Pembro…",
      "summary": "Not Yet Recruiting · Phase 1 · Keytruda — Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from an acute COVID-19 infection may continue to have symptoms that persist for months or years. These can include neurological symptoms, such as headaches, loss of taste or sm",
      "tags": [
        "Long COVID",
        "Not Yet Recruiting",
        "Keytruda"
      ],
      "_osmf": {
        "nct_id": "NCT07388550",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE1",
        "start_date": "2026-10-13",
        "last_updated": "2026-10-08",
        "agents": [
          "Keytruda"
        ]
      },
      "date_published": "2026-10-08T08:00:00+00:00",
      "date_modified": "2026-10-08T08:00:00+00:00"
    },
    {
      "id": "NCT06822179:2026-10-08",
      "url": "https://clinicaltrials.gov/study/NCT06822179",
      "title": "Effectiveness of a Personalized In-home Telerehabilitation Program on Self-Care in Patients With Long COVID",
      "content_text": "Completed · Phase 2 · Personalised Exercise Program — The goal of this clinical trial is to evaluate whether a 12-week tele-rehabilitation programme roduces medium-term improvements in self-management, fatigue and quality of life in patients affected by persistent COVID. The main questions it aims to answer are: * Will a multimodal program (exercise wi…",
      "summary": "Completed · Phase 2 · Personalised Exercise Program — The goal of this clinical trial is to evaluate whether a 12-week tele-rehabilitation programme roduces medium-term improvements in self-management, fatigue and quality of life in patients affected by persistent COVID. The main questions it aims t",
      "tags": [
        "Long COVID",
        "Completed",
        "Personalised Exercise Program"
      ],
      "_osmf": {
        "nct_id": "NCT06822179",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2025-03-01",
        "last_updated": "2026-10-08",
        "agents": [
          "Personalised Exercise Program"
        ]
      },
      "date_published": "2026-10-08T08:00:00+00:00",
      "date_modified": "2026-10-08T08:00:00+00:00"
    },
    {
      "id": "NCT06766825:2026-10-08",
      "url": "https://clinicaltrials.gov/study/NCT06766825",
      "title": "Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)",
      "content_text": "Completed · Phase 2 · Plitidepsin 1.5 Mg/Day — The study aims to prove that plitidepsin could be an efficacious, safe, and well-tolerated therapy for PCC. To this end, we will perform a randomized, double-blind study comparing the clinical and laboratory benefits of plitidepsin vs. placebo in 90 subjects with moderate to severe functional disabi…",
      "summary": "Completed · Phase 2 · Plitidepsin 1.5 Mg/Day — The study aims to prove that plitidepsin could be an efficacious, safe, and well-tolerated therapy for PCC. To this end, we will perform a randomized, double-blind study comparing the clinical and laboratory benefits of plitidepsin vs. placebo in 90 sub",
      "tags": [
        "Long COVID",
        "Completed",
        "Plitidepsin 1.5 Mg/Day"
      ],
      "_osmf": {
        "nct_id": "NCT06766825",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2025-02-07",
        "last_updated": "2026-10-08",
        "agents": [
          "Plitidepsin 1.5 Mg/Day"
        ]
      },
      "date_published": "2026-10-08T08:00:00+00:00",
      "date_modified": "2026-10-08T08:00:00+00:00"
    },
    {
      "id": "NCT05874037:2026-10-07",
      "url": "https://clinicaltrials.gov/study/NCT05874037",
      "title": "Fluvoxamine for Long COVID-19",
      "content_text": "Completed · Phase 2 · Fluvoxamine — This clinical trial aims to test the effects of fluvoxamine as a treatment for Long COVID. Fluvoxamine is an FDA approved SSRI for Obsessive Compulsive Disorder (OCD), that has already had success in preventing hospitalization in patients with COVID-19 (STOP COVID and TOGETHER trials). This trial is…",
      "summary": "Completed · Phase 2 · Fluvoxamine — This clinical trial aims to test the effects of fluvoxamine as a treatment for Long COVID. Fluvoxamine is an FDA approved SSRI for Obsessive Compulsive Disorder (OCD), that has already had success in preventing hospitalization in patients with COVID-19 (STOP COVID",
      "tags": [
        "Long COVID",
        "Completed",
        "Fluvoxamine"
      ],
      "_osmf": {
        "nct_id": "NCT05874037",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2023-05-15",
        "last_updated": "2026-10-07",
        "agents": [
          "Fluvoxamine"
        ]
      },
      "date_published": "2026-10-07T08:00:00+00:00",
      "date_modified": "2026-10-07T08:00:00+00:00"
    },
    {
      "id": "NCT07661862:2026-10-06",
      "url": "https://clinicaltrials.gov/study/NCT07661862",
      "title": "PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID",
      "content_text": "Recruiting · Not applicable · Perceive-Outreach Disease Management Program — Some people who had COVID-19 continue to have symptoms for weeks, months, or even years after their infection. This is often called \"Long COVID\" or Post-Acute Sequelae of SARS-CoV-2 (PASC). For some people, Long COVID can affect the heart and lungs, making it harder to exercise or carry out daily ac…",
      "summary": "Recruiting · Not applicable · Perceive-Outreach Disease Management Program — Some people who had COVID-19 continue to have symptoms for weeks, months, or even years after their infection. This is often called \"Long COVID\" or Post-Acute Sequelae of SARS-CoV-2 (PASC). For some people, Long COVID can a",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Perceive-Outreach Disease Management Program"
      ],
      "_osmf": {
        "nct_id": "NCT07661862",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2026-04-01",
        "last_updated": "2026-10-06",
        "agents": [
          "Perceive-Outreach Disease Management Program"
        ]
      },
      "date_published": "2026-10-06T08:00:00+00:00",
      "date_modified": "2026-10-06T08:00:00+00:00"
    },
    {
      "id": "NCT06928272:2026-10-06",
      "url": "https://clinicaltrials.gov/study/NCT06928272",
      "title": "Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study",
      "content_text": "Recruiting · Phase 3 · Pirfenidone, Upadacitinib — The Long-Covid (LC)-Revitalize clinical study is testing repurposed drug treatments for Long Covid, involving adult participants from Brazil, Canada, Italy, South Africa, Uganda, the United States, and Zambia. To qualify, participants must have had Covid-19 and experienced Long Covid symptoms for at…",
      "summary": "Recruiting · Phase 3 · Pirfenidone, Upadacitinib — The Long-Covid (LC)-Revitalize clinical study is testing repurposed drug treatments for Long Covid, involving adult participants from Brazil, Canada, Italy, South Africa, Uganda, the United States, and Zambia. To qualify, participants must have had ",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Pirfenidone",
        "Upadacitinib"
      ],
      "_osmf": {
        "nct_id": "NCT06928272",
        "status": "RECRUITING",
        "phase": "PHASE3",
        "start_date": "2025-09-10",
        "last_updated": "2026-10-06",
        "agents": [
          "Pirfenidone",
          "Upadacitinib"
        ]
      },
      "date_published": "2026-10-06T08:00:00+00:00",
      "date_modified": "2026-10-06T08:00:00+00:00"
    },
    {
      "id": "NCT06404073:2026-10-06",
      "url": "https://clinicaltrials.gov/study/NCT06404073",
      "title": "RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM))",
      "content_text": "Completed · Not applicable · Structured Pacing — This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management programs and treatment plans if results achieve key study outcomes. This…",
      "summary": "Completed · Not applicable · Structured Pacing — This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management programs and treatment ",
      "tags": [
        "Long COVID",
        "Completed",
        "Structured Pacing"
      ],
      "_osmf": {
        "nct_id": "NCT06404073",
        "status": "COMPLETED",
        "phase": "NA",
        "start_date": "2024-07-17",
        "last_updated": "2026-10-06",
        "agents": [
          "Structured Pacing"
        ]
      },
      "date_published": "2026-10-06T08:00:00+00:00",
      "date_modified": "2026-10-06T08:00:00+00:00"
    },
    {
      "id": "NCT07621588:2026-09-29",
      "url": "https://clinicaltrials.gov/study/NCT07621588",
      "title": "Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID",
      "content_text": "Completed · Not applicable · Diaphragmatic Electrostimulation Using Kots Currents, Diaphragmatic Breathing Exercises — This study will evaluate the effects of diaphragmatic breathing exercises combined with diaphragmatic electrostimulation using KOTS currents in patients with Long COVID. Participants will be randomly assigned to one of two groups. The control group will perform diaphragmatic breathing exercises, whi…",
      "summary": "Completed · Not applicable · Diaphragmatic Electrostimulation Using Kots Currents, Diaphragmatic Breathing Exercises — This study will evaluate the effects of diaphragmatic breathing exercises combined with diaphragmatic electrostimulation using KOTS currents in patients with Long COVID. Participant",
      "tags": [
        "Long COVID",
        "Completed",
        "Diaphragmatic Electrostimulation Using Kots Currents",
        "Diaphragmatic Breathing Exercises"
      ],
      "_osmf": {
        "nct_id": "NCT07621588",
        "status": "COMPLETED",
        "phase": "NA",
        "start_date": "2026-06-14",
        "last_updated": "2026-09-29",
        "agents": [
          "Diaphragmatic Electrostimulation Using Kots Currents",
          "Diaphragmatic Breathing Exercises"
        ]
      },
      "date_published": "2026-09-29T08:00:00+00:00",
      "date_modified": "2026-09-29T08:00:00+00:00"
    },
    {
      "id": "NCT07021794:2026-09-29",
      "url": "https://clinicaltrials.gov/study/NCT07021794",
      "title": "SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID)",
      "content_text": "Recruiting · Phase 2 · Sipavibart — This placebo-controlled, randomized, blinded, two-arm phase II study will test the safety and potential efficacy of the targeted mAb, Sipavibart (formerly AZD3152) in patients with Long COVID.",
      "summary": "Recruiting · Phase 2 · Sipavibart — This placebo-controlled, randomized, blinded, two-arm phase II study will test the safety and potential efficacy of the targeted mAb, Sipavibart (formerly AZD3152) in patients with Long COVID.",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Sipavibart"
      ],
      "_osmf": {
        "nct_id": "NCT07021794",
        "status": "RECRUITING",
        "phase": "PHASE2",
        "start_date": "2025-07-28",
        "last_updated": "2026-09-29",
        "agents": [
          "Sipavibart"
        ]
      },
      "date_published": "2026-09-29T08:00:00+00:00",
      "date_modified": "2026-09-29T08:00:00+00:00"
    },
    {
      "id": "NCT06928116:2026-09-28",
      "url": "https://clinicaltrials.gov/study/NCT06928116",
      "title": "Heat thErapy And mobiLity in COVID-19 Survivors",
      "content_text": "Recruiting · Not applicable · Heat Therapy, Walking — Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Although exercise intervention is a common strategy to restor…",
      "summary": "Recruiting · Not applicable · Heat Therapy, Walking — Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Althoug",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Heat Therapy",
        "Walking"
      ],
      "_osmf": {
        "nct_id": "NCT06928116",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2025-01-16",
        "last_updated": "2026-09-28",
        "agents": [
          "Heat Therapy",
          "Walking"
        ]
      },
      "date_published": "2026-09-28T08:00:00+00:00",
      "date_modified": "2026-09-28T08:00:00+00:00"
    },
    {
      "id": "NCT07005921:2026-09-25",
      "url": "https://clinicaltrials.gov/study/NCT07005921",
      "title": "QEEG-NEUROFEEDBACK FOR COGNITIVE REHABILITATION IN LONG COVID-19 SURVIVORS WITH BRAIN FOG",
      "content_text": "Completed · Not applicable · Qeeg-Neurofeedback — The pandemic has highlighted social, economic, educational, and political issues that have affected the health and quality of life of millions of Brazilians. Currently, attention and memory impairment remains predominant among the cognitive symptoms of Coronavirus observed in adults. The persistance…",
      "summary": "Completed · Not applicable · Qeeg-Neurofeedback — The pandemic has highlighted social, economic, educational, and political issues that have affected the health and quality of life of millions of Brazilians. Currently, attention and memory impairment remains predominant among the cognitive symptoms ",
      "tags": [
        "Long COVID",
        "Completed",
        "Qeeg-Neurofeedback"
      ],
      "_osmf": {
        "nct_id": "NCT07005921",
        "status": "COMPLETED",
        "phase": "NA",
        "start_date": "2025-06-10",
        "last_updated": "2026-09-25",
        "agents": [
          "Qeeg-Neurofeedback"
        ]
      },
      "date_published": "2026-09-25T08:00:00+00:00",
      "date_modified": "2026-09-25T08:00:00+00:00"
    },
    {
      "id": "NCT06631287:2026-09-25",
      "url": "https://clinicaltrials.gov/study/NCT06631287",
      "title": "Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID",
      "content_text": "Recruiting · Phase 3 · Baricitinib — The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post-COVID-19 symptom burden, and biomark…",
      "summary": "Recruiting · Phase 3 · Baricitinib — The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Baricitinib"
      ],
      "_osmf": {
        "nct_id": "NCT06631287",
        "status": "RECRUITING",
        "phase": "PHASE3",
        "start_date": "2024-10-21",
        "last_updated": "2026-09-25",
        "agents": [
          "Baricitinib"
        ]
      },
      "date_published": "2026-09-25T08:00:00+00:00",
      "date_modified": "2026-09-25T08:00:00+00:00"
    },
    {
      "id": "NCT07123727:2026-09-24",
      "url": "https://clinicaltrials.gov/study/NCT07123727",
      "title": "A Study to Examine Anktiva for the Treatment of COVID-19.",
      "content_text": "Recruiting · Phase 2 · Anktiva — This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.",
      "summary": "Recruiting · Phase 2 · Anktiva — This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Anktiva"
      ],
      "_osmf": {
        "nct_id": "NCT07123727",
        "status": "RECRUITING",
        "phase": "PHASE2",
        "start_date": "2025-09-04",
        "last_updated": "2026-09-24",
        "agents": [
          "Anktiva"
        ]
      },
      "date_published": "2026-09-24T08:00:00+00:00",
      "date_modified": "2026-09-24T08:00:00+00:00"
    },
    {
      "id": "NCT06847191:2026-09-22",
      "url": "https://clinicaltrials.gov/study/NCT06847191",
      "title": "NE3107 in Adults With Neurological Symptoms of Long COVID",
      "content_text": "Completed · Phase 2 · Ne3107 — Long COVID is a condition where debilitating symptoms can persist for months after a COVID-19 infection. This study aims to evaluate the effects of NE3107 on several neurological symptoms reported in people with Long COVID including difficulty concentrating or remembering things (\"brain fog\") and fa…",
      "summary": "Completed · Phase 2 · Ne3107 — Long COVID is a condition where debilitating symptoms can persist for months after a COVID-19 infection. This study aims to evaluate the effects of NE3107 on several neurological symptoms reported in people with Long COVID including difficulty concentrating or remember",
      "tags": [
        "Long COVID",
        "Completed",
        "Ne3107"
      ],
      "_osmf": {
        "nct_id": "NCT06847191",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2025-04-29",
        "last_updated": "2026-09-22",
        "agents": [
          "Ne3107"
        ]
      },
      "date_published": "2026-09-22T08:00:00+00:00",
      "date_modified": "2026-09-22T08:00:00+00:00"
    },
    {
      "id": "NCT06721949:2026-09-18",
      "url": "https://clinicaltrials.gov/study/NCT06721949",
      "title": "Taurine Supplementation in Long COVID",
      "content_text": "Recruiting · Phase 2 · Taurine — The COVID-19 pandemic has swept across the globe, affecting millions of individuals with varying degrees of severity. While many individuals recover from the acute phase of the infection, a significant proportion continue to experience persistent and debilitating symptoms long after the initial SARS…",
      "summary": "Recruiting · Phase 2 · Taurine — The COVID-19 pandemic has swept across the globe, affecting millions of individuals with varying degrees of severity. While many individuals recover from the acute phase of the infection, a significant proportion continue to experience persistent and debilitating sym",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Taurine"
      ],
      "_osmf": {
        "nct_id": "NCT06721949",
        "status": "RECRUITING",
        "phase": "PHASE2",
        "start_date": "2025-11-18",
        "last_updated": "2026-09-18",
        "agents": [
          "Taurine"
        ]
      },
      "date_published": "2026-09-18T08:00:00+00:00",
      "date_modified": "2026-09-18T08:00:00+00:00"
    },
    {
      "id": "NCT06821087:2026-09-17",
      "url": "https://clinicaltrials.gov/study/NCT06821087",
      "title": "Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19",
      "content_text": "Completed · Phase 2 · Ketamine Only — Plain Language Summary: This study is a clinical trial to see if ketamine can help treat symptoms of Long COVID, especially fatigue and problems with thinking clearly (often called \"brain fog\"). Long COVID is a condition that affects people even after they have recovered from COVID-19, causing ongoi…",
      "summary": "Completed · Phase 2 · Ketamine Only — Plain Language Summary: This study is a clinical trial to see if ketamine can help treat symptoms of Long COVID, especially fatigue and problems with thinking clearly (often called \"brain fog\"). Long COVID is a condition that affects people even after they have ",
      "tags": [
        "Long COVID",
        "Completed",
        "Ketamine Only"
      ],
      "_osmf": {
        "nct_id": "NCT06821087",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2025-06-05",
        "last_updated": "2026-09-17",
        "agents": [
          "Ketamine Only"
        ]
      },
      "date_published": "2026-09-17T08:00:00+00:00",
      "date_modified": "2026-09-17T08:00:00+00:00"
    },
    {
      "id": "NCT05851859:2026-09-14",
      "url": "https://clinicaltrials.gov/study/NCT05851859",
      "title": "Evaluation of the Effectiveness of Breathing Control Technique on Long COVID Symptoms at the Reunion University Hospital",
      "content_text": "Recruiting · Not applicable · Cardiac Coherence — Despite the controversy, on October 6, 2021, the World Health Organization (WHO) recognized Long Coronavirus disease (COVID) by officially defining it: \" symptoms appeared 3 months after the onset of the primary infection by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), persistin…",
      "summary": "Recruiting · Not applicable · Cardiac Coherence — Despite the controversy, on October 6, 2021, the World Health Organization (WHO) recognized Long Coronavirus disease (COVID) by officially defining it: \" symptoms appeared 3 months after the onset of the primary infection by the Severe Acute Respirat",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Cardiac Coherence"
      ],
      "_osmf": {
        "nct_id": "NCT05851859",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2025-05-05",
        "last_updated": "2026-09-14",
        "agents": [
          "Cardiac Coherence"
        ]
      },
      "date_published": "2026-09-14T08:00:00+00:00",
      "date_modified": "2026-09-14T08:00:00+00:00"
    },
    {
      "id": "NCT05858515:2026-09-09",
      "url": "https://clinicaltrials.gov/study/NCT05858515",
      "title": "REVERSE-Long COVID-19 With Baricitinib Study",
      "content_text": "Withdrawn · Phase 3 · Baricitinib 4 Mg — REVERSE-LC is a phase 3 trial of baricitinib versus placebo in adults with neurocognitive impairment (a form of Alzheimer's Disease and Related Dementias or ADRD) or cardiopulmonary symptoms due to Long COVID.",
      "summary": "Withdrawn · Phase 3 · Baricitinib 4 Mg — REVERSE-LC is a phase 3 trial of baricitinib versus placebo in adults with neurocognitive impairment (a form of Alzheimer's Disease and Related Dementias or ADRD) or cardiopulmonary symptoms due to Long COVID.",
      "tags": [
        "Long COVID",
        "Withdrawn",
        "Baricitinib 4 Mg"
      ],
      "_osmf": {
        "nct_id": "NCT05858515",
        "status": "WITHDRAWN",
        "phase": "PHASE3",
        "start_date": "2024-10-21",
        "last_updated": "2026-09-09",
        "agents": [
          "Baricitinib 4 Mg"
        ]
      },
      "date_published": "2026-09-09T08:00:00+00:00",
      "date_modified": "2026-09-09T08:00:00+00:00"
    },
    {
      "id": "NCT07798570:2026-09-01",
      "url": "https://clinicaltrials.gov/study/NCT07798570",
      "title": "Observational Study With CICR-NAM as a Food for Special Medicinal Purposes in Post-COVID Syndrome (PCS)",
      "content_text": "Not Yet Recruiting · Not applicable · Cicr-Nam — In patients with post-COVID syndrome, changes in tryptophan metabolism, energy metabolism, and the gut microbiome may occur. In an earlier nutritional study, patients with COVID-19 recovered their physical performance more quickly when taking nicotinamide (vitamin B3). Patients who responded to nico…",
      "summary": "Not Yet Recruiting · Not applicable · Cicr-Nam — In patients with post-COVID syndrome, changes in tryptophan metabolism, energy metabolism, and the gut microbiome may occur. In an earlier nutritional study, patients with COVID-19 recovered their physical performance more quickly when taking nicotina",
      "tags": [
        "Long COVID",
        "Not Yet Recruiting",
        "Cicr-Nam"
      ],
      "_osmf": {
        "nct_id": "NCT07798570",
        "status": "NOT_YET_RECRUITING",
        "phase": "NA",
        "start_date": "2026-09-06",
        "last_updated": "2026-09-01",
        "agents": [
          "Cicr-Nam"
        ]
      },
      "date_published": "2026-09-01T08:00:00+00:00",
      "date_modified": "2026-09-01T08:00:00+00:00"
    },
    {
      "id": "NCT07140094:2026-08-31",
      "url": "https://clinicaltrials.gov/study/NCT07140094",
      "title": "Long-Covid-19 Alleviation Through Learning Mindfulness Study",
      "content_text": "Recruiting · Not applicable · Structured Mindfulness Intervention — This research is being done to study a mindfulness intervention among people who have symptoms of Post-Acute Sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID. Mindfulness is defined as paying attention to the present moment with non-judgment and acceptance. Here the investigators ar…",
      "summary": "Recruiting · Not applicable · Structured Mindfulness Intervention — This research is being done to study a mindfulness intervention among people who have symptoms of Post-Acute Sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID. Mindfulness is defined as paying attention to the presen",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Structured Mindfulness Intervention"
      ],
      "_osmf": {
        "nct_id": "NCT07140094",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2024-05-21",
        "last_updated": "2026-08-31",
        "agents": [
          "Structured Mindfulness Intervention"
        ]
      },
      "date_published": "2026-08-31T08:00:00+00:00",
      "date_modified": "2026-08-31T08:00:00+00:00"
    },
    {
      "id": "NCT05618574:2026-08-26",
      "url": "https://clinicaltrials.gov/study/NCT05618574",
      "title": "Nitrite Supplementation in Long COVID Patients",
      "content_text": "Completed · Phase 2 · 140 Ml Per Day Of Beet-It Nitrate Beverage — Potential benefits of a nitrate-rich juice supplement to improve skeletal muscle function and associated physical capacity will be studied in patients with Long COVID. Consenting patients with Long-COVID will be randomized to receive Beet-It nitrate beverage group versus a nitrate-depleted placebo b…",
      "summary": "Completed · Phase 2 · 140 Ml Per Day Of Beet-It Nitrate Beverage — Potential benefits of a nitrate-rich juice supplement to improve skeletal muscle function and associated physical capacity will be studied in patients with Long COVID. Consenting patients with Long-COVID will be randomized to receive",
      "tags": [
        "Long COVID",
        "Completed",
        "140 Ml Per Day Of Beet-It Nitrate Beverage"
      ],
      "_osmf": {
        "nct_id": "NCT05618574",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2023-12-01",
        "last_updated": "2026-08-26",
        "agents": [
          "140 Ml Per Day Of Beet-It Nitrate Beverage"
        ]
      },
      "date_published": "2026-08-26T08:00:00+00:00",
      "date_modified": "2026-08-26T08:00:00+00:00"
    },
    {
      "id": "NCT05703074:2026-08-25",
      "url": "https://clinicaltrials.gov/study/NCT05703074",
      "title": "Mental Intervention and Nicotinamide Riboside Supplementation in Long Covid",
      "content_text": "Completed · Phase 2 · Nicotinamide Riboside, Mind-Body Reprocessing Therapy, Care As Usual — Long COVID, also referred to as post-acute sequela of COVID-19 (PASC), is present in a substantial number of individuals, and treatment for this is warranted. Two different hypothetical models of Long COVID suggest attenuated mitochondrial energy production and functional brain alterations associate…",
      "summary": "Completed · Phase 2 · Nicotinamide Riboside, Mind-Body Reprocessing Therapy, Care As Usual — Long COVID, also referred to as post-acute sequela of COVID-19 (PASC), is present in a substantial number of individuals, and treatment for this is warranted. Two different hypothetical models of Long COVID ",
      "tags": [
        "Long COVID",
        "Completed",
        "Nicotinamide Riboside",
        "Mind-Body Reprocessing Therapy",
        "Care As Usual"
      ],
      "_osmf": {
        "nct_id": "NCT05703074",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2023-01-30",
        "last_updated": "2026-08-25",
        "agents": [
          "Nicotinamide Riboside",
          "Mind-Body Reprocessing Therapy",
          "Care As Usual"
        ]
      },
      "date_published": "2026-08-25T08:00:00+00:00",
      "date_modified": "2026-08-25T08:00:00+00:00"
    },
    {
      "id": "NCT07726082:2026-08-18",
      "url": "https://clinicaltrials.gov/study/NCT07726082",
      "title": "Micro-choice-based Intervention for Multicausal Fatigue",
      "content_text": "Recruiting · Not applicable · Micro-Choice-Based Intervention — This proof-of-concept study aims to evaluate the feasibility, acceptability, and potential benefits of a novel multimodal approach: the micro-choice-based intervention.",
      "summary": "Recruiting · Not applicable · Micro-Choice-Based Intervention — This proof-of-concept study aims to evaluate the feasibility, acceptability, and potential benefits of a novel multimodal approach: the micro-choice-based intervention.",
      "tags": [
        "Long COVID",
        "Recruiting",
        "Micro-Choice-Based Intervention"
      ],
      "_osmf": {
        "nct_id": "NCT07726082",
        "status": "RECRUITING",
        "phase": "NA",
        "start_date": "2026-08-13",
        "last_updated": "2026-08-18",
        "agents": [
          "Micro-Choice-Based Intervention"
        ]
      },
      "date_published": "2026-08-18T08:00:00+00:00",
      "date_modified": "2026-08-18T08:00:00+00:00"
    },
    {
      "id": "NCT05747534:2026-08-18",
      "url": "https://clinicaltrials.gov/study/NCT05747534",
      "title": "AT1001 for the Treatment of Long COVID",
      "content_text": "Completed · Phase 2 · Larazotide Acetate — The primary objective of this study is to evaluate the safety and efficacy of Larazotide (AT1001) versus placebo in children and adults 7 to ≤50 years of age who present with symptoms of Long COVID in the presence of SARS-CoV-2 antigenemia. AT1001 (n=100) or placebo (n=50) will be administered orall…",
      "summary": "Completed · Phase 2 · Larazotide Acetate — The primary objective of this study is to evaluate the safety and efficacy of Larazotide (AT1001) versus placebo in children and adults 7 to ≤50 years of age who present with symptoms of Long COVID in the presence of SARS-CoV-2 antigenemia. AT1001 (n=100) o",
      "tags": [
        "Long COVID",
        "Completed",
        "Larazotide Acetate"
      ],
      "_osmf": {
        "nct_id": "NCT05747534",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2023-05-31",
        "last_updated": "2026-08-18",
        "agents": [
          "Larazotide Acetate"
        ]
      },
      "date_published": "2026-08-18T08:00:00+00:00",
      "date_modified": "2026-08-18T08:00:00+00:00"
    },
    {
      "id": "NCT05705193:2026-08-14",
      "url": "https://clinicaltrials.gov/study/NCT05705193",
      "title": "Brain-Training Treatment for Long COVID in Older Adults",
      "content_text": "Completed · Not applicable · Neuroflex — This research is being done to collect preliminary data on the potential of computerized \"brain-training\" exercises for treating Long COVID symptoms in older adults. The investigators hypothesize that computerized brain-training will be an acceptable and feasible intervention for treating Long COVID…",
      "summary": "Completed · Not applicable · Neuroflex — This research is being done to collect preliminary data on the potential of computerized \"brain-training\" exercises for treating Long COVID symptoms in older adults. The investigators hypothesize that computerized brain-training will be an acceptable and feas",
      "tags": [
        "Long COVID",
        "Completed",
        "Neuroflex"
      ],
      "_osmf": {
        "nct_id": "NCT05705193",
        "status": "COMPLETED",
        "phase": "NA",
        "start_date": "2023-04-07",
        "last_updated": "2026-08-14",
        "agents": [
          "Neuroflex"
        ]
      },
      "date_published": "2026-08-14T08:00:00+00:00",
      "date_modified": "2026-08-14T08:00:00+00:00"
    },
    {
      "id": "NCT07682402:2026-08-13",
      "url": "https://clinicaltrials.gov/study/NCT07682402",
      "title": "Taurine Supplementation in Adolescents With Post-COVID Condition",
      "content_text": "Not Yet Recruiting · Phase 1 · Taurine — The COVID-19 pandemic has swept across the globe, affecting millions of individuals with varying degrees of severity. While many individuals recover from the acute phase of the infection, a significant proportion continue to experience persistent and debilitating symptoms long after the initial SARS…",
      "summary": "Not Yet Recruiting · Phase 1 · Taurine — The COVID-19 pandemic has swept across the globe, affecting millions of individuals with varying degrees of severity. While many individuals recover from the acute phase of the infection, a significant proportion continue to experience persistent and debilita",
      "tags": [
        "Long COVID",
        "Not Yet Recruiting",
        "Taurine"
      ],
      "_osmf": {
        "nct_id": "NCT07682402",
        "status": "NOT_YET_RECRUITING",
        "phase": "PHASE1",
        "start_date": "2026-09-30",
        "last_updated": "2026-08-13",
        "agents": [
          "Taurine"
        ]
      },
      "date_published": "2026-08-13T08:00:00+00:00",
      "date_modified": "2026-08-13T08:00:00+00:00"
    },
    {
      "id": "NCT05530317:2026-08-13",
      "url": "https://clinicaltrials.gov/study/NCT05530317",
      "title": "CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19",
      "content_text": "Terminated · Not applicable · Cardiac Rehabilitation — The goal of this proof-of-concept clinical trial is to determine whether cardiac rehabilitation improves exercise capacity and chronotropic (heart rate) response to exercise among people with Long COVID. The study will include individuals with confirmed SARS-CoV-2 infection, symptoms not present pri…",
      "summary": "Terminated · Not applicable · Cardiac Rehabilitation — The goal of this proof-of-concept clinical trial is to determine whether cardiac rehabilitation improves exercise capacity and chronotropic (heart rate) response to exercise among people with Long COVID. The study will include individuals with c",
      "tags": [
        "Long COVID",
        "Terminated",
        "Cardiac Rehabilitation"
      ],
      "_osmf": {
        "nct_id": "NCT05530317",
        "status": "TERMINATED",
        "phase": "NA",
        "start_date": "2022-12-21",
        "last_updated": "2026-08-13",
        "agents": [
          "Cardiac Rehabilitation"
        ]
      },
      "date_published": "2026-08-13T08:00:00+00:00",
      "date_modified": "2026-08-13T08:00:00+00:00"
    },
    {
      "id": "NCT05965739:2026-08-11",
      "url": "https://clinicaltrials.gov/study/NCT05965739",
      "title": "RECOVER-NEURO: Platform Protocol, Appendix_A to Measure the Effects of BrainHQ, PASC CoRE and tDCS Interventions on Long COVID Symptoms",
      "content_text": "Completed · Not applicable · Brainhq/Active Comparator Activity, Brainhq, Pasc Core, Tdcs-Active — This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-cen…",
      "summary": "Completed · Not applicable · Brainhq/Active Comparator Activity, Brainhq, Pasc Core, Tdcs-Active — This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrat",
      "tags": [
        "Long COVID",
        "Completed",
        "Brainhq/Active Comparator Activity",
        "Brainhq",
        "Pasc Core",
        "Tdcs-Active"
      ],
      "_osmf": {
        "nct_id": "NCT05965739",
        "status": "COMPLETED",
        "phase": "NA",
        "start_date": "2023-09-01",
        "last_updated": "2026-08-11",
        "agents": [
          "Brainhq/Active Comparator Activity",
          "Brainhq",
          "Pasc Core",
          "Tdcs-Active"
        ]
      },
      "date_published": "2026-08-11T08:00:00+00:00",
      "date_modified": "2026-08-11T08:00:00+00:00"
    },
    {
      "id": "NCT06643299:2026-08-07",
      "url": "https://clinicaltrials.gov/study/NCT06643299",
      "title": "Probiotic Use for Recovery Enhancement From Long COVID-19",
      "content_text": "Completed · Phase 2 · Probiotic Agent — The goal of this clinical trial is to learn if probiotics can improve symptoms and quality of life in participants with Long COVID.",
      "summary": "Completed · Phase 2 · Probiotic Agent — The goal of this clinical trial is to learn if probiotics can improve symptoms and quality of life in participants with Long COVID.",
      "tags": [
        "Long COVID",
        "Completed",
        "Probiotic Agent"
      ],
      "_osmf": {
        "nct_id": "NCT06643299",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "start_date": "2025-05-13",
        "last_updated": "2026-08-07",
        "agents": [
          "Probiotic Agent"
        ]
      },
      "date_published": "2026-08-07T08:00:00+00:00",
      "date_modified": "2026-08-07T08:00:00+00:00"
    },
    {
      "id": "NCT07745699:2026-08-06",
      "url": "https://clinicaltrials.gov/study/NCT07745699",
      "title": "Fully Remote, Telehealth-based Ketogenic Metabolic Therapy for Long COVID",
      "content_text": "Completed · Not applicable · Ketogenic Metabolic Therapy, Lifestyle Intervention — The goal of this clinical trial is to learn if a 12-week ketogenic diet program combined with lifestyle strategies (called KMT-LS) is practical and acceptable as a fully remote intervention for adults with Long COVID who also have Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. (ME/CFS) and dysa…",
      "summary": "Completed · Not applicable · Ketogenic Metabolic Therapy, Lifestyle Intervention — The goal of this clinical trial is to learn if a 12-week ketogenic diet program combined with lifestyle strategies (called KMT-LS) is practical and acceptable as a fully remote intervention for adults with Long COVID ",
      "tags": [
        "Long COVID",
        "Completed",
        "Ketogenic Metabolic Therapy",
        "Lifestyle Intervention"
      ],
      "_osmf": {
        "nct_id": "NCT07745699",
        "status": "COMPLETED",
        "phase": "NA",
        "start_date": "2024-12-10",
        "last_updated": "2026-08-06",
        "agents": [
          "Ketogenic Metabolic Therapy",
          "Lifestyle Intervention"
        ]
      },
      "date_published": "2026-08-06T08:00:00+00:00",
      "date_modified": "2026-08-06T08:00:00+00:00"
    }
  ]
}